UniProtKB - Q16696 (CP2AD_HUMAN)

BLAST

>sp|Q16696|CP2AD_HUMAN Cytochrome P450 2A13 OS=Homo sapiens OX=9606 GN=CYP2A13 PE=1 SV=3
MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK
ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN
GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN
VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE
LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF
AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ
RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK
GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF
ATIPRNYTMSFLPR

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History
Entry version 174 (07 Nov 2018)
Sequence version 3 (11 Oct 2005)
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Protein

Cytochrome P450 2A13

Gene

CYP2A13

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.1 Publication

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

heme

Kineticsⁱ

K_M=
10.7 µM for phenacetin
1 Publication
Manual assertion based on experiment inⁱ
- Ref.4
  "Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes."
  DeVore N.M., Smith B.D., Urban M.J., Scott E.E.
  Drug Metab. Dispos. 36:2582-2590(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, MUTAGENESIS OF LEU-110; ALA-117; SER-208; ALA-213; PHE-300; ALA-301; MET-365; LEU-366; GLY-369 AND HIS-372.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	297	Substrate		1
Metal bindingⁱ	439	Iron (heme axial ligand)		1

GO - Molecular functionⁱ

arachidonic acid epoxygenase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
aromatase activity Source: UniProtKB-EC
coumarin 7-hydroxylase activity Source: Reactome
heme binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17428784
iron ion binding Source: InterPro
monooxygenase activity Source: Reactome
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hydroxylase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

coumarin metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
epoxygenase P450 pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exogenous drug catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
organic acid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
oxidation-reduction process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
xenobiotic metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-5423646 Aflatoxin activation and detoxification
SABIO-RKⁱ	Q16696

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2A13 (EC:1.14.14.1) Alternative name(s): CYPIIA13
Gene namesⁱ	Name:CYP2A13
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197838.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2608 CYP2A13
MIMⁱ	608055 gene
neXtProtⁱ	NX_Q16696

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	110	L → V: Decreases phenacetin O-deethylation activity 8 fold. 1 Publication	1
Mutagenesisⁱ	117	A → V: Increases phenacetin O-deethylation activity 5 fold. 1 Publication	1
Mutagenesisⁱ	208	S → I: Decreases phenacetin O-deethylation activity 10 fold. 1 Publication	1
Mutagenesisⁱ	213	A → S: Decreases phenacetin O-deethylation activity 2 fold. 1 Publication	1
Mutagenesisⁱ	300	F → I: Decreases phenacetin O-deethylation activity 40 fold. 1 Publication	1
Mutagenesisⁱ	301	A → G: Decreases phenacetin O-deethylation activity 20 fold. 1 Publication	1
Mutagenesisⁱ	365	M → V: Decreases phenacetin O-deethylation activity 7 fold. 1 Publication	1
Mutagenesisⁱ	366	L → I: Increases phenacetin O-deethylation activity 3 fold. 1 Publication	1
Mutagenesisⁱ	369	G → S: Decreases phenacetin O-deethylation activity 9 fold. 1 Publication	1
Mutagenesisⁱ	372	H → R: Decreases phenacetin O-deethylation activity 3 fold. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1553
Open Targets More...OpenTargetsⁱ	ENSG00000197838
PharmGKBⁱ	PA27101

Chemistry databases

ChEMBLⁱ	CHEMBL3542436
Drug and drug target database More...DrugBankⁱ	DB00553 Methoxsalen DB00184 Nicotine DB03783 Phenacetin DB00624 Testosterone

Polymorphism and mutation databases

BioMutaⁱ	CYP2A13
DMDMⁱ	77416854

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051676	1 – 494	Cytochrome P450 2A13Add BLAST		494

Proteomic databases

EPDⁱ	Q16696
PaxDbⁱ	Q16696
PeptideAtlas More...PeptideAtlasⁱ	Q16696
PRIDEⁱ	Q16696
ProteomicsDBⁱ	61036

PTM databases

iPTMnetⁱ	Q16696
PhosphoSitePlusⁱ	Q16696

Expressionⁱ

Tissue specificityⁱ

Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000197838 Expressed in 87 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_CYP2A13
Genevisibleⁱ	Q16696 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046713 HPA047262

HPAⁱ

HPA046713
HPA047262

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107931, 1 interactor
STRINGⁱ	9606.ENSP00000332679

Chemistry databases

BindingDBⁱ

Q16696

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	41 – 43	Combined sources	3
Helixⁱ	46 – 48	Combined sources	3
Helixⁱ	51 – 53	Combined sources	3
Helixⁱ	54 – 65	Combined sources	12
Beta strandⁱ	67 – 73	Combined sources	7
Beta strandⁱ	76 – 81	Combined sources	6
Helixⁱ	84 – 91	Combined sources	8
Turnⁱ	92 – 98	Combined sources	7
Helixⁱ	105 – 111	Combined sources	7
Turnⁱ	116 – 118	Combined sources	3
Helixⁱ	121 – 137	Combined sources	17
Turnⁱ	138 – 141	Combined sources	4
Helixⁱ	143 – 161	Combined sources	19
Turnⁱ	162 – 165	Combined sources	4
Helixⁱ	171 – 187	Combined sources	17
Helixⁱ	196 – 212	Combined sources	17
Helixⁱ	215 – 227	Combined sources	13
Beta strandⁱ	230 – 232	Combined sources	3
Helixⁱ	233 – 256	Combined sources	24
Helixⁱ	267 – 277	Combined sources	11
Turnⁱ	278 – 280	Combined sources	3
Helixⁱ	288 – 319	Combined sources	32
Helixⁱ	321 – 334	Combined sources	14
Beta strandⁱ	337 – 339	Combined sources	3
Helixⁱ	343 – 348	Combined sources	6
Helixⁱ	350 – 363	Combined sources	14
Beta strandⁱ	378 – 380	Combined sources	3
Beta strandⁱ	383 – 385	Combined sources	3
Beta strandⁱ	390 – 393	Combined sources	4
Helixⁱ	395 – 399	Combined sources	5
Turnⁱ	402 – 404	Combined sources	3
Helixⁱ	413 – 416	Combined sources	4
Beta strandⁱ	419 – 421	Combined sources	3
Helixⁱ	442 – 459	Combined sources	18
Beta strandⁱ	460 – 466	Combined sources	7
Helixⁱ	468 – 470	Combined sources	3
Beta strandⁱ	476 – 483	Combined sources	8
Beta strandⁱ	489 – 493	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16696
SMRⁱ	Q16696
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q16696

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG015789
InParanoidⁱ	Q16696
KEGG Orthology (KO) More...KOⁱ	K17685
OMAⁱ	QYLSFGC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	Q16696
TreeFamⁱ	TF352043

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008067 Cyt_P450_E_grp-I_CYP2A-like IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01684 EP450ICYP2A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q16696-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLASGLLLVT LLACLTVMVL MSVWRQRKSR GKLPPGPTPL PFIGNYLQLN 
        60         70         80         90        100
TEQMYNSLMK ISERYGPVFT IHLGPRRVVV LCGHDAVKEA LVDQAEEFSG 
       110        120        130        140        150
RGEQATFDWL FKGYGVAFSN GERAKQLRRF SIATLRGFGV GKRGIEERIQ 
       160        170        180        190        200
EEAGFLIDAL RGTHGANIDP TFFLSRTVSN VISSIVFGDR FDYEDKEFLS 
       210        220        230        240        250
LLRMMLGSFQ FTATSTGQLY EMFSSVMKHL PGPQQQAFKE LQGLEDFIAK 
       260        270        280        290        300
KVEHNQRTLD PNSPRDFIDS FLIRMQEEEK NPNTEFYLKN LVMTTLNLFF 
       310        320        330        340        350
AGTETVSTTL RYGFLLLMKH PEVEAKVHEE IDRVIGKNRQ PKFEDRAKMP 
       360        370        380        390        400
YTEAVIHEIQ RFGDMLPMGL AHRVNKDTKF RDFFLPKGTE VFPMLGSVLR 
       410        420        430        440        450
DPRFFSNPRD FNPQHFLDKK GQFKKSDAFV PFSIGKRYCF GEGLARMELF 
       460        470        480        490 
LFFTTIMQNF RFKSPQSPKD IDVSPKHVGF ATIPRNYTMS FLPR

Length:494

Mass (Da):56,688

Last modified:October 11, 2005 - v3

Checksum:ⁱA39F18AD71C28821

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	208	S → R in AAB40519 (PubMed:7668294).Curated	1
Sequence conflictⁱ	213	A → G in AAB40519 (PubMed:7668294).Curated	1
Sequence conflictⁱ	398	V → E in AAB40519 (PubMed:7668294).Curated	1
Sequence conflictⁱ	409 – 412	RDFN → QDCS in AAB40519 (PubMed:7668294).Curated	4
Sequence conflictⁱ	419	K → E in AAB40519 (PubMed:7668294).Curated	1

Polymorphismⁱ

The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested.

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018334	25	R → Q in allele CYP2A13*2. 2 PublicationsCorresponds to variant dbSNP:rs8192784Ensembl.	1
Natural variantⁱVAR_018335	101	R → Q in allele CYP2A13*4. 1 PublicationCorresponds to variant dbSNP:rs148044792Ensembl.	1
Natural variantⁱVAR_018336	134	T → TT in allele CYP2A13*3. 1 Publication	1
Natural variantⁱVAR_018337	158	D → E in allele CYP2A133 and allele CYP2A138. 2 PublicationsCorresponds to variant dbSNP:rs112337232Ensembl.	1
Natural variantⁱVAR_013835	257	R → C in allele CYP2A13*2. 2 PublicationsCorresponds to variant dbSNP:rs8192789Ensembl.	1
Natural variantⁱVAR_018356	323	V → L in allele CYP2A13*9. 1 Publication	1
Natural variantⁱVAR_018338	453	F → Y in allele CYP2A13*5. 1 PublicationCorresponds to variant dbSNP:rs72547590Ensembl.	1
Natural variantⁱVAR_018339	494	R → C in allele CYP2A13*6. 1 PublicationCorresponds to variant dbSNP:rs138870349Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U22028 Genomic DNA Translation: AAB40519.1 AF209774 mRNA Translation: AAG35775.1 AY513604 mRNA Translation: AAR90935.1 AY513605 mRNA Translation: AAR90936.1 AY513606 mRNA Translation: AAR90937.1 AY513608 mRNA Translation: AAR90939.1 AY513609 mRNA Translation: AAR90940.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12571.1
PIRⁱ	I38966
NCBI Reference Sequences More...RefSeqⁱ	NP_000757.2, NM_000766.4
UniGeneⁱ	Hs.567252

Genome annotation databases

Ensemblⁱ	ENST00000330436; ENSP00000332679; ENSG00000197838
GeneIDⁱ	1553
KEGGⁱ	hsa:1553
UCSC genome browser More...UCSCⁱ	uc002opt.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16696	Cytochrome P450 2A6	)	HUMAN		494	UniRef90_P11509
Uncharacterized protein		CEREH		506
Cytochrome P450 2A3		HETGA		502
Cytochrome P450 2A3		FUKDA		500
Uncharacterized protein		CHLSB		497
+130

Protein	Similar proteins		Species	Score	Length	Source
Q16696	Cytochrome P450 2A6	)	HUMAN		494	UniRef50_P11509
Cytochrome P450 2C2		RABIT		490
Cytochrome P450 2A9		MESAU		493
Cytochrome P450 2C55		RAT		490
Cytochrome P450 2C39		MOUSE		490
+1276

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP2A13 alleles

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U22028 Genomic DNA Translation: AAB40519.1 AF209774 mRNA Translation: AAG35775.1 AY513604 mRNA Translation: AAR90935.1 AY513605 mRNA Translation: AAR90936.1 AY513606 mRNA Translation: AAR90937.1 AY513608 mRNA Translation: AAR90939.1 AY513609 mRNA Translation: AAR90940.1
CCDSⁱ	CCDS12571.1
PIRⁱ	I38966
RefSeqⁱ	NP_000757.2, NM_000766.4
UniGeneⁱ	Hs.567252

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2P85	X-ray	2.35	A/B/C/D/E/F	26-494	[»]
	2PG5	X-ray	1.95	A/B/C/D	31-494	[»]
	2PG6	X-ray	2.53	A/B/C/D	31-494	[»]
	2PG7	X-ray	2.80	A/B/C/D	31-494	[»]
	3T3S	X-ray	3.00	A/B/C/D/E/F/G/H	31-494	[»]
	4EJG	X-ray	2.50	A/B/C/D/E/F/G/H	31-494	[»]
	4EJH	X-ray	2.35	A/B/C/D/E/F/G/H	31-494	[»]
	4EJI	X-ray	2.10	A	31-494	[»]
ProteinModelPortalⁱ	Q16696
SMRⁱ	Q16696
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107931, 1 interactor
STRINGⁱ	9606.ENSP00000332679

Chemistry databases

BindingDBⁱ	Q16696
ChEMBLⁱ	CHEMBL3542436
DrugBankⁱ	DB00553 Methoxsalen DB00184 Nicotine DB03783 Phenacetin DB00624 Testosterone

PTM databases

iPTMnetⁱ	Q16696
PhosphoSitePlusⁱ	Q16696

Polymorphism and mutation databases

BioMutaⁱ	CYP2A13
DMDMⁱ	77416854

Proteomic databases

EPDⁱ	Q16696
PaxDbⁱ	Q16696
PeptideAtlasⁱ	Q16696
PRIDEⁱ	Q16696
ProteomicsDBⁱ	61036

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1553
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000330436; ENSP00000332679; ENSG00000197838
GeneIDⁱ	1553
KEGGⁱ	hsa:1553
UCSCⁱ	uc002opt.5 human

Organism-specific databases

CTDⁱ	1553
DisGeNETⁱ	1553
EuPathDBⁱ	HostDB:ENSG00000197838.4
GeneCardsⁱ	CYP2A13
HGNCⁱ	HGNC:2608 CYP2A13
HPAⁱ	HPA046713 HPA047262
MIMⁱ	608055 gene
neXtProtⁱ	NX_Q16696
OpenTargetsⁱ	ENSG00000197838
PharmGKBⁱ	PA27101
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00880000137861
HOGENOMⁱ	HOG000036992
HOVERGENⁱ	HBG015789
InParanoidⁱ	Q16696
KOⁱ	K17685
OMAⁱ	QYLSFGC
OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	Q16696
TreeFamⁱ	TF352043

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211981 Xenobiotics R-HSA-211999 CYP2E1 reactions R-HSA-5423646 Aflatoxin activation and detoxification
SABIO-RKⁱ	Q16696

Miscellaneous databases

EvolutionaryTraceⁱ	Q16696
GeneWikiⁱ	CYP2A13
GenomeRNAiⁱ	1553
Protein Ontology More...PROⁱ	PR:Q16696
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197838 Expressed in 87 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_CYP2A13
Genevisibleⁱ	Q16696 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008067 Cyt_P450_E_grp-I_CYP2A-like IPR036396 Cyt_P450_sf
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01684 EP450ICYP2A PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2AD_HUMAN
Accessionⁱ	Q16696Primary (citable) accession number: Q16696 Secondary accession number(s): Q53YR8 , Q6R569, Q6R570, Q9H2X2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16696 (CP2AD_HUMAN)

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Cytochrome P450 2A13

CYP2A13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ