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UniProtKB - Q16656 (NRF1_HUMAN)

Entry version 176 (02 Dec 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Nuclear respiratory factor 1

Gene

NRF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi109 – 305Add BLAST197

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16656

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16656

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16656

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear respiratory factor 1
Short name:
NRF-1
Alternative name(s):
Alpha palindromic-binding protein
Short name:
Alpha-pal
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000106459.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:7996, NRF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600879, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16656

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4899

Open Targets

More...OpenTargetsi		ENSG00000106459

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31775

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16656, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NRF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		12643732

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001002081 – 503Nuclear respiratory factor 1Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39Phosphoserine; by CK21 Publication1
Modified residuei44Phosphoserine; by CK21 Publication1
Modified residuei46Phosphoserine; by CK21 Publication1
Modified residuei47Phosphoserine; by CK21 Publication1
Modified residuei52Phosphoserine; by CK21 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation enhances DNA binding.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16656

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16656

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16656

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16656

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16656

PeptideAtlas

More...PeptideAtlasi		Q16656

PRoteomics IDEntifications database

More...PRIDEi		Q16656

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3895
61015 [Q16656-1]
61016 [Q16656-2]
75975

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q16656, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16656

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16656

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with strongest expression in skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106459, Expressed in corpus callosum and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16656, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16656, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106459, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds DNA as a dimer.

Interacts with PPRC1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q16656
With#Exp.IntAct
CCND1 [P24385]2EBI-2547810,EBI-375001
FHL2 [Q14192]3EBI-2547810,EBI-701903
POGZ [Q7Z3K3]3EBI-2547810,EBI-1389308
SIRT7 [Q9NRC8]2EBI-2547810,EBI-716046
SP4 [Q02446]3EBI-2547810,EBI-10198587
TRAF2 [Q12933]3EBI-2547810,EBI-355744
Isoform 4 [Q16656-4]
With#Exp.IntAct
AGR2 [O95994]5EBI-11742836,EBI-712648
BBS2 [Q9BXC9]3EBI-11742836,EBI-748297
BICRAL [Q6AI39]3EBI-11742836,EBI-1012434
BRWD1 - isoform D [Q9NSI6-4]3EBI-11742836,EBI-10693038
C10orf55 [Q5SWW7]3EBI-11742836,EBI-12809220
C3orf36 [Q3SXR2]3EBI-11742836,EBI-18036948
CKMT2 [P17540]3EBI-11742836,EBI-712973
COL10A1 [Q03692]3EBI-11742836,EBI-2528309
CSNK2B [P67870]3EBI-11742836,EBI-348169
ESM1 [Q9NQ30]3EBI-11742836,EBI-12260294
FHL2 [Q14192]3EBI-11742836,EBI-701903
HHIPL1 - isoform 2 [Q96JK4-2]3EBI-11742836,EBI-12083878
KHDC4 - isoform 4 [Q7Z7F0-4]3EBI-11742836,EBI-9089060
KLF15 [Q9UIH9]3EBI-11742836,EBI-2796400
KRT83 [P78385]3EBI-11742836,EBI-10221390
L3MBTL2 [Q969R5]3EBI-11742836,EBI-739909
L3MBTL3 - isoform 2 [Q96JM7-2]3EBI-11742836,EBI-11985629
LHX3 - isoform B [Q9UBR4-2]3EBI-11742836,EBI-12039345
LHX4 [A0A0S2Z5S9]3EBI-11742836,EBI-16429099
LHX6 [Q9UPM6]3EBI-11742836,EBI-10258746
LMO4 [P61968]3EBI-11742836,EBI-2798728
MVP [Q14764]3EBI-11742836,EBI-2816254
NDUFAB1 [O14561]3EBI-11742836,EBI-1246261
PANX2 [Q495U3]3EBI-11742836,EBI-17242559
POGZ [Q7Z3K3]7EBI-11742836,EBI-1389308
SLC22A18AS - isoform 2 [Q8N1D0-2]3EBI-11742836,EBI-12829638
SP2 - isoform 2 [Q02086-2]3EBI-11742836,EBI-9088579
SP4 [Q02446]3EBI-11742836,EBI-10198587
SPSB2 [Q99619]3EBI-11742836,EBI-2323209
SRARP [Q8NEQ6]3EBI-11742836,EBI-17858294
TESMIN - isoform 2 [Q9Y4I5-2]3EBI-11742836,EBI-12840664
TEX43 [Q6ZNM6]3EBI-11742836,EBI-18115728
TOLLIP [Q9H0E2]3EBI-11742836,EBI-74615
TRAF2 [Q12933]3EBI-11742836,EBI-355744
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-11742836,EBI-17716262
VEZF1 [Q14119]3EBI-11742836,EBI-11980193
ZMYM6 - isoform 4 [O95789-4]3EBI-11742836,EBI-12949277

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110955, 61 interactors

Database of interacting proteins

More...DIPi		DIP-56958N

Protein interaction database and analysis system

More...IntActi		Q16656, 51 interactors

Molecular INTeraction database

More...MINTi		Q16656

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000376924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16656, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 78DimerizationAdd BLAST78
Regioni301 – 476Required for transcriptional activationAdd BLAST176

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi88 – 116Nuclear localization signalAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi41 – 66Asp/Glu-rich (acidic)Add BLAST26
Compositional biasi80 – 86Poly-Ala7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRF1/Ewg family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTK1, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006835

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018156_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16656

Identification of Orthologs from Complete Genome Data

More...OMAi		DHTVHQT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16656

TreeFam database of animal gene trees

More...TreeFami		TF105308

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039142, NRF1/Ewg
IPR019526, Nrf1_activation-bd
IPR019525, Nrf1_NLS/DNA-bd_dimer

The PANTHER Classification System

More...PANTHERi		PTHR20338, PTHR20338, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10492, Nrf1_activ_bdg, 1 hit
PF10491, Nrf1_DNA-bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: Q16656-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED 
        60         70         80         90        100
TSYDDSDILN STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN 
       110        120        130        140        150
PSIRKRQQTR LLRKLRATLD EYTTRVGQQA IVLCISPSKP NPVFKVFGAA 
       160        170        180        190        200
PLENVVRKYK SMILEDLESA LAEHAPAPQE VNSELPPLTI DGIPVSVDKM 
       210        220        230        240        250
TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW ANVRSDVRTE 
       260        270        280        290        300
EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATATHSIAHL 
       310        320        330        340        350
VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA 
       360        370        380        390        400
VADGEVEQNW ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA 
       410        420        430        440        450
TVTMALNSEA AAHAVATLAE ATLQGGGQIV LSGETAAAVG ALTGVQDANG 
       460        470        480        490        500
LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV TTRISDSAVT MDGQAVEVVT 

LEQ
Length:503
Mass (Da):53,541
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF31C358278371929
GO
Isoform Short (identifier: Q16656-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-321: Missing.

Show »
Length:437
Mass (Da):46,157
Checksum:iD7B62154D8D015B2
GO
Isoform 3 (identifier: Q16656-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Show »
Length:342
Mass (Da):36,051
Checksum:i5130FF5034DC7362
GO
Isoform 4 (identifier: Q16656-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     449-449: N → NGLFMADRAGRKWILTDKAT

Show »
Length:522
Mass (Da):55,674
Checksum:i580AC14584586AEF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JP85C9JP85_HUMAN
Nuclear respiratory factor 1
NRF1
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti322V → VV in AAA79013 (PubMed:7629110).Curated1
Sequence conflicti403T → A in BAG56867 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0543301 – 161Missing in isoform 3. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_003598256 – 321Missing in isoform Short. CuratedAdd BLAST66
Alternative sequenceiVSP_054331449N → NGLFMADRAGRKWILTDKAT in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L22454 mRNA Translation: AAA16918.1
U02683 mRNA Translation: AAA21647.1
U18383 U18382 Genomic DNA Translation: AAA79013.1
EU159452 mRNA Translation: ABV90872.1
AK290891 mRNA Translation: BAF83580.1
AK293351 mRNA Translation: BAG56867.1
AC078846 Genomic DNA No translation available.
AC084864 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24100.1
CH471070 Genomic DNA Translation: EAW83728.1
BC016925 mRNA Translation: AAH16925.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5813.2 [Q16656-1]
CCDS78273.1 [Q16656-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A54868

NCBI Reference Sequences

More...RefSeqi		NP_001035199.1, NM_001040110.1 [Q16656-1]
NP_001280092.1, NM_001293163.1 [Q16656-4]
NP_001280093.1, NM_001293164.1 [Q16656-3]
NP_005002.3, NM_005011.4 [Q16656-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000223190; ENSP00000223190; ENSG00000106459 [Q16656-1]
ENST00000311967; ENSP00000309826; ENSG00000106459 [Q16656-4]
ENST00000353868; ENSP00000342351; ENSG00000106459 [Q16656-4]
ENST00000393230; ENSP00000376922; ENSG00000106459 [Q16656-1]
ENST00000393232; ENSP00000376924; ENSG00000106459 [Q16656-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4899

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4899

UCSC genome browser

More...UCSCi		uc003voz.4, human [Q16656-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22454 mRNA Translation: AAA16918.1
U02683 mRNA Translation: AAA21647.1
U18383 U18382 Genomic DNA Translation: AAA79013.1
EU159452 mRNA Translation: ABV90872.1
AK290891 mRNA Translation: BAF83580.1
AK293351 mRNA Translation: BAG56867.1
AC078846 Genomic DNA No translation available.
AC084864 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24100.1
CH471070 Genomic DNA Translation: EAW83728.1
BC016925 mRNA Translation: AAH16925.1
CCDSiCCDS5813.2 [Q16656-1]
CCDS78273.1 [Q16656-4]
PIRiA54868
RefSeqiNP_001035199.1, NM_001040110.1 [Q16656-1]
NP_001280092.1, NM_001293163.1 [Q16656-4]
NP_001280093.1, NM_001293164.1 [Q16656-3]
NP_005002.3, NM_005011.4 [Q16656-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110955, 61 interactors
DIPiDIP-56958N
IntActiQ16656, 51 interactors
MINTiQ16656
STRINGi9606.ENSP00000376924

PTM databases

GlyGeniQ16656, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ16656
PhosphoSitePlusiQ16656

Polymorphism and mutation databases

BioMutaiNRF1
DMDMi12643732

Proteomic databases

EPDiQ16656
jPOSTiQ16656
MassIVEiQ16656
MaxQBiQ16656
PaxDbiQ16656
PeptideAtlasiQ16656
PRIDEiQ16656
ProteomicsDBi3895
61015 [Q16656-1]
61016 [Q16656-2]
75975

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17908, 443 antibodies

The DNASU plasmid repository

More...DNASUi		4899

Genome annotation databases

EnsembliENST00000223190; ENSP00000223190; ENSG00000106459 [Q16656-1]
ENST00000311967; ENSP00000309826; ENSG00000106459 [Q16656-4]
ENST00000353868; ENSP00000342351; ENSG00000106459 [Q16656-4]
ENST00000393230; ENSP00000376922; ENSG00000106459 [Q16656-1]
ENST00000393232; ENSP00000376924; ENSG00000106459 [Q16656-1]
GeneIDi4899
KEGGihsa:4899
UCSCiuc003voz.4, human [Q16656-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4899
DisGeNETi4899
EuPathDBiHostDB:ENSG00000106459.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		NRF1
HGNCiHGNC:7996, NRF1
HPAiENSG00000106459, Low tissue specificity
MIMi600879, gene
neXtProtiNX_Q16656
OpenTargetsiENSG00000106459
PharmGKBiPA31775

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTK1, Eukaryota
GeneTreeiENSGT00390000006835
HOGENOMiCLU_018156_3_1_1
InParanoidiQ16656
OMAiDHTVHQT
PhylomeDBiQ16656
TreeFamiTF105308

Enzyme and pathway databases

PathwayCommonsiQ16656
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
SignaLinkiQ16656
SIGNORiQ16656

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4899, 755 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NRF1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NRF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4899
PharosiQ16656, Tbio

Protein Ontology

More...PROi		PR:Q16656
RNActiQ16656, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106459, Expressed in corpus callosum and 194 other tissues
ExpressionAtlasiQ16656, baseline and differential
GenevisibleiQ16656, HS

Family and domain databases

InterProiView protein in InterPro
IPR039142, NRF1/Ewg
IPR019526, Nrf1_activation-bd
IPR019525, Nrf1_NLS/DNA-bd_dimer
PANTHERiPTHR20338, PTHR20338, 1 hit
PfamiView protein in Pfam
PF10492, Nrf1_activ_bdg, 1 hit
PF10491, Nrf1_DNA-bind, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16656
Secondary accession number(s): A8K4C6
, B4DDV6, Q15305, Q96AN2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: December 2, 2020
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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