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UniProtKB - Q16667 (CDKN3_HUMAN)

Entry version 193 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Cyclin-dependent kinase inhibitor 3

Gene

CDKN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei140Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16667

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16667

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphatase
Cyclin-dependent kinase interactor 1
Cyclin-dependent kinase-interacting protein 2
Kinase-associated phosphatase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDKN3
Synonyms:CDI1, CIP2, KAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1791, CDKN3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		123832, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16667

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100526.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hepatocellular carcinoma (HCC)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01384231W → R in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384378F → L in HCC; patient T9. 1 Publication1
Natural variantiVAR_01384479C → Y in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384591N → K in HCC; patient BX-10. 1 PublicationCorresponds to variant dbSNP:rs760687800Ensembl.1
Natural variantiVAR_01384694D → V in HCC; patient NT1. 1 Publication1
Natural variantiVAR_01384795L → F in HCC; patient BX-05. 1 Publication1
Natural variantiVAR_013848108I → V in HCC; patient T9. 1 PublicationCorresponds to variant dbSNP:rs144479038Ensembl.1
Natural variantiVAR_013849187N → S in HCC; patient NT4. 1 Publication1
Natural variantiVAR_013850195K → I in HCC; patient NT4. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		1033

MalaCards human disease database

More...MalaCardsi		CDKN3
MIMi114550, phenotype

Open Targets

More...OpenTargetsi		ENSG00000100526

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16667, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDKN3

Domain mapping of disease mutations (DMDM)

More...DMDMi		2499769

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000949491 – 212Cyclin-dependent kinase inhibitor 3Add BLAST212

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16667

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16667

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16667

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16667

PeptideAtlas

More...PeptideAtlasi		Q16667

PRoteomics IDEntifications database

More...PRIDEi		Q16667

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61026 [Q16667-1]
61027 [Q16667-2]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		CDKN3

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16667

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16667

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in breast and prostate cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100526, Expressed in testis and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16667, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16667, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100526, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4.

Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix).

Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107467, 51 interactors

Database of interacting proteins

More...DIPi		DIP-245N

Protein interaction database and analysis system

More...IntActi		Q16667, 10 interactors

Molecular INTeraction database

More...MINTi		Q16667

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000335357

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16667, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16667

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16667

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 201Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST169

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34Interaction with CDK2Add BLAST34
Regioni1 – 20DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1720, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004717

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16667

Identification of Orthologs from Complete Genome Data

More...OMAi		QVNCSQF

Database of Orthologous Groups

More...OrthoDBi		1539111at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16667

TreeFam database of animal gene trees

More...TreeFami		TF101040

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.90.190.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00605

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008425, CDK_inhib_3
IPR022778, CDKN3
IPR029021, Prot-tyrosine_phosphatase-like
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05706, CDKN3, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037322, CDKN3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16667-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG 
        60         70         80         90        100
CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG 
       110        120        130        140        150
IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV 
       160        170        180        190        200
AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL 
       210 
SSRDSQSRSV SR
Length:212
Mass (Da):23,805
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD87FAC8E28F6525F
GO
Isoform 2 (identifier: Q16667-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-50: Missing.

Show »
Length:172
Mass (Da):19,359
Checksum:iE1F3AA29AAABE3DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2J7G3V2J7_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
203Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0S3H7C0S3_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
211Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWK3A0A087WWK3_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
207Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD24F8WD24_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H232F5H232_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1K6G3V1K6_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW25A0A087WW25_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2K → E in AAC04932 (PubMed:8242750).Curated1
Sequence conflicti2K → E in AAV38258 (Ref. 8) Curated1
Sequence conflicti10S → G in AAK06380 (PubMed:10987270).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01384231W → R in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384378F → L in HCC; patient T9. 1 Publication1
Natural variantiVAR_01384479C → Y in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384591N → K in HCC; patient BX-10. 1 PublicationCorresponds to variant dbSNP:rs760687800Ensembl.1
Natural variantiVAR_01384694D → V in HCC; patient NT1. 1 Publication1
Natural variantiVAR_01384795L → F in HCC; patient BX-05. 1 Publication1
Natural variantiVAR_013848108I → V in HCC; patient T9. 1 PublicationCorresponds to variant dbSNP:rs144479038Ensembl.1
Natural variantiVAR_051769159S → F. Corresponds to variant dbSNP:rs1803843Ensembl.1
Natural variantiVAR_013849187N → S in HCC; patient NT4. 1 Publication1
Natural variantiVAR_013850195K → I in HCC; patient NT4. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03661311 – 50Missing in isoform 2. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U02681 mRNA Translation: AAC04932.1
L27711 mRNA Translation: AAA66496.1
AF213033 mRNA Translation: AAK06365.1
AF213036 mRNA Translation: AAK06368.1
AF213038 mRNA Translation: AAK06370.1
AF213039 mRNA Translation: AAK06371.1
AF213041 mRNA Translation: AAK06373.1
AF213042 mRNA Translation: AAK06374.1
AF213046 mRNA Translation: AAK06377.1
AF213047 mRNA Translation: AAK06378.1
AF213049 mRNA Translation: AAK06380.1
AF213053 mRNA Translation: AAK06384.1
AY257474 mRNA Translation: AAP13062.1
L25876 mRNA Translation: AAA60222.1
EF560750 mRNA Translation: ABQ59060.1
CR407666 mRNA Translation: CAG28594.1
BT019451 mRNA Translation: AAV38258.1
AY194117 Genomic DNA Translation: AAN86348.1
CH471061 Genomic DNA Translation: EAW80632.1
CH471061 Genomic DNA Translation: EAW80634.1
BC064965 mRNA Translation: AAH64965.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45109.1 [Q16667-2]
CCDS9716.1 [Q16667-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A49436

NCBI Reference Sequences

More...RefSeqi		NP_001124323.1, NM_001130851.1 [Q16667-2]
NP_005183.2, NM_005192.3 [Q16667-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000335183; ENSP00000335357; ENSG00000100526 [Q16667-1]
ENST00000442975; ENSP00000415333; ENSG00000100526 [Q16667-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1033

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1033

UCSC genome browser

More...UCSCi		uc001xap.4, human [Q16667-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02681 mRNA Translation: AAC04932.1
L27711 mRNA Translation: AAA66496.1
AF213033 mRNA Translation: AAK06365.1
AF213036 mRNA Translation: AAK06368.1
AF213038 mRNA Translation: AAK06370.1
AF213039 mRNA Translation: AAK06371.1
AF213041 mRNA Translation: AAK06373.1
AF213042 mRNA Translation: AAK06374.1
AF213046 mRNA Translation: AAK06377.1
AF213047 mRNA Translation: AAK06378.1
AF213049 mRNA Translation: AAK06380.1
AF213053 mRNA Translation: AAK06384.1
AY257474 mRNA Translation: AAP13062.1
L25876 mRNA Translation: AAA60222.1
EF560750 mRNA Translation: ABQ59060.1
CR407666 mRNA Translation: CAG28594.1
BT019451 mRNA Translation: AAV38258.1
AY194117 Genomic DNA Translation: AAN86348.1
CH471061 Genomic DNA Translation: EAW80632.1
CH471061 Genomic DNA Translation: EAW80634.1
BC064965 mRNA Translation: AAH64965.1
CCDSiCCDS45109.1 [Q16667-2]
CCDS9716.1 [Q16667-1]
PIRiA49436
RefSeqiNP_001124323.1, NM_001130851.1 [Q16667-2]
NP_005183.2, NM_005192.3 [Q16667-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FPZX-ray2.00A/B/C/D/E/F1-212[»]
1FQ1X-ray3.00A1-212[»]
SMRiQ16667
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107467, 51 interactors
DIPiDIP-245N
IntActiQ16667, 10 interactors
MINTiQ16667
STRINGi9606.ENSP00000335357

PTM databases

DEPODiCDKN3
iPTMnetiQ16667
PhosphoSitePlusiQ16667

Genetic variation databases

BioMutaiCDKN3
DMDMi2499769

Proteomic databases

jPOSTiQ16667
MassIVEiQ16667
MaxQBiQ16667
PaxDbiQ16667
PeptideAtlasiQ16667
PRIDEiQ16667
ProteomicsDBi61026 [Q16667-1]
61027 [Q16667-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3940, 506 antibodies

The DNASU plasmid repository

More...DNASUi		1033

Genome annotation databases

EnsembliENST00000335183; ENSP00000335357; ENSG00000100526 [Q16667-1]
ENST00000442975; ENSP00000415333; ENSG00000100526 [Q16667-2]
GeneIDi1033
KEGGihsa:1033
UCSCiuc001xap.4, human [Q16667-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1033
DisGeNETi1033

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDKN3
HGNCiHGNC:1791, CDKN3
HPAiENSG00000100526, Tissue enriched (testis)
MalaCardsiCDKN3
MIMi114550, phenotype
123832, gene
neXtProtiNX_Q16667
OpenTargetsiENSG00000100526
PharmGKBiPA26324
VEuPathDBiHostDB:ENSG00000100526.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1720, Eukaryota
GeneTreeiENSGT00390000004717
InParanoidiQ16667
OMAiQVNCSQF
OrthoDBi1539111at2759
PhylomeDBiQ16667
TreeFamiTF101040

Enzyme and pathway databases

PathwayCommonsiQ16667
SIGNORiQ16667

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1033, 3 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDKN3, human
EvolutionaryTraceiQ16667

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CDKN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1033
PharosiQ16667, Tbio

Protein Ontology

More...PROi		PR:Q16667
RNActiQ16667, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100526, Expressed in testis and 176 other tissues
ExpressionAtlasiQ16667, baseline and differential
GenevisibleiQ16667, HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
IDEALiIID00605
InterProiView protein in InterPro
IPR008425, CDK_inhib_3
IPR022778, CDKN3
IPR029021, Prot-tyrosine_phosphatase-like
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF05706, CDKN3, 1 hit
PIRSFiPIRSF037322, CDKN3, 1 hit
SMARTiView protein in SMART
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDKN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16667
Secondary accession number(s): Q53ZU6
, Q5U0M4, Q6P1N8, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C046, Q9C047, Q9C049, Q9C051, Q9C053
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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