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UniProtKB - Q16670 (ZSC26_HUMAN)
Protein
Zinc finger and SCAN domain-containing protein 26
Gene
ZSCAN26
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
CuratedRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 231 – 253 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q16670 |
SignaLinki | Q16670 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 26Alternative name(s): Protein SRE-ZBP Zinc finger protein 187 |
Gene namesi | Name:ZSCAN26 Synonyms:ZNF187 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12978, ZSCAN26 |
MIMi | 616474, gene |
neXtProti | NX_Q16670 |
VEuPathDBi | HostDB:ENSG00000197062 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7741 |
OpenTargetsi | ENSG00000197062 |
PharmGKBi | PA37559 |
Miscellaneous databases
Pharosi | Q16670, Tdark |
Genetic variation databases
BioMutai | ZSCAN26 |
DMDMi | 160221312 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307313 | 1 – 478 | Zinc finger and SCAN domain-containing protein 26Add BLAST | 478 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 17 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q16670 |
jPOSTi | Q16670 |
MassIVEi | Q16670 |
MaxQBi | Q16670 |
PeptideAtlasi | Q16670 |
PRIDEi | Q16670 |
ProteomicsDBi | 61028 [Q16670-1] 61029 [Q16670-2] |
PTM databases
iPTMneti | Q16670 |
PhosphoSitePlusi | Q16670 |
Expressioni
Inductioni
By serum stimulation.1 Publication
Gene expression databases
Bgeei | ENSG00000197062, Expressed in female gonad and 213 other tissues |
ExpressionAtlasi | Q16670, baseline and differential |
Genevisiblei | Q16670, HS |
Organism-specific databases
HPAi | ENSG00000197062, Low tissue specificity |
Interactioni
Binary interactionsi
Q16670
Protein-protein interaction databases
BioGRIDi | 113526, 53 interactors |
IntActi | Q16670, 44 interactors |
STRINGi | 9606.ENSP00000484931 |
Miscellaneous databases
RNActi | Q16670, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 133 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 159 – 181 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 200 – 226 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 163 – 181 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 231 – 253 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 282 – 304 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 338 – 360 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 366 – 388 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 394 – 416 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 444 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 450 – 472 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162298 |
HOGENOMi | CLU_002678_49_2_1 |
InParanoidi | Q16670 |
OMAi | EKTEYKC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q16670 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q16670-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATALVSAHS LAPLNLKKEG LRVVREDHYS TWEQGFKLQG NSKGLGQEPL
60 70 80 90 100
CKQFRQLRYE ETTGPREALS RLRELCQQWL QPETHTKEQI LELLVLEQFL
110 120 130 140 150
IILPKELQAR VQEHHPESRE DVVVVLEDLQ LDLGETGQQD PDQPKKQKIL
160 170 180 190 200
VEEMAPLKGV QEQQVRHECE VTKPEKEKGE ETRIENGKLI VVTDSCGRVE
210 220 230 240 250
SSGKISEPME AHNEGSNLER HQAKPKEKIE YKCSEREQRF IQHLDLIEHA
260 270 280 290 300
STHTGKKLCE SDVCQSSSLT GHKKVLSREK GHQCHECGKA FQRSSHLVRH
310 320 330 340 350
QKIHLGEKPY QCNECGKVFS QNAGLLEHLR IHTGEKPYLC IHCGKNFRRS
360 370 380 390 400
SHLNRHQRIH SQEEPCECKE CGKTFSQALL LTHHQRIHSH SKSHQCNECG
410 420 430 440 450
KAFSLTSDLI RHHRIHTGEK PFKCNICQKA FRLNSHLAQH VRIHNEEKPY
460 470
QCSECGEAFR QRSGLFQHQR YHHKDKLA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X2F1 | A0A087X2F1_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN26 ZNF187, hCG_31430 | 344 | Annotation score: | ||
A0A024RCN4 | A0A024RCN4_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN26 ZNF187, hCG_31430 | 479 | Annotation score: | ||
A0A087WXH0 | A0A087WXH0_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN26 | 150 | Annotation score: | ||
B4DMT1 | B4DMT1_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN26 | 270 | Annotation score: |
Sequence cautioni
The sequence CAD97775 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 230 | E → G in CAI46119 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 258 | L → S in CAA77818 (PubMed:1569959).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059900 | 59 | Y → C. Corresponds to variant dbSNP:rs16893892Ensembl. | 1 | |
Natural variantiVAR_059901 | 73 | R → Q. Corresponds to variant dbSNP:rs11965538Ensembl. | 1 | |
Natural variantiVAR_059902 | 83 | E → K. Corresponds to variant dbSNP:rs11965542Ensembl. | 1 | |
Natural variantiVAR_035405 | 220 | R → S1 PublicationCorresponds to variant dbSNP:rs17851075Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028702 | 1 – 153 | Missing in isoform 2. 2 PublicationsAdd BLAST | 153 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX537535 mRNA Translation: CAD97775.1 Frameshift. AL832741 mRNA Translation: CAI46119.1 AL021997 Genomic DNA No translation available. BC013951 mRNA Translation: AAH13951.1 BC013962 mRNA Translation: AAH13962.1 Z11773 mRNA Translation: CAA77818.1 |
CCDSi | CCDS78119.1 [Q16670-1] |
PIRi | A44391 |
RefSeqi | NP_001018854.2, NM_001023560.3 NP_001104509.1, NM_001111039.2 [Q16670-1] NP_001274350.1, NM_001287421.1 NP_001274351.1, NM_001287422.1 NP_689949.3, NM_152736.5 XP_016866753.1, XM_017011264.1 [Q16670-1] |
Genome annotation databases
Ensembli | ENST00000623276.3; ENSP00000485228.1; ENSG00000197062.12 |
GeneIDi | 7741 |
KEGGi | hsa:7741 |
UCSCi | uc032wpm.2, human [Q16670-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX537535 mRNA Translation: CAD97775.1 Frameshift. AL832741 mRNA Translation: CAI46119.1 AL021997 Genomic DNA No translation available. BC013951 mRNA Translation: AAH13951.1 BC013962 mRNA Translation: AAH13962.1 Z11773 mRNA Translation: CAA77818.1 |
CCDSi | CCDS78119.1 [Q16670-1] |
PIRi | A44391 |
RefSeqi | NP_001018854.2, NM_001023560.3 NP_001104509.1, NM_001111039.2 [Q16670-1] NP_001274350.1, NM_001287421.1 NP_001274351.1, NM_001287422.1 NP_689949.3, NM_152736.5 XP_016866753.1, XM_017011264.1 [Q16670-1] |
3D structure databases
AlphaFoldDBi | Q16670 |
SMRi | Q16670 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113526, 53 interactors |
IntActi | Q16670, 44 interactors |
STRINGi | 9606.ENSP00000484931 |
PTM databases
iPTMneti | Q16670 |
PhosphoSitePlusi | Q16670 |
Genetic variation databases
BioMutai | ZSCAN26 |
DMDMi | 160221312 |
Proteomic databases
EPDi | Q16670 |
jPOSTi | Q16670 |
MassIVEi | Q16670 |
MaxQBi | Q16670 |
PeptideAtlasi | Q16670 |
PRIDEi | Q16670 |
ProteomicsDBi | 61028 [Q16670-1] 61029 [Q16670-2] |
Protocols and materials databases
ABCDi | Q16670, 2 sequenced antibodies |
Antibodypediai | 6168, 202 antibodies from 24 providers |
DNASUi | 7741 |
Genome annotation databases
Ensembli | ENST00000623276.3; ENSP00000485228.1; ENSG00000197062.12 |
GeneIDi | 7741 |
KEGGi | hsa:7741 |
UCSCi | uc032wpm.2, human [Q16670-1] |
Organism-specific databases
CTDi | 7741 |
DisGeNETi | 7741 |
GeneCardsi | ZSCAN26 |
HGNCi | HGNC:12978, ZSCAN26 |
HPAi | ENSG00000197062, Low tissue specificity |
MIMi | 616474, gene |
neXtProti | NX_Q16670 |
OpenTargetsi | ENSG00000197062 |
PharmGKBi | PA37559 |
VEuPathDBi | HostDB:ENSG00000197062 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162298 |
HOGENOMi | CLU_002678_49_2_1 |
InParanoidi | Q16670 |
OMAi | EKTEYKC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q16670 |
Enzyme and pathway databases
PathwayCommonsi | Q16670 |
SignaLinki | Q16670 |
Miscellaneous databases
BioGRID-ORCSi | 7741, 4 hits in 165 CRISPR screens |
ChiTaRSi | ZSCAN26, human |
GenomeRNAii | 7741 |
Pharosi | Q16670, Tdark |
PROi | PR:Q16670 |
RNActi | Q16670, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197062, Expressed in female gonad and 213 other tissues |
ExpressionAtlasi | Q16670, baseline and differential |
Genevisiblei | Q16670, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSC26_HUMAN | |
Accessioni | Q16670Primary (citable) accession number: Q16670 Secondary accession number(s): Q5JPG4, Q7Z3Q6, Q96A17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot