UniProtKB - Q16666 (IF16_HUMAN)
Gamma-interferon-inducible protein 16
IFI16
Functioni
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
12 PublicationsGO - Molecular functioni
- double-stranded DNA binding Source: GO_Central
- identical protein binding Source: IntAct
- RNA binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
GO - Biological processi
- activation of cysteine-type endopeptidase activity Source: UniProtKB
- activation of innate immune response Source: UniProtKB
- autophagy Source: UniProtKB-KW
- cellular response to glucose starvation Source: UniProtKB
- cellular response to interferon-beta Source: GO_Central
- cellular response to ionizing radiation Source: UniProtKB
- defense response to virus Source: UniProtKB
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
- monocyte differentiation Source: UniProtKB
- myeloid cell differentiation Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of innate immune response Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of viral genome replication Source: UniProtKB
- positive regulation of cytokine production Source: UniProtKB
- positive regulation of interleukin-1 beta production Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of autophagy Source: UniProtKB
- regulation of gene expression, epigenetic Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Apoptosis, Autophagy, Immunity, Inflammatory response, Innate immunity, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q16666 |
Reactomei | R-HSA-1834941, STING mediated induction of host immune responses R-HSA-3270619, IRF3-mediated induction of type I IFN |
SignaLinki | Q16666 |
SIGNORi | Q16666 |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-interferon-inducible protein 16Short name: Ifi-16 Alternative name(s): Interferon-inducible myeloid differentiation transcriptional activator |
Gene namesi | Name:IFI16 Synonyms:IFNGIP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5395, IFI16 |
MIMi | 147586, gene |
neXtProti | NX_Q16666 |
VEuPathDBi | HostDB:ENSG00000163565 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear speck Source: MGI
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 96 – 100 | Missing : Predominant cytoplasmic localization. 1 Publication | 5 | |
Mutagenesisi | 99 | K → Q: Predominant cytoplasmic, reduces nuclear localization (mimics non-acetylated state). 1 Publication | 1 | |
Mutagenesisi | 99 | K → R: Minor effect on nuclear localization (mimics acetylated state). 1 Publication | 1 | |
Mutagenesisi | 128 – 131 | Missing : Predominant nuclear, some cytoplasmic localization. 1 Publication | 4 | |
Mutagenesisi | 128 | K → Q: Predominant cytoplasmic, reduces nuclear localization (mimics non-acetylated state). 1 Publication | 1 | |
Mutagenesisi | 128 | K → R: Minor effect on nuclear localization (mimics acetylated state). 1 Publication | 1 | |
Mutagenesisi | 134 – 136 | Missing : Mostly nuclear, minor cytoplasmic localization. 1 Publication | 3 | |
Mutagenesisi | 140 – 143 | Missing : Mostly nuclear, minor cytoplasmic localization. 1 Publication | 4 | |
Mutagenesisi | 218 | Y → A: Abolishes TP53-mediated transcriptional activation; when associated with A-267. 1 Publication | 1 | |
Mutagenesisi | 222 | E → A: Abolishes TP53-mediated transcriptional activation; when associated with A-272. 1 Publication | 1 | |
Mutagenesisi | 267 | Y → A: Abolishes TP53-mediated transcriptional activation; when associated with A-218. 1 Publication | 1 | |
Mutagenesisi | 272 | E → A: Abolishes TP53-mediated transcriptional activation; when associated with A-222. 1 Publication | 1 | |
Mutagenesisi | 627 | K → A: Impairs DNA binding; when associated with A-663; A-667; A-670; A-674; A-732; A-734 and A-759. 1 Publication | 1 | |
Mutagenesisi | 663 | K → A: Impairs DNA binding; when associated with A-627; A-667; A-670; A-674; A-732; A-734 and A-759. 1 Publication | 1 | |
Mutagenesisi | 667 | R → A: Impairs DNA binding; when associated with A-627; A-663; A-670; A-674; A-732; A-734 and A-759. 1 Publication | 1 | |
Mutagenesisi | 670 | S → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-674; A-732; A-734 and A-759. 1 Publication | 1 | |
Mutagenesisi | 674 | K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A-732; A-734 and A-759. 1 Publication | 1 | |
Mutagenesisi | 732 | K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A- 674; A-734 and A-759. 1 Publication | 1 | |
Mutagenesisi | 734 | K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A- 674; A-732 and A-759. 1 Publication | 1 | |
Mutagenesisi | 759 | K → A: Impairs DNA binding; when associated with A-627; A-663; A-667; A-670; A- 674; A-732 and A-734. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3428 |
OpenTargetsi | ENSG00000163565 |
PharmGKBi | PA29642 |
Miscellaneous databases
Pharosi | Q16666, Tbio |
Genetic variation databases
BioMutai | IFI16 |
DMDMi | 118572657 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153723 | 1 – 785 | Gamma-interferon-inducible protein 16Add BLAST | 785 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 45 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 95 | Phosphoserine1 Publication | 1 | |
Modified residuei | 99 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 106 | PhosphoserineCombined sources1 Publication | 1 | |
Cross-linki | 116 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 128 | N6-acetyllysine; alternate1 Publication | 1 | |
Cross-linki | 128 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 153 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 168 | Phosphoserine1 Publication | 1 | |
Modified residuei | 174 | Phosphoserine1 Publication | 1 | |
Modified residuei | 214 | N6-acetyllysineCombined sources1 Publication | 1 | |
Modified residuei | 444 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 451 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 561 | N6-acetyllysine; alternate1 Publication | 1 | |
Cross-linki | 561 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 561 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 575 | PhosphoserineCombined sources | 1 | |
Modified residuei | 598 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 614 | N6-acetyllysine1 Publication | 1 | |
Cross-linki | 683 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 780 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q16666 |
jPOSTi | Q16666 |
MassIVEi | Q16666 |
MaxQBi | Q16666 |
PaxDbi | Q16666 |
PeptideAtlasi | Q16666 |
PRIDEi | Q16666 |
ProteomicsDBi | 40733 61023 [Q16666-1] 61024 [Q16666-2] 61025 [Q16666-3] |
PTM databases
CarbonylDBi | Q16666 |
GlyConnecti | 1263, 1 N-Linked glycan (1 site) |
GlyGeni | Q16666, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site) |
iPTMneti | Q16666 |
MetOSitei | Q16666 |
PhosphoSitePlusi | Q16666 |
SwissPalmi | Q16666 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000163565, Expressed in peritoneum and 248 other tissues |
ExpressionAtlasi | Q16666, baseline and differential |
Genevisiblei | Q16666, HS |
Organism-specific databases
HPAi | ENSG00000163565, Low tissue specificity |
Interactioni
Subunit structurei
Forms homooligomers; isoform 2 can self-associate or associate with isoform 1 or isoform 3.
Interacts with TMEM173, AIM2, PYCARD and CASP1.
Interacts with BRCA1, TP53, E2F1, RB1 and SP1.
Interacts with MTA1.
Interacts with PYDC5 (PubMed:24531343).
10 PublicationsBinary interactionsi
Q16666
With | #Exp. | IntAct |
---|---|---|
AR [P10275] | 3 | EBI-2867186,EBI-608057 |
BRCA1 [P38398] | 9 | EBI-2867186,EBI-349905 |
DHX58 [Q96C10] | 2 | EBI-2867186,EBI-744193 |
STING1 [Q86WV6] | 2 | EBI-2867186,EBI-2800345 |
IFI16 - isoform 2 [Q16666-2]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-6273540,EBI-6273540 |
TP53 [P04637] | 6 | EBI-6273540,EBI-366083 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109654, 738 interactors |
DIPi | DIP-42868N |
IntActi | Q16666, 177 interactors |
MINTi | Q16666 |
STRINGi | 9606.ENSP00000357113 |
Miscellaneous databases
RNActi | Q16666, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q16666 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16666 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 88 | PyrinPROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 189 – 389 | HIN-200 1PROSITE-ProRule annotationAdd BLAST | 201 | |
Domaini | 562 – 761 | HIN-200 2PROSITE-ProRule annotationAdd BLAST | 200 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 91 – 191 | DisorderedSequence analysisAdd BLAST | 101 | |
Regioni | 192 – 393 | Interaction with TP53 C-terminusAdd BLAST | 202 | |
Regioni | 390 – 442 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 571 – 766 | Interaction with TP53 core domainAdd BLAST | 196 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 96 – 100 | Nuclear localization signal | 5 | |
Motifi | 128 – 131 | Nuclear localization signal | 4 | |
Motifi | 134 – 136 | Nuclear localization signal | 3 | |
Motifi | 140 – 143 | Nuclear localization signal | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 105 – 120 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 123 – 142 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 164 – 191 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 390 – 404 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 411 – 442 | Polar residuesSequence analysisAdd BLAST | 32 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QTQS, Eukaryota |
GeneTreei | ENSGT00390000013296 |
HOGENOMi | CLU_022874_0_0_1 |
InParanoidi | Q16666 |
OMAi | NPDRKME |
PhylomeDBi | Q16666 |
TreeFami | TF337385 |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit |
IDEALi | IID00478 |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR040205, HIN-200 IPR004021, HIN200/IF120x |
PANTHERi | PTHR12200, PTHR12200, 2 hits |
Pfami | View protein in Pfam PF02760, HIN, 2 hits PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS50834, HIN_200, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD
60 70 80 90 100
LMEEKFRGDA GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK
110 120 130 140 150
EVDATSPAPS TSSTVKTEGA EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ
160 170 180 190 200
PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS STENPKTVAK CQVTPRRNVL
210 220 230 240 250
QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF HVKVLNTSLK
260 270 280 290 300
EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE
310 320 330 340 350
TLKIDILHKQ ASGNIVYGVF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ
360 370 380 390 400
CHNIPCEEGD KLQLFCFRLR KKNQMSKLIS EMHSFIQIKK KTNPRNNDPK
410 420 430 440 450
SMKLPQEQRQ LPYPSEASTT FPESHLRTPQ MPPTTPSSSF FTKKSEDTIS
460 470 480 490 500
KMNDFMRMQI LKEGSHFPGP FMTSIGPAES HPHTPQMPPS TPSSSFLTTK
510 520 530 540 550
SEDTISKMND FMRMQILKEG SHFPGPFMTS IGPAESHPHT PQMPPSTPSS
560 570 580 590 600
SFLTTLKPRL KTEPEEVSIE DSAQSDLKEV MVLNATESFV YEPKEQKKMF
610 620 630 640 650
HATVATENEV FRVKVFNIDL KEKFTPKKII AIANYVCRNG FLEVYPFTLV
660 670 680 690 700
ADVNADRNME IPKGLIRSAS VTPKINQLCS QTKGSFVNGV FEVHKKNVRG
710 720 730 740 750
EFTYYEIQDN TGKMEVVVHG RLTTINCEEG DKLKLTCFEL APKSGNTGEL
760 770 780
RSVIHSHIKV IKTRKNKKDI LNPDSSMETS PDFFF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRB1 | A0A0A0MRB1_HUMAN | Gamma-interferon-inducible protein ... | IFI16 | 243 | Annotation score: | ||
H3BM18 | H3BM18_HUMAN | Gamma-interferon-inducible protein ... | IFI16 | 167 | Annotation score: | ||
X6RHM1 | X6RHM1_HUMAN | Gamma-interferon-inducible protein ... | IFI16 | 180 | Annotation score: | ||
H3BR65 | H3BR65_HUMAN | Gamma-interferon-inducible protein ... | IFI16 | 74 | Annotation score: | ||
H3BR88 | H3BR88_HUMAN | Gamma-interferon-inducible protein ... | IFI16 | 229 | Annotation score: | ||
H3BVE6 | H3BVE6_HUMAN | Gamma-interferon-inducible protein ... | IFI16 | 83 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 401 | S → G in BAG58950 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 544 | P → S in BAG58950 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 683 | K → R in AAM96005 (PubMed:12894224).Curated | 1 | |
Sequence conflicti | 723 | T → N in AAA58683 (PubMed:1526658).Curated | 1 | |
Sequence conflicti | 723 | T → N in AAB32519 (PubMed:7959953).Curated | 1 | |
Sequence conflicti | 737 | C → S in AAA58683 (PubMed:1526658).Curated | 1 | |
Sequence conflicti | 737 | C → S in AAB32519 (PubMed:7959953).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029486 | 103 | D → H3 PublicationsCorresponds to variant dbSNP:rs1057018Ensembl. | 1 | |
Natural variantiVAR_029487 | 179 | S → T3 PublicationsCorresponds to variant dbSNP:rs866484Ensembl. | 1 | |
Natural variantiVAR_029488 | 202 | K → E. Corresponds to variant dbSNP:rs11585341Ensembl. | 1 | |
Natural variantiVAR_029489 | 409 | R → S4 PublicationsCorresponds to variant dbSNP:rs1057027Ensembl. | 1 | |
Natural variantiVAR_029490 | 413 | Y → N4 PublicationsCorresponds to variant dbSNP:rs1057028Ensembl. | 1 | |
Natural variantiVAR_029491 | 723 | T → S. Corresponds to variant dbSNP:rs6940Ensembl. | 1 | |
Natural variantiVAR_057582 | 779 | T → S. Corresponds to variant dbSNP:rs6940Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044691 | 128 – 183 | Missing in isoform 4. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_002675 | 444 – 555 | Missing in isoform 3. CuratedAdd BLAST | 112 | |
Alternative sequenceiVSP_002676 | 444 – 499 | Missing in isoform 2. 5 PublicationsAdd BLAST | 56 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63838 mRNA Translation: AAA58683.1 S75433 , S75417, S75419, S75421, S75423, S75424, S75426, S75429, S75431 Genomic DNA Translation: AAB32519.2 AF208043 mRNA Translation: AAF20997.1 Sequence problems. AY138863 mRNA Translation: AAM96005.1 AK094968 mRNA Translation: BAC04462.1 Sequence problems. AK296228 mRNA Translation: BAG58950.1 Different initiation. AB208989 mRNA Translation: BAD92226.1 Different initiation. AL359753 Genomic DNA No translation available. BC017059 mRNA Translation: AAH17059.1 |
CCDSi | CCDS1180.3 [Q16666-2] CCDS58039.1 [Q16666-6] |
PIRi | I54501 |
RefSeqi | NP_001193496.1, NM_001206567.1 [Q16666-6] NP_005522.2, NM_005531.2 [Q16666-2] |
Genome annotation databases
Ensembli | ENST00000295809; ENSP00000295809; ENSG00000163565 ENST00000359709; ENSP00000352740; ENSG00000163565 [Q16666-6] ENST00000368131; ENSP00000357113; ENSG00000163565 [Q16666-2] ENST00000368132; ENSP00000357114; ENSG00000163565 [Q16666-2] ENST00000448393; ENSP00000404325; ENSG00000163565 [Q16666-3] |
GeneIDi | 3428 |
KEGGi | hsa:3428 |
MANE-Selecti | ENST00000295809.12; ENSP00000295809.7; NM_001376587.1; NP_001363516.1 |
UCSCi | uc001ftg.4, human [Q16666-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63838 mRNA Translation: AAA58683.1 S75433 , S75417, S75419, S75421, S75423, S75424, S75426, S75429, S75431 Genomic DNA Translation: AAB32519.2 AF208043 mRNA Translation: AAF20997.1 Sequence problems. AY138863 mRNA Translation: AAM96005.1 AK094968 mRNA Translation: BAC04462.1 Sequence problems. AK296228 mRNA Translation: BAG58950.1 Different initiation. AB208989 mRNA Translation: BAD92226.1 Different initiation. AL359753 Genomic DNA No translation available. BC017059 mRNA Translation: AAH17059.1 |
CCDSi | CCDS1180.3 [Q16666-2] CCDS58039.1 [Q16666-6] |
PIRi | I54501 |
RefSeqi | NP_001193496.1, NM_001206567.1 [Q16666-6] NP_005522.2, NM_005531.2 [Q16666-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OQ0 | X-ray | 2.00 | A/B/C/D | 192-393 | [»] | |
3B6Y | X-ray | 2.35 | A/B | 571-766 | [»] | |
3RLN | X-ray | 2.25 | A | 571-766 | [»] | |
3RLO | X-ray | 1.80 | A | 571-766 | [»] | |
3RNU | X-ray | 2.50 | A/B/C/D | 571-766 | [»] | |
4QGU | X-ray | 2.54 | A/B | 192-393 | [»] | |
SMRi | Q16666 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109654, 738 interactors |
DIPi | DIP-42868N |
IntActi | Q16666, 177 interactors |
MINTi | Q16666 |
STRINGi | 9606.ENSP00000357113 |
PTM databases
CarbonylDBi | Q16666 |
GlyConnecti | 1263, 1 N-Linked glycan (1 site) |
GlyGeni | Q16666, 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site) |
iPTMneti | Q16666 |
MetOSitei | Q16666 |
PhosphoSitePlusi | Q16666 |
SwissPalmi | Q16666 |
Genetic variation databases
BioMutai | IFI16 |
DMDMi | 118572657 |
Proteomic databases
EPDi | Q16666 |
jPOSTi | Q16666 |
MassIVEi | Q16666 |
MaxQBi | Q16666 |
PaxDbi | Q16666 |
PeptideAtlasi | Q16666 |
PRIDEi | Q16666 |
ProteomicsDBi | 40733 61023 [Q16666-1] 61024 [Q16666-2] 61025 [Q16666-3] |
Protocols and materials databases
Antibodypediai | 988, 335 antibodies from 33 providers |
DNASUi | 3428 |
Genome annotation databases
Ensembli | ENST00000295809; ENSP00000295809; ENSG00000163565 ENST00000359709; ENSP00000352740; ENSG00000163565 [Q16666-6] ENST00000368131; ENSP00000357113; ENSG00000163565 [Q16666-2] ENST00000368132; ENSP00000357114; ENSG00000163565 [Q16666-2] ENST00000448393; ENSP00000404325; ENSG00000163565 [Q16666-3] |
GeneIDi | 3428 |
KEGGi | hsa:3428 |
MANE-Selecti | ENST00000295809.12; ENSP00000295809.7; NM_001376587.1; NP_001363516.1 |
UCSCi | uc001ftg.4, human [Q16666-1] |
Organism-specific databases
CTDi | 3428 |
DisGeNETi | 3428 |
GeneCardsi | IFI16 |
HGNCi | HGNC:5395, IFI16 |
HPAi | ENSG00000163565, Low tissue specificity |
MIMi | 147586, gene |
neXtProti | NX_Q16666 |
OpenTargetsi | ENSG00000163565 |
PharmGKBi | PA29642 |
VEuPathDBi | HostDB:ENSG00000163565 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTQS, Eukaryota |
GeneTreei | ENSGT00390000013296 |
HOGENOMi | CLU_022874_0_0_1 |
InParanoidi | Q16666 |
OMAi | NPDRKME |
PhylomeDBi | Q16666 |
TreeFami | TF337385 |
Enzyme and pathway databases
PathwayCommonsi | Q16666 |
Reactomei | R-HSA-1834941, STING mediated induction of host immune responses R-HSA-3270619, IRF3-mediated induction of type I IFN |
SignaLinki | Q16666 |
SIGNORi | Q16666 |
Miscellaneous databases
BioGRID-ORCSi | 3428, 10 hits in 1051 CRISPR screens |
ChiTaRSi | IFI16, human |
EvolutionaryTracei | Q16666 |
GeneWikii | IFI16 |
GenomeRNAii | 3428 |
Pharosi | Q16666, Tbio |
PROi | PR:Q16666 |
RNActi | Q16666, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163565, Expressed in peritoneum and 248 other tissues |
ExpressionAtlasi | Q16666, baseline and differential |
Genevisiblei | Q16666, HS |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit |
IDEALi | IID00478 |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR040205, HIN-200 IPR004021, HIN200/IF120x |
PANTHERi | PTHR12200, PTHR12200, 2 hits |
Pfami | View protein in Pfam PF02760, HIN, 2 hits PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS50834, HIN_200, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | IF16_HUMAN | |
Accessioni | Q16666Primary (citable) accession number: Q16666 Secondary accession number(s): B4DJT8 Q9UH78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 28, 2006 | |
Last modified: | February 23, 2022 | |
This is version 217 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families