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Protein
Submitted name:

Debrisoquine 4-hydroxylase mutant allele (CYP2D6-MA1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Debrisoquine 4-hydroxylase mutant allele (CYP2D6-MA1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 23HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiQ16753

Structurei

3D structure databases

ProteinModelPortaliQ16753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG015789

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q16753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYSPGPLPL PGLGNLLHVD
60 70 80 90 100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA MVTRGEDTAD
110 120 130 140 150
RPPVPITQIL GFGPRSQGKQ RGVPGALWAR VARAEALLRL HLAQLGPGQE
160 170 180 190 200
VAGAVGDRGG RLPLCRLRQP LRRPFRPNGL LDKAVSNVIA SLTCGRRFEY
210 220 230 240 250
DDPRFLRLLD LAQEGLKEES GFLREVLNAV PVLLHIPALA GKVLRFQKAF
260 270 280 290 300
LTQLDELLTE HRMTWDPAQP PRDLTEAFLA EMEKAKGNPE SSFNDENLRI
310 320 330 340 350
VVADLFSAGM VTTSTTLAWG LLLMILHPDV QRRVQQEIDD VIGQVRRPEM
360 370 380 390 400
GDQAHMPYTT AVIHEVQRFG DIVPLGVTHM TSRDIEVQGF RIPKGTTLIT
410 420 430 440 450
NLSSVLKDEA VWEKPFRFHP EHFLDAQGHF VKPEAFLPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TSLLQHFSFS VPTGQPRPSH HGVFAFLVTP SPYELCAVPR
Length:500
Mass (Da):55,890
Last modified:November 1, 1996 - v1
Checksum:iD5293E9BF74692C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33189 Genomic DNA Translation: AAA35737.1
UniGeneiHs.648256

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33189 Genomic DNA Translation: AAA35737.1
UniGeneiHs.648256

3D structure databases

ProteinModelPortaliQ16753
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ16753

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG015789

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008069 Cyt_P450_E_grp-I_CYP2D-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01686 EP450ICYP2D
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ16753_HUMAN
AccessioniPrimary (citable) accession number: Q16753
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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