UniProtKB - Q16667 (CDKN3_HUMAN)
Cyclin-dependent kinase inhibitor 3
CDKN3
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 140 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein serine/threonine phosphatase activity Source: MGI
- protein tyrosine/serine/threonine phosphatase activity Source: ProtInc
- protein tyrosine phosphatase activity Source: MGI
GO - Biological processi
- cell cycle arrest Source: MGI
- G1/S transition of mitotic cell cycle Source: ProtInc
- negative regulation of cell population proliferation Source: ProtInc
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | Cell cycle |
Enzyme and pathway databases
PathwayCommonsi | Q16667 |
SIGNORi | Q16667 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CDKN3 Synonyms:CDI1, CIP2, KAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100526.19 |
HGNCi | HGNC:1791, CDKN3 |
MIMi | 123832, gene |
neXtProti | NX_Q16667 |
Subcellular locationi
Other locations
- perinuclear region 1 Publication
Cytosol
- cytosol Source: HPA
Other locations
- cytoplasm Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Hepatocellular carcinoma (HCC)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013842 | 31 | W → R in HCC; patient BX-01. 1 Publication | 1 | |
Natural variantiVAR_013843 | 78 | F → L in HCC; patient T9. 1 Publication | 1 | |
Natural variantiVAR_013844 | 79 | C → Y in HCC; patient BX-01. 1 Publication | 1 | |
Natural variantiVAR_013845 | 91 | N → K in HCC; patient BX-10. 1 PublicationCorresponds to variant dbSNP:rs760687800Ensembl. | 1 | |
Natural variantiVAR_013846 | 94 | D → V in HCC; patient NT1. 1 Publication | 1 | |
Natural variantiVAR_013847 | 95 | L → F in HCC; patient BX-05. 1 Publication | 1 | |
Natural variantiVAR_013848 | 108 | I → V in HCC; patient T9. 1 PublicationCorresponds to variant dbSNP:rs144479038Ensembl. | 1 | |
Natural variantiVAR_013849 | 187 | N → S in HCC; patient NT4. 1 Publication | 1 | |
Natural variantiVAR_013850 | 195 | K → I in HCC; patient NT4. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 1033 |
MalaCardsi | CDKN3 |
MIMi | 114550, phenotype |
OpenTargetsi | ENSG00000100526 |
PharmGKBi | PA26324 |
Miscellaneous databases
Pharosi | Q16667, Tbio |
Polymorphism and mutation databases
BioMutai | CDKN3 |
DMDMi | 2499769 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094949 | 1 – 212 | Cyclin-dependent kinase inhibitor 3Add BLAST | 212 |
Proteomic databases
jPOSTi | Q16667 |
MassIVEi | Q16667 |
MaxQBi | Q16667 |
PaxDbi | Q16667 |
PeptideAtlasi | Q16667 |
PRIDEi | Q16667 |
ProteomicsDBi | 61026 [Q16667-1] 61027 [Q16667-2] |
PTM databases
DEPODi | CDKN3 |
iPTMneti | Q16667 |
PhosphoSitePlusi | Q16667 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000100526, Expressed in testis and 176 other tissues |
ExpressionAtlasi | Q16667, baseline and differential |
Genevisiblei | Q16667, HS |
Organism-specific databases
HPAi | ENSG00000100526, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4.
Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix).
Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.
6 PublicationsBinary interactionsi
Q16667
With | #Exp. | IntAct |
---|---|---|
CDK2 [P24941] | 7 | EBI-1031527,EBI-375096 |
Protein-protein interaction databases
BioGRIDi | 107467, 50 interactors |
DIPi | DIP-245N |
IntActi | Q16667, 10 interactors |
MINTi | Q16667 |
STRINGi | 9606.ENSP00000335357 |
Miscellaneous databases
RNActi | Q16667, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q16667 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16667 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 201 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 169 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 34 | Interaction with CDK2Add BLAST | 34 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1720, Eukaryota |
GeneTreei | ENSGT00390000004717 |
InParanoidi | Q16667 |
OMAi | QVNCSQF |
OrthoDBi | 1539111at2759 |
PhylomeDBi | Q16667 |
TreeFami | TF101040 |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
IDEALi | IID00605 |
InterProi | View protein in InterPro IPR008425, CDK_inhib_3 IPR022778, CDKN3 IPR029021, Prot-tyrosine_phosphatase-like IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF05706, CDKN3, 1 hit |
PIRSFi | PIRSF037322, CDKN3, 1 hit |
SMARTi | View protein in SMART SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG
60 70 80 90 100
CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG
110 120 130 140 150
IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV
160 170 180 190 200
AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL
210
SSRDSQSRSV SR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2J7 | G3V2J7_HUMAN | Cyclin-dependent kinase inhibitor 3 | CDKN3 | 203 | Annotation score: | ||
H7C0S3 | H7C0S3_HUMAN | Cyclin-dependent kinase inhibitor 3 | CDKN3 | 211 | Annotation score: | ||
A0A087WWK3 | A0A087WWK3_HUMAN | Cyclin-dependent kinase inhibitor 3 | CDKN3 | 207 | Annotation score: | ||
F8WD24 | F8WD24_HUMAN | Cyclin-dependent kinase inhibitor 3 | CDKN3 | 166 | Annotation score: | ||
F5H232 | F5H232_HUMAN | Cyclin-dependent kinase inhibitor 3 | CDKN3 | 146 | Annotation score: | ||
G3V1K6 | G3V1K6_HUMAN | Cyclin-dependent kinase inhibitor 3 | CDKN3 | 148 | Annotation score: | ||
A0A087WW25 | A0A087WW25_HUMAN | Cyclin-dependent kinase inhibitor 3 | CDKN3 | 35 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | K → E in AAC04932 (PubMed:8242750).Curated | 1 | |
Sequence conflicti | 2 | K → E in AAV38258 (Ref. 8) Curated | 1 | |
Sequence conflicti | 10 | S → G in AAK06380 (PubMed:10987270).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013842 | 31 | W → R in HCC; patient BX-01. 1 Publication | 1 | |
Natural variantiVAR_013843 | 78 | F → L in HCC; patient T9. 1 Publication | 1 | |
Natural variantiVAR_013844 | 79 | C → Y in HCC; patient BX-01. 1 Publication | 1 | |
Natural variantiVAR_013845 | 91 | N → K in HCC; patient BX-10. 1 PublicationCorresponds to variant dbSNP:rs760687800Ensembl. | 1 | |
Natural variantiVAR_013846 | 94 | D → V in HCC; patient NT1. 1 Publication | 1 | |
Natural variantiVAR_013847 | 95 | L → F in HCC; patient BX-05. 1 Publication | 1 | |
Natural variantiVAR_013848 | 108 | I → V in HCC; patient T9. 1 PublicationCorresponds to variant dbSNP:rs144479038Ensembl. | 1 | |
Natural variantiVAR_051769 | 159 | S → F. Corresponds to variant dbSNP:rs1803843Ensembl. | 1 | |
Natural variantiVAR_013849 | 187 | N → S in HCC; patient NT4. 1 Publication | 1 | |
Natural variantiVAR_013850 | 195 | K → I in HCC; patient NT4. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036613 | 11 – 50 | Missing in isoform 2. 2 PublicationsAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02681 mRNA Translation: AAC04932.1 L27711 mRNA Translation: AAA66496.1 AF213033 mRNA Translation: AAK06365.1 AF213036 mRNA Translation: AAK06368.1 AF213038 mRNA Translation: AAK06370.1 AF213039 mRNA Translation: AAK06371.1 AF213041 mRNA Translation: AAK06373.1 AF213042 mRNA Translation: AAK06374.1 AF213046 mRNA Translation: AAK06377.1 AF213047 mRNA Translation: AAK06378.1 AF213049 mRNA Translation: AAK06380.1 AF213053 mRNA Translation: AAK06384.1 AY257474 mRNA Translation: AAP13062.1 L25876 mRNA Translation: AAA60222.1 EF560750 mRNA Translation: ABQ59060.1 CR407666 mRNA Translation: CAG28594.1 BT019451 mRNA Translation: AAV38258.1 AY194117 Genomic DNA Translation: AAN86348.1 CH471061 Genomic DNA Translation: EAW80632.1 CH471061 Genomic DNA Translation: EAW80634.1 BC064965 mRNA Translation: AAH64965.1 |
CCDSi | CCDS45109.1 [Q16667-2] CCDS9716.1 [Q16667-1] |
PIRi | A49436 |
RefSeqi | NP_001124323.1, NM_001130851.1 [Q16667-2] NP_005183.2, NM_005192.3 [Q16667-1] |
Genome annotation databases
Ensembli | ENST00000335183; ENSP00000335357; ENSG00000100526 [Q16667-1] ENST00000442975; ENSP00000415333; ENSG00000100526 [Q16667-2] |
GeneIDi | 1033 |
KEGGi | hsa:1033 |
UCSCi | uc001xap.4, human [Q16667-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U02681 mRNA Translation: AAC04932.1 L27711 mRNA Translation: AAA66496.1 AF213033 mRNA Translation: AAK06365.1 AF213036 mRNA Translation: AAK06368.1 AF213038 mRNA Translation: AAK06370.1 AF213039 mRNA Translation: AAK06371.1 AF213041 mRNA Translation: AAK06373.1 AF213042 mRNA Translation: AAK06374.1 AF213046 mRNA Translation: AAK06377.1 AF213047 mRNA Translation: AAK06378.1 AF213049 mRNA Translation: AAK06380.1 AF213053 mRNA Translation: AAK06384.1 AY257474 mRNA Translation: AAP13062.1 L25876 mRNA Translation: AAA60222.1 EF560750 mRNA Translation: ABQ59060.1 CR407666 mRNA Translation: CAG28594.1 BT019451 mRNA Translation: AAV38258.1 AY194117 Genomic DNA Translation: AAN86348.1 CH471061 Genomic DNA Translation: EAW80632.1 CH471061 Genomic DNA Translation: EAW80634.1 BC064965 mRNA Translation: AAH64965.1 |
CCDSi | CCDS45109.1 [Q16667-2] CCDS9716.1 [Q16667-1] |
PIRi | A49436 |
RefSeqi | NP_001124323.1, NM_001130851.1 [Q16667-2] NP_005183.2, NM_005192.3 [Q16667-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FPZ | X-ray | 2.00 | A/B/C/D/E/F | 1-212 | [»] | |
1FQ1 | X-ray | 3.00 | A | 1-212 | [»] | |
SMRi | Q16667 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107467, 50 interactors |
DIPi | DIP-245N |
IntActi | Q16667, 10 interactors |
MINTi | Q16667 |
STRINGi | 9606.ENSP00000335357 |
PTM databases
DEPODi | CDKN3 |
iPTMneti | Q16667 |
PhosphoSitePlusi | Q16667 |
Polymorphism and mutation databases
BioMutai | CDKN3 |
DMDMi | 2499769 |
Proteomic databases
jPOSTi | Q16667 |
MassIVEi | Q16667 |
MaxQBi | Q16667 |
PaxDbi | Q16667 |
PeptideAtlasi | Q16667 |
PRIDEi | Q16667 |
ProteomicsDBi | 61026 [Q16667-1] 61027 [Q16667-2] |
Protocols and materials databases
Antibodypediai | 3940, 494 antibodies |
DNASUi | 1033 |
Genome annotation databases
Ensembli | ENST00000335183; ENSP00000335357; ENSG00000100526 [Q16667-1] ENST00000442975; ENSP00000415333; ENSG00000100526 [Q16667-2] |
GeneIDi | 1033 |
KEGGi | hsa:1033 |
UCSCi | uc001xap.4, human [Q16667-1] |
Organism-specific databases
CTDi | 1033 |
DisGeNETi | 1033 |
EuPathDBi | HostDB:ENSG00000100526.19 |
GeneCardsi | CDKN3 |
HGNCi | HGNC:1791, CDKN3 |
HPAi | ENSG00000100526, Tissue enriched (testis) |
MalaCardsi | CDKN3 |
MIMi | 114550, phenotype 123832, gene |
neXtProti | NX_Q16667 |
OpenTargetsi | ENSG00000100526 |
PharmGKBi | PA26324 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1720, Eukaryota |
GeneTreei | ENSGT00390000004717 |
InParanoidi | Q16667 |
OMAi | QVNCSQF |
OrthoDBi | 1539111at2759 |
PhylomeDBi | Q16667 |
TreeFami | TF101040 |
Enzyme and pathway databases
PathwayCommonsi | Q16667 |
SIGNORi | Q16667 |
Miscellaneous databases
BioGRID-ORCSi | 1033, 2 hits in 852 CRISPR screens |
ChiTaRSi | CDKN3, human |
EvolutionaryTracei | Q16667 |
GeneWikii | CDKN3 |
GenomeRNAii | 1033 |
Pharosi | Q16667, Tbio |
PROi | PR:Q16667 |
RNActi | Q16667, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100526, Expressed in testis and 176 other tissues |
ExpressionAtlasi | Q16667, baseline and differential |
Genevisiblei | Q16667, HS |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
IDEALi | IID00605 |
InterProi | View protein in InterPro IPR008425, CDK_inhib_3 IPR022778, CDKN3 IPR029021, Prot-tyrosine_phosphatase-like IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF05706, CDKN3, 1 hit |
PIRSFi | PIRSF037322, CDKN3, 1 hit |
SMARTi | View protein in SMART SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDKN3_HUMAN | |
Accessioni | Q16667Primary (citable) accession number: Q16667 Secondary accession number(s): Q53ZU6 Q9C053 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations