UniProtKB - Q16760 (DGKD_HUMAN)
Diacylglycerol kinase delta
DGKD
Functioni
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095).
Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity).
May also regulate clathrin-dependent endocytosis (PubMed:17880279).
By similarityCurated3 PublicationsCatalytic activityi
- EC:2.7.1.1073 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H+2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H+1 PublicationThis reaction proceeds in the forward1 Publication direction.
: glycerolipid metabolism Pathwayi
This protein is involved in the pathway glycerolipid metabolism, which is part of Lipid metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway glycerolipid metabolism and in Lipid metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 163 – 213 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 235 – 286 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 52 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- diacylglycerol binding Source: UniProtKB
- diacylglycerol kinase activity Source: UniProtKB
- identical protein binding Source: UniProtKB
- kinase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- NAD+ kinase activity Source: InterPro
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
GO - Biological processi
- diacylglycerol metabolic process Source: UniProtKB
- endocytosis Source: UniProtKB-KW
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- intracellular signal transduction Source: GO_Central
- lipid phosphorylation Source: UniProtKB
- negative regulation of protein kinase C signaling Source: UniProtKB
- phosphatidic acid biosynthetic process Source: UniProtKB
- platelet activation Source: Reactome
- positive regulation of clathrin-dependent endocytosis Source: UniProtKB
- positive regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- protein transport Source: UniProtKB-KW
- response to organic substance Source: UniProtKB
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Endocytosis, Lipid metabolism, Protein transport, Transport |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.1.107, 2681 |
PathwayCommonsi | Q16760 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis |
SignaLinki | Q16760 |
SIGNORi | Q16760 |
UniPathwayi | UPA00230 |
Chemistry databases
SwissLipidsi | SLP:000000939 [Q16760-2] |
Names & Taxonomyi
Protein namesi | Recommended name: Diacylglycerol kinase deltaCurated (EC:2.7.1.1073 Publications)Short name: DAG kinase delta Alternative name(s): 130 kDa diacylglycerol kinase Diglyceride kinase delta Short name: DGK-delta |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2851, DGKD |
MIMi | 601826, gene |
neXtProti | NX_Q16760 |
VEuPathDBi | HostDB:ENSG00000077044 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- clathrin-coated pit 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Isoform 1 translocation from cytoplasm to the plasma membrane is induced by phorbol esters (PubMed:12200442). Phorbol esters induce the conversion into the monomeric form which can translocate to the plasma membrane (PubMed:12084710).2 Publications
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleus Source: BHF-UCL
Plasma Membrane
- clathrin-coated pit Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: MGI
Keywords - Cellular componenti
Cell membrane, Coated pit, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 369 | F → A: Decreased interaction with AP2A2; when associated with A-372. 1 Publication | 1 | |
Mutagenesisi | 372 | F → A: Decreased interaction with AP2A2; when associated with A-369. 1 Publication | 1 | |
Mutagenesisi | 748 | F → A: Decreased interaction with AP2A2. 1 Publication | 1 | |
Mutagenesisi | 1145 | W → G: Loss of homooligomerization. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8527 |
OpenTargetsi | ENSG00000077044 |
PharmGKBi | PA27312 |
Miscellaneous databases
Pharosi | Q16760, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1075120 |
DrugBanki | DB14001, alpha-Tocopherol succinate DB00144, Phosphatidyl serine |
Genetic variation databases
BioMutai | DGKD |
DMDMi | 116241328 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218462 | 1 – 1214 | Diacylglycerol kinase deltaAdd BLAST | 1214 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q16760 |
jPOSTi | Q16760 |
MassIVEi | Q16760 |
MaxQBi | Q16760 |
PaxDbi | Q16760 |
PeptideAtlasi | Q16760 |
PRIDEi | Q16760 |
ProteomicsDBi | 61052 [Q16760-1] 61053 [Q16760-2] |
PTM databases
iPTMneti | Q16760 |
PhosphoSitePlusi | Q16760 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000077044, Expressed in stomach and 241 other tissues |
ExpressionAtlasi | Q16760, baseline and differential |
Genevisiblei | Q16760, HS |
Organism-specific databases
HPAi | ENSG00000077044, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Binary interactionsi
DGKD - isoform 1 [Q16760-2]
With | #Exp. | IntAct |
---|---|---|
itself | 5 | EBI-11147675,EBI-11147675 |
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- kinase binding Source: UniProtKB
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 114097, 25 interactors |
DIPi | DIP-29646N |
IntActi | Q16760, 16 interactors |
MINTi | Q16760 |
STRINGi | 9606.ENSP00000264057 |
Miscellaneous databases
RNActi | Q16760, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q16760 |
BMRBi | Q16760 |
SMRi | Q16760 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16760 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 146 | PHPROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 317 – 451 | DAGKcPROSITE-ProRule annotationAdd BLAST | 135 | |
Domaini | 1145 – 1208 | SAMPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | Regulates association with membranes1 PublicationAdd BLAST | 52 | |
Regioni | 1 – 47 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 554 – 584 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 655 – 684 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 24 | Pro residuesSequence analysisAdd BLAST | 24 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 163 – 213 | Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 235 – 286 | Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST | 52 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1170, Eukaryota |
GeneTreei | ENSGT00940000159041 |
HOGENOMi | CLU_001799_3_0_1 |
InParanoidi | Q16760 |
OMAi | SKAPCEK |
OrthoDBi | 43384at2759 |
PhylomeDBi | Q16760 |
TreeFami | TF313104 |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd09575, SAM_DGK-delta, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR046349, C1-like_sf IPR037607, DGK IPR037606, DGK-delta_SAM IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001660, SAM IPR013761, SAM/pointed_sf |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit PF00169, PH, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit SM00233, PH, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit SSF47769, SSF47769, 1 hit SSF57889, SSF57889, 2 hits |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit PS50003, PH_DOMAIN, 1 hit PS50105, SAM_DOMAIN, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAGAPPP GPPQPPPPPP PEESSDSEPE AEPGSPQKLI RKVSTSGQIR
60 70 80 90 100
QKTIIKEGML TKQNNSFQRS KRRYFKLRGR TLYYAKTAKS IIFDEVDLTD
110 120 130 140 150
ASVAESSTKN VNNSFTVITP CRKLILCADN RKEMEDWIAA LKTVQNREHF
160 170 180 190 200
EPTQYSMDHF SGMHNWYACS HARPTYCNVC REALSGVTSH GLSCEVCKFK
210 220 230 240 250
AHKRCAVRAT NNCKWTTLAS IGKDIIEDAD GIAMPHQWLE GNLPVSAKCT
260 270 280 290 300
VCDKTCGSVL RLQDWRCLWC KAMVHTSCKE SLLTKCPLGL CKVSVIPPTA
310 320 330 340 350
LNSIDSDGFW KASCPPSCTS PLLVFVNSKS GDNQGVKFLR RFKQLLNPAQ
360 370 380 390 400
VFDLMNGGPH LGLRLFQKFD TFRILVCGGD GSVGWVLSEI DSLNLHKQCQ
410 420 430 440 450
LGVLPLGTGN DLARVLGWGS ACDDDTQLPQ ILEKLERAST KMLDRWSVMA
460 470 480 490 500
YEAKLPRQAS SSTVTEDFSE DSEVQQILFY EDSVAAHLSK ILTSDQHSVV
510 520 530 540 550
ISSAKVLCET VKDFVARVGK AYEKTTESSE ESEVMAKKCS VLKEKLDSLL
560 570 580 590 600
KTLDDESQAS SSLPNPPPTI AEEAEDGDGS GSICGSTGDR LVASACPARP
610 620 630 640 650
QIFRPREQLM LRANSLKKAI RQIIEHTEKA VDEQNAQTQE QEGFVLGLSE
660 670 680 690 700
SEEKMDHRVC PPLSHSESFG VPKGRSQRKV SKSPCEKLIS KGSLSLGSSA
710 720 730 740 750
SLPPQPGSRD GLPALNTKIL YPNVRAGMSG SLPGGSVISR LLINADPFNS
760 770 780 790 800
EPETLEYYTE KCVMNNYFGI GLDAKISLDF NNKRDEHPEK CRSRTKNMMW
810 820 830 840 850
YGVLGTKELL HRTYKNLEQK VLLECDGRPI PLPSLQGIAV LNIPSYAGGT
860 870 880 890 900
NFWGGTKEDD TFAAPSFDDK ILEVVAVFGS MQMAVSRVIR LQHHRIAQCR
910 920 930 940 950
TVKISILGDE GVPVQVDGEA WVQPPGYIRI VHKNRAQTLT RDRAFESTLK
960 970 980 990 1000
SWEDKQKCEL PRPPSCSLHP EMLSEEEATQ MDQFGQAAGV LIHSIREIAQ
1010 1020 1030 1040 1050
SHRDMEQELA HAVNASSKSM DRVYGKPRTT EGLNCSFVLE MVNNFRALRS
1060 1070 1080 1090 1100
ETELLLSGKM ALQLDPPQKE QLGSALAEMD RQLRRLADTP WLCQSAEPGD
1110 1120 1130 1140 1150
EESVMLDLAK RSRSGKFRLV TKFKKEKNNK NKEAHSSLGA PVHLWGTEEV
1160 1170 1180 1190 1200
AAWLEHLSLC EYKDIFTRHD IRGSELLHLE RRDLKDLGVT KVGHMKRILC
1210
GIKELSRSAP AVEA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZR7 | H7BZR7_HUMAN | Diacylglycerol kinase delta | DGKD | 451 | Annotation score: | ||
C9JY42 | C9JY42_HUMAN | Diacylglycerol kinase delta | DGKD | 157 | Annotation score: | ||
H7C0L1 | H7C0L1_HUMAN | Diacylglycerol kinase delta | DGKD | 164 | Annotation score: | ||
A0A096LNI6 | A0A096LNI6_HUMAN | Diacylglycerol kinase delta | DGKD | 163 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 511 | V → P in BAA11134 (PubMed:8626538).Curated | 1 | |
Sequence conflicti | 828 – 834 | RPIPLPS → DPSHSPV in BAA11134 (PubMed:8626538).Curated | 7 | |
Sequence conflicti | 960 | L → V in BAC11809 (PubMed:12200442).Curated | 1 | |
Sequence conflicti | 960 | L → V in BAA11134 (PubMed:8626538).Curated | 1 | |
Sequence conflicti | 1054 | Missing in BAA11134 (PubMed:8626538).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012891 | 1 – 52 | MAAAA…QIRQK → MNMFLYFQ in isoform 1. 2 PublicationsAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB078966 mRNA Translation: BAC11809.1 D63479 mRNA Translation: BAA09766.3 D73409 mRNA Translation: BAA11134.1 BC006561 mRNA Translation: AAH06561.1 |
CCDSi | CCDS2504.1 [Q16760-1] CCDS46546.1 [Q16760-2] |
RefSeqi | NP_003639.2, NM_003648.2 [Q16760-2] NP_690618.2, NM_152879.2 [Q16760-1] |
Genome annotation databases
Ensembli | ENST00000264057.7; ENSP00000264057.2; ENSG00000077044.11 ENST00000409813.7; ENSP00000386455.3; ENSG00000077044.11 [Q16760-2] ENST00000628356.4; ENSP00000487220.1; ENSG00000280873.5 ENST00000628527.2; ENSP00000487423.1; ENSG00000280873.5 [Q16760-2] |
GeneIDi | 8527 |
KEGGi | hsa:8527 |
MANE-Selecti | ENST00000264057.7; ENSP00000264057.2; NM_152879.3; NP_690618.2 |
UCSCi | uc002vui.2, human [Q16760-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB078966 mRNA Translation: BAC11809.1 D63479 mRNA Translation: BAA09766.3 D73409 mRNA Translation: BAA11134.1 BC006561 mRNA Translation: AAH06561.1 |
CCDSi | CCDS2504.1 [Q16760-1] CCDS46546.1 [Q16760-2] |
RefSeqi | NP_003639.2, NM_003648.2 [Q16760-2] NP_690618.2, NM_152879.2 [Q16760-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1R79 | NMR | - | A | 216-286 | [»] | |
3BQ7 | X-ray | 2.90 | A/B/C/D/E/F | 1141-1208 | [»] | |
AlphaFoldDBi | Q16760 | |||||
BMRBi | Q16760 | |||||
SMRi | Q16760 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114097, 25 interactors |
DIPi | DIP-29646N |
IntActi | Q16760, 16 interactors |
MINTi | Q16760 |
STRINGi | 9606.ENSP00000264057 |
Chemistry databases
ChEMBLi | CHEMBL1075120 |
DrugBanki | DB14001, alpha-Tocopherol succinate DB00144, Phosphatidyl serine |
SwissLipidsi | SLP:000000939 [Q16760-2] |
PTM databases
iPTMneti | Q16760 |
PhosphoSitePlusi | Q16760 |
Genetic variation databases
BioMutai | DGKD |
DMDMi | 116241328 |
Proteomic databases
EPDi | Q16760 |
jPOSTi | Q16760 |
MassIVEi | Q16760 |
MaxQBi | Q16760 |
PaxDbi | Q16760 |
PeptideAtlasi | Q16760 |
PRIDEi | Q16760 |
ProteomicsDBi | 61052 [Q16760-1] 61053 [Q16760-2] |
Protocols and materials databases
Antibodypediai | 34452, 171 antibodies from 28 providers |
DNASUi | 8527 |
Genome annotation databases
Ensembli | ENST00000264057.7; ENSP00000264057.2; ENSG00000077044.11 ENST00000409813.7; ENSP00000386455.3; ENSG00000077044.11 [Q16760-2] ENST00000628356.4; ENSP00000487220.1; ENSG00000280873.5 ENST00000628527.2; ENSP00000487423.1; ENSG00000280873.5 [Q16760-2] |
GeneIDi | 8527 |
KEGGi | hsa:8527 |
MANE-Selecti | ENST00000264057.7; ENSP00000264057.2; NM_152879.3; NP_690618.2 |
UCSCi | uc002vui.2, human [Q16760-1] |
Organism-specific databases
CTDi | 8527 |
DisGeNETi | 8527 |
GeneCardsi | DGKD |
HGNCi | HGNC:2851, DGKD |
HPAi | ENSG00000077044, Tissue enhanced (skeletal) |
MIMi | 601826, gene |
neXtProti | NX_Q16760 |
OpenTargetsi | ENSG00000077044 |
PharmGKBi | PA27312 |
VEuPathDBi | HostDB:ENSG00000077044 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1170, Eukaryota |
GeneTreei | ENSGT00940000159041 |
HOGENOMi | CLU_001799_3_0_1 |
InParanoidi | Q16760 |
OMAi | SKAPCEK |
OrthoDBi | 43384at2759 |
PhylomeDBi | Q16760 |
TreeFami | TF313104 |
Enzyme and pathway databases
UniPathwayi | UPA00230 |
BRENDAi | 2.7.1.107, 2681 |
PathwayCommonsi | Q16760 |
Reactomei | R-HSA-114508, Effects of PIP2 hydrolysis |
SignaLinki | Q16760 |
SIGNORi | Q16760 |
Miscellaneous databases
BioGRID-ORCSi | 8527, 39 hits in 1093 CRISPR screens |
ChiTaRSi | DGKD, human |
EvolutionaryTracei | Q16760 |
GeneWikii | DGKD |
GenomeRNAii | 8527 |
Pharosi | Q16760, Tbio |
PROi | PR:Q16760 |
RNActi | Q16760, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077044, Expressed in stomach and 241 other tissues |
ExpressionAtlasi | Q16760, baseline and differential |
Genevisiblei | Q16760, HS |
Family and domain databases
CDDi | cd00029, C1, 2 hits cd09575, SAM_DGK-delta, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit 3.40.50.10330, 1 hit |
InterProi | View protein in InterPro IPR017438, ATP-NAD_kinase_N IPR046349, C1-like_sf IPR037607, DGK IPR037606, DGK-delta_SAM IPR000756, Diacylglycerol_kin_accessory IPR001206, Diacylglycerol_kinase_cat_dom IPR016064, NAD/diacylglycerol_kinase_sf IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001660, SAM IPR013761, SAM/pointed_sf |
PANTHERi | PTHR11255, PTHR11255, 1 hit |
Pfami | View protein in Pfam PF00130, C1_1, 2 hits PF00609, DAGK_acc, 1 hit PF00781, DAGK_cat, 1 hit PF00169, PH, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 2 hits SM00045, DAGKa, 1 hit SM00046, DAGKc, 1 hit SM00233, PH, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF111331, SSF111331, 1 hit SSF47769, SSF47769, 1 hit SSF57889, SSF57889, 2 hits |
PROSITEi | View protein in PROSITE PS50146, DAGK, 1 hit PS50003, PH_DOMAIN, 1 hit PS50105, SAM_DOMAIN, 1 hit PS00479, ZF_DAG_PE_1, 2 hits PS50081, ZF_DAG_PE_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | DGKD_HUMAN | |
Accessioni | Q16760Primary (citable) accession number: Q16760 Secondary accession number(s): Q14158, Q6PK55, Q8NG53 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | May 25, 2022 | |
This is version 221 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families