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UniProtKB - Q16696 (CP2AD_HUMAN)

Entry version 192 (23 Feb 2022)
Sequence version 3 (11 Oct 2005)
Previous versions | rss
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Protein

Cytochrome P450 2A13

Gene

CYP2A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.7 µM for phenacetin1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei297Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi439Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16696

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-211935, Fatty acids
R-HSA-211981, Xenobiotics
R-HSA-211999, CYP2E1 reactions
R-HSA-5423646, Aflatoxin activation and detoxification

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q16696

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16696

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2A13 (EC:1.14.14.1)
Alternative name(s):
CYPIIA13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2A13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2608, CYP2A13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608055, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16696

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197838

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi110L → V: Decreases phenacetin O-deethylation activity 8 fold. 1 Publication1
Mutagenesisi117A → V: Increases phenacetin O-deethylation activity 5 fold. 1 Publication1
Mutagenesisi208S → I: Decreases phenacetin O-deethylation activity 10 fold. 1 Publication1
Mutagenesisi213A → S: Decreases phenacetin O-deethylation activity 2 fold. 1 Publication1
Mutagenesisi300F → I: Decreases phenacetin O-deethylation activity 40 fold. 1 Publication1
Mutagenesisi301A → G: Decreases phenacetin O-deethylation activity 20 fold. 1 Publication1
Mutagenesisi365M → V: Decreases phenacetin O-deethylation activity 7 fold. 1 Publication1
Mutagenesisi366L → I: Increases phenacetin O-deethylation activity 3 fold. 1 Publication1
Mutagenesisi369G → S: Decreases phenacetin O-deethylation activity 9 fold. 1 Publication1
Mutagenesisi372H → R: Decreases phenacetin O-deethylation activity 3 fold. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1553

Open Targets

More...OpenTargetsi		ENSG00000197838

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27101

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16696, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3542436

Drug and drug target database

More...DrugBanki		DB00553, Methoxsalen
DB00184, Nicotine
DB03783, Phenacetin
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1323

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CYP2A13

Domain mapping of disease mutations (DMDM)

More...DMDMi		77416854

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516761 – 494Cytochrome P450 2A13Add BLAST494

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16696

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16696

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16696

PeptideAtlas

More...PeptideAtlasi		Q16696

PRoteomics IDEntifications database

More...PRIDEi		Q16696

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61036

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16696

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16696

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197838, Expressed in nasal cavity epithelium and 91 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16696, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197838, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107931, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q16696, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332679

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q16696

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16696, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1494
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16696

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16696

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0156, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154117

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001570_22_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16696

Identification of Orthologs from Complete Genome Data

More...OMAi		FVSHPKP

Database of Orthologous Groups

More...OrthoDBi		702827at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16696

TreeFam database of animal gene trees

More...TreeFami		TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008067, Cyt_P450_E_grp-I_CYP2A-like
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00463, EP450I
PR01684, EP450ICYP2A
PR00385, P450

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q16696-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLASGLLLVT LLACLTVMVL MSVWRQRKSR GKLPPGPTPL PFIGNYLQLN 
        60         70         80         90        100
TEQMYNSLMK ISERYGPVFT IHLGPRRVVV LCGHDAVKEA LVDQAEEFSG 
       110        120        130        140        150
RGEQATFDWL FKGYGVAFSN GERAKQLRRF SIATLRGFGV GKRGIEERIQ 
       160        170        180        190        200
EEAGFLIDAL RGTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS 
       210        220        230        240        250
LLRMMLGSFQ FTATSTGQLY EMFSSVMKHL PGPQQQAFKE LQGLEDFIAK 
       260        270        280        290        300
KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFF 
       310        320        330        340        350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP 
       360        370        380        390        400
YTEAVIHEIQ RFGDMLPMGL AHRVNKDTKF RDFFLPKGTE VFPMLGSVLR 
       410        420        430        440        450
DPRFFSNPRD FNPQHFLDKK GQFKKSDAFV PFSIGKRYCF GEGLARMELF 
       460        470        480        490 
LFFTTIMQNF RFKSPQSPKD IDVSPKHVGF ATIPRNYTMS FLPR
Length:494
Mass (Da):56,688
Last modified:October 11, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA39F18AD71C28821
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti208S → R in AAB40519 (PubMed:7668294).Curated1
Sequence conflicti213A → G in AAB40519 (PubMed:7668294).Curated1
Sequence conflicti398V → E in AAB40519 (PubMed:7668294).Curated1
Sequence conflicti409 – 412RDFN → QDCS in AAB40519 (PubMed:7668294).Curated4
Sequence conflicti419K → E in AAB40519 (PubMed:7668294).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01833425R → Q in allele CYP2A13*2. 2 PublicationsCorresponds to variant dbSNP:rs8192784Ensembl.1
Natural variantiVAR_018335101R → Q in allele CYP2A13*4. 1 PublicationCorresponds to variant dbSNP:rs148044792Ensembl.1
Natural variantiVAR_018336134T → TT in allele CYP2A13*3. 1 Publication1
Natural variantiVAR_018337158D → E in allele CYP2A13*3 and allele CYP2A13*8. 2 PublicationsCorresponds to variant dbSNP:rs112337232Ensembl.1
Natural variantiVAR_013835257R → C in allele CYP2A13*2. 2 PublicationsCorresponds to variant dbSNP:rs8192789Ensembl.1
Natural variantiVAR_018356323V → L in allele CYP2A13*9. 1 Publication1
Natural variantiVAR_018338453F → Y in allele CYP2A13*5. 1 PublicationCorresponds to variant dbSNP:rs72547590Ensembl.1
Natural variantiVAR_018339494R → C in allele CYP2A13*6. 1 PublicationCorresponds to variant dbSNP:rs138870349Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U22028 Genomic DNA Translation: AAB40519.1
AF209774 mRNA Translation: AAG35775.1
AY513604 mRNA Translation: AAR90935.1
AY513605 mRNA Translation: AAR90936.1
AY513606 mRNA Translation: AAR90937.1
AY513608 mRNA Translation: AAR90939.1
AY513609 mRNA Translation: AAR90940.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12571.1

Protein sequence database of the Protein Information Resource

More...PIRi		I38966

NCBI Reference Sequences

More...RefSeqi		NP_000757.2, NM_000766.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000330436; ENSP00000332679; ENSG00000197838

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1553

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1553

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000330436.4; ENSP00000332679.1; NM_000766.5; NP_000757.2

UCSC genome browser

More...UCSCi		uc002opt.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

PharmVar Pharmacogen Variation Consortium

CYP2A13 alleles

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22028 Genomic DNA Translation: AAB40519.1
AF209774 mRNA Translation: AAG35775.1
AY513604 mRNA Translation: AAR90935.1
AY513605 mRNA Translation: AAR90936.1
AY513606 mRNA Translation: AAR90937.1
AY513608 mRNA Translation: AAR90939.1
AY513609 mRNA Translation: AAR90940.1
CCDSiCCDS12571.1
PIRiI38966
RefSeqiNP_000757.2, NM_000766.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P85X-ray2.35A/B/C/D/E/F26-494[»]
2PG5X-ray1.95A/B/C/D31-494[»]
2PG6X-ray2.53A/B/C/D31-494[»]
2PG7X-ray2.80A/B/C/D31-494[»]
3T3SX-ray3.00A/B/C/D/E/F/G/H31-494[»]
4EJGX-ray2.50A/B/C/D/E/F/G/H31-494[»]
4EJHX-ray2.35A/B/C/D/E/F/G/H31-494[»]
4EJIX-ray2.10A31-494[»]
SMRiQ16696
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107931, 4 interactors
IntActiQ16696, 1 interactor
STRINGi9606.ENSP00000332679

Chemistry databases

BindingDBiQ16696
ChEMBLiCHEMBL3542436
DrugBankiDB00553, Methoxsalen
DB00184, Nicotine
DB03783, Phenacetin
DB00624, Testosterone
DB13943, Testosterone cypionate
DB13944, Testosterone enanthate
DB13946, Testosterone undecanoate
GuidetoPHARMACOLOGYi1323

PTM databases

iPTMnetiQ16696
PhosphoSitePlusiQ16696

Genetic variation databases

BioMutaiCYP2A13
DMDMi77416854

Proteomic databases

EPDiQ16696
MassIVEiQ16696
PaxDbiQ16696
PeptideAtlasiQ16696
PRIDEiQ16696
ProteomicsDBi61036

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17121, 183 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		1553

Genome annotation databases

EnsembliENST00000330436; ENSP00000332679; ENSG00000197838
GeneIDi1553
KEGGihsa:1553
MANE-SelectiENST00000330436.4; ENSP00000332679.1; NM_000766.5; NP_000757.2
UCSCiuc002opt.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1553
DisGeNETi1553

GeneCards: human genes, protein and diseases

More...GeneCardsi		CYP2A13
HGNCiHGNC:2608, CYP2A13
HPAiENSG00000197838, Tissue enriched (liver)
MIMi608055, gene
neXtProtiNX_Q16696
OpenTargetsiENSG00000197838
PharmGKBiPA27101
VEuPathDBiHostDB:ENSG00000197838

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0156, Eukaryota
GeneTreeiENSGT00940000154117
HOGENOMiCLU_001570_22_3_1
InParanoidiQ16696
OMAiFVSHPKP
OrthoDBi702827at2759
PhylomeDBiQ16696
TreeFamiTF352043

Enzyme and pathway databases

PathwayCommonsiQ16696
ReactomeiR-HSA-211935, Fatty acids
R-HSA-211981, Xenobiotics
R-HSA-211999, CYP2E1 reactions
R-HSA-5423646, Aflatoxin activation and detoxification
SABIO-RKiQ16696
SignaLinkiQ16696

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1553, 156 hits in 1031 CRISPR screens
EvolutionaryTraceiQ16696

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CYP2A13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1553
PharosiQ16696, Tbio

Protein Ontology

More...PROi		PR:Q16696
RNActiQ16696, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197838, Expressed in nasal cavity epithelium and 91 other tissues
GenevisibleiQ16696, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008067, Cyt_P450_E_grp-I_CYP2A-like
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR01684, EP450ICYP2A
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2AD_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16696
Secondary accession number(s): Q53YR8
, Q6R569, Q6R570, Q9H2X2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 11, 2005
Last modified: February 23, 2022
This is version 192 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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