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UniProtKB - Q16655 (MAR1_HUMAN)
Protein
Melanoma antigen recognized by T-cells 1
Gene
MLANA
Organism
Homo sapiens (Human)
Status
Functioni
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
2 PublicationsEnzyme and pathway databases
PathwayCommonsi | Q16655 |
SignaLinki | Q16655 |
SIGNORi | Q16655 |
Names & Taxonomyi
Protein namesi | Recommended name: Melanoma antigen recognized by T-cells 1Short name: MART-1 Alternative name(s): Antigen LB39-AA Antigen SK29-AA Protein Melan-A |
Gene namesi | Name:MLANA Synonyms:MART1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7124, MLANA |
MIMi | 605513, gene |
neXtProti | NX_Q16655 |
VEuPathDBi | HostDB:ENSG00000120215 |
Subcellular locationi
Golgi apparatus
Endoplasmic reticulum
Other locations
Note: Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- trans-Golgi network Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
Other locations
- melanosome Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 27 – 47 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 48 – 118 | CytoplasmicSequence analysisAdd BLAST | 71 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2315 |
OpenTargetsi | ENSG00000120215 |
PharmGKBi | PA30842 |
Miscellaneous databases
Pharosi | Q16655, Tbio |
Genetic variation databases
BioMutai | MLANA |
DMDMi | 2833278 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096238 | 1 – 118 | Melanoma antigen recognized by T-cells 1Add BLAST | 118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Acylated.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q16655 |
jPOSTi | Q16655 |
MassIVEi | Q16655 |
PaxDbi | Q16655 |
PeptideAtlasi | Q16655 |
PRIDEi | Q16655 |
ProteomicsDBi | 61014 |
PTM databases
GlyGeni | Q16655, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q16655 |
PhosphoSitePlusi | Q16655 |
SwissPalmi | Q16655 |
Expressioni
Tissue specificityi
Expression is restricted to melanoma and melanocyte cell lines and retina.
Gene expression databases
Bgeei | ENSG00000120215, Expressed in material anatomical entity and 124 other tissues |
ExpressionAtlasi | Q16655, baseline and differential |
Genevisiblei | Q16655, HS |
Organism-specific databases
HPAi | ENSG00000120215, Tissue enriched (skin) |
Interactioni
Subunit structurei
Interacts with PMEL.
Interacts with GPR143.
3 PublicationsBinary interactionsi
Q16655
With | #Exp. | IntAct |
---|---|---|
EPN2 - isoform 2 [O95208-2] | 3 | EBI-2509726,EBI-12135243 |
Protein-protein interaction databases
BioGRIDi | 108604, 3 interactors |
IntActi | Q16655, 5 interactors |
MINTi | Q16655 |
STRINGi | 9606.ENSP00000370886 |
Miscellaneous databases
RNActi | Q16655, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q16655 |
SMRi | Q16655 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16655 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 78 – 118 | DisorderedSequence analysisAdd BLAST | 41 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S51B, Eukaryota |
GeneTreei | ENSGT00390000009531 |
HOGENOMi | CLU_167667_0_0_1 |
InParanoidi | Q16655 |
OMAi | GMPRGDF |
PhylomeDBi | Q16655 |
TreeFami | TF338577 |
Family and domain databases
InterProi | View protein in InterPro IPR029242, MLANA |
PANTHERi | PTHR15305, PTHR15305, 1 hit |
Pfami | View protein in Pfam PF14991, MLANA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q16655-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR
60 70 80 90 100
RNGYRALMDK SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA
110
PPAYEKLSAE QSPPPYSP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06452 mRNA Translation: AAA19238.1 U06654 mRNA Translation: AAA20389.1 CR450299 mRNA Translation: CAG29295.1 AK312149 mRNA Translation: BAG35083.1 AL365360 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58755.1 CH471071 Genomic DNA Translation: EAW58756.1 BC014423 mRNA Translation: AAH14423.1 |
CCDSi | CCDS6466.1 |
PIRi | A55253 |
RefSeqi | NP_005502.1, NM_005511.1 |
Genome annotation databases
Ensembli | ENST00000381471.1; ENSP00000370880.1; ENSG00000120215.10 ENST00000381476.5; ENSP00000370885.1; ENSG00000120215.10 ENST00000381477.8; ENSP00000370886.3; ENSG00000120215.10 |
GeneIDi | 2315 |
KEGGi | hsa:2315 |
MANE-Selecti | ENST00000381477.8; ENSP00000370886.3; NM_005511.2; NP_005502.1 |
UCSCi | uc003zjo.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06452 mRNA Translation: AAA19238.1 U06654 mRNA Translation: AAA20389.1 CR450299 mRNA Translation: CAG29295.1 AK312149 mRNA Translation: BAG35083.1 AL365360 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58755.1 CH471071 Genomic DNA Translation: EAW58756.1 BC014423 mRNA Translation: AAH14423.1 |
CCDSi | CCDS6466.1 |
PIRi | A55253 |
RefSeqi | NP_005502.1, NM_005511.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GT9 | X-ray | 1.75 | C/F | 26-35 | [»] | |
2GTW | X-ray | 1.55 | C/F | 27-35 | [»] | |
2GTZ | X-ray | 1.70 | C/F | 27-35 | [»] | |
2GUO | X-ray | 1.90 | C/F | 27-35 | [»] | |
3HG1 | X-ray | 3.00 | C | 26-35 | [»] | |
3L6F | X-ray | 2.10 | C | 100-114 | [»] | |
3MRO | X-ray | 2.35 | P | 26-35 | [»] | |
3MRP | X-ray | 2.10 | P | 26-35 | [»] | |
3MRQ | X-ray | 2.20 | P | 26-35 | [»] | |
3QDM | X-ray | 2.80 | C | 26-35 | [»] | |
3QEQ | X-ray | 2.59 | C | 27-35 | [»] | |
3QFD | X-ray | 1.68 | C/F | 27-35 | [»] | |
4EUP | X-ray | 2.88 | C/F | 27-35 | [»] | |
4JFF | X-ray | 2.43 | C | 26-35 | [»] | |
4L3E | X-ray | 2.56 | C | 26-35 | [»] | |
4QOK | X-ray | 3.00 | C | 26-35 | [»] | |
4WJ5 | X-ray | 1.65 | C/F | 28-34 | [»] | |
5E9D | X-ray | 2.51 | C/H | 26-35 | [»] | |
5NHT | X-ray | 3.20 | P | 26-35 | [»] | |
5NQK | X-ray | 3.25 | P | 26-35 | [»] | |
6D78 | X-ray | 2.35 | C | 27-35 | [»] | |
6DKP | X-ray | 2.97 | C | 26-35 | [»] | |
6TMO | X-ray | 2.10 | C | 26-35 | [»] | |
AlphaFoldDBi | Q16655 | |||||
SMRi | Q16655 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108604, 3 interactors |
IntActi | Q16655, 5 interactors |
MINTi | Q16655 |
STRINGi | 9606.ENSP00000370886 |
PTM databases
GlyGeni | Q16655, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q16655 |
PhosphoSitePlusi | Q16655 |
SwissPalmi | Q16655 |
Genetic variation databases
BioMutai | MLANA |
DMDMi | 2833278 |
Proteomic databases
EPDi | Q16655 |
jPOSTi | Q16655 |
MassIVEi | Q16655 |
PaxDbi | Q16655 |
PeptideAtlasi | Q16655 |
PRIDEi | Q16655 |
ProteomicsDBi | 61014 |
Protocols and materials databases
ABCDi | Q16655, 7 sequenced antibodies |
Antibodypediai | 3661, 2283 antibodies from 48 providers |
DNASUi | 2315 |
Genome annotation databases
Ensembli | ENST00000381471.1; ENSP00000370880.1; ENSG00000120215.10 ENST00000381476.5; ENSP00000370885.1; ENSG00000120215.10 ENST00000381477.8; ENSP00000370886.3; ENSG00000120215.10 |
GeneIDi | 2315 |
KEGGi | hsa:2315 |
MANE-Selecti | ENST00000381477.8; ENSP00000370886.3; NM_005511.2; NP_005502.1 |
UCSCi | uc003zjo.2, human |
Organism-specific databases
CTDi | 2315 |
DisGeNETi | 2315 |
GeneCardsi | MLANA |
HGNCi | HGNC:7124, MLANA |
HPAi | ENSG00000120215, Tissue enriched (skin) |
MIMi | 605513, gene |
neXtProti | NX_Q16655 |
OpenTargetsi | ENSG00000120215 |
PharmGKBi | PA30842 |
VEuPathDBi | HostDB:ENSG00000120215 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S51B, Eukaryota |
GeneTreei | ENSGT00390000009531 |
HOGENOMi | CLU_167667_0_0_1 |
InParanoidi | Q16655 |
OMAi | GMPRGDF |
PhylomeDBi | Q16655 |
TreeFami | TF338577 |
Enzyme and pathway databases
PathwayCommonsi | Q16655 |
SignaLinki | Q16655 |
SIGNORi | Q16655 |
Miscellaneous databases
BioGRID-ORCSi | 2315, 10 hits in 1059 CRISPR screens |
ChiTaRSi | MLANA, human |
EvolutionaryTracei | Q16655 |
GeneWikii | MLANA |
GenomeRNAii | 2315 |
Pharosi | Q16655, Tbio |
PROi | PR:Q16655 |
RNActi | Q16655, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120215, Expressed in material anatomical entity and 124 other tissues |
ExpressionAtlasi | Q16655, baseline and differential |
Genevisiblei | Q16655, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029242, MLANA |
PANTHERi | PTHR15305, PTHR15305, 1 hit |
Pfami | View protein in Pfam PF14991, MLANA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MAR1_HUMAN | |
Accessioni | Q16655Primary (citable) accession number: Q16655 Secondary accession number(s): Q6ICU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references