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Protein

Cyclin-dependent kinase inhibitor 3

Gene

CDKN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.3 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei140Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • protein serine/threonine phosphatase activity Source: MGI
  • protein tyrosine/serine/threonine phosphatase activity Source: ProtInc
  • protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle

Enzyme and pathway databases

SIGNORiQ16667

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase inhibitor 3 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
CDK2-associated dual-specificity phosphatase
Cyclin-dependent kinase interactor 1
Cyclin-dependent kinase-interacting protein 2
Kinase-associated phosphatase
Gene namesi
Name:CDKN3
Synonyms:CDI1, CIP2, KAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100526.19
HGNCiHGNC:1791 CDKN3
MIMi123832 gene
neXtProtiNX_Q16667

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Hepatocellular carcinoma (HCC)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.
See also OMIM:114550
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01384231W → R in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384378F → L in HCC; patient T9. 1 Publication1
Natural variantiVAR_01384479C → Y in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384591N → K in HCC; patient BX-10. 1 PublicationCorresponds to variant dbSNP:rs760687800Ensembl.1
Natural variantiVAR_01384694D → V in HCC; patient NT1. 1 Publication1
Natural variantiVAR_01384795L → F in HCC; patient BX-05. 1 Publication1
Natural variantiVAR_013848108I → V in HCC; patient T9. 1 PublicationCorresponds to variant dbSNP:rs144479038Ensembl.1
Natural variantiVAR_013849187N → S in HCC; patient NT4. 1 Publication1
Natural variantiVAR_013850195K → I in HCC; patient NT4. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi1033
MalaCardsiCDKN3
MIMi114550 phenotype
OpenTargetsiENSG00000100526
PharmGKBiPA26324

Polymorphism and mutation databases

BioMutaiCDKN3
DMDMi2499769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949491 – 212Cyclin-dependent kinase inhibitor 3Add BLAST212

Proteomic databases

EPDiQ16667
MaxQBiQ16667
PaxDbiQ16667
PeptideAtlasiQ16667
PRIDEiQ16667
ProteomicsDBi61026
61027 [Q16667-2]

PTM databases

DEPODiQ16667
iPTMnetiQ16667
PhosphoSitePlusiQ16667

Expressioni

Inductioni

Up-regulated in breast and prostate cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000100526 Expressed in 164 organ(s), highest expression level in right testis
ExpressionAtlasiQ16667 baseline and differential
GenevisibleiQ16667 HS

Organism-specific databases

HPAiCAB005285
HPA039311
HPA058874

Interactioni

Subunit structurei

Interacts with cyclin-dependent kinases such as CDK1, CDK2 and CDK3. Does not interact with CDK4. Interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix). Interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK2P249417EBI-1031527,EBI-375096

Protein-protein interaction databases

BioGridi107467, 33 interactors
DIPiDIP-245N
IntActiQ16667, 9 interactors
MINTiQ16667
STRINGi9606.ENSP00000335357

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16667
SMRiQ16667
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16667

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 34Interaction with CDK2Add BLAST34

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1720 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00390000004717
HOVERGENiHBG075798
InParanoidiQ16667
KOiK14167
OMAiTVKQYNF
OrthoDBiEOG091G0MIF
PhylomeDBiQ16667
TreeFamiTF101040

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR008425 CDK_inhib_3
IPR022778 CDKN3
IPR029021 Prot-tyrosine_phosphatase-like
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF05706 CDKN3, 1 hit
PIRSFiPIRSF037322 CDKN3, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16667-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG
60 70 80 90 100
CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG
110 120 130 140 150
IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV
160 170 180 190 200
AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL
210
SSRDSQSRSV SR
Length:212
Mass (Da):23,805
Last modified:November 1, 1996 - v1
Checksum:iD87FAC8E28F6525F
GO
Isoform 2 (identifier: Q16667-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-50: Missing.

Show »
Length:172
Mass (Da):19,359
Checksum:iE1F3AA29AAABE3DE
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2J7G3V2J7_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
203Annotation score:
H7C0S3H7C0S3_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
211Annotation score:
A0A087WWK3A0A087WWK3_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
207Annotation score:
F8WD24F8WD24_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
166Annotation score:
F5H232F5H232_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
146Annotation score:
G3V1K6G3V1K6_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
148Annotation score:
A0A087WW25A0A087WW25_HUMAN
Cyclin-dependent kinase inhibitor 3
CDKN3
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2K → E in AAC04932 (PubMed:8242750).Curated1
Sequence conflicti2K → E in AAV38258 (Ref. 8) Curated1
Sequence conflicti10S → G in AAK06380 (PubMed:10987270).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01384231W → R in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384378F → L in HCC; patient T9. 1 Publication1
Natural variantiVAR_01384479C → Y in HCC; patient BX-01. 1 Publication1
Natural variantiVAR_01384591N → K in HCC; patient BX-10. 1 PublicationCorresponds to variant dbSNP:rs760687800Ensembl.1
Natural variantiVAR_01384694D → V in HCC; patient NT1. 1 Publication1
Natural variantiVAR_01384795L → F in HCC; patient BX-05. 1 Publication1
Natural variantiVAR_013848108I → V in HCC; patient T9. 1 PublicationCorresponds to variant dbSNP:rs144479038Ensembl.1
Natural variantiVAR_051769159S → F. Corresponds to variant dbSNP:rs1803843Ensembl.1
Natural variantiVAR_013849187N → S in HCC; patient NT4. 1 Publication1
Natural variantiVAR_013850195K → I in HCC; patient NT4. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03661311 – 50Missing in isoform 2. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02681 mRNA Translation: AAC04932.1
L27711 mRNA Translation: AAA66496.1
AF213033 mRNA Translation: AAK06365.1
AF213036 mRNA Translation: AAK06368.1
AF213038 mRNA Translation: AAK06370.1
AF213039 mRNA Translation: AAK06371.1
AF213041 mRNA Translation: AAK06373.1
AF213042 mRNA Translation: AAK06374.1
AF213046 mRNA Translation: AAK06377.1
AF213047 mRNA Translation: AAK06378.1
AF213049 mRNA Translation: AAK06380.1
AF213053 mRNA Translation: AAK06384.1
AY257474 mRNA Translation: AAP13062.1
L25876 mRNA Translation: AAA60222.1
EF560750 mRNA Translation: ABQ59060.1
CR407666 mRNA Translation: CAG28594.1
BT019451 mRNA Translation: AAV38258.1
AY194117 Genomic DNA Translation: AAN86348.1
CH471061 Genomic DNA Translation: EAW80632.1
CH471061 Genomic DNA Translation: EAW80634.1
BC064965 mRNA Translation: AAH64965.1
CCDSiCCDS45109.1 [Q16667-2]
CCDS9716.1 [Q16667-1]
PIRiA49436
RefSeqiNP_001124323.1, NM_001130851.1 [Q16667-2]
NP_005183.2, NM_005192.3 [Q16667-1]
UniGeneiHs.84113

Genome annotation databases

EnsembliENST00000335183; ENSP00000335357; ENSG00000100526 [Q16667-1]
ENST00000442975; ENSP00000415333; ENSG00000100526 [Q16667-2]
GeneIDi1033
KEGGihsa:1033
UCSCiuc001xap.4 human [Q16667-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02681 mRNA Translation: AAC04932.1
L27711 mRNA Translation: AAA66496.1
AF213033 mRNA Translation: AAK06365.1
AF213036 mRNA Translation: AAK06368.1
AF213038 mRNA Translation: AAK06370.1
AF213039 mRNA Translation: AAK06371.1
AF213041 mRNA Translation: AAK06373.1
AF213042 mRNA Translation: AAK06374.1
AF213046 mRNA Translation: AAK06377.1
AF213047 mRNA Translation: AAK06378.1
AF213049 mRNA Translation: AAK06380.1
AF213053 mRNA Translation: AAK06384.1
AY257474 mRNA Translation: AAP13062.1
L25876 mRNA Translation: AAA60222.1
EF560750 mRNA Translation: ABQ59060.1
CR407666 mRNA Translation: CAG28594.1
BT019451 mRNA Translation: AAV38258.1
AY194117 Genomic DNA Translation: AAN86348.1
CH471061 Genomic DNA Translation: EAW80632.1
CH471061 Genomic DNA Translation: EAW80634.1
BC064965 mRNA Translation: AAH64965.1
CCDSiCCDS45109.1 [Q16667-2]
CCDS9716.1 [Q16667-1]
PIRiA49436
RefSeqiNP_001124323.1, NM_001130851.1 [Q16667-2]
NP_005183.2, NM_005192.3 [Q16667-1]
UniGeneiHs.84113

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FPZX-ray2.00A/B/C/D/E/F1-212[»]
1FQ1X-ray3.00A1-212[»]
ProteinModelPortaliQ16667
SMRiQ16667
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107467, 33 interactors
DIPiDIP-245N
IntActiQ16667, 9 interactors
MINTiQ16667
STRINGi9606.ENSP00000335357

PTM databases

DEPODiQ16667
iPTMnetiQ16667
PhosphoSitePlusiQ16667

Polymorphism and mutation databases

BioMutaiCDKN3
DMDMi2499769

Proteomic databases

EPDiQ16667
MaxQBiQ16667
PaxDbiQ16667
PeptideAtlasiQ16667
PRIDEiQ16667
ProteomicsDBi61026
61027 [Q16667-2]

Protocols and materials databases

DNASUi1033
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335183; ENSP00000335357; ENSG00000100526 [Q16667-1]
ENST00000442975; ENSP00000415333; ENSG00000100526 [Q16667-2]
GeneIDi1033
KEGGihsa:1033
UCSCiuc001xap.4 human [Q16667-1]

Organism-specific databases

CTDi1033
DisGeNETi1033
EuPathDBiHostDB:ENSG00000100526.19
GeneCardsiCDKN3
HGNCiHGNC:1791 CDKN3
HPAiCAB005285
HPA039311
HPA058874
MalaCardsiCDKN3
MIMi114550 phenotype
123832 gene
neXtProtiNX_Q16667
OpenTargetsiENSG00000100526
PharmGKBiPA26324
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1720 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00390000004717
HOVERGENiHBG075798
InParanoidiQ16667
KOiK14167
OMAiTVKQYNF
OrthoDBiEOG091G0MIF
PhylomeDBiQ16667
TreeFamiTF101040

Enzyme and pathway databases

SIGNORiQ16667

Miscellaneous databases

ChiTaRSiCDKN3 human
EvolutionaryTraceiQ16667
GeneWikiiCDKN3
GenomeRNAii1033
PROiPR:Q16667
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100526 Expressed in 164 organ(s), highest expression level in right testis
ExpressionAtlasiQ16667 baseline and differential
GenevisibleiQ16667 HS

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR008425 CDK_inhib_3
IPR022778 CDKN3
IPR029021 Prot-tyrosine_phosphatase-like
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF05706 CDKN3, 1 hit
PIRSFiPIRSF037322 CDKN3, 1 hit
SMARTiView protein in SMART
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDKN3_HUMAN
AccessioniPrimary (citable) accession number: Q16667
Secondary accession number(s): Q53ZU6
, Q5U0M4, Q6P1N8, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C046, Q9C047, Q9C049, Q9C051, Q9C053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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