ATP2B3

Functionⁱ

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Catalytic activityⁱ

ATP + H₂O + Ca²⁺(Side 1) = ADP + phosphate + Ca²⁺(Side 2).

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	473	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	794	MagnesiumBy similarity	1
Metal bindingⁱ	798	MagnesiumBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
calcium ion transmembrane transporter activity
Source: SynGO-UCL
Inferred from direct assayⁱ
- 18029012
calcium-transporting ATPase activity Source: GO_Central
calmodulin binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
PDZ domain binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion export across plasma membrane
Source: SynGO-UCL
Inferred from direct assayⁱ
- 18029012
ion transmembrane transport Source: Reactome
regulation of cardiac conduction Source: Reactome
regulation of cytosolic calcium ion concentration
Source: SynGO-UCL
Inferred from direct assayⁱ
- 18029012

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Hydrolase
Biological process	Calcium transport, Ion transport, Transport
Ligand	ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	3.6.3.8 2681
Reactomeⁱ	R-HSA-418359 Reduction of cytosolic Ca++ levels R-HSA-5578775 Ion homeostasis R-HSA-936837 Ion transport by P-type ATPases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasma membrane calcium-transporting ATPase 3 (EC:3.6.3.8) Short name: PMCA3 Alternative name(s): Plasma membrane calcium ATPase isoform 3 Plasma membrane calcium pump isoform 3
Gene namesⁱ	Name:ATP2B3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000067842.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:816 ATP2B3
MIMⁱ	300014 gene
neXtProtⁱ	NX_Q16720

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 97	CytoplasmicSequence analysisAdd BLAST	97
Transmembraneⁱ	98 – 118	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	119 – 155	ExtracellularSequence analysisAdd BLAST	37
Transmembraneⁱ	156 – 176	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	177 – 364	CytoplasmicSequence analysisAdd BLAST	188
Transmembraneⁱ	365 – 384	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	385 – 417	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	418 – 435	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	436 – 849	CytoplasmicSequence analysisAdd BLAST	414
Transmembraneⁱ	850 – 869	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	870 – 879	ExtracellularSequence analysis	10
Transmembraneⁱ	880 – 900	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	901 – 920	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	921 – 943	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	944 – 961	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	962 – 983	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	984 – 1002	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	1003 – 1024	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	1025 – 1034	ExtracellularSequence analysis	10
Transmembraneⁱ	1035 – 1056	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	1057 – 1220	CytoplasmicSequence analysisAdd BLAST	164

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spinocerebellar ataxia, X-linked 1 (SCAX1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAX1 is characterized by hypotonia at birth, delayed motor development, gait ataxia, difficulty standing, dysarthria, and slow eye movements. Brain MRI shows cerebellar ataxia.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_069308	1107	G → D in SCAX1; the mutant protein is expressed at the plasma membrane but shows impaired extrusion of intracellular calcium with prolonged retention of cytoplasmic calcium compared to wild-type under physiologic conditions. 1 PublicationCorresponds to variant dbSNP:rs397514619EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	492
MalaCards human disease database More...MalaCardsⁱ	ATP2B3
MIMⁱ	302500 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000067842
Orphanetⁱ	85142 Aldosterone-producing adenoma 314978 X-linked non progressive cerebellar ataxia
PharmGKBⁱ	PA25109

Polymorphism and mutation databases

BioMutaⁱ	ATP2B3
DMDMⁱ	116241261

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046218	1 – 1220	Plasma membrane calcium-transporting ATPase 3Add BLAST		1220

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	8	PhosphoserineBy similarity	1
Modified residueⁱ	1079	PhosphothreonineBy similarity	1
Modified residueⁱ	1113	Phosphothreonine; by PKCBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q16720
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16720
PaxDbⁱ	Q16720
PeptideAtlas More...PeptideAtlasⁱ	Q16720
PRIDEⁱ	Q16720
ProteomicsDBⁱ	61042 61043 [Q16720-2] 61044 [Q16720-3] 61045 [Q16720-4] 61046 [Q16720-5] 61047 [Q16720-6] 61048 [Q16720-7] 61049 [Q16720-8]

PTM databases

iPTMnetⁱ	Q16720
PhosphoSitePlusⁱ	Q16720
SwissPalmⁱ	Q16720

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the cerebellum, particulary in the presynaptic terminals of parallel fibers-Purkinje neurons. Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000067842 Expressed in 106 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_ATP2B3
Genevisibleⁱ	Q16720 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001583

HPAⁱ

HPA001583

Interactionⁱ

Subunit structureⁱ

Interacts with PDZD11.1 Publication

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW
PDZ domain binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106982, 44 interactors
IntActⁱ	Q16720, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q16720
STRINGⁱ	9606.ENSP00000263519

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16720
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1097 – 1114	Calmodulin-binding subdomain ABy similarityAdd BLAST		18
Regionⁱ	1115 – 1124	Calmodulin-binding subdomain BBy similarity		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	297 – 300	Poly-Glu		4
Compositional biasⁱ	1174 – 1179	Poly-Pro		6

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0204 Eukaryota ENOG410XNNC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046331
HOGENOMⁱ	HOG000265623
HOVERGENⁱ	HBG061286
InParanoidⁱ	Q16720
KEGG Orthology (KO) More...KOⁱ	K05850
OMAⁱ	SNPIFCT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G057D
PhylomeDBⁱ	Q16720
TreeFamⁱ	TF300330

Family and domain databases

Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 2 hits
InterProⁱ	View protein in InterPro IPR030325 ATP2B3 IPR022141 ATP_Ca_trans_C IPR006068 ATPase_P-typ_cation-transptr_C IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006408 P-type_ATPase_IIB IPR001757 P_typ_ATPase
PANTHERⁱ	PTHR24093:SF284 PTHR24093:SF284, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12424 ATP_Ca_trans_C, 1 hit PF00689 Cation_ATPase_C, 1 hit PF00690 Cation_ATPase_N, 1 hit
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 2 hits SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 3 hits
TIGRFAMsⁱ	TIGR01517 ATPase-IIB_Ca, 1 hit TIGR01494 ATPase_P-type, 3 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequences (8)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, E and G). The splice sites have mostly been studied independently. Full isoforms so far detected are isoform XA and isoform XB. Experimental confirmation may be lacking for some isoforms.

Isoform XB (identifier: Q16720-1) [UniParc]FASTA Add to basket

Also known as: AIICI

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA 
       360        370        380        390        400
NAPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR 
       410        420        430        440        450
TWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK 
       460        470        480        490        500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA 
       510        520        530        540        550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF 
       560        570        580        590        600
VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 
       610        620        630        640        650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY 
       660        670        680        690        700
RDFSAGQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT 
       710        720        730        740        750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE 
       760        770        780        790        800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP 
       810        820        830        840        850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS 
       860        870        880        890        900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 
       910        920        930        940        950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF 
       960        970        980        990       1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI 
      1010       1020       1030       1040       1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV 
      1060       1070       1080       1090       1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG 
      1110       1120       1130       1140       1150
QILWFRGLNR IQTQIRVVKA FRSSLYEGLE KPESKTSIHN FMATPEFLIN 
      1160       1170       1180       1190       1200
DYTHNIPLID DTDVDENEER LRAPPPPSPN QNNNAIDSGI YLTTHVTKSA 
      1210       1220
TSSVFSSSPG SPLHSVETSL

Length:1,220

Mass (Da):134,197

Last modified:October 17, 2006 - v3

Checksum:ⁱ03B2BA8A0A33B193

GO

Isoform XA (identifier: Q16720-2) [UniParc]FASTA Add to basket

Also known as: AIICII

The sequence of this isoform differs from the canonical sequence as follows:
1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA 
       360        370        380        390        400
NAPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR 
       410        420        430        440        450
TWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK 
       460        470        480        490        500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA 
       510        520        530        540        550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF 
       560        570        580        590        600
VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 
       610        620        630        640        650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY 
       660        670        680        690        700
RDFSAGQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT 
       710        720        730        740        750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE 
       760        770        780        790        800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP 
       810        820        830        840        850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS 
       860        870        880        890        900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 
       910        920        930        940        950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF 
       960        970        980        990       1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI 
      1010       1020       1030       1040       1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV 
      1060       1070       1080       1090       1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG 
      1110       1120       1130       1140       1150
QILWFRGLNR IQTQMEVVST FKRSGSVQGA VRRRSSVLSQ LHDVTNLSTP 
      1160       1170 
THAILSAANP TSAAGNPGGE SVP

Show »

Length:1,173

Mass (Da):128,545

Checksum:ⁱEF3ACDF02DF40B8C

GO

Isoform ZA (identifier: Q16720-3) [UniParc]FASTA Add to basket

Also known as: AICII

The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...AGNPGGESVP

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL 
       360        370        380        390        400
TKLAVQIGKA GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF 
       410        420        430        440        450
VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM 
       460        470        480        490        500
GNATAICSDK TGTLTTNRMT VVQSYLGDTH YKEIPAPSAL TPKILDLLVH 
       510        520        530        540        550
AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL KRDFQPVREQ 
       560        570        580        590        600
IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 
       610        620        630        640        650
SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE 
       660        670        680        690        700
NEVVGDLTCI AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA 
       710        720        730        740        750
IAAKCGIIQP GEDFLCLEGK EFNRRIRNEK GEIEQERLDK VWPKLRVLAR 
       760        770        780        790        800
SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 
       810        820        830        840        850
GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV 
       860        870        880        890        900
IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 
       910        920        930        940        950
GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP 
       960        970        980        990       1000
PSEHYTIIFN TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF 
      1010       1020       1030       1040       1050
GIQIVIVQFG GKPFSCSPLS TEQWLWCLFV GVGELVWGQV IATIPTSQLK 
      1060       1070       1080       1090       1100
CLKEAGHGPG KDEMTDEELA EGEEEIDHAE RELRRGQILW FRGLNRIQTQ 
      1110       1120       1130       1140       1150
MEVVSTFKRS GSVQGAVRRR SSVLSQLHDV TNLSTPTHAI LSAANPTSAA 

GNPGGESVP

Show »

Length:1,159

Mass (Da):127,068

Checksum:ⁱD092487DFC13E8A3

GO

Isoform ZB (identifier: Q16720-4) [UniParc]FASTA Add to basket

Also known as: AICI

The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL 
       360        370        380        390        400
TKLAVQIGKA GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF 
       410        420        430        440        450
VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM 
       460        470        480        490        500
GNATAICSDK TGTLTTNRMT VVQSYLGDTH YKEIPAPSAL TPKILDLLVH 
       510        520        530        540        550
AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL KRDFQPVREQ 
       560        570        580        590        600
IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 
       610        620        630        640        650
SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE 
       660        670        680        690        700
NEVVGDLTCI AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA 
       710        720        730        740        750
IAAKCGIIQP GEDFLCLEGK EFNRRIRNEK GEIEQERLDK VWPKLRVLAR 
       760        770        780        790        800
SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 
       810        820        830        840        850
GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV 
       860        870        880        890        900
IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 
       910        920        930        940        950
GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP 
       960        970        980        990       1000
PSEHYTIIFN TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF 
      1010       1020       1030       1040       1050
GIQIVIVQFG GKPFSCSPLS TEQWLWCLFV GVGELVWGQV IATIPTSQLK 
      1060       1070       1080       1090       1100
CLKEAGHGPG KDEMTDEELA EGEEEIDHAE RELRRGQILW FRGLNRIQTQ 
      1110       1120       1130       1140       1150
IRVVKAFRSS LYEGLEKPES KTSIHNFMAT PEFLINDYTH NIPLIDDTDV 
      1160       1170       1180       1190       1200
DENEERLRAP PPPSPNQNNN AIDSGIYLTT HVTKSATSSV FSSSPGSPLH 

SVETSL

Show »

Length:1,206

Mass (Da):132,721

Checksum:ⁱ2366490D5E398C08

GO

Isoform XE (identifier: Q16720-5) [UniParc]FASTA Add to basket

Also known as: AIICV

The sequence of this isoform differs from the canonical sequence as follows:
1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA 
       360        370        380        390        400
NAPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR 
       410        420        430        440        450
TWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK 
       460        470        480        490        500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA 
       510        520        530        540        550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF 
       560        570        580        590        600
VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 
       610        620        630        640        650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY 
       660        670        680        690        700
RDFSAGQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT 
       710        720        730        740        750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE 
       760        770        780        790        800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP 
       810        820        830        840        850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS 
       860        870        880        890        900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 
       910        920        930        940        950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF 
       960        970        980        990       1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI 
      1010       1020       1030       1040       1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV 
      1060       1070       1080       1090       1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG 
      1110       1120       1130       1140       1150
QILWFRGLNR IQTQMEVVST FKRSGSVQGA VRRRSSVLSQ LHDVTNLSTP 
      1160 
THAILSAANP TSAAGSES

Show »

Length:1,168

Mass (Da):128,110

Checksum:ⁱ79D7ED01B8F1BA88

GO

Isoform ZE (identifier: Q16720-6) [UniParc]FASTA Add to basket

Also known as: AICV

The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1115-1220: IRVVKAFRSS...SPLHSVETSL → MEVVSTFKRS...NPTSAAGSES

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL 
       360        370        380        390        400
TKLAVQIGKA GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF 
       410        420        430        440        450
VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM 
       460        470        480        490        500
GNATAICSDK TGTLTTNRMT VVQSYLGDTH YKEIPAPSAL TPKILDLLVH 
       510        520        530        540        550
AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL KRDFQPVREQ 
       560        570        580        590        600
IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 
       610        620        630        640        650
SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE 
       660        670        680        690        700
NEVVGDLTCI AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA 
       710        720        730        740        750
IAAKCGIIQP GEDFLCLEGK EFNRRIRNEK GEIEQERLDK VWPKLRVLAR 
       760        770        780        790        800
SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 
       810        820        830        840        850
GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV 
       860        870        880        890        900
IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 
       910        920        930        940        950
GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP 
       960        970        980        990       1000
PSEHYTIIFN TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF 
      1010       1020       1030       1040       1050
GIQIVIVQFG GKPFSCSPLS TEQWLWCLFV GVGELVWGQV IATIPTSQLK 
      1060       1070       1080       1090       1100
CLKEAGHGPG KDEMTDEELA EGEEEIDHAE RELRRGQILW FRGLNRIQTQ 
      1110       1120       1130       1140       1150
MEVVSTFKRS GSVQGAVRRR SSVLSQLHDV TNLSTPTHAI LSAANPTSAA 

GSES

Show »

Length:1,154

Mass (Da):126,634

Checksum:ⁱ6E34C22E92BEAE95

GO

Isoform XG (identifier: Q16720-7) [UniParc]FASTA Add to basket

Also known as: AIICVII

The sequence of this isoform differs from the canonical sequence as follows:
1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA 
       360        370        380        390        400
NAPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVEGR 
       410        420        430        440        450
TWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK 
       460        470        480        490        500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA 
       510        520        530        540        550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF 
       560        570        580        590        600
VLDLKRDFQP VREQIPEDKL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 
       610        620        630        640        650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VRKIIEPMAC DGLRTICIAY 
       660        670        680        690        700
RDFSAGQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT 
       710        720        730        740        750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE 
       760        770        780        790        800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP 
       810        820        830        840        850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS 
       860        870        880        890        900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 
       910        920        930        940        950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLAII FTLLFVGELF 
       960        970        980        990       1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI 
      1010       1020       1030       1040       1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV 
      1060       1070       1080       1090       1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG 
      1110       1120 
QILWFRGLNR IQTQVCWDGK KMLRTTEVG

Show »

Length:1,129

Mass (Da):124,236

Checksum:ⁱ17805052F1230AEF

GO

Isoform ZG (identifier: Q16720-8) [UniParc]FASTA Add to basket

Also known as: AICVII

The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1115-1220: IRVVKAFRSS...SPLHSVETSL → VCWDGKKMLRTTEVG

« Hide

        10         20         30         40         50
MGDMANSSIE FHPKPQQQRD VPQAGGFGCT LAELRTLMEL RGAEALQKIE 
        60         70         80         90        100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ 
       110        120        130        140        150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA 
       160        170        180        190        200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN 
       210        220        230        240        250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQANDLKID ESSLTGESDH 
       260        270        280        290        300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 
       310        320        330        340        350
KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANAPK KEKSVLQGKL 
       360        370        380        390        400
TKLAVQIGKA GLVMSAITVI ILVLYFVIET FVVEGRTWLA ECTPVYVQYF 
       410        420        430        440        450
VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL VRHLDACETM 
       460        470        480        490        500
GNATAICSDK TGTLTTNRMT VVQSYLGDTH YKEIPAPSAL TPKILDLLVH 
       510        520        530        540        550
AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFVLDL KRDFQPVREQ 
       560        570        580        590        600
IPEDKLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 
       610        620        630        640        650
SNGELRGFRP RDRDDMVRKI IEPMACDGLR TICIAYRDFS AGQEPDWDNE 
       660        670        680        690        700
NEVVGDLTCI AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA 
       710        720        730        740        750
IAAKCGIIQP GEDFLCLEGK EFNRRIRNEK GEIEQERLDK VWPKLRVLAR 
       760        770        780        790        800
SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA 
       810        820        830        840        850
GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV 
       860        870        880        890        900
IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 
       910        920        930        940        950
GRDKPLISRT MMKNILGHAV YQLAIIFTLL FVGELFFDID SGRNAPLHSP 
       960        970        980        990       1000
PSEHYTIIFN TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF 
      1010       1020       1030       1040       1050
GIQIVIVQFG GKPFSCSPLS TEQWLWCLFV GVGELVWGQV IATIPTSQLK 
      1060       1070       1080       1090       1100
CLKEAGHGPG KDEMTDEELA EGEEEIDHAE RELRRGQILW FRGLNRIQTQ 
      1110 
VCWDGKKMLR TTEVG

Show »

Length:1,115

Mass (Da):122,760

Checksum:ⁱ46F7F01999CFA318

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	587	I → V in AAB09762 (PubMed:8765088).Curated	1
Sequence conflictⁱ	587	I → V in AAB38530 (PubMed:8765088).Curated	1
Sequence conflictⁱ	654	S → Y in AAB09762 (PubMed:8765088).Curated	1
Sequence conflictⁱ	654	S → Y in AAB38530 (PubMed:8765088).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027928	198	I → M. Corresponds to variant dbSNP:rs2269409Ensembl.		1
Natural variantⁱVAR_069308	1107	G → D in SCAX1; the mutant protein is expressed at the plasma membrane but shows impaired extrusion of intracellular calcium with prolonged retention of cytoplasmic calcium compared to wild-type under physiologic conditions. 1 PublicationCorresponds to variant dbSNP:rs397514619EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000392	306 – 319	Missing in isoform ZA, isoform ZB, isoform ZE and isoform ZG. CuratedAdd BLAST	14
Alternative sequenceⁱVSP_000393	1115 – 1220	IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGNPGGESVP in isoform XA and isoform ZA. 1 PublicationAdd BLAST	106
Alternative sequenceⁱVSP_000394	1115 – 1220	IRVVK…VETSL → MEVVSTFKRSGSVQGAVRRR SSVLSQLHDVTNLSTPTHAI LSAANPTSAAGSES in isoform XE and isoform ZE. CuratedAdd BLAST	106
Alternative sequenceⁱVSP_000395	1115 – 1220	IRVVK…VETSL → VCWDGKKMLRTTEVG in isoform XG and isoform ZG. CuratedAdd BLAST	106

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57971 mRNA Translation: AAB09762.1 U60414 mRNA Translation: AAB38530.1 AH006061 Genomic DNA Translation: AAC15078.1 CH471172 Genomic DNA Translation: EAW72859.1 U82695 Genomic DNA No translation available. U15689 mRNA Translation: AAA60986.1 U15690 mRNA Translation: AAA60987.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14722.1 [Q16720-2] CCDS35440.1 [Q16720-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001001344.1, NM_001001344.2 [Q16720-1] NP_068768.2, NM_021949.3 [Q16720-2] XP_005274747.1, XM_005274690.3 [Q16720-1] XP_005274748.1, XM_005274691.3 [Q16720-4] XP_005274749.1, XM_005274692.3 [Q16720-2]
UniGeneⁱ	Hs.533956 Hs.658008

Genome annotation databases

Ensemblⁱ	ENST00000263519; ENSP00000263519; ENSG00000067842 [Q16720-1] ENST00000349466; ENSP00000343886; ENSG00000067842 [Q16720-1] ENST00000359149; ENSP00000352062; ENSG00000067842 [Q16720-2] ENST00000370186; ENSP00000359205; ENSG00000067842 [Q16720-3] ENST00000393842; ENSP00000377425; ENSG00000067842 [Q16720-6]
GeneIDⁱ	492
KEGGⁱ	hsa:492
UCSC genome browser More...UCSCⁱ	uc004fhs.2 human [Q16720-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16720	Calcium-transporting ATPase		PANTR		1220	UniRef100_Q16720
Calcium-transporting ATPase		PANPA		1220
Calcium-transporting ATPase		GORGO		1220
Q16720-2	Calcium-transporting ATPase		PANTR		1173	UniRef100_Q16720-2
Calcium-transporting ATPase		PANPA		1173
Calcium-transporting ATPase		GORGO		1173
Plasma membrane calcium-transporting ATPase 3 isoform 3a (Fragment)		MACMU		212
Q16720-4	Calcium-transporting ATPase		PANTR		1206	UniRef100_Q16720-4
Calcium-transporting ATPase		PANPA		1206
Calcium-transporting ATPase		GORGO		1206

Protein	Similar proteins		Species	Score	Length	Source
Q16720	Plasma membrane calcium-transporting ATPase 3		RAT		1258	UniRef90_Q16720
Calcium-transporting ATPase		PANTR		1220
Calcium-transporting ATPase		PANPA		1220
Calcium-transporting ATPase		GORGO		1220
Calcium-transporting ATPase		CRIGR		1273
+431

Protein	Similar proteins		Species	Score	Length	Source
Q16720	Plasma membrane calcium-transporting ATPase 4	)	HUMAN		1241	UniRef50_P23634
Plasma membrane calcium-transporting ATPase 3		RAT		1258
Plasma membrane calcium-transporting ATPase 4		MOUSE		1205
Plasma membrane calcium-transporting ATPase 1		PIG		1220
Plasma membrane calcium-transporting ATPase 4		BOVIN		1207
+2699

Entry informationⁱ

Entry nameⁱ	AT2B3_HUMAN
Accessionⁱ	Q16720Primary (citable) accession number: Q16720 Secondary accession number(s): B7WNR8 , B7WNY5, Q12995, Q16858
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	October 17, 2006
	Last modified:	September 12, 2018
	This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16720 (AT2B3_HUMAN)

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Plasma membrane calcium-transporting ATPase 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ