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UniProtKB - Q16666 (IF16_HUMAN)

Entry version 207 (11 Dec 2019)
Sequence version 3 (28 Nov 2006)
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Protein

Gamma-interferon-inducible protein 16

Gene

IFI16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.12 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processApoptosis, Autophagy, Immunity, Inflammatory response, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1834941 STING mediated induction of host immune responses
R-HSA-3270619 IRF3-mediated induction of type I IFN

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16666

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-interferon-inducible protein 16
Short name:
Ifi-16
Alternative name(s):
Interferon-inducible myeloid differentiation transcriptional activator
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFI16
Synonyms:IFNGIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163565.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:5395 IFI16

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147586 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16666

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi96 – 100Missing : Predominant cytoplasmic localization. 1 Publication5
Mutagenesisi99K → Q: Predominant cytoplasmic, reduces nuclear localization (mimics non-acetylated state). 1 Publication1
Mutagenesisi99K → R: Minor effect on nuclear localization (mimics acetylated state). 1 Publication1
Mutagenesisi128 – 131Missing : Predominant nuclear, some cytoplasmic localization. 1 Publication4
Mutagenesisi128K → Q: Predominant cytoplasmic, reduces nuclear localization (mimics non-acetylated state). 1 Publication1
Mutagenesisi128K → R: Minor effect on nuclear localization (mimics acetylated state). 1 Publication1
Mutagenesisi134 – 136Missing : Mostly nuclear, minor cytoplasmic localization. 1 Publication3
Mutagenesisi140 – 143Missing : Mostly nuclear, minor cytoplasmic localization. 1 Publication4
Mutagenesisi218Y → A: Abolishes TP53-mediated transcriptional activation; when associated with A-267. 1 Publication1
Mutagenesisi222E → A: Abolishes TP53-mediated transcriptional activation; when associated with A-272. 1 Publication1
Mutagenesisi267Y → A: Abolishes TP53-mediated transcriptional activation; when associated with A-218. 1 Publication1
Mutagenesisi272E → A: Abolishes TP53-mediated transcriptional activation; when associated with A-222. 1 Publication1
Mutagenesisi627K → A: Impairs DNA binding; when associated with A-663; A-667; A-670; A-674; A-732; A-734 and A-759. 1 Publication1
Mutagenesisi663K → A: Impairs DNA binding; when associated with A-627; A-667; A-670; A-674; A-732; A-734 and A-759. 1 Publication1
Mutagenesisi667R → A: Impairs DNA binding; when associated with A-627; A-663; A-670; A-674; A-732; A-734 and A-759. 1 Publication1
Mutagenesisi670S → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-674; A-732; A-734 and A-759. 1 Publication1
Mutagenesisi674K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A-732; A-734 and A-759. 1 Publication1
Mutagenesisi732K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A- 674; A-734 and A-759. 1 Publication1
Mutagenesisi734K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A- 674; A-732 and A-759. 1 Publication1
Mutagenesisi759K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A- 674; A-732 and A-734. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3428

Open Targets

More...OpenTargetsi		ENSG00000163565

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29642

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16666 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IFI16

Domain mapping of disease mutations (DMDM)

More...DMDMi		118572657

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001537231 – 785Gamma-interferon-inducible protein 16Add BLAST785

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45N6-acetyllysine1 Publication1
Modified residuei95Phosphoserine1 Publication1
Modified residuei99N6-acetyllysine1 Publication1
Modified residuei106PhosphoserineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki116Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei128N6-acetyllysine; alternate1 Publication1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei153PhosphoserineCombined sources1 Publication1
Modified residuei168Phosphoserine1 Publication1
Modified residuei174Phosphoserine1 Publication1
Modified residuei214N6-acetyllysineCombined sources1 Publication1
Modified residuei444N6-acetyllysine1 Publication1
Modified residuei451N6-acetyllysine1 Publication1
Modified residuei561N6-acetyllysine; alternate1 Publication1
Cross-linki561Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki561Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei575PhosphoserineCombined sources1
Modified residuei598N6-acetyllysine1 Publication1
Modified residuei614N6-acetyllysine1 Publication1
Cross-linki683Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei780Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by human herpes simplex virus 1 (HHV-1) ICP0 protein; leading to degradation by the proteasome.
Lysine acetylation in the multipartite nuclear localization signal (NLS) regulates the subcellular location. In vitro can be acetylated by p300/EP300 coupled to cytoplasmic localization.1 Publication
Phosphorylated on Ser and Thr.2 Publications
Isoform 3 seems to show a minor degree of complex carbohydrate addition.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16666

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16666

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16666

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16666

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16666

PeptideAtlas

More...PeptideAtlasi		Q16666

PRoteomics IDEntifications database

More...PRIDEi		Q16666

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		40733
61023 [Q16666-1]
61024 [Q16666-2]
61025 [Q16666-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q16666

GlyConnect protein glycosylation platform

More...GlyConnecti		1263

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16666

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16666

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q16666

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly induced by IFNG/IFN-gamma and, to a lesser extent, by alpha interferon. In HL-60 cells, maximum induction by IFNG/IFN-gamma occurs within 12 hours whereas, for IFN-alpha, only 10-fold induction was observed after 36 hours. Induced in vitro by dimethylsulfoxide, retinoic acid and 1,25 dihydroxyvitamin D3. Induced in monocytes by IFN-alpha and viral dsDNA. Induced by glucose restriction.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163565 Expressed in 237 organ(s), highest expression level in peritoneum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16666 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16666 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB016293
HPA002134

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homooligomers; isoform 2 can self-associate or associate with isoform 1 or isoform 3.

Interacts with TMEM173, AIM2, PYCARD and CASP1.

Interacts with BRCA1, TP53, E2F1, RB1 and SP1.

Interacts with MTA1.

Interacts with PYDC5 (PubMed:24531343).

10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109654, 402 interactors

Database of interacting proteins

More...DIPi		DIP-42868N

Protein interaction database and analysis system

More...IntActi		Q16666, 177 interactors

Molecular INTeraction database

More...MINTi		Q16666

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357113

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16666 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1785
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16666

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16666

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 88PyrinPROSITE-ProRule annotationAdd BLAST88
Domaini189 – 389HIN-200 1PROSITE-ProRule annotationAdd BLAST201
Domaini562 – 761HIN-200 2PROSITE-ProRule annotationAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni192 – 393Interaction with TP53 C-terminusAdd BLAST202
Regioni571 – 766Interaction with TP53 core domainAdd BLAST196

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi96 – 100Nuclear localization signal5
Motifi128 – 131Nuclear localization signal4
Motifi134 – 136Nuclear localization signal3
Motifi140 – 143Nuclear localization signal4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 150Lys-richAdd BLAST150
Compositional biasi258 – 261Poly-Ile4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HIN-20 domains mediates dsDNA binding via electrostatic interactions.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HIN-200 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J5NP Eukaryota
ENOG410Y78B LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013296

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000033871

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16666

KEGG Orthology (KO)

More...KOi		K20914

Identification of Orthologs from Complete Genome Data

More...OMAi		WGQLGQP

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16666

TreeFam database of animal gene trees

More...TreeFami		TF337385

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004020 DAPIN
IPR040205 HIN-200
IPR004021 HIN200/IF120x

The PANTHER Classification System

More...PANTHERi		PTHR12200 PTHR12200, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02760 HIN, 2 hits
PF02758 PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01289 PYRIN, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16666-1) [UniParc]FASTAAdd to basket
Also known as: IFI 16A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD 
        60         70         80         90        100
LMEEKFRGDA GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK 
       110        120        130        140        150
EVDATSPAPS TSSTVKTEGA EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ 
       160        170        180        190        200
PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS STENPKTVAK CQVTPRRNVL 
       210        220        230        240        250
QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF HVKVLNTSLK 
       260        270        280        290        300
EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE 
       310        320        330        340        350
TLKIDILHKQ ASGNIVYGVF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ 
       360        370        380        390        400
CHNIPCEEGD KLQLFCFRLR KKNQMSKLIS EMHSFIQIKK KTNPRNNDPK 
       410        420        430        440        450
SMKLPQEQRQ LPYPSEASTT FPESHLRTPQ MPPTTPSSSF FTKKSEDTIS 
       460        470        480        490        500
KMNDFMRMQI LKEGSHFPGP FMTSIGPAES HPHTPQMPPS TPSSSFLTTK 
       510        520        530        540        550
SEDTISKMND FMRMQILKEG SHFPGPFMTS IGPAESHPHT PQMPPSTPSS 
       560        570        580        590        600
SFLTTLKPRL KTEPEEVSIE DSAQSDLKEV MVLNATESFV YEPKEQKKMF 
       610        620        630        640        650
HATVATENEV FRVKVFNIDL KEKFTPKKII AIANYVCRNG FLEVYPFTLV 
       660        670        680        690        700
ADVNADRNME IPKGLIRSAS VTPKINQLCS QTKGSFVNGV FEVHKKNVRG 
       710        720        730        740        750
EFTYYEIQDN TGKMEVVVHG RLTTINCEEG DKLKLTCFEL APKSGNTGEL 
       760        770        780 
RSVIHSHIKV IKTRKNKKDI LNPDSSMETS PDFFF
Length:785
Mass (Da):88,256
Last modified:November 28, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i216CD103D8F5206A
GO
Isoform 2 (identifier: Q16666-2) [UniParc]FASTAAdd to basket
Also known as: IFI 16B

The sequence of this isoform differs from the canonical sequence as follows:
     444-499: Missing.

Note: Major isoform.Curated
Show »
Length:729
Mass (Da):82,096
Checksum:i27C820A058DE6A92
GO
Isoform 3 (identifier: Q16666-3) [UniParc]FASTAAdd to basket
Also known as: IFI 16C

The sequence of this isoform differs from the canonical sequence as follows:
     444-555: Missing.

Show »
Length:673
Mass (Da):75,936
Checksum:i4D80A41BD9AA13A5
GO
Isoform 4 (identifier: Q16666-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-183: Missing.

Show »
Length:729
Mass (Da):82,588
Checksum:iFEB03DF1E8B09D0A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRB1A0A0A0MRB1_HUMAN
Gamma-interferon-inducible protein ...
IFI16
243Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM18H3BM18_HUMAN
Gamma-interferon-inducible protein ...
IFI16
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RHM1X6RHM1_HUMAN
Gamma-interferon-inducible protein ...
IFI16
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR88H3BR88_HUMAN
Gamma-interferon-inducible protein ...
IFI16
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR65H3BR65_HUMAN
Gamma-interferon-inducible protein ...
IFI16
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BVE6H3BVE6_HUMAN
Gamma-interferon-inducible protein ...
IFI16
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF20997 differs from that shown. Intron retention.Curated
The sequence AAF20997 differs from that shown. Reason: Frameshift.Curated
The sequence BAC04462 differs from that shown. Probable cloning artifact.Curated
The sequence BAD92226 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG58950 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti401S → G in BAG58950 (PubMed:14702039).Curated1
Sequence conflicti544P → S in BAG58950 (PubMed:14702039).Curated1
Sequence conflicti683K → R in AAM96005 (PubMed:12894224).Curated1
Sequence conflicti723T → N in AAA58683 (PubMed:1526658).Curated1
Sequence conflicti723T → N in AAB32519 (PubMed:7959953).Curated1
Sequence conflicti737C → S in AAA58683 (PubMed:1526658).Curated1
Sequence conflicti737C → S in AAB32519 (PubMed:7959953).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029486103D → H3 PublicationsCorresponds to variant dbSNP:rs1057018Ensembl.1
Natural variantiVAR_029487179S → T3 PublicationsCorresponds to variant dbSNP:rs866484Ensembl.1
Natural variantiVAR_029488202K → E. Corresponds to variant dbSNP:rs11585341Ensembl.1
Natural variantiVAR_029489409R → S4 PublicationsCorresponds to variant dbSNP:rs1057027Ensembl.1
Natural variantiVAR_029490413Y → N4 PublicationsCorresponds to variant dbSNP:rs1057028Ensembl.1
Natural variantiVAR_029491723T → S. Corresponds to variant dbSNP:rs6940Ensembl.1
Natural variantiVAR_057582779T → S. Corresponds to variant dbSNP:rs6940Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044691128 – 183Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_002675444 – 555Missing in isoform 3. CuratedAdd BLAST112
Alternative sequenceiVSP_002676444 – 499Missing in isoform 2. 5 PublicationsAdd BLAST56

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M63838 mRNA Translation: AAA58683.1
S75433 S75431 Genomic DNA Translation: AAB32519.2
AF208043 mRNA Translation: AAF20997.1 Sequence problems.
AY138863 mRNA Translation: AAM96005.1
AK094968 mRNA Translation: BAC04462.1 Sequence problems.
AK296228 mRNA Translation: BAG58950.1 Different initiation.
AB208989 mRNA Translation: BAD92226.1 Different initiation.
AL359753 Genomic DNA No translation available.
BC017059 mRNA Translation: AAH17059.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1180.3 [Q16666-2]
CCDS58039.1 [Q16666-6]

Protein sequence database of the Protein Information Resource

More...PIRi		I54501

NCBI Reference Sequences

More...RefSeqi		NP_001193496.1, NM_001206567.1 [Q16666-6]
NP_005522.2, NM_005531.2 [Q16666-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295809; ENSP00000295809; ENSG00000163565 [Q16666-1]
ENST00000359709; ENSP00000352740; ENSG00000163565 [Q16666-6]
ENST00000368131; ENSP00000357113; ENSG00000163565 [Q16666-2]
ENST00000368132; ENSP00000357114; ENSG00000163565 [Q16666-2]
ENST00000448393; ENSP00000404325; ENSG00000163565 [Q16666-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3428

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3428

UCSC genome browser

More...UCSCi		uc001ftg.4 human [Q16666-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63838 mRNA Translation: AAA58683.1
S75433 S75431 Genomic DNA Translation: AAB32519.2
AF208043 mRNA Translation: AAF20997.1 Sequence problems.
AY138863 mRNA Translation: AAM96005.1
AK094968 mRNA Translation: BAC04462.1 Sequence problems.
AK296228 mRNA Translation: BAG58950.1 Different initiation.
AB208989 mRNA Translation: BAD92226.1 Different initiation.
AL359753 Genomic DNA No translation available.
BC017059 mRNA Translation: AAH17059.1
CCDSiCCDS1180.3 [Q16666-2]
CCDS58039.1 [Q16666-6]
PIRiI54501
RefSeqiNP_001193496.1, NM_001206567.1 [Q16666-6]
NP_005522.2, NM_005531.2 [Q16666-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OQ0X-ray2.00A/B/C/D192-393[»]
3B6YX-ray2.35A/B571-766[»]
3RLNX-ray2.25A571-766[»]
3RLOX-ray1.80A571-766[»]
3RNUX-ray2.50A/B/C/D571-766[»]
4QGUX-ray2.54A/B192-393[»]
SMRiQ16666
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109654, 402 interactors
DIPiDIP-42868N
IntActiQ16666, 177 interactors
MINTiQ16666
STRINGi9606.ENSP00000357113

PTM databases

CarbonylDBiQ16666
GlyConnecti1263
iPTMnetiQ16666
PhosphoSitePlusiQ16666
SwissPalmiQ16666

Polymorphism and mutation databases

BioMutaiIFI16
DMDMi118572657

Proteomic databases

EPDiQ16666
jPOSTiQ16666
MassIVEiQ16666
MaxQBiQ16666
PaxDbiQ16666
PeptideAtlasiQ16666
PRIDEiQ16666
ProteomicsDBi40733
61023 [Q16666-1]
61024 [Q16666-2]
61025 [Q16666-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3428

Genome annotation databases

EnsembliENST00000295809; ENSP00000295809; ENSG00000163565 [Q16666-1]
ENST00000359709; ENSP00000352740; ENSG00000163565 [Q16666-6]
ENST00000368131; ENSP00000357113; ENSG00000163565 [Q16666-2]
ENST00000368132; ENSP00000357114; ENSG00000163565 [Q16666-2]
ENST00000448393; ENSP00000404325; ENSG00000163565 [Q16666-3]
GeneIDi3428
KEGGihsa:3428
UCSCiuc001ftg.4 human [Q16666-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3428
DisGeNETi3428
EuPathDBiHostDB:ENSG00000163565.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		IFI16
HGNCiHGNC:5395 IFI16
HPAiCAB016293
HPA002134
MIMi147586 gene
neXtProtiNX_Q16666
OpenTargetsiENSG00000163565
PharmGKBiPA29642

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J5NP Eukaryota
ENOG410Y78B LUCA
GeneTreeiENSGT00390000013296
HOGENOMiHOG000033871
InParanoidiQ16666
KOiK20914
OMAiWGQLGQP
PhylomeDBiQ16666
TreeFamiTF337385

Enzyme and pathway databases

ReactomeiR-HSA-1834941 STING mediated induction of host immune responses
R-HSA-3270619 IRF3-mediated induction of type I IFN
SIGNORiQ16666

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IFI16 human
EvolutionaryTraceiQ16666

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IFI16

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3428
PharosiQ16666 Tbio

Protein Ontology

More...PROi		PR:Q16666
RNActiQ16666 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163565 Expressed in 237 organ(s), highest expression level in peritoneum
ExpressionAtlasiQ16666 baseline and differential
GenevisibleiQ16666 HS

Family and domain databases

InterProiView protein in InterPro
IPR004020 DAPIN
IPR040205 HIN-200
IPR004021 HIN200/IF120x
PANTHERiPTHR12200 PTHR12200, 2 hits
PfamiView protein in Pfam
PF02760 HIN, 2 hits
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50834 HIN_200, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16666
Secondary accession number(s): B4DJT8
, H3BLV7, Q59GX0, Q5T3W7, Q5T3W8, Q5T3X0, Q5T3X1, Q5T3X2, Q8N9E5, Q8NEQ7, Q96AJ5, Q9UH78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2006
Last modified: December 11, 2019
This is version 207 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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