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Entry version 169 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

Gene

NDUFA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Alternative name(s):
Complex I subunit B13
Complex I-13kD-B
Short name:
CI-13kD-B
NADH-ubiquinone oxidoreductase 13 kDa-B subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFA5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7688 NDUFA5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601677 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16718

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4698

Open Targets

More...
OpenTargetsi
ENSG00000128609

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31494

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16718

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2363065

Drug and drug target database

More...
DrugBanki
DB00157 NADH

DrugCentral

More...
DrugCentrali
Q16718

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NDUFA5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2499316

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001186322 – 116NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei30N6-acetyllysineCombined sources1
Modified residuei46N6-acetyllysineBy similarity1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei98N6-acetyllysine; alternateBy similarity1
Modified residuei98N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16718

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16718

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16718

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16718

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16718

PeptideAtlas

More...
PeptideAtlasi
Q16718

PRoteomics IDEntifications database

More...
PRIDEi
Q16718

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61039 [Q16718-1]
62900

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q16718-1 [Q16718-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q16718

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16718

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16718

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q16718

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined with highest levels in heart, skeletal muscle and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128609 Expressed in 230 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16718 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16718 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043175

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Complex I is composed of 45 different subunits.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NDUFS3O754898EBI-746417,EBI-1224896

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110778, 65 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-577 Mitochondrial respiratory chain complex I

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q16718

Protein interaction database and analysis system

More...
IntActi
Q16718, 63 interactors

Molecular INTeraction database

More...
MINTi
Q16718

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417142

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16718

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFA5 subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3365 Eukaryota
ENOG4111V89 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008099

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000240009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16718

KEGG Orthology (KO)

More...
KOi
K03949

Identification of Orthologs from Complete Genome Data

More...
OMAi
EWKAWEP

Database of Orthologous Groups

More...
OrthoDBi
1372253at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16718

TreeFam database of animal gene trees

More...
TreeFami
TF313785

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006806 NDUFA5

The PANTHER Classification System

More...
PANTHERi
PTHR12653 PTHR12653, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04716 ETC_C1_NDUFA5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16718-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGVLKKTTG LVGLAVCNTP HERLRILYTK ILDVLEEIPK NAAYRKYTEQ
60 70 80 90 100
ITNEKLAMVK AEPDVKKLED QLQGGQLEEV ILQAEHELNL ARKMREWKLW
110
EPLVEEPPAD QWKWPI
Length:116
Mass (Da):13,459
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i652339C1127E6F22
GO
Isoform 2 (identifier: Q16718-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MAGVLKK → MPYRVGQ

Note: No experimental confirmation available.
Show »
Length:116
Mass (Da):13,563
Checksum:iBD8CF570C1ED77EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1G1A0A087X1G1_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA5
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYD0H7BYD0_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA5
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXR5A0A087WXR5_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA5
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAS3F8WAS3_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA5
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZN5C9IZN5_HUMAN
NADH dehydrogenase [ubiquinone] 1 a...
NDUFA5
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52T → I in AAH70236 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0551641 – 7MAGVLKK → MPYRVGQ in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U53468 mRNA Translation: AAB02224.1
U64028 mRNA Translation: AAB37259.1
AF044418
, AF044415, AF044416, AF044417 Genomic DNA Translation: AAD21526.1
BT006695 mRNA Translation: AAP35341.1
AK315458 mRNA Translation: BAG37845.1
CR933664 mRNA Translation: CAI45962.1
AC073323 Genomic DNA Translation: AAQ96854.1
CH471070 Genomic DNA Translation: EAW83588.1
BC000813 mRNA Translation: AAH00813.1
BC020821 mRNA Translation: AAH20821.1
BC070236 mRNA Translation: AAH70236.1
BC070237 mRNA Translation: AAH70237.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5788.1 [Q16718-1]
CCDS64760.1 [Q16718-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
G02526

NCBI Reference Sequences

More...
RefSeqi
NP_001269348.1, NM_001282419.2
NP_001269349.1, NM_001282420.2 [Q16718-2]
NP_001269350.1, NM_001282421.2
NP_001269351.1, NM_001282422.2
NP_004991.1, NM_005000.4 [Q16718-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355749; ENSP00000347988; ENSG00000128609 [Q16718-1]
ENST00000471770; ENSP00000417142; ENSG00000128609 [Q16718-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4698

UCSC genome browser

More...
UCSCi
uc003vks.4 human [Q16718-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53468 mRNA Translation: AAB02224.1
U64028 mRNA Translation: AAB37259.1
AF044418
, AF044415, AF044416, AF044417 Genomic DNA Translation: AAD21526.1
BT006695 mRNA Translation: AAP35341.1
AK315458 mRNA Translation: BAG37845.1
CR933664 mRNA Translation: CAI45962.1
AC073323 Genomic DNA Translation: AAQ96854.1
CH471070 Genomic DNA Translation: EAW83588.1
BC000813 mRNA Translation: AAH00813.1
BC020821 mRNA Translation: AAH20821.1
BC070236 mRNA Translation: AAH70236.1
BC070237 mRNA Translation: AAH70237.1
CCDSiCCDS5788.1 [Q16718-1]
CCDS64760.1 [Q16718-2]
PIRiG02526
RefSeqiNP_001269348.1, NM_001282419.2
NP_001269349.1, NM_001282420.2 [Q16718-2]
NP_001269350.1, NM_001282421.2
NP_001269351.1, NM_001282422.2
NP_004991.1, NM_005000.4 [Q16718-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTBelectron microscopy3.40H5-116[»]
5XTDelectron microscopy3.70H5-116[»]
5XTHelectron microscopy3.90H5-116[»]
5XTIelectron microscopy17.40BH/H5-116[»]
SMRiQ16718
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110778, 65 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiQ16718
IntActiQ16718, 63 interactors
MINTiQ16718
STRINGi9606.ENSP00000417142

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH
DrugCentraliQ16718

PTM databases

CarbonylDBiQ16718
iPTMnetiQ16718
PhosphoSitePlusiQ16718
SwissPalmiQ16718

Polymorphism and mutation databases

BioMutaiNDUFA5
DMDMi2499316

Proteomic databases

EPDiQ16718
jPOSTiQ16718
MassIVEiQ16718
MaxQBiQ16718
PaxDbiQ16718
PeptideAtlasiQ16718
PRIDEiQ16718
ProteomicsDBi61039 [Q16718-1]
62900
TopDownProteomicsiQ16718-1 [Q16718-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4698

Genome annotation databases

EnsembliENST00000355749; ENSP00000347988; ENSG00000128609 [Q16718-1]
ENST00000471770; ENSP00000417142; ENSG00000128609 [Q16718-2]
GeneIDi4698
KEGGihsa:4698
UCSCiuc003vks.4 human [Q16718-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4698
DisGeNETi4698

GeneCards: human genes, protein and diseases

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GeneCardsi
NDUFA5
HGNCiHGNC:7688 NDUFA5
HPAiHPA043175
MIMi601677 gene
neXtProtiNX_Q16718
OpenTargetsiENSG00000128609
PharmGKBiPA31494

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3365 Eukaryota
ENOG4111V89 LUCA
GeneTreeiENSGT00390000008099
HOGENOMiHOG000240009
InParanoidiQ16718
KOiK03949
OMAiEWKAWEP
OrthoDBi1372253at2759
PhylomeDBiQ16718
TreeFamiTF313785

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NDUFA5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NDUFA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4698
PharosiQ16718

Protein Ontology

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PROi
PR:Q16718

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000128609 Expressed in 230 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ16718 baseline and differential
GenevisibleiQ16718 HS

Family and domain databases

InterProiView protein in InterPro
IPR006806 NDUFA5
PANTHERiPTHR12653 PTHR12653, 1 hit
PfamiView protein in Pfam
PF04716 ETC_C1_NDUFA5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDUA5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16718
Secondary accession number(s): B2RD98, Q5H9R2, Q6IRX7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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