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UniProtKB - Q16720 (AT2B3_HUMAN)

Entry version 207 (25 May 2022)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Plasma membrane calcium-transporting ATPase 3

Gene

ATP2B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-driven Ca2+ ion pump involved in the maintenance of basal intracellular Ca2+ levels at the presynaptic terminals (PubMed:25953895, PubMed:27035656, PubMed:22912398, PubMed:18029012).

Uses ATP as an energy source to transport cytosolic Ca2+ ions across the plasma membrane to the extracellular compartment (PubMed:25953895, PubMed:27035656).

May counter-transport protons, but the mechanism and the stoichiometry of this Ca2+/H+ exchange remains to be established (By similarity).

By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Down-regulated by YWHAE.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4734-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi794MagnesiumBy similarity1
Metal bindingi798MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Translocase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		7.2.2.10, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16720

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418359, Reduction of cytosolic Ca++ levels
R-HSA-5578775, Ion homeostasis
R-HSA-936837, Ion transport by P-type ATPases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16720

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasma membrane calcium-transporting ATPase 3 (EC:7.2.2.102 Publications)
Short name:
PMCA31 Publication
Alternative name(s):
Plasma membrane calcium ATPase isoform 3
Plasma membrane calcium pump isoform 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP2B31 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:816, ATP2B3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300014, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16720

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000067842

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 155ExtracellularSequence analysisAdd BLAST37
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 364CytoplasmicSequence analysisAdd BLAST188
Transmembranei365 – 384HelicalSequence analysisAdd BLAST20
Topological domaini385 – 417ExtracellularSequence analysisAdd BLAST33
Transmembranei418 – 435HelicalSequence analysisAdd BLAST18
Topological domaini436 – 849CytoplasmicSequence analysisAdd BLAST414
Transmembranei850 – 869HelicalSequence analysisAdd BLAST20
Topological domaini870 – 879ExtracellularSequence analysis10
Transmembranei880 – 900HelicalSequence analysisAdd BLAST21
Topological domaini901 – 920CytoplasmicSequence analysisAdd BLAST20
Transmembranei921 – 943HelicalSequence analysisAdd BLAST23
Topological domaini944 – 961ExtracellularSequence analysisAdd BLAST18
Transmembranei962 – 983HelicalSequence analysisAdd BLAST22
Topological domaini984 – 1002CytoplasmicSequence analysisAdd BLAST19
Transmembranei1003 – 1024HelicalSequence analysisAdd BLAST22
Topological domaini1025 – 1034ExtracellularSequence analysis10
Transmembranei1035 – 1056HelicalSequence analysisAdd BLAST22
Topological domaini1057 – 1220CytoplasmicSequence analysisAdd BLAST164

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia, X-linked 1 (SCAX1)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAX1 is characterized by hypotonia at birth, delayed motor development, gait ataxia, difficulty standing, dysarthria, and slow eye movements. Brain MRI shows cerebellar ataxia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_084698482R → H in SCAX1; the mutant protein is expressed at the plasma membrane, but shows impaired extrusion of intracellular calcium. 1 Publication1
Natural variantiVAR_0693081107G → D in SCAX1; the mutant protein is expressed at the plasma membrane but shows impaired extrusion of intracellular calcium with prolonged retention of cytoplasmic calcium compared to wild-type under physiologic conditions. 1 PublicationCorresponds to variant dbSNP:rs397514619EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi473D → A: Impaired ATPase activity. 1 Publication1

Keywords - Diseasei

Disease variant, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		492

MalaCards human disease database

More...MalaCardsi		ATP2B3
MIMi302500, phenotype

Open Targets

More...OpenTargetsi		ENSG00000067842

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		85142, NON RARE IN EUROPE: Aldosterone-producing adenoma
314978, X-linked non progressive cerebellar ataxia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25109

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16720, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01189, Desflurane
DB01159, Halothane

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP2B3

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241261

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000462181 – 1220Plasma membrane calcium-transporting ATPase 3Add BLAST1220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineBy similarity1
Modified residuei1079PhosphothreonineBy similarity1
Modified residuei1113Phosphothreonine; by PKCBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16720

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16720

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16720

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16720

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16720

PeptideAtlas

More...PeptideAtlasi		Q16720

PRoteomics IDEntifications database

More...PRIDEi		Q16720

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61042 [Q16720-1]
61043 [Q16720-2]
61044 [Q16720-3]
61045 [Q16720-4]
61046 [Q16720-5]
61047 [Q16720-6]
61048 [Q16720-7]
61049 [Q16720-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16720

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16720

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q16720

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the cerebellum (PubMed:8187550). Expressed in adrenal glands (PubMed:27035656).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000067842, Expressed in endothelial cell and 123 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16720, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000067842, Tissue enriched (choroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDZD11 (PubMed:12763866).

Interacts (via N-terminus) with YWHAE (PubMed:18029012).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106982, 85 interactors

Protein interaction database and analysis system

More...IntActi		Q16720, 30 interactors

Molecular INTeraction database

More...MINTi		Q16720

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263519

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16720, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q16720

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16720

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni298 – 355DisorderedSequence analysisAdd BLAST58
Regioni1097 – 1114Calmodulin-binding subdomain ABy similarityAdd BLAST18
Regioni1115 – 1124Calmodulin-binding subdomain BBy similarity10
Regioni1166 – 1186DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi337 – 355Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0204, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160765

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002360_9_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16720

Identification of Orthologs from Complete Genome Data

More...OMAi		NRSPDFG

Database of Orthologous Groups

More...OrthoDBi		115892at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16720

TreeFam database of animal gene trees

More...TreeFami		TF300330

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022141, ATP_Ca_trans_C
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006408, P-type_ATPase_IIB
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12424, ATP_Ca_trans_C, 1 hit
PF00689, Cation_ATPase_C, 1 hit
PF00690, Cation_ATPase_N, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDF00027, p-type_atpase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00831, Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01517, ATPase-IIB_Ca, 1 hit
TIGR01494, ATPase_P-type, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, E and G). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.

This entry has 8 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform XB (identifier: Q16720-1) [UniParc]FASTAAdd to basket
Also known as: AIICI

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA 
       360        370        380        390        400
NAPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR 
       410        420        430        440        450
TWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK 
       460        470        480        490        500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA 
       510        520        530        540        550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF 
       560        570        580        590        600
VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 
       610        620        630        640        650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY 
       660        670        680        690        700
RDFSAGQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT 
       710        720        730        740        750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE 
       760        770        780        790        800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP 
       810        820        830        840        850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS 
       860        870        880        890        900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 
       910        920        930        940        950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF 
       960        970        980        990       1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI 
      1010       1020       1030       1040       1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV 
      1060       1070       1080       1090       1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG 
      1110       1120       1130       1140       1150
QILWFRGLNR IQTQIRVVKA FRSSLYEGLE KPESKTSIHN FMATPEFLIN 
      1160       1170       1180       1190       1200
DYTHNIPLID DTDVDENEER LRAPPPPSPN QNNNAIDSGI YLTTHVTKSA 
      1210       1220
TSSVFSSSPG SPLHSVETSL
Length:1,220
Mass (Da):134,197
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03B2BA8A0A33B193
GO
Isoform XA (identifier: Q16720-2) [UniParc]FASTAAdd to basket
Also known as: AIICII

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

Show »
Length:1,173
Mass (Da):128,545
Checksum:iEF3ACDF02DF40B8C
GO
Isoform ZA (identifier: Q16720-3) [UniParc]FASTAAdd to basket
Also known as: AICII

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

Show »
Length:1,159
Mass (Da):127,068
Checksum:iD092487DFC13E8A3
GO
Isoform ZB (identifier: Q16720-4) [UniParc]FASTAAdd to basket
Also known as: AICI

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.

Show »
Length:1,206
Mass (Da):132,721
Checksum:i2366490D5E398C08
GO
Isoform XE (identifier: Q16720-5) [UniParc]FASTAAdd to basket
Also known as: AIICV

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

Show »
Length:1,168
Mass (Da):128,110
Checksum:i79D7ED01B8F1BA88
GO
Isoform ZE (identifier: Q16720-6) [UniParc]FASTAAdd to basket
Also known as: AICV

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

Show »
Length:1,154
Mass (Da):126,634
Checksum:i6E34C22E92BEAE95
GO
Isoform XG (identifier: Q16720-7) [UniParc]FASTAAdd to basket
Also known as: AIICVII

The sequence of this isoform differs from the canonical sequence as follows:
     1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

Show »
Length:1,129
Mass (Da):124,236
Checksum:i17805052F1230AEF
GO
Isoform ZG (identifier: Q16720-8) [UniParc]FASTAAdd to basket
Also known as: AICVII

The sequence of this isoform differs from the canonical sequence as follows:
     306-319: Missing.
     1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

Show »
Length:1,115
Mass (Da):122,760
Checksum:i46F7F01999CFA318
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A804HKZ0A0A804HKZ0_HUMAN
Calcium-transporting ATPase
ATP2B3
895Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti587I → V in AAB09762 (PubMed:8765088).Curated1
Sequence conflicti587I → V in AAB38530 (PubMed:8765088).Curated1
Sequence conflicti654S → Y in AAB09762 (PubMed:8765088).Curated1
Sequence conflicti654S → Y in AAB38530 (PubMed:8765088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027928198I → M. Corresponds to variant dbSNP:rs2269409Ensembl.1
Natural variantiVAR_084697425 – 426Missing in an aldosterone-producing adenoma sample; somatic mutation; increases intracellular calcium concentration that leads to autonomous aldosterone secretion. 1 Publication2
Natural variantiVAR_084698482R → H in SCAX1; the mutant protein is expressed at the plasma membrane, but shows impaired extrusion of intracellular calcium. 1 Publication1
Natural variantiVAR_0693081107G → D in SCAX1; the mutant protein is expressed at the plasma membrane but shows impaired extrusion of intracellular calcium with prolonged retention of cytoplasmic calcium compared to wild-type under physiologic conditions. 1 PublicationCorresponds to variant dbSNP:rs397514619EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000392306 – 319Missing in isoform ZA, isoform ZB, isoform ZE and isoform ZG. CuratedAdd BLAST14
Alternative sequenceiVSP_0003931115 – 1220IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGNPGGESVP in isoform XA and isoform ZA. 1 PublicationAdd BLAST106
Alternative sequenceiVSP_0003941115 – 1220IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGSES in isoform XE and isoform ZE. CuratedAdd BLAST106
Alternative sequenceiVSP_0003951115 – 1220IRVVK…VETSL → VCWDGKKMLRTTEVG in isoform XG and isoform ZG. CuratedAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U57971 mRNA Translation: AAB09762.1
U60414 mRNA Translation: AAB38530.1
AH006061 Genomic DNA Translation: AAC15078.1
CH471172 Genomic DNA Translation: EAW72859.1
U82695 Genomic DNA No translation available.
U15689 mRNA Translation: AAA60986.1
U15690 mRNA Translation: AAA60987.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14722.1 [Q16720-2]
CCDS35440.1 [Q16720-1]

NCBI Reference Sequences

More...RefSeqi		NP_001001344.1, NM_001001344.2 [Q16720-1]
NP_068768.2, NM_021949.3 [Q16720-2]
XP_005274747.1, XM_005274690.3 [Q16720-1]
XP_005274748.1, XM_005274691.3 [Q16720-4]
XP_005274749.1, XM_005274692.3 [Q16720-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263519.5; ENSP00000263519.4; ENSG00000067842.18
ENST00000349466.6; ENSP00000343886.2; ENSG00000067842.18
ENST00000359149.8; ENSP00000352062.3; ENSG00000067842.18 [Q16720-2]
ENST00000370186.5; ENSP00000359205.1; ENSG00000067842.18 [Q16720-3]
ENST00000393842.5; ENSP00000377425.1; ENSG00000067842.18 [Q16720-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		492

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:492

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000263519.5; ENSP00000263519.4; NM_001001344.3; NP_001001344.1

UCSC genome browser

More...UCSCi		uc004fhs.2, human [Q16720-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57971 mRNA Translation: AAB09762.1
U60414 mRNA Translation: AAB38530.1
AH006061 Genomic DNA Translation: AAC15078.1
CH471172 Genomic DNA Translation: EAW72859.1
U82695 Genomic DNA No translation available.
U15689 mRNA Translation: AAA60986.1
U15690 mRNA Translation: AAA60987.1
CCDSiCCDS14722.1 [Q16720-2]
CCDS35440.1 [Q16720-1]
RefSeqiNP_001001344.1, NM_001001344.2 [Q16720-1]
NP_068768.2, NM_021949.3 [Q16720-2]
XP_005274747.1, XM_005274690.3 [Q16720-1]
XP_005274748.1, XM_005274691.3 [Q16720-4]
XP_005274749.1, XM_005274692.3 [Q16720-2]

3D structure databases

AlphaFoldDBiQ16720
SMRiQ16720
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106982, 85 interactors
IntActiQ16720, 30 interactors
MINTiQ16720
STRINGi9606.ENSP00000263519

Chemistry databases

DrugBankiDB01189, Desflurane
DB01159, Halothane

PTM databases

iPTMnetiQ16720
PhosphoSitePlusiQ16720
SwissPalmiQ16720

Genetic variation databases

BioMutaiATP2B3
DMDMi116241261

Proteomic databases

EPDiQ16720
jPOSTiQ16720
MassIVEiQ16720
MaxQBiQ16720
PaxDbiQ16720
PeptideAtlasiQ16720
PRIDEiQ16720
ProteomicsDBi61042 [Q16720-1]
61043 [Q16720-2]
61044 [Q16720-3]
61045 [Q16720-4]
61046 [Q16720-5]
61047 [Q16720-6]
61048 [Q16720-7]
61049 [Q16720-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		443, 71 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		492

Genome annotation databases

EnsembliENST00000263519.5; ENSP00000263519.4; ENSG00000067842.18
ENST00000349466.6; ENSP00000343886.2; ENSG00000067842.18
ENST00000359149.8; ENSP00000352062.3; ENSG00000067842.18 [Q16720-2]
ENST00000370186.5; ENSP00000359205.1; ENSG00000067842.18 [Q16720-3]
ENST00000393842.5; ENSP00000377425.1; ENSG00000067842.18 [Q16720-6]
GeneIDi492
KEGGihsa:492
MANE-SelectiENST00000263519.5; ENSP00000263519.4; NM_001001344.3; NP_001001344.1
UCSCiuc004fhs.2, human [Q16720-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		492
DisGeNETi492

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP2B3
HGNCiHGNC:816, ATP2B3
HPAiENSG00000067842, Tissue enriched (choroid)
MalaCardsiATP2B3
MIMi300014, gene
302500, phenotype
neXtProtiNX_Q16720
OpenTargetsiENSG00000067842
Orphaneti85142, NON RARE IN EUROPE: Aldosterone-producing adenoma
314978, X-linked non progressive cerebellar ataxia
PharmGKBiPA25109
VEuPathDBiHostDB:ENSG00000067842

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0204, Eukaryota
GeneTreeiENSGT00940000160765
HOGENOMiCLU_002360_9_0_1
InParanoidiQ16720
OMAiNRSPDFG
OrthoDBi115892at2759
PhylomeDBiQ16720
TreeFamiTF300330

Enzyme and pathway databases

BRENDAi7.2.2.10, 2681
PathwayCommonsiQ16720
ReactomeiR-HSA-418359, Reduction of cytosolic Ca++ levels
R-HSA-5578775, Ion homeostasis
R-HSA-936837, Ion transport by P-type ATPases
SignaLinkiQ16720

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		492, 13 hits in 696 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP2B3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATP2B3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		492
PharosiQ16720, Tbio

Protein Ontology

More...PROi		PR:Q16720
RNActiQ16720, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000067842, Expressed in endothelial cell and 123 other tissues
GenevisibleiQ16720, HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR022141, ATP_Ca_trans_C
IPR006068, ATPase_P-typ_cation-transptr_C
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006408, P-type_ATPase_IIB
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF12424, ATP_Ca_trans_C, 1 hit
PF00689, Cation_ATPase_C, 1 hit
PF00690, Cation_ATPase_N, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SMARTiView protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01517, ATPase-IIB_Ca, 1 hit
TIGR01494, ATPase_P-type, 3 hits
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT2B3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16720
Secondary accession number(s): B7WNR8
, B7WNY5, Q12995, Q16858
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: May 25, 2022
This is version 207 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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