UniProtKB - Q16690 (DUS5_HUMAN)
Protein
Dual specificity protein phosphatase 5
Gene
DUSP5
Organism
Homo sapiens (Human)
Status
Functioni
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1.1 Publication
Catalytic activityi
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphatePROSITE-ProRule annotation1 PublicationEC:3.1.3.48PROSITE-ProRule annotation1 Publication
- EC:3.1.3.161 Publication
- EC:3.1.3.161 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 263 | Phosphocysteine intermediatePROSITE-ProRule annotation1 Publication | 1 |
GO - Molecular functioni
- MAP kinase tyrosine/serine/threonine phosphatase activity Source: GO_Central
- mitogen-activated protein kinase binding Source: GO_Central
- phosphatase activity Source: UniProtKB
- phosphoprotein phosphatase activity Source: GO_Central
- protein tyrosine/serine/threonine phosphatase activity Source: UniProtKB
- protein tyrosine/threonine phosphatase activity Source: GO_Central
- protein tyrosine phosphatase activity Source: ProtInc
GO - Biological processi
- activation of MAPK activity Source: Reactome
- dephosphorylation Source: UniProtKB
- endoderm formation Source: GO_Central
- inactivation of MAPK activity Source: GO_Central
- MAPK cascade Source: Reactome
- peptidyl-threonine dephosphorylation Source: UniProtKB
- peptidyl-tyrosine dephosphorylation Source: UniProtKB
- protein dephosphorylation Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
PathwayCommonsi | Q16690 |
Reactomei | R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-5675221, Negative regulation of MAPK pathway |
SignaLinki | Q16690 |
SIGNORi | Q16690 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DUSP5 Synonyms:VH3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138166.5 |
HGNCi | HGNC:3071, DUSP5 |
MIMi | 603069, gene |
neXtProti | NX_Q16690 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 1847 |
OpenTargetsi | ENSG00000138166 |
PharmGKBi | PA27528 |
Miscellaneous databases
Pharosi | Q16690, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1250380 |
Polymorphism and mutation databases
BioMutai | DUSP5 |
DMDMi | 215273975 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094802 | 1 – 384 | Dual specificity protein phosphatase 5Add BLAST | 384 |
Proteomic databases
EPDi | Q16690 |
MassIVEi | Q16690 |
MaxQBi | Q16690 |
PaxDbi | Q16690 |
PeptideAtlasi | Q16690 |
PRIDEi | Q16690 |
ProteomicsDBi | 61034 |
PTM databases
DEPODi | DUSP5 |
iPTMneti | Q16690 |
PhosphoSitePlusi | Q16690 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138166, Expressed in ectocervix and 211 other tissues |
Genevisiblei | Q16690, HS |
Organism-specific databases
HPAi | ENSG00000138166, Low tissue specificity |
Interactioni
Binary interactionsi
Q16690
With | #Exp. | IntAct |
---|---|---|
MAPK1 [P28482] | 3 | EBI-7487376,EBI-959949 |
GO - Molecular functioni
- mitogen-activated protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108180, 47 interactors |
IntActi | Q16690, 2 interactors |
MINTi | Q16690 |
STRINGi | 9606.ENSP00000358596 |
Chemistry databases
BindingDBi | Q16690 |
Miscellaneous databases
RNActi | Q16690, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q16690 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16690 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 141 | RhodanesePROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 178 – 319 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 142 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 53 – 74 | Nuclear localization signalSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 79 – 82 | Poly-Gly | 4 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1716, Eukaryota |
GeneTreei | ENSGT00940000159529 |
HOGENOMi | CLU_027074_0_2_1 |
InParanoidi | Q16690 |
OMAi | SYCTFPT |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q16690 |
TreeFami | TF105122 |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR008343, MKP IPR029021, Prot-tyrosine_phosphatase-like IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit PF00581, Rhodanese, 1 hit |
PIRSFi | PIRSF000939, MAPK_Ptase, 1 hit |
PRINTSi | PR01764, MAPKPHPHTASE |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit SM00404, PTPc_motif, 1 hit SM00450, RHOD, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q16690-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVTSLDGRQ LRKMLRKEAA ARCVVLDCRP YLAFAASNVR GSLNVNLNSV
60 70 80 90 100
VLRRARGGAV SARYVLPDEA ARARLLQEGG GGVAAVVVLD QGSRHWQKLR
110 120 130 140 150
EESAARVVLT SLLACLPAGP RVYFLKGGYE TFYSEYPECC VDVKPISQEK
160 170 180 190 200
IESERALISQ CGKPVVNVSY RPAYDQGGPV EILPFLYLGS AYHASKCEFL
210 220 230 240 250
ANLHITALLN VSRRTSEACA THLHYKWIPV EDSHTADISS HFQEAIDFID
260 270 280 290 300
CVREKGGKVL VHCEAGISRS PTICMAYLMK TKQFRLKEAF DYIKQRRSMV
310 320 330 340 350
SPNFGFMGQL LQYESEILPS TPNPQPPSCQ GEAAGSSLIG HLQTLSPDMQ
360 370 380
GAYCTFPASV LAPVPTHSTV SELSRSPVAT ATSC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 – 11 | RQL → GHV in AAA64693 (PubMed:7961985).Curated | 3 | |
Sequence conflicti | 71 | A → R in AAA64693 (PubMed:7961985).Curated | 1 | |
Sequence conflicti | 105 – 106 | AR → F in AAA64693 (PubMed:7961985).Curated | 2 | |
Sequence conflicti | 220 | A → M in AAA64693 (PubMed:7961985).Curated | 1 | |
Sequence conflicti | 220 | A → M in AAB06261 (PubMed:7836374).Curated | 1 | |
Sequence conflicti | 220 | A → M in AAH62545 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 382 | T → Q in AAA64693 (PubMed:7961985).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020298 | 154 | E → D. Corresponds to variant dbSNP:rs2282238Ensembl. | 1 | |
Natural variantiVAR_059777 | 220 | A → T. Corresponds to variant dbSNP:rs1889566Ensembl. | 1 | |
Natural variantiVAR_059778 | 220 | A → V. Corresponds to variant dbSNP:rs1889565Ensembl. | 1 | |
Natural variantiVAR_047368 | 322 | P → L. Corresponds to variant dbSNP:rs35101549Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15932 mRNA Translation: AAA64693.2 U16996 mRNA Translation: AAB06261.1 AL355512 Genomic DNA No translation available. BC062545 mRNA Translation: AAH62545.1 |
CCDSi | CCDS7566.1 |
PIRi | I38890 |
RefSeqi | NP_004410.3, NM_004419.3 |
Genome annotation databases
Ensembli | ENST00000369583; ENSP00000358596; ENSG00000138166 |
GeneIDi | 1847 |
KEGGi | hsa:1847 |
UCSCi | uc001kzd.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U15932 mRNA Translation: AAA64693.2 U16996 mRNA Translation: AAB06261.1 AL355512 Genomic DNA No translation available. BC062545 mRNA Translation: AAH62545.1 |
CCDSi | CCDS7566.1 |
PIRi | I38890 |
RefSeqi | NP_004410.3, NM_004419.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G6Z | X-ray | 2.70 | A/B/C | 178-384 | [»] | |
SMRi | Q16690 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108180, 47 interactors |
IntActi | Q16690, 2 interactors |
MINTi | Q16690 |
STRINGi | 9606.ENSP00000358596 |
Chemistry databases
BindingDBi | Q16690 |
ChEMBLi | CHEMBL1250380 |
PTM databases
DEPODi | DUSP5 |
iPTMneti | Q16690 |
PhosphoSitePlusi | Q16690 |
Polymorphism and mutation databases
BioMutai | DUSP5 |
DMDMi | 215273975 |
Proteomic databases
EPDi | Q16690 |
MassIVEi | Q16690 |
MaxQBi | Q16690 |
PaxDbi | Q16690 |
PeptideAtlasi | Q16690 |
PRIDEi | Q16690 |
ProteomicsDBi | 61034 |
Protocols and materials databases
Antibodypediai | 18355, 279 antibodies |
DNASUi | 1847 |
Genome annotation databases
Ensembli | ENST00000369583; ENSP00000358596; ENSG00000138166 |
GeneIDi | 1847 |
KEGGi | hsa:1847 |
UCSCi | uc001kzd.4, human |
Organism-specific databases
CTDi | 1847 |
DisGeNETi | 1847 |
EuPathDBi | HostDB:ENSG00000138166.5 |
GeneCardsi | DUSP5 |
HGNCi | HGNC:3071, DUSP5 |
HPAi | ENSG00000138166, Low tissue specificity |
MIMi | 603069, gene |
neXtProti | NX_Q16690 |
OpenTargetsi | ENSG00000138166 |
PharmGKBi | PA27528 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1716, Eukaryota |
GeneTreei | ENSGT00940000159529 |
HOGENOMi | CLU_027074_0_2_1 |
InParanoidi | Q16690 |
OMAi | SYCTFPT |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q16690 |
TreeFami | TF105122 |
Enzyme and pathway databases
PathwayCommonsi | Q16690 |
Reactomei | R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-5675221, Negative regulation of MAPK pathway |
SignaLinki | Q16690 |
SIGNORi | Q16690 |
Miscellaneous databases
BioGRID-ORCSi | 1847, 6 hits in 845 CRISPR screens |
ChiTaRSi | DUSP5, human |
EvolutionaryTracei | Q16690 |
GeneWikii | DUSP5 |
GenomeRNAii | 1847 |
Pharosi | Q16690, Tbio |
PROi | PR:Q16690 |
RNActi | Q16690, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138166, Expressed in ectocervix and 211 other tissues |
Genevisiblei | Q16690, HS |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR008343, MKP IPR029021, Prot-tyrosine_phosphatase-like IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit PF00581, Rhodanese, 1 hit |
PIRSFi | PIRSF000939, MAPK_Ptase, 1 hit |
PRINTSi | PR01764, MAPKPHPHTASE |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit SM00404, PTPc_motif, 1 hit SM00450, RHOD, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DUS5_HUMAN | |
Accessioni | Q16690Primary (citable) accession number: Q16690 Secondary accession number(s): Q12997, Q5T603 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations