UniProtKB - Q16760 (DGKD_HUMAN)

BLAST

>sp|Q16760|DGKD_HUMAN Diacylglycerol kinase delta OS=Homo sapiens OX=9606 GN=DGKD PE=1 SV=4
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGML
TKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITP
CRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVC
REALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLE
GNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTA
LNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPH
LGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGS
ACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFY
EDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCS
VLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARP
QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVC
PPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKIL
YPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDF
NNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAV
LNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCR
TVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCEL
PRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSM
DRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMD
RQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGA
PVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILC
GIKELSRSAPAVEA

Align

Format
Add to basket Added to basket
History
Entry version 199 (07 Nov 2018)
Sequence version 4 (17 Oct 2006)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Diacylglycerol kinase delta

Gene

DGKD

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May function as signaling molecule.1 Publication

Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.1 Publication

Catalytic activityⁱ

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Activity regulationⁱ

Partially inhibited by phosphatidylserine.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	163 – 213	Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST		51
Zinc fingerⁱ	235 – 286	Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST		52

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
diacylglycerol binding
Source: UniProtKB
Non-traceable author statementⁱ
- 12200442
diacylglycerol kinase activity
Source: MGI
Inferred from direct assayⁱ
- 12200442
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18334213
metal ion binding Source: UniProtKB-KW
NAD+ kinase activity Source: InterPro
protein heterodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 12200442
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 12200442

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

diacylglycerol metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 12200442
endocytosis Source: UniProtKB-KW
epidermal growth factor receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 12200442
lipid phosphorylation
Source: BHF-UCL
Traceable author statementⁱ
- 11309392
multicellular organism development
Source: UniProtKB
Non-traceable author statementⁱ
- 12200442
platelet activation Source: Reactome
protein homooligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 12200442
protein kinase C-activating G protein-coupled receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 12200442
protein transport Source: UniProtKB-KW
response to organic substance
Source: UniProtKB
Inferred from direct assayⁱ
- 12200442
second-messenger-mediated signaling
Source: UniProtKB
Non-traceable author statementⁱ
- 12200442
signal transduction
Source: UniProtKB
Traceable author statementⁱ
- 8626538

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Endocytosis, Protein transport, Transport
Ligand	ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAⁱ	2.7.1.107 2681
Reactomeⁱ	R-HSA-114508 Effects of PIP2 hydrolysis
SIGNORⁱ	Q16760

Chemistry databases

SwissLipidsⁱ	SLP:000000939 [Q16760-2]

SwissLipidsⁱ

SLP:000000939 [Q16760-2]

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Diacylglycerol kinase delta (EC:2.7.1.107) Short name: DAG kinase delta Alternative name(s): 130 kDa diacylglycerol kinase Diglyceride kinase delta Short name: DGK-delta
Gene namesⁱ	Name:DGKD Synonyms:KIAA0145
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000077044.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2851 DGKD
MIMⁱ	601826 gene
neXtProtⁱ	NX_Q16760

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	369	F → A: Reduces interaction with AP2A2; when associated with A-372. 1 Publication	1
Mutagenesisⁱ	372	F → A: Reduces interaction with AP2A2; when associated with A-369. 1 Publication	1
Mutagenesisⁱ	748	F → A: Reduces interaction with AP2A2. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8527
Open Targets More...OpenTargetsⁱ	ENSG00000077044
PharmGKBⁱ	PA27312

Chemistry databases

ChEMBLⁱ	CHEMBL1075120
Drug and drug target database More...DrugBankⁱ	DB00144 Phosphatidyl serine

Polymorphism and mutation databases

BioMutaⁱ	DGKD
DMDMⁱ	116241328

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218462	1 – 1214	Diacylglycerol kinase deltaAdd BLAST		1214

Post-translational modificationⁱ

Isoform 1 H domain is phosphorylated.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16760
PaxDbⁱ	Q16760
PeptideAtlas More...PeptideAtlasⁱ	Q16760
PRIDEⁱ	Q16760
ProteomicsDBⁱ	61052 61053 [Q16760-2]

PTM databases

iPTMnetⁱ	Q16760
PhosphoSitePlusⁱ	Q16760

Expressionⁱ

Tissue specificityⁱ

Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000077044 Expressed in 227 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_DGKD
ExpressionAtlasⁱ	Q16760 baseline and differential
Genevisibleⁱ	Q16760 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027530 HPA049101

HPAⁱ

HPA027530
HPA049101

Interactionⁱ

Subunit structureⁱ

The two isoforms are able to form homo- and hetero-oligomer structures (at least tetramers). Isoform 2 interacts with AP2A2.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DYSF	O75923	3	EBI-719333,EBI-2799016

With

Entry

#Exp.

IntAct

Notes

DYSF

O75923

EBI-719333,EBI-2799016

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18334213
protein heterodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 12200442
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 12200442

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114097, 12 interactors
Database of interacting proteins More...DIPⁱ	DIP-29646N
IntActⁱ	Q16760, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q16760
STRINGⁱ	9606.ENSP00000264057

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	238 – 241	Combined sources	4
Beta strandⁱ	250 – 252	Combined sources	3
Turnⁱ	259 – 261	Combined sources	3
Beta strandⁱ	265 – 270	Combined sources	6
Helixⁱ	276 – 281	Combined sources	6
Helixⁱ	1142 – 1144	Combined sources	3
Helixⁱ	1147 – 1156	Combined sources	10
Helixⁱ	1160 – 1162	Combined sources	3
Helixⁱ	1163 – 1168	Combined sources	6
Helixⁱ	1173 – 1176	Combined sources	4
Helixⁱ	1181 – 1186	Combined sources	6
Helixⁱ	1192 – 1206	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16760
SMRⁱ	Q16760
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q16760

EvolutionaryTraceⁱ

Q16760

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	53 – 146	PHPROSITE-ProRule annotationAdd BLAST	94
Domainⁱ	317 – 451	DAGKcPROSITE-ProRule annotationAdd BLAST	135
Domainⁱ	1145 – 1208	SAMPROSITE-ProRule annotationAdd BLAST	64

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	8 – 36	Pro-richAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the eukaryotic diacylglycerol kinase family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	163 – 213	Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST		51
Zinc fingerⁱ	235 – 286	Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST		52

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1170 Eukaryota ENOG410XSJR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119050
HOGENOMⁱ	HOG000234676
HOVERGENⁱ	HBG051346
InParanoidⁱ	Q16760
KEGG Orthology (KO) More...KOⁱ	K00901
OMAⁱ	VVEMVNN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00SK
PhylomeDBⁱ	Q16760
TreeFamⁱ	TF313104

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029 C1, 2 hits cd09575 SAM_DGK-delta, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.40.50.10330, 1 hit
InterProⁱ	View protein in InterPro IPR017438 ATP-NAD_kinase_N IPR037607 DGK IPR037606 DGK-delta_SAM IPR000756 Diacylglycerol_kin_accessory IPR001206 Diacylglycerol_kinase_cat_dom IPR016064 NAD/diacylglycerol_kinase_sf IPR002219 PE/DAG-bd IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR001660 SAM IPR013761 SAM/pointed_sf
PANTHERⁱ	PTHR11255 PTHR11255, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00130 C1_1, 2 hits PF00609 DAGK_acc, 1 hit PF00781 DAGK_cat, 1 hit PF00169 PH, 1 hit PF07647 SAM_2, 1 hit
SMARTⁱ	View protein in SMART SM00109 C1, 2 hits SM00045 DAGKa, 1 hit SM00046 DAGKc, 1 hit SM00233 PH, 1 hit SM00454 SAM, 1 hit
SUPFAMⁱ	SSF111331 SSF111331, 1 hit SSF47769 SSF47769, 1 hit
PROSITEⁱ	View protein in PROSITE PS50146 DAGK, 1 hit PS50003 PH_DOMAIN, 1 hit PS50105 SAM_DOMAIN, 1 hit PS00479 ZF_DAG_PE_1, 2 hits PS50081 ZF_DAG_PE_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 2 (identifier: Q16760-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAGAPPP GPPQPPPPPP PEESSDSEPE AEPGSPQKLI RKVSTSGQIR 
        60         70         80         90        100
QKTIIKEGML TKQNNSFQRS KRRYFKLRGR TLYYAKTAKS IIFDEVDLTD 
       110        120        130        140        150
ASVAESSTKN VNNSFTVITP CRKLILCADN RKEMEDWIAA LKTVQNREHF 
       160        170        180        190        200
EPTQYSMDHF SGMHNWYACS HARPTYCNVC REALSGVTSH GLSCEVCKFK 
       210        220        230        240        250
AHKRCAVRAT NNCKWTTLAS IGKDIIEDAD GIAMPHQWLE GNLPVSAKCT 
       260        270        280        290        300
VCDKTCGSVL RLQDWRCLWC KAMVHTSCKE SLLTKCPLGL CKVSVIPPTA 
       310        320        330        340        350
LNSIDSDGFW KASCPPSCTS PLLVFVNSKS GDNQGVKFLR RFKQLLNPAQ 
       360        370        380        390        400
VFDLMNGGPH LGLRLFQKFD TFRILVCGGD GSVGWVLSEI DSLNLHKQCQ 
       410        420        430        440        450
LGVLPLGTGN DLARVLGWGS ACDDDTQLPQ ILEKLERAST KMLDRWSVMA 
       460        470        480        490        500
YEAKLPRQAS SSTVTEDFSE DSEVQQILFY EDSVAAHLSK ILTSDQHSVV 
       510        520        530        540        550
ISSAKVLCET VKDFVARVGK AYEKTTESSE ESEVMAKKCS VLKEKLDSLL 
       560        570        580        590        600
KTLDDESQAS SSLPNPPPTI AEEAEDGDGS GSICGSTGDR LVASACPARP 
       610        620        630        640        650
QIFRPREQLM LRANSLKKAI RQIIEHTEKA VDEQNAQTQE QEGFVLGLSE 
       660        670        680        690        700
SEEKMDHRVC PPLSHSESFG VPKGRSQRKV SKSPCEKLIS KGSLSLGSSA 
       710        720        730        740        750
SLPPQPGSRD GLPALNTKIL YPNVRAGMSG SLPGGSVISR LLINADPFNS 
       760        770        780        790        800
EPETLEYYTE KCVMNNYFGI GLDAKISLDF NNKRDEHPEK CRSRTKNMMW 
       810        820        830        840        850
YGVLGTKELL HRTYKNLEQK VLLECDGRPI PLPSLQGIAV LNIPSYAGGT 
       860        870        880        890        900
NFWGGTKEDD TFAAPSFDDK ILEVVAVFGS MQMAVSRVIR LQHHRIAQCR 
       910        920        930        940        950
TVKISILGDE GVPVQVDGEA WVQPPGYIRI VHKNRAQTLT RDRAFESTLK 
       960        970        980        990       1000
SWEDKQKCEL PRPPSCSLHP EMLSEEEATQ MDQFGQAAGV LIHSIREIAQ 
      1010       1020       1030       1040       1050
SHRDMEQELA HAVNASSKSM DRVYGKPRTT EGLNCSFVLE MVNNFRALRS 
      1060       1070       1080       1090       1100
ETELLLSGKM ALQLDPPQKE QLGSALAEMD RQLRRLADTP WLCQSAEPGD 
      1110       1120       1130       1140       1150
EESVMLDLAK RSRSGKFRLV TKFKKEKNNK NKEAHSSLGA PVHLWGTEEV 
      1160       1170       1180       1190       1200
AAWLEHLSLC EYKDIFTRHD IRGSELLHLE RRDLKDLGVT KVGHMKRILC 
      1210 
GIKELSRSAP AVEA

Length:1,214

Mass (Da):134,525

Last modified:October 17, 2006 - v4

Checksum:ⁱED114429096D2112

Isoform 1 (identifier: Q16760-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-52: MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQK → MNMFLYFQ

« Hide

        10         20         30         40         50
MNMFLYFQTI IKEGMLTKQN NSFQRSKRRY FKLRGRTLYY AKTAKSIIFD 
        60         70         80         90        100
EVDLTDASVA ESSTKNVNNS FTVITPCRKL ILCADNRKEM EDWIAALKTV 
       110        120        130        140        150
QNREHFEPTQ YSMDHFSGMH NWYACSHARP TYCNVCREAL SGVTSHGLSC 
       160        170        180        190        200
EVCKFKAHKR CAVRATNNCK WTTLASIGKD IIEDADGIAM PHQWLEGNLP 
       210        220        230        240        250
VSAKCTVCDK TCGSVLRLQD WRCLWCKAMV HTSCKESLLT KCPLGLCKVS 
       260        270        280        290        300
VIPPTALNSI DSDGFWKASC PPSCTSPLLV FVNSKSGDNQ GVKFLRRFKQ 
       310        320        330        340        350
LLNPAQVFDL MNGGPHLGLR LFQKFDTFRI LVCGGDGSVG WVLSEIDSLN 
       360        370        380        390        400
LHKQCQLGVL PLGTGNDLAR VLGWGSACDD DTQLPQILEK LERASTKMLD 
       410        420        430        440        450
RWSVMAYEAK LPRQASSSTV TEDFSEDSEV QQILFYEDSV AAHLSKILTS 
       460        470        480        490        500
DQHSVVISSA KVLCETVKDF VARVGKAYEK TTESSEESEV MAKKCSVLKE 
       510        520        530        540        550
KLDSLLKTLD DESQASSSLP NPPPTIAEEA EDGDGSGSIC GSTGDRLVAS 
       560        570        580        590        600
ACPARPQIFR PREQLMLRAN SLKKAIRQII EHTEKAVDEQ NAQTQEQEGF 
       610        620        630        640        650
VLGLSESEEK MDHRVCPPLS HSESFGVPKG RSQRKVSKSP CEKLISKGSL 
       660        670        680        690        700
SLGSSASLPP QPGSRDGLPA LNTKILYPNV RAGMSGSLPG GSVISRLLIN 
       710        720        730        740        750
ADPFNSEPET LEYYTEKCVM NNYFGIGLDA KISLDFNNKR DEHPEKCRSR 
       760        770        780        790        800
TKNMMWYGVL GTKELLHRTY KNLEQKVLLE CDGRPIPLPS LQGIAVLNIP 
       810        820        830        840        850
SYAGGTNFWG GTKEDDTFAA PSFDDKILEV VAVFGSMQMA VSRVIRLQHH 
       860        870        880        890        900
RIAQCRTVKI SILGDEGVPV QVDGEAWVQP PGYIRIVHKN RAQTLTRDRA 
       910        920        930        940        950
FESTLKSWED KQKCELPRPP SCSLHPEMLS EEEATQMDQF GQAAGVLIHS 
       960        970        980        990       1000
IREIAQSHRD MEQELAHAVN ASSKSMDRVY GKPRTTEGLN CSFVLEMVNN 
      1010       1020       1030       1040       1050
FRALRSETEL LLSGKMALQL DPPQKEQLGS ALAEMDRQLR RLADTPWLCQ 
      1060       1070       1080       1090       1100
SAEPGDEESV MLDLAKRSRS GKFRLVTKFK KEKNNKNKEA HSSLGAPVHL 
      1110       1120       1130       1140       1150
WGTEEVAAWL EHLSLCEYKD IFTRHDIRGS ELLHLERRDL KDLGVTKVGH 
      1160       1170
MKRILCGIKE LSRSAPAVEA

Show »

Length:1,170

Mass (Da):130,326

Checksum:ⁱ00B7946AE15BC0A3

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7BZR7	H7BZR7_HUMAN	Diacylglycerol kinase delta Diacylglycerol kinase delta	DGKD	451	Annotation score:
C9JY42	C9JY42_HUMAN	Diacylglycerol kinase delta Diacylglycerol kinase delta	DGKD	157	Annotation score:
H7C0L1	H7C0L1_HUMAN	Diacylglycerol kinase delta Diacylglycerol kinase delta	DGKD	164	Annotation score:
A0A096LNI6	A0A096LNI6_HUMAN	Diacylglycerol kinase delta Diacylglycerol kinase delta	DGKD	163	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	511	V → P in BAA11134 (PubMed:8626538).Curated	1
Sequence conflictⁱ	828 – 834	RPIPLPS → DPSHSPV in BAA11134 (PubMed:8626538).Curated	7
Sequence conflictⁱ	960	L → V in BAC11809 (PubMed:12200442).Curated	1
Sequence conflictⁱ	960	L → V in BAA11134 (PubMed:8626538).Curated	1
Sequence conflictⁱ	1054	Missing in BAA11134 (PubMed:8626538).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012891	1 – 52	MAAAA…QIRQK → MNMFLYFQ in isoform 1. 2 PublicationsAdd BLAST		52

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB078966 mRNA Translation: BAC11809.1 D63479 mRNA Translation: BAA09766.3 D73409 mRNA Translation: BAA11134.1 BC006561 mRNA Translation: AAH06561.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2504.1 [Q16760-1] CCDS46546.1 [Q16760-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_003639.2, NM_003648.2 [Q16760-2] NP_690618.2, NM_152879.2 [Q16760-1]
UniGeneⁱ	Hs.471675

Genome annotation databases

Ensemblⁱ	ENST00000264057; ENSP00000264057; ENSG00000077044 [Q16760-1] ENST00000409813; ENSP00000386455; ENSG00000077044 [Q16760-2] ENST00000628356; ENSP00000487220; ENSG00000280873 [Q16760-1] ENST00000628527; ENSP00000487423; ENSG00000280873 [Q16760-2]
GeneIDⁱ	8527
KEGGⁱ	hsa:8527
UCSC genome browser More...UCSCⁱ	uc002vui.2 human [Q16760-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16760	Uncharacterized protein DGKD (Fragment)		HUMAN		116	UniRef100_Q16760
Q16760-2	Diacylglycerol kinase		HUMAN		1170	UniRef100_A0A024R495

Protein	Similar proteins		Species	Score	Length	Source
Q16760	Uncharacterized protein DGKD (Fragment)		HUMAN		116	UniRef90_Q16760
Diacylglycerol kinase		MACMU		1301
Diacylglycerol kinase		PANTR		1254
Diacylglycerol kinase		PANPA		1254
Diacylglycerol kinase		GORGO		1254
+115
Q16760-2	Diacylglycerol kinase		BOVIN		1164	UniRef90_F1MDC8
Diacylglycerol kinase		LIPVE		1222
Diacylglycerol kinase		DELLE		1216
Diacylglycerol kinase		PHYCD		1216
Diacylglycerol kinase		PIG		1216
+201

Protein	Similar proteins		Species	Score	Length	Source
Q16760	Diacylglycerol kinase eta		HUMAN		1220	UniRef50_Q16760
Diacylglycerol kinase		MACMU		1301
Diacylglycerol kinase		PANPA		1254
Diacylglycerol kinase		GORGO		1254
Diacylglycerol kinase		PANTR		1254
+929

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB078966 mRNA Translation: BAC11809.1 D63479 mRNA Translation: BAA09766.3 D73409 mRNA Translation: BAA11134.1 BC006561 mRNA Translation: AAH06561.1
CCDSⁱ	CCDS2504.1 [Q16760-1] CCDS46546.1 [Q16760-2]
RefSeqⁱ	NP_003639.2, NM_003648.2 [Q16760-2] NP_690618.2, NM_152879.2 [Q16760-1]
UniGeneⁱ	Hs.471675

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1R79	NMR	-	A	216-286	[»]
	3BQ7	X-ray	2.90	A/B/C/D/E/F	1141-1208	[»]
ProteinModelPortalⁱ	Q16760
SMRⁱ	Q16760
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114097, 12 interactors
DIPⁱ	DIP-29646N
IntActⁱ	Q16760, 10 interactors
MINTⁱ	Q16760
STRINGⁱ	9606.ENSP00000264057

Chemistry databases

ChEMBLⁱ	CHEMBL1075120
DrugBankⁱ	DB00144 Phosphatidyl serine
SwissLipidsⁱ	SLP:000000939 [Q16760-2]

PTM databases

iPTMnetⁱ	Q16760
PhosphoSitePlusⁱ	Q16760

Polymorphism and mutation databases

BioMutaⁱ	DGKD
DMDMⁱ	116241328

Proteomic databases

MaxQBⁱ	Q16760
PaxDbⁱ	Q16760
PeptideAtlasⁱ	Q16760
PRIDEⁱ	Q16760
ProteomicsDBⁱ	61052 61053 [Q16760-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000264057; ENSP00000264057; ENSG00000077044 [Q16760-1] ENST00000409813; ENSP00000386455; ENSG00000077044 [Q16760-2] ENST00000628356; ENSP00000487220; ENSG00000280873 [Q16760-1] ENST00000628527; ENSP00000487423; ENSG00000280873 [Q16760-2]
GeneIDⁱ	8527
KEGGⁱ	hsa:8527
UCSCⁱ	uc002vui.2 human [Q16760-1]

Organism-specific databases

CTDⁱ	8527
DisGeNETⁱ	8527
EuPathDBⁱ	HostDB:ENSG00000077044.9
GeneCardsⁱ	DGKD
H-InvDBⁱ	HIX0002934
HGNCⁱ	HGNC:2851 DGKD
HPAⁱ	HPA027530 HPA049101
MIMⁱ	601826 gene
neXtProtⁱ	NX_Q16760
OpenTargetsⁱ	ENSG00000077044
PharmGKBⁱ	PA27312
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1170 Eukaryota ENOG410XSJR LUCA
GeneTreeⁱ	ENSGT00760000119050
HOGENOMⁱ	HOG000234676
HOVERGENⁱ	HBG051346
InParanoidⁱ	Q16760
KOⁱ	K00901
OMAⁱ	VVEMVNN
OrthoDBⁱ	EOG091G00SK
PhylomeDBⁱ	Q16760
TreeFamⁱ	TF313104

Enzyme and pathway databases

BRENDAⁱ	2.7.1.107 2681
Reactomeⁱ	R-HSA-114508 Effects of PIP2 hydrolysis
SIGNORⁱ	Q16760

Miscellaneous databases

ChiTaRSⁱ	DGKD human
EvolutionaryTraceⁱ	Q16760
GeneWikiⁱ	DGKD
GenomeRNAiⁱ	8527
Protein Ontology More...PROⁱ	PR:Q16760
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000077044 Expressed in 227 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_DGKD
ExpressionAtlasⁱ	Q16760 baseline and differential
Genevisibleⁱ	Q16760 HS

Family and domain databases

CDDⁱ	cd00029 C1, 2 hits cd09575 SAM_DGK-delta, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit 3.40.50.10330, 1 hit
InterProⁱ	View protein in InterPro IPR017438 ATP-NAD_kinase_N IPR037607 DGK IPR037606 DGK-delta_SAM IPR000756 Diacylglycerol_kin_accessory IPR001206 Diacylglycerol_kinase_cat_dom IPR016064 NAD/diacylglycerol_kinase_sf IPR002219 PE/DAG-bd IPR011993 PH-like_dom_sf IPR001849 PH_domain IPR001660 SAM IPR013761 SAM/pointed_sf
PANTHERⁱ	PTHR11255 PTHR11255, 1 hit
Pfamⁱ	View protein in Pfam PF00130 C1_1, 2 hits PF00609 DAGK_acc, 1 hit PF00781 DAGK_cat, 1 hit PF00169 PH, 1 hit PF07647 SAM_2, 1 hit
SMARTⁱ	View protein in SMART SM00109 C1, 2 hits SM00045 DAGKa, 1 hit SM00046 DAGKc, 1 hit SM00233 PH, 1 hit SM00454 SAM, 1 hit
SUPFAMⁱ	SSF111331 SSF111331, 1 hit SSF47769 SSF47769, 1 hit
PROSITEⁱ	View protein in PROSITE PS50146 DAGK, 1 hit PS50003 PH_DOMAIN, 1 hit PS50105 SAM_DOMAIN, 1 hit PS00479 ZF_DAG_PE_1, 2 hits PS50081 ZF_DAG_PE_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DGKD_HUMAN
Accessionⁱ	Q16760Primary (citable) accession number: Q16760 Secondary accession number(s): Q14158, Q6PK55, Q8NG53
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 199 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16760 (DGKD_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Diacylglycerol kinase delta

DGKD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ