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Protein

Fascin

Gene

FSCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORiQ16658

Names & Taxonomyi

Protein namesi
Recommended name:
Fascin
Alternative name(s):
55 kDa actin-bundling protein
Singed-like protein
p55
Gene namesi
Name:FSCN1
Synonyms:FAN1, HSN, SNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000075618.17
HGNCiHGNC:11148 FSCN1
MIMi602689 gene
neXtProtiNX_Q16658

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39S → A: Loss of phosphorylation. 1 Publication1
Mutagenesisi392H → A: Decreased actin-bundling activity. 1 Publication1
Mutagenesisi471K → A: Decreased actin-bundling activity. 1 Publication1
Mutagenesisi488A → W: Decreased actin-bundling activity. 1 Publication1

Organism-specific databases

DisGeNETi6624
OpenTargetsiENSG00000075618
PharmGKBiPA128394534

Polymorphism and mutation databases

BioMutaiFSCN1
DMDMi2498357

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002193792 – 493FascinAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1 Publication1
Modified residuei38PhosphoserineCombined sources1
Modified residuei39Phosphoserine; by PKC1 Publication1
Modified residuei74N6-acetyllysineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei239PhosphothreonineCombined sources1
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei403PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ16658
MaxQBiQ16658
PaxDbiQ16658
PeptideAtlasiQ16658
PRIDEiQ16658
ProteomicsDBi61017

2D gel databases

REPRODUCTION-2DPAGEiIPI00163187
Q16658
UCD-2DPAGEiQ16658

PTM databases

iPTMnetiQ16658
PhosphoSitePlusiQ16658
SwissPalmiQ16658

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000075618 Expressed in 215 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_FSCN1
ExpressionAtlasiQ16658 baseline and differential
GenevisibleiQ16658 HS

Organism-specific databases

HPAiCAB000121
CAB035991
HPA005723
HPA050654

Interactioni

Subunit structurei

Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development. Associates with beta-catenin (By similarity). Interacts with PLXNB3 (PubMed:21706053).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112508, 50 interactors
DIPiDIP-33171N
IntActiQ16658, 35 interactors
MINTiQ16658
STRINGi9606.ENSP00000371798

Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16658
SMRiQ16658
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16658

Family & Domainsi

Domaini

Composed of four beta-trefoil domains.1 Publication

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000267034
HOVERGENiHBG000968
InParanoidiQ16658
KOiK17455
OMAiCTAKAPG
OrthoDBiEOG091G0C6S
PhylomeDBiQ16658
TreeFamiTF323992

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030146 FSCN1
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF8 PTHR10551:SF8, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q16658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ
60 70 80 90 100
PPDEAGSAAV CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR
110 120 130 140 150
WSLQSEAHRR YFGGTEDRLS CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK
160 170 180 190 200
RYAHLSARPA DEIAVDRDVP WGVDSLITLA FQDQRYSVQT ADHRFLRHDG
210 220 230 240 250
RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL KAGKATKVGK
260 270 280 290 300
DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR
310 320 330 340 350
DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS
360 370 380 390 400
NGKFVTSKKN GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV
410 420 430 440 450
TGTLDANRSS YDVFQLEFND GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD
460 470 480 490
FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA SAETVDPASL WEY
Length:493
Mass (Da):54,530
Last modified:January 23, 2007 - v3
Checksum:iC1453714BED6109A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JFC0C9JFC0_HUMAN
Fascin
FSCN1
132Annotation score:
C9JPH9C9JPH9_HUMAN
Fascin
FSCN1
120Annotation score:
A0A0A0MSB2A0A0A0MSB2_HUMAN
Fascin
FSCN1
137Annotation score:

Sequence cautioni

The sequence AAH07539 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440A → V in AAH06304 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03057 mRNA Translation: AAA86442.1
U09873 mRNA Translation: AAA62201.1
AY044229 Genomic DNA Translation: AAL01526.1
AK316607 mRNA Translation: BAG38194.1
BT006636 mRNA Translation: AAP35282.1
AC006483 Genomic DNA No translation available.
CH471144 Genomic DNA Translation: EAW87346.1
BC000521 mRNA Translation: AAH00521.1
BC006304 mRNA Translation: AAH06304.1
BC007539 mRNA Translation: AAH07539.1 Different initiation.
BC007643 mRNA Translation: AAH07643.1
BC007948 mRNA Translation: AAH07948.1
BC007988 mRNA Translation: AAH07988.1
CCDSiCCDS5342.1
PIRiI38621
RefSeqiNP_003079.1, NM_003088.3
UniGeneiHs.118400

Genome annotation databases

EnsembliENST00000382361; ENSP00000371798; ENSG00000075618
GeneIDi6624
KEGGihsa:6624
UCSCiuc003sou.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03057 mRNA Translation: AAA86442.1
U09873 mRNA Translation: AAA62201.1
AY044229 Genomic DNA Translation: AAL01526.1
AK316607 mRNA Translation: BAG38194.1
BT006636 mRNA Translation: AAP35282.1
AC006483 Genomic DNA No translation available.
CH471144 Genomic DNA Translation: EAW87346.1
BC000521 mRNA Translation: AAH00521.1
BC006304 mRNA Translation: AAH06304.1
BC007539 mRNA Translation: AAH07539.1 Different initiation.
BC007643 mRNA Translation: AAH07643.1
BC007948 mRNA Translation: AAH07948.1
BC007988 mRNA Translation: AAH07988.1
CCDSiCCDS5342.1
PIRiI38621
RefSeqiNP_003079.1, NM_003088.3
UniGeneiHs.118400

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DFCX-ray2.90A/B1-493[»]
3LLPX-ray1.80A/B1-493[»]
3P53X-ray2.00A/B1-493[»]
4GOVX-ray2.20A/B1-493[»]
4GOYX-ray2.30A/B1-493[»]
4GP0X-ray2.50A/B1-493[»]
4GP3X-ray2.25A/B1-493[»]
6B0TX-ray2.80A/B/C/D/E/F7-493[»]
ProteinModelPortaliQ16658
SMRiQ16658
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112508, 50 interactors
DIPiDIP-33171N
IntActiQ16658, 35 interactors
MINTiQ16658
STRINGi9606.ENSP00000371798

PTM databases

iPTMnetiQ16658
PhosphoSitePlusiQ16658
SwissPalmiQ16658

Polymorphism and mutation databases

BioMutaiFSCN1
DMDMi2498357

2D gel databases

REPRODUCTION-2DPAGEiIPI00163187
Q16658
UCD-2DPAGEiQ16658

Proteomic databases

EPDiQ16658
MaxQBiQ16658
PaxDbiQ16658
PeptideAtlasiQ16658
PRIDEiQ16658
ProteomicsDBi61017

Protocols and materials databases

DNASUi6624
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382361; ENSP00000371798; ENSG00000075618
GeneIDi6624
KEGGihsa:6624
UCSCiuc003sou.4 human

Organism-specific databases

CTDi6624
DisGeNETi6624
EuPathDBiHostDB:ENSG00000075618.17
GeneCardsiFSCN1
H-InvDBiHIX0033686
HGNCiHGNC:11148 FSCN1
HPAiCAB000121
CAB035991
HPA005723
HPA050654
MIMi602689 gene
neXtProtiNX_Q16658
OpenTargetsiENSG00000075618
PharmGKBiPA128394534
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000267034
HOVERGENiHBG000968
InParanoidiQ16658
KOiK17455
OMAiCTAKAPG
OrthoDBiEOG091G0C6S
PhylomeDBiQ16658
TreeFamiTF323992

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORiQ16658

Miscellaneous databases

ChiTaRSiFSCN1 human
EvolutionaryTraceiQ16658
GeneWikiiFSCN1
GenomeRNAii6624
PROiPR:Q16658
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075618 Expressed in 215 organ(s), highest expression level in epithelium of bronchus
CleanExiHS_FSCN1
ExpressionAtlasiQ16658 baseline and differential
GenevisibleiQ16658 HS

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030146 FSCN1
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF8 PTHR10551:SF8, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFSCN1_HUMAN
AccessioniPrimary (citable) accession number: Q16658
Secondary accession number(s): A6NI89
, B2RE97, Q96IC5, Q96IH1, Q9BRF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 193 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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