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UniProtKB - Q16670 (ZSC26_HUMAN)

Entry version 160 (25 May 2022)
Sequence version 2 (23 Oct 2007)
Previous versions | rss
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Protein

Zinc finger and SCAN domain-containing protein 26

Gene

ZSCAN26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16670

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16670

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 26
Alternative name(s):
Protein SRE-ZBP
Zinc finger protein 187
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN26
Synonyms:ZNF187
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12978, ZSCAN26

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616474, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16670

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000197062

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7741

Open Targets

More...OpenTargetsi		ENSG00000197062

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37559

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16670, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZSCAN26

Domain mapping of disease mutations (DMDM)

More...DMDMi		160221312

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073131 – 478Zinc finger and SCAN domain-containing protein 26Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16670

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16670

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16670

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16670

PeptideAtlas

More...PeptideAtlasi		Q16670

PRoteomics IDEntifications database

More...PRIDEi		Q16670

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61028 [Q16670-1]
61029 [Q16670-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16670

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16670

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By serum stimulation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197062, Expressed in female gonad and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16670, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16670, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197062, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113526, 53 interactors

Protein interaction database and analysis system

More...IntActi		Q16670, 44 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000484931

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16670, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q16670

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16670

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 133SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni159 – 181DisorderedSequence analysisAdd BLAST23
Regioni200 – 226DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi163 – 181Basic and acidic residuesSequence analysisAdd BLAST19

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162298

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16670

Identification of Orthologs from Complete Genome Data

More...OMAi		EKTEYKC

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16670

Family and domain databases

Conserved Domains Database

More...CDDi		cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16670-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATALVSAHS LAPLNLKKEG LRVVREDHYS TWEQGFKLQG NSKGLGQEPL 
        60         70         80         90        100
CKQFRQLRYE ETTGPREALS RLRELCQQWL QPETHTKEQI LELLVLEQFL 
       110        120        130        140        150
IILPKELQAR VQEHHPESRE DVVVVLEDLQ LDLGETGQQD PDQPKKQKIL 
       160        170        180        190        200
VEEMAPLKGV QEQQVRHECE VTKPEKEKGE ETRIENGKLI VVTDSCGRVE 
       210        220        230        240        250
SSGKISEPME AHNEGSNLER HQAKPKEKIE YKCSEREQRF IQHLDLIEHA 
       260        270        280        290        300
STHTGKKLCE SDVCQSSSLT GHKKVLSREK GHQCHECGKA FQRSSHLVRH 
       310        320        330        340        350
QKIHLGEKPY QCNECGKVFS QNAGLLEHLR IHTGEKPYLC IHCGKNFRRS 
       360        370        380        390        400
SHLNRHQRIH SQEEPCECKE CGKTFSQALL LTHHQRIHSH SKSHQCNECG 
       410        420        430        440        450
KAFSLTSDLI RHHRIHTGEK PFKCNICQKA FRLNSHLAQH VRIHNEEKPY 
       460        470 
QCSECGEAFR QRSGLFQHQR YHHKDKLA
Length:478
Mass (Da):55,254
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91D1230831FC5C77
GO
Isoform 2 (identifier: Q16670-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Show »
Length:325
Mass (Da):37,560
Checksum:i3B7215F1B2D4621E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X2F1A0A087X2F1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN26 ZNF187, hCG_31430
344Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A024RCN4A0A024RCN4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN26 ZNF187, hCG_31430
479Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXH0A0A087WXH0_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN26
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DMT1B4DMT1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN26
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD97775 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230E → G in CAI46119 (PubMed:17974005).Curated1
Sequence conflicti258L → S in CAA77818 (PubMed:1569959).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05990059Y → C. Corresponds to variant dbSNP:rs16893892Ensembl.1
Natural variantiVAR_05990173R → Q. Corresponds to variant dbSNP:rs11965538Ensembl.1
Natural variantiVAR_05990283E → K. Corresponds to variant dbSNP:rs11965542Ensembl.1
Natural variantiVAR_035405220R → S1 PublicationCorresponds to variant dbSNP:rs17851075Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0287021 – 153Missing in isoform 2. 2 PublicationsAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX537535 mRNA Translation: CAD97775.1 Frameshift.
AL832741 mRNA Translation: CAI46119.1
AL021997 Genomic DNA No translation available.
BC013951 mRNA Translation: AAH13951.1
BC013962 mRNA Translation: AAH13962.1
Z11773 mRNA Translation: CAA77818.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS78119.1 [Q16670-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A44391

NCBI Reference Sequences

More...RefSeqi		NP_001018854.2, NM_001023560.3
NP_001104509.1, NM_001111039.2 [Q16670-1]
NP_001274350.1, NM_001287421.1
NP_001274351.1, NM_001287422.1
NP_689949.3, NM_152736.5
XP_016866753.1, XM_017011264.1 [Q16670-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000623276.3; ENSP00000485228.1; ENSG00000197062.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7741

UCSC genome browser

More...UCSCi		uc032wpm.2, human [Q16670-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537535 mRNA Translation: CAD97775.1 Frameshift.
AL832741 mRNA Translation: CAI46119.1
AL021997 Genomic DNA No translation available.
BC013951 mRNA Translation: AAH13951.1
BC013962 mRNA Translation: AAH13962.1
Z11773 mRNA Translation: CAA77818.1
CCDSiCCDS78119.1 [Q16670-1]
PIRiA44391
RefSeqiNP_001018854.2, NM_001023560.3
NP_001104509.1, NM_001111039.2 [Q16670-1]
NP_001274350.1, NM_001287421.1
NP_001274351.1, NM_001287422.1
NP_689949.3, NM_152736.5
XP_016866753.1, XM_017011264.1 [Q16670-1]

3D structure databases

AlphaFoldDBiQ16670
SMRiQ16670
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113526, 53 interactors
IntActiQ16670, 44 interactors
STRINGi9606.ENSP00000484931

PTM databases

iPTMnetiQ16670
PhosphoSitePlusiQ16670

Genetic variation databases

BioMutaiZSCAN26
DMDMi160221312

Proteomic databases

EPDiQ16670
jPOSTiQ16670
MassIVEiQ16670
MaxQBiQ16670
PeptideAtlasiQ16670
PRIDEiQ16670
ProteomicsDBi61028 [Q16670-1]
61029 [Q16670-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q16670, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		6168, 202 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		7741

Genome annotation databases

EnsembliENST00000623276.3; ENSP00000485228.1; ENSG00000197062.12
GeneIDi7741
KEGGihsa:7741
UCSCiuc032wpm.2, human [Q16670-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7741
DisGeNETi7741

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZSCAN26
HGNCiHGNC:12978, ZSCAN26
HPAiENSG00000197062, Low tissue specificity
MIMi616474, gene
neXtProtiNX_Q16670
OpenTargetsiENSG00000197062
PharmGKBiPA37559
VEuPathDBiHostDB:ENSG00000197062

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162298
HOGENOMiCLU_002678_49_2_1
InParanoidiQ16670
OMAiEKTEYKC
OrthoDBi1318335at2759
PhylomeDBiQ16670

Enzyme and pathway databases

PathwayCommonsiQ16670
SignaLinkiQ16670

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7741, 4 hits in 165 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZSCAN26, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7741
PharosiQ16670, Tdark

Protein Ontology

More...PROi		PR:Q16670
RNActiQ16670, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197062, Expressed in female gonad and 213 other tissues
ExpressionAtlasiQ16670, baseline and differential
GenevisibleiQ16670, HS

Family and domain databases

CDDicd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC26_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16670
Secondary accession number(s): Q5JPG4, Q7Z3Q6, Q96A17
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 25, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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