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UniProtKB - Q16696 (CP2AD_HUMAN)

Entry version 187 (02 Dec 2020)
Sequence version 3 (11 Oct 2005)
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Protein

Cytochrome P450 2A13

Gene

CYP2A13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.7 µM for phenacetin1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei297Substrate1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi439Iron (heme axial ligand)1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMonooxygenase, Oxidoreductase
    LigandHeme, Iron, Metal-binding

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q16696

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-211935, Fatty acids
    R-HSA-211981, Xenobiotics
    R-HSA-211999, CYP2E1 reactions
    R-HSA-5423646, Aflatoxin activation and detoxification

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q16696

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytochrome P450 2A13 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIA13
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CYP2A13
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen and Host Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000197838.4

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:2608, CYP2A13

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		608055, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q16696

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi110L → V: Decreases phenacetin O-deethylation activity 8 fold. 1 Publication1
    Mutagenesisi117A → V: Increases phenacetin O-deethylation activity 5 fold. 1 Publication1
    Mutagenesisi208S → I: Decreases phenacetin O-deethylation activity 10 fold. 1 Publication1
    Mutagenesisi213A → S: Decreases phenacetin O-deethylation activity 2 fold. 1 Publication1
    Mutagenesisi300F → I: Decreases phenacetin O-deethylation activity 40 fold. 1 Publication1
    Mutagenesisi301A → G: Decreases phenacetin O-deethylation activity 20 fold. 1 Publication1
    Mutagenesisi365M → V: Decreases phenacetin O-deethylation activity 7 fold. 1 Publication1
    Mutagenesisi366L → I: Increases phenacetin O-deethylation activity 3 fold. 1 Publication1
    Mutagenesisi369G → S: Decreases phenacetin O-deethylation activity 9 fold. 1 Publication1
    Mutagenesisi372H → R: Decreases phenacetin O-deethylation activity 3 fold. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		1553

    Open Targets

    More...    OpenTargetsi    		ENSG00000197838

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA27101

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q16696, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3542436

    Drug and drug target database

    More...    DrugBanki    		DB00553, Methoxsalen
    DB00184, Nicotine
    DB03783, Phenacetin
    DB00624, Testosterone
    DB13943, Testosterone cypionate
    DB13944, Testosterone enanthate
    DB13946, Testosterone undecanoate

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		CYP2A13

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		77416854

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516761 – 494Cytochrome P450 2A13Add BLAST494

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q16696

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q16696

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q16696

    PeptideAtlas

    More...    PeptideAtlasi    		Q16696

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q16696

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		61036

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q16696

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q16696

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000197838, Expressed in nasal cavity epithelium and 90 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q16696, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000197838, Tissue enriched (liver)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		107931, 1 interactor

    Protein interaction database and analysis system

    More...    IntActi    		Q16696, 1 interactor

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000332679

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q16696

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q16696, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1494
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q16696

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q16696

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG0156, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000154117

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_001570_22_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q16696

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		TQQMYNS

    Database of Orthologous Groups

    More...    OrthoDBi    		702827at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q16696

    TreeFam database of animal gene trees

    More...    TreeFami    		TF352043

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		1.10.630.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR001128, Cyt_P450
    IPR017972, Cyt_P450_CS
    IPR002401, Cyt_P450_E_grp-I
    IPR008067, Cyt_P450_E_grp-I_CYP2A-like
    IPR036396, Cyt_P450_sf

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00067, p450, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00463, EP450I
    PR01684, EP450ICYP2A
    PR00385, P450

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF48264, SSF48264, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00086, CYTOCHROME_P450, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q16696-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLASGLLLVT LLACLTVMVL MSVWRQRKSR GKLPPGPTPL PFIGNYLQLN 
            60         70         80         90        100
    TEQMYNSLMK ISERYGPVFT IHLGPRRVVV LCGHDAVKEA LVDQAEEFSG 
           110        120        130        140        150
    RGEQATFDWL FKGYGVAFSN GERAKQLRRF SIATLRGFGV GKRGIEERIQ 
           160        170        180        190        200
    EEAGFLIDAL RGTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS 
           210        220        230        240        250
    LLRMMLGSFQ FTATSTGQLY EMFSSVMKHL PGPQQQAFKE LQGLEDFIAK 
           260        270        280        290        300
    KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFF 
           310        320        330        340        350
    AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP 
           360        370        380        390        400
    YTEAVIHEIQ RFGDMLPMGL AHRVNKDTKF RDFFLPKGTE VFPMLGSVLR 
           410        420        430        440        450
    DPRFFSNPRD FNPQHFLDKK GQFKKSDAFV PFSIGKRYCF GEGLARMELF 
           460        470        480        490 
    LFFTTIMQNF RFKSPQSPKD IDVSPKHVGF ATIPRNYTMS FLPR
    Length:494
    Mass (Da):56,688
    Last modified:October 11, 2005 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA39F18AD71C28821
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti208S → R in AAB40519 (PubMed:7668294).Curated1
    Sequence conflicti213A → G in AAB40519 (PubMed:7668294).Curated1
    Sequence conflicti398V → E in AAB40519 (PubMed:7668294).Curated1
    Sequence conflicti409 – 412RDFN → QDCS in AAB40519 (PubMed:7668294).Curated4
    Sequence conflicti419K → E in AAB40519 (PubMed:7668294).Curated1

    <p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested.

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01833425R → Q in allele CYP2A13*2. 2 PublicationsCorresponds to variant dbSNP:rs8192784Ensembl.1
    Natural variantiVAR_018335101R → Q in allele CYP2A13*4. 1 PublicationCorresponds to variant dbSNP:rs148044792Ensembl.1
    Natural variantiVAR_018336134T → TT in allele CYP2A13*3. 1 Publication1
    Natural variantiVAR_018337158D → E in allele CYP2A13*3 and allele CYP2A13*8. 2 PublicationsCorresponds to variant dbSNP:rs112337232Ensembl.1
    Natural variantiVAR_013835257R → C in allele CYP2A13*2. 2 PublicationsCorresponds to variant dbSNP:rs8192789Ensembl.1
    Natural variantiVAR_018356323V → L in allele CYP2A13*9. 1 Publication1
    Natural variantiVAR_018338453F → Y in allele CYP2A13*5. 1 PublicationCorresponds to variant dbSNP:rs72547590Ensembl.1
    Natural variantiVAR_018339494R → C in allele CYP2A13*6. 1 PublicationCorresponds to variant dbSNP:rs138870349Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U22028 Genomic DNA Translation: AAB40519.1
    AF209774 mRNA Translation: AAG35775.1
    AY513604 mRNA Translation: AAR90935.1
    AY513605 mRNA Translation: AAR90936.1
    AY513606 mRNA Translation: AAR90937.1
    AY513608 mRNA Translation: AAR90939.1
    AY513609 mRNA Translation: AAR90940.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS12571.1

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		I38966

    NCBI Reference Sequences

    More...    RefSeqi    		NP_000757.2, NM_000766.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000330436; ENSP00000332679; ENSG00000197838

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		1553

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:1553

    UCSC genome browser

    More...    UCSCi    		uc002opt.5, human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Cytochrome P450 Allele Nomenclature Committee

    CYP2A13 alleles

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U22028 Genomic DNA Translation: AAB40519.1
    AF209774 mRNA Translation: AAG35775.1
    AY513604 mRNA Translation: AAR90935.1
    AY513605 mRNA Translation: AAR90936.1
    AY513606 mRNA Translation: AAR90937.1
    AY513608 mRNA Translation: AAR90939.1
    AY513609 mRNA Translation: AAR90940.1
    CCDSiCCDS12571.1
    PIRiI38966
    RefSeqiNP_000757.2, NM_000766.4

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2P85X-ray2.35A/B/C/D/E/F26-494[»]
    2PG5X-ray1.95A/B/C/D31-494[»]
    2PG6X-ray2.53A/B/C/D31-494[»]
    2PG7X-ray2.80A/B/C/D31-494[»]
    3T3SX-ray3.00A/B/C/D/E/F/G/H31-494[»]
    4EJGX-ray2.50A/B/C/D/E/F/G/H31-494[»]
    4EJHX-ray2.35A/B/C/D/E/F/G/H31-494[»]
    4EJIX-ray2.10A31-494[»]
    SMRiQ16696
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi107931, 1 interactor
    IntActiQ16696, 1 interactor
    STRINGi9606.ENSP00000332679

    Chemistry databases

    BindingDBiQ16696
    ChEMBLiCHEMBL3542436
    DrugBankiDB00553, Methoxsalen
    DB00184, Nicotine
    DB03783, Phenacetin
    DB00624, Testosterone
    DB13943, Testosterone cypionate
    DB13944, Testosterone enanthate
    DB13946, Testosterone undecanoate

    PTM databases

    iPTMnetiQ16696
    PhosphoSitePlusiQ16696

    Polymorphism and mutation databases

    BioMutaiCYP2A13
    DMDMi77416854

    Proteomic databases

    EPDiQ16696
    MassIVEiQ16696
    PaxDbiQ16696
    PeptideAtlasiQ16696
    PRIDEiQ16696
    ProteomicsDBi61036

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		17121, 163 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		1553

    Genome annotation databases

    EnsembliENST00000330436; ENSP00000332679; ENSG00000197838
    GeneIDi1553
    KEGGihsa:1553
    UCSCiuc002opt.5, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		1553
    DisGeNETi1553
    EuPathDBiHostDB:ENSG00000197838.4

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		CYP2A13
    HGNCiHGNC:2608, CYP2A13
    HPAiENSG00000197838, Tissue enriched (liver)
    MIMi608055, gene
    neXtProtiNX_Q16696
    OpenTargetsiENSG00000197838
    PharmGKBiPA27101

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG0156, Eukaryota
    GeneTreeiENSGT00940000154117
    HOGENOMiCLU_001570_22_3_1
    InParanoidiQ16696
    OMAiTQQMYNS
    OrthoDBi702827at2759
    PhylomeDBiQ16696
    TreeFamiTF352043

    Enzyme and pathway databases

    PathwayCommonsiQ16696
    ReactomeiR-HSA-211935, Fatty acids
    R-HSA-211981, Xenobiotics
    R-HSA-211999, CYP2E1 reactions
    R-HSA-5423646, Aflatoxin activation and detoxification
    SABIO-RKiQ16696

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		1553, 153 hits in 841 CRISPR screens
    EvolutionaryTraceiQ16696

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		CYP2A13

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		1553
    PharosiQ16696, Tbio

    Protein Ontology

    More...    PROi    		PR:Q16696
    RNActiQ16696, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000197838, Expressed in nasal cavity epithelium and 90 other tissues
    GenevisibleiQ16696, HS

    Family and domain databases

    Gene3Di1.10.630.10, 1 hit
    InterProiView protein in InterPro
    IPR001128, Cyt_P450
    IPR017972, Cyt_P450_CS
    IPR002401, Cyt_P450_E_grp-I
    IPR008067, Cyt_P450_E_grp-I_CYP2A-like
    IPR036396, Cyt_P450_sf
    PfamiView protein in Pfam
    PF00067, p450, 1 hit
    PRINTSiPR00463, EP450I
    PR01684, EP450ICYP2A
    PR00385, P450
    SUPFAMiSSF48264, SSF48264, 1 hit
    PROSITEiView protein in PROSITE
    PS00086, CYTOCHROME_P450, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2AD_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16696
    Secondary accession number(s): Q53YR8
    , Q6R569, Q6R570, Q9H2X2
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 11, 2005
    Last modified: December 2, 2020
    This is version 187 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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