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UniProtKB - Q16740 (CLPP_HUMAN)

Entry version 188 (25 May 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

ATP-dependent Clp protease proteolytic subunit, mitochondrial

Gene

CLPP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782).

Cleaves PINK1 in the mitochondrion (PubMed:22354088).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei153Nucleophile1 Publication1
Active sitei178By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.21.92, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16740

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16740

Protein family/group databases

MEROPS protease database

More...MEROPSi		S14.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC:3.4.21.923 Publications)
Alternative name(s):
Endopeptidase Clp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2084, CLPP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601119, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16740

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125656

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Perrault syndrome 3 (PRLTS3)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA sex-influenced disorder characterized by sensorineural deafness in both males and females, and ovarian dysgenesis in females. Affected females have primary amenorrhea, streak gonads, and infertility, whereas affected males show normal pubertal development and are fertile. A spectrum of additional clinical features, including cerebellar ataxia, learning disability, and peripheral neuropathy, have been described in some PRLTS3 affected individuals.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070092145T → P in PRLTS3. 1 PublicationCorresponds to variant dbSNP:rs398123033EnsemblClinVar.1
Natural variantiVAR_070093147C → S in PRLTS3. 1 PublicationCorresponds to variant dbSNP:rs398123034EnsemblClinVar.1
Natural variantiVAR_074160229Y → D in PRLTS3. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58 – 61Missing : Abolishes protease activity. 1 Publication4
Mutagenesisi153S → A or C: Abolishes protease activity. 1 Publication1

Keywords - Diseasei

Deafness, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		8192

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CLPP

MalaCards human disease database

More...MalaCardsi		CLPP
MIMi614129, phenotype

Open Targets

More...OpenTargetsi		ENSG00000125656

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2855, Perrault syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26610

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16740, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523305

Drug and drug target database

More...DrugBanki		DB04464, N-Formylmethionine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CLPP

Domain mapping of disease mutations (DMDM)

More...DMDMi		3023512

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 56MitochondrionCombined sources1 PublicationAdd BLAST56
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000551657 – 277ATP-dependent Clp protease proteolytic subunit, mitochondrialAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei200N6-succinyllysineBy similarity1
Modified residuei211N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16740

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16740

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16740

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16740

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16740

PeptideAtlas

More...PeptideAtlasi		Q16740

PRoteomics IDEntifications database

More...PRIDEi		Q16740

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61051

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q16740

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16740

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q16740

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16740

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125656, Expressed in gastrocnemius and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16740, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16740, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125656, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Fourteen CLPP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity.

Component of the Clp complex formed by the assembly of two CLPP heptameric rings with two CLPX hexameric rings, giving rise to a symmetrical structure with two central CLPP rings flanked by a CLPX ring at either end of the complex.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113835, 344 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6177, Mitochondrial endopeptidase ClpXP complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q16740

Database of interacting proteins

More...DIPi		DIP-50384N

Protein interaction database and analysis system

More...IntActi		Q16740, 108 interactors

Molecular INTeraction database

More...MINTi		Q16740

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000245816

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q16740

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16740, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1277
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q16740

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16740

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16740

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni246 – 277DisorderedSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S14 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0840, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005830

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16740

Identification of Orthologs from Complete Genome Data

More...OMAi		RDYWMKA

Database of Orthologous Groups

More...OrthoDBi		1274502at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16740

TreeFam database of animal gene trees

More...TreeFami		TF105002

Family and domain databases

Conserved Domains Database

More...CDDi		cd07017, S14_ClpP_2, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00444, ClpP, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001907, ClpP
IPR029045, ClpP/crotonase-like_dom_sf
IPR023562, ClpP/TepA
IPR033135, ClpP_His_AS
IPR018215, ClpP_Ser_AS

The PANTHER Classification System

More...PANTHERi		PTHR10381, PTHR10381, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00574, CLP_protease, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00127, CLPPROTEASEP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52096, SSF52096, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00382, CLP_PROTEASE_HIS, 1 hit
PS00381, CLP_PROTEASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q16740-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPGILVGGA RVASCRYPAL GPRLAAHFPA QRPPQRTLQN GLALQRCLHA 
        60         70         80         90        100
TATRALPLIP IVVEQTGRGE RAYDIYSRLL RERIVCVMGP IDDSVASLVI 
       110        120        130        140        150
AQLLFLQSES NKKPIHMYIN SPGGVVTAGL AIYDTMQYIL NPICTWCVGQ 
       160        170        180        190        200
AASMGSLLLA AGTPGMRHSL PNSRIMIHQP SGGARGQATD IAIQAEEIMK 
       210        220        230        240        250
LKKQLYNIYA KHTKQSLQVI ESAMERDRYM SPMEAQEFGI LDKVLVHPPQ 
       260        270 
DGEDEPTLVQ KEPVEAAPAA EPVPAST
Length:277
Mass (Da):30,180
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB03AAC5D50F7880E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R208M0R208_HUMAN
ATP-dependent Clp protease proteoly...
CLPP
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEF5A0A2R8YEF5_HUMAN
Endopeptidase Clp
CLPP
33Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXE9M0QXE9_HUMAN
ATP-dependent Clp protease proteoly...
CLPP
71Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYV5M0QYV5_HUMAN
ATP-dependent Clp protease proteoly...
CLPP
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111N → S in BAG34912 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070092145T → P in PRLTS3. 1 PublicationCorresponds to variant dbSNP:rs398123033EnsemblClinVar.1
Natural variantiVAR_070093147C → S in PRLTS3. 1 PublicationCorresponds to variant dbSNP:rs398123034EnsemblClinVar.1
Natural variantiVAR_074160229Y → D in PRLTS3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z50853 mRNA Translation: CAA90705.1
AK311973 mRNA Translation: BAG34912.1
BC002956 mRNA Translation: AAH02956.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12162.1

Protein sequence database of the Protein Information Resource

More...PIRi		S68421

NCBI Reference Sequences

More...RefSeqi		NP_006003.1, NM_006012.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000245816.11; ENSP00000245816.3; ENSG00000125656.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8192

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8192

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000245816.11; ENSP00000245816.3; NM_006012.4; NP_006003.1

UCSC genome browser

More...UCSCi		uc002mem.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50853 mRNA Translation: CAA90705.1
AK311973 mRNA Translation: BAG34912.1
BC002956 mRNA Translation: AAH02956.1
CCDSiCCDS12162.1
PIRiS68421
RefSeqiNP_006003.1, NM_006012.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TG6X-ray2.10A/B/C/D/E/F/G1-277[»]
6BBAX-ray2.80A/B/C/D/E/F/G58-277[»]
6DL7X-ray2.00A/B/C/D/E/F/G58-277[»]
6H23X-ray3.09A/B/C/D/E/F/G/H/I/J/K/L/M/N57-277[»]
AlphaFoldDBiQ16740
SMRiQ16740
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113835, 344 interactors
ComplexPortaliCPX-6177, Mitochondrial endopeptidase ClpXP complex
CORUMiQ16740
DIPiDIP-50384N
IntActiQ16740, 108 interactors
MINTiQ16740
STRINGi9606.ENSP00000245816

Chemistry databases

BindingDBiQ16740
ChEMBLiCHEMBL4523305
DrugBankiDB04464, N-Formylmethionine

Protein family/group databases

MEROPSiS14.003

PTM databases

iPTMnetiQ16740
MetOSiteiQ16740
PhosphoSitePlusiQ16740

Genetic variation databases

BioMutaiCLPP
DMDMi3023512

Proteomic databases

EPDiQ16740
jPOSTiQ16740
MassIVEiQ16740
MaxQBiQ16740
PaxDbiQ16740
PeptideAtlasiQ16740
PRIDEiQ16740
ProteomicsDBi61051
TopDownProteomicsiQ16740

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1703, 350 antibodies from 35 providers

The DNASU plasmid repository

More...DNASUi		8192

Genome annotation databases

EnsembliENST00000245816.11; ENSP00000245816.3; ENSG00000125656.11
GeneIDi8192
KEGGihsa:8192
MANE-SelectiENST00000245816.11; ENSP00000245816.3; NM_006012.4; NP_006003.1
UCSCiuc002mem.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8192
DisGeNETi8192

GeneCards: human genes, protein and diseases

More...GeneCardsi		CLPP
GeneReviewsiCLPP
HGNCiHGNC:2084, CLPP
HPAiENSG00000125656, Low tissue specificity
MalaCardsiCLPP
MIMi601119, gene
614129, phenotype
neXtProtiNX_Q16740
OpenTargetsiENSG00000125656
Orphaneti2855, Perrault syndrome
PharmGKBiPA26610
VEuPathDBiHostDB:ENSG00000125656

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0840, Eukaryota
GeneTreeiENSGT00390000005830
InParanoidiQ16740
OMAiRDYWMKA
OrthoDBi1274502at2759
PhylomeDBiQ16740
TreeFamiTF105002

Enzyme and pathway databases

BRENDAi3.4.21.92, 2681
PathwayCommonsiQ16740
SignaLinkiQ16740

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8192, 38 hits in 1076 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CLPP, human
EvolutionaryTraceiQ16740

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CLPP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8192
PharosiQ16740, Tchem

Protein Ontology

More...PROi		PR:Q16740
RNActiQ16740, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125656, Expressed in gastrocnemius and 241 other tissues
ExpressionAtlasiQ16740, baseline and differential
GenevisibleiQ16740, HS

Family and domain databases

CDDicd07017, S14_ClpP_2, 1 hit
HAMAPiMF_00444, ClpP, 1 hit
InterProiView protein in InterPro
IPR001907, ClpP
IPR029045, ClpP/crotonase-like_dom_sf
IPR023562, ClpP/TepA
IPR033135, ClpP_His_AS
IPR018215, ClpP_Ser_AS
PANTHERiPTHR10381, PTHR10381, 1 hit
PfamiView protein in Pfam
PF00574, CLP_protease, 1 hit
PRINTSiPR00127, CLPPROTEASEP
SUPFAMiSSF52096, SSF52096, 1 hit
PROSITEiView protein in PROSITE
PS00382, CLP_PROTEASE_HIS, 1 hit
PS00381, CLP_PROTEASE_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLPP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16740
Secondary accession number(s): B2R4W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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