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Protein

C-C motif chemokine 15

Gene

CCL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.1 Publication

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemoattractant activity Source: UniProtKB
  • chemokine activity Source: GO_Central
  • heparin binding Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine, Heparin-binding
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 15
Alternative name(s):
Chemokine CC-2
Short name:
HCC-2
Leukotactin-1
Short name:
LKN-1
MIP-1 delta
Macrophage inflammatory protein 5
Short name:
MIP-5
Mrp-2b
NCC-3
Small-inducible cytokine A15
Cleaved into the following 3 chains:
Gene namesi
Name:CCL15
Synonyms:MIP5, NCC3, SCYA15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000275718.1
HGNCiHGNC:10613 CCL15
MIMi601393 gene
neXtProtiNX_Q16663

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6359
PharmGKBiPA35546

Polymorphism and mutation databases

BioMutaiCCL15
DMDMi3915594

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000520822 – 113C-C motif chemokine 15Add BLAST92
ChainiPRO_000004186843 – 113CCL15(22-92)Add BLAST71
ChainiPRO_000004186946 – 113CCL15(25-92)Add BLAST68
ChainiPRO_000004187050 – 113CCL15(29-92)Add BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 771 Publication
Disulfide bondi54 ↔ 931 Publication
Disulfide bondi64 ↔ 1041 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ16663
PeptideAtlasiQ16663
PRIDEiQ16663
ProteomicsDBi61020

Expressioni

Tissue specificityi

Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.2 Publications

Gene expression databases

BgeeiENSG00000275718 Expressed in 56 organ(s), highest expression level in sigmoid colon
ExpressionAtlasiQ16663 baseline and differential
GenevisibleiQ16663 HS

Organism-specific databases

HPAiHPA058608

Interactioni

Subunit structurei

Monomer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112262, 4 interactors
DIPiDIP-6218N
IntActiQ16663, 1 interactor
STRINGi9606.ENSP00000432034

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16663
SMRiQ16663
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16663

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG Eukaryota
ENOG4111C2C LUCA
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ16663
KOiK05511
OrthoDBiEOG091G14Y2
PhylomeDBiQ16663
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR030592 CCL15
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PTHR12015:SF76 PTHR12015:SF76, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q16663-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVSVAALSC LMLVAVLGSQ AQFINDAETE LMMSKLPLEN PVVLNSFHFA
60 70 80 90 100
ADCCTSYISQ SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG
110
VQDCMKKLKP YSI
Length:113
Mass (Da):12,248
Last modified:December 15, 1998 - v2
Checksum:i0BA0FCE7B8A30A04
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1J9A0A087X1J9_HUMAN
C-C motif chemokine 15
CCL15
61Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14V → I in AAD10847 (PubMed:9548457).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01164024I → T5 PublicationsCorresponds to variant dbSNP:rs854625Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58914 mRNA Translation: AAD10847.1
AF031587 mRNA Translation: AAB94617.1
Z70293 mRNA Translation: CAA94308.1
Z70292 mRNA Translation: CAA94306.1
AF088219 Genomic DNA Translation: AAC63328.1
CH471147 Genomic DNA Translation: EAW80110.1
CH471147 Genomic DNA Translation: EAW80111.1
CH471147 Genomic DNA Translation: EAW80112.1
CH471147 Genomic DNA Translation: EAW80113.1
BC140941 mRNA Translation: AAI40942.1
CCDSiCCDS11304.1
RefSeqiNP_116741.2, NM_032965.5
UniGeneiHs.272493

Genome annotation databases

EnsembliENST00000614050; ENSP00000477788; ENSG00000275528
ENST00000617897; ENSP00000484078; ENSG00000275718
GeneIDi6359
KEGGihsa:6359
UCSCiuc032gbw.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL15 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58914 mRNA Translation: AAD10847.1
AF031587 mRNA Translation: AAB94617.1
Z70293 mRNA Translation: CAA94308.1
Z70292 mRNA Translation: CAA94306.1
AF088219 Genomic DNA Translation: AAC63328.1
CH471147 Genomic DNA Translation: EAW80110.1
CH471147 Genomic DNA Translation: EAW80111.1
CH471147 Genomic DNA Translation: EAW80112.1
CH471147 Genomic DNA Translation: EAW80113.1
BC140941 mRNA Translation: AAI40942.1
CCDSiCCDS11304.1
RefSeqiNP_116741.2, NM_032965.5
UniGeneiHs.272493

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HCCNMR-A48-113[»]
ProteinModelPortaliQ16663
SMRiQ16663
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112262, 4 interactors
DIPiDIP-6218N
IntActiQ16663, 1 interactor
STRINGi9606.ENSP00000432034

Polymorphism and mutation databases

BioMutaiCCL15
DMDMi3915594

Proteomic databases

PaxDbiQ16663
PeptideAtlasiQ16663
PRIDEiQ16663
ProteomicsDBi61020

Protocols and materials databases

DNASUi6359
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614050; ENSP00000477788; ENSG00000275528
ENST00000617897; ENSP00000484078; ENSG00000275718
GeneIDi6359
KEGGihsa:6359
UCSCiuc032gbw.1 human

Organism-specific databases

CTDi6359
DisGeNETi6359
EuPathDBiHostDB:ENSG00000275718.1
GeneCardsiCCL15
HGNCiHGNC:10613 CCL15
HPAiHPA058608
MIMi601393 gene
neXtProtiNX_Q16663
PharmGKBiPA35546
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4DG Eukaryota
ENOG4111C2C LUCA
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ16663
KOiK05511
OrthoDBiEOG091G14Y2
PhylomeDBiQ16663
TreeFamiTF334888

Miscellaneous databases

EvolutionaryTraceiQ16663
GenomeRNAii6359
PROiPR:Q16663
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000275718 Expressed in 56 organ(s), highest expression level in sigmoid colon
ExpressionAtlasiQ16663 baseline and differential
GenevisibleiQ16663 HS

Family and domain databases

InterProiView protein in InterPro
IPR030592 CCL15
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PTHR12015:SF76 PTHR12015:SF76, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL15_HUMAN
AccessioniPrimary (citable) accession number: Q16663
Secondary accession number(s): B2RU34, E1P651, Q9UM74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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