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Protein

Dual specificity protein phosphatase 5

Gene

DUSP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation1 Publication
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei263Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

  • MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
  • phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: UniProtKB
  • protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • activation of MAPK activity Source: Reactome
  • dephosphorylation Source: UniProtKB
  • endoderm formation Source: GO_Central
  • MAPK cascade Source: Reactome
  • peptidyl-threonine dephosphorylation Source: UniProtKB
  • peptidyl-tyrosine dephosphorylation Source: UniProtKB
  • protein dephosphorylation Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SignaLinkiQ16690
SIGNORiQ16690

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 5 (EC:3.1.3.161 Publication, EC:3.1.3.481 Publication)
Alternative name(s):
Dual specificity protein phosphatase hVH3
Gene namesi
Name:DUSP5
Synonyms:VH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138166.5
HGNCiHGNC:3071 DUSP5
MIMi603069 gene
neXtProtiNX_Q16690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1847
OpenTargetsiENSG00000138166
PharmGKBiPA27528

Chemistry databases

ChEMBLiCHEMBL1250380

Polymorphism and mutation databases

BioMutaiDUSP5
DMDMi215273975

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948021 – 384Dual specificity protein phosphatase 5Add BLAST384

Proteomic databases

EPDiQ16690
MaxQBiQ16690
PaxDbiQ16690
PeptideAtlasiQ16690
PRIDEiQ16690
ProteomicsDBi61034

PTM databases

DEPODiQ16690
iPTMnetiQ16690
PhosphoSitePlusiQ16690

Expressioni

Gene expression databases

BgeeiENSG00000138166
CleanExiHS_DUSP5
GenevisibleiQ16690 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPK1P284824EBI-7487376,EBI-959949

Protein-protein interaction databases

BioGridi108180, 17 interactors
IntActiQ16690, 1 interactor
MINTiQ16690
STRINGi9606.ENSP00000358596

Chemistry databases

BindingDBiQ16690

Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi180 – 183Combined sources4
Beta strandi186 – 190Combined sources5
Helixi191 – 194Combined sources4
Helixi197 – 203Combined sources7
Beta strandi207 – 210Combined sources4
Beta strandi223 – 227Combined sources5
Helixi239 – 241Combined sources3
Helixi242 – 254Combined sources13
Beta strandi259 – 268Combined sources10
Helixi269 – 282Combined sources14
Helixi286 – 296Combined sources11
Helixi304 – 317Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G6ZX-ray2.70A/B/C178-384[»]
ProteinModelPortaliQ16690
SMRiQ16690
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16690

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 141RhodanesePROSITE-ProRule annotationAdd BLAST123
Domaini180 – 384Tyrosine-protein phosphataseAdd BLAST205

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi53 – 74Nuclear localization signalSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 82Poly-Gly4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOVERGENiHBG007347
InParanoidiQ16690
KOiK04459
OMAiCVREKGG
OrthoDBiEOG091G0249
PhylomeDBiQ16690
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q16690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTSLDGRQ LRKMLRKEAA ARCVVLDCRP YLAFAASNVR GSLNVNLNSV
60 70 80 90 100
VLRRARGGAV SARYVLPDEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR
110 120 130 140 150
EESAARVVLT SLLACLPAGP RVYFLKGGYE TFYSEYPECC VDVKPISQEK
160 170 180 190 200
IESERALISQ CGKPVVNVSY RPAYDQGGPV EILPFLYLGS AYHASKCEFL
210 220 230 240 250
ANLHITALLN VSRRTSEACA THLHYKWIPV EDSHTADISS HFQEAIDFID
260 270 280 290 300
CVREKGGKVL VHCEAGISRS PTICMAYLMK TKQFRLKEAF DYIKQRRSMV
310 320 330 340 350
SPNFGFMGQL LQYESEILPS TPNPQPPSCQ GEAAGSSLIG HLQTLSPDMQ
360 370 380
GAYCTFPASV LAPVPTHSTV SELSRSPVAT ATSC
Length:384
Mass (Da):42,047
Last modified:November 25, 2008 - v2
Checksum:i2E4B2938F886CB4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 11RQL → GHV in AAA64693 (PubMed:7961985).Curated3
Sequence conflicti71A → R in AAA64693 (PubMed:7961985).Curated1
Sequence conflicti105 – 106AR → F in AAA64693 (PubMed:7961985).Curated2
Sequence conflicti220A → M in AAA64693 (PubMed:7961985).Curated1
Sequence conflicti220A → M in AAB06261 (PubMed:7836374).Curated1
Sequence conflicti220A → M in AAH62545 (PubMed:15489334).Curated1
Sequence conflicti382T → Q in AAA64693 (PubMed:7961985).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020298154E → D. Corresponds to variant dbSNP:rs2282238Ensembl.1
Natural variantiVAR_059777220A → T. Corresponds to variant dbSNP:rs1889566Ensembl.1
Natural variantiVAR_059778220A → V. Corresponds to variant dbSNP:rs1889565Ensembl.1
Natural variantiVAR_047368322P → L. Corresponds to variant dbSNP:rs35101549Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15932 mRNA Translation: AAA64693.2
U16996 mRNA Translation: AAB06261.1
AL355512 Genomic DNA No translation available.
BC062545 mRNA Translation: AAH62545.1
CCDSiCCDS7566.1
PIRiI38890
RefSeqiNP_004410.3, NM_004419.3
UniGeneiHs.2128

Genome annotation databases

EnsembliENST00000369583; ENSP00000358596; ENSG00000138166
GeneIDi1847
KEGGihsa:1847
UCSCiuc001kzd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDUS5_HUMAN
AccessioniPrimary (citable) accession number: Q16690
Secondary accession number(s): Q12997, Q5T603
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: June 20, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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