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Protein

Nuclear factor interleukin-3-regulated protein

Gene

NFIL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cellular response to interleukin-4 Source: Ensembl
  • circadian rhythm Source: GO_Central
  • immune response Source: ProtInc
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of gene expression Source: Ensembl
  • transcription by RNA polymerase II Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-400253 Circadian Clock

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q16649

SIGNOR Signaling Network Open Resource

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SIGNORi
Q16649

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor interleukin-3-regulated protein
Alternative name(s):
E4 promoter-binding protein 4
Interleukin-3 promoter transcriptional activator
Interleukin-3-binding protein 1
Transcriptional activator NF-IL3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFIL3
Synonyms:E4BP4, IL3BP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000165030.3

Human Gene Nomenclature Database

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HGNCi
HGNC:7787 NFIL3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605327 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16649

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi330K → A: Interacts with DR1 and partially affects transcriptional repression; when associated with E-332. 1 Publication1
Mutagenesisi330K → E: Does not interact with DR1 and drastically affects transcriptional repression; when associated with E-332. 1 Publication1
Mutagenesisi332K → A: Interacts with DR1 and partially affects transcriptional repression; when associated with E-330. 1 Publication1
Mutagenesisi332K → E: Does not interact with DR1 and drastically affects transcriptional repression; when associated with E-330. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4783

Open Targets

More...
OpenTargetsi
ENSG00000165030

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31593

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NFIL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
150385077

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002926671 – 462Nuclear factor interleukin-3-regulated proteinAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki219Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki219Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei301PhosphoserineCombined sources1
Cross-linki306Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki314Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei353PhosphoserineCombined sources1
Cross-linki360Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki394Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki406Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki412Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki419Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki424Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki434Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki448Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q16649

MaxQB - The MaxQuant DataBase

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MaxQBi
Q16649

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q16649

PeptideAtlas

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PeptideAtlasi
Q16649

PRoteomics IDEntifications database

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PRIDEi
Q16649

ProteomicsDB human proteome resource

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ProteomicsDBi
61000

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q16649

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q16649

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by PHA or TPA.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165030 Expressed in 225 organ(s), highest expression level in ectocervix

CleanEx database of gene expression profiles

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CleanExi
HS_NFIL3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16649 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q16649 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA003261

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Binds DNA as a dimer. Interacts with DR1. Interacts with PER2 and CRY2 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110855, 16 interactors

Protein interaction database and analysis system

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IntActi
Q16649, 18 interactors

Molecular INTeraction database

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MINTi
Q16649

STRING: functional protein association networks

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STRINGi
9606.ENSP00000297689

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q16649

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16649

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 136bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 95Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni99 – 106Leucine-zipperPROSITE-ProRule annotation8
Regioni299 – 363Necessary for transcriptional repression and sufficient for interaction with DR11 PublicationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi155 – 210Ser-richAdd BLAST56

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. NFIL3 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ISXX Eukaryota
ENOG410Z2VS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160540

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000059596

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG105717

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16649

KEGG Orthology (KO)

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KOi
K09059

Identification of Orthologs from Complete Genome Data

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OMAi
KVEAFDH

Database of Orthologous Groups

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OrthoDBi
EOG091G06SA

Database for complete collections of gene phylogenies

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PhylomeDBi
Q16649

TreeFam database of animal gene trees

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TreeFami
TF328374

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004827 bZIP
IPR016743 NFIL3/E4BP4
IPR010533 Vert_IL3-reg_TF

The PANTHER Classification System

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PANTHERi
PTHR15284:SF1 PTHR15284:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07716 bZIP_2, 1 hit
PF06529 Vert_IL3-reg_TF, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF019029 bZIP_E4BP4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00338 BRLZ, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q16649-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLRKMQTVK KEQASLDASS NVDKMMVLNS ALTEVSEDST TGEELLLSEG
60 70 80 90 100
SVGKNKSSAC RRKREFIPDE KKDAMYWEKR RKNNEAAKRS REKRRLNDLV
110 120 130 140 150
LENKLIALGE ENATLKAELL SLKLKFGLIS STAYAQEIQK LSNSTAVYFQ
160 170 180 190 200
DYQTSKSNVS SFVDEHEPSM VSSSCISVIK HSPQSSLSDV SEVSSVEHTQ
210 220 230 240 250
ESSVQGSCRS PENKFQIIKQ EPMELESYTR EPRDDRGSYT ASIYQNYMGN
260 270 280 290 300
SFSGYSHSPP LLQVNRSSSN SPRTSETDDG VVGKSSDGED EQQVPKGPIH
310 320 330 340 350
SPVELKHVHA TVVKVPEVNS SALPHKLRIK AKAMQIKVEA FDNEFEATQK
360 370 380 390 400
LSSPIDMTSK RHFELEKHSA PSMVHSSLTP FSVQVTNIQD WSLKSEHWHQ
410 420 430 440 450
KELSGKTQNS FKTGVVEMKD SGYKVSDPEN LYLKQGIANL SAEVVSLKRL
460
IATQPISASD SG
Length:462
Mass (Da):51,472
Last modified:June 26, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD19946AAC774C3E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44 – 45EL → DV in AAA93067 (PubMed:1620116).Curated2
Sequence conflicti44 – 45EL → DV in CAA45597 (PubMed:1620116).Curated2
Sequence conflicti44 – 45EL → DV in AAB35410 (PubMed:7565758).Curated2
Sequence conflicti149F → S in CAG46846 (Ref. 4) Curated1
Sequence conflicti273R → G in AAA93067 (PubMed:1620116).Curated1
Sequence conflicti273R → G in CAA45597 (PubMed:1620116).Curated1
Sequence conflicti273R → G in AAB35410 (PubMed:7565758).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U26173 mRNA Translation: AAA93067.1
X64318 mRNA Translation: CAA45597.1
S79880 mRNA Translation: AAB35410.1
EF028070 Genomic DNA Translation: ABK15691.1
CR542049 mRNA Translation: CAG46846.1
AK313970 mRNA Translation: BAG36685.1
AL353764 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62796.1
BC008197 mRNA Translation: AAH08197.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6690.1

Protein sequence database of the Protein Information Resource

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PIRi
G01804

NCBI Reference Sequences

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RefSeqi
NP_001276928.1, NM_001289999.1
NP_001276929.1, NM_001290000.1
NP_005375.2, NM_005384.2
XP_016870232.1, XM_017014743.1
XP_016870233.1, XM_017014744.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.79334

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297689; ENSP00000297689; ENSG00000165030

Database of genes from NCBI RefSeq genomes

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GeneIDi
4783

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4783

UCSC genome browser

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UCSCi
uc004arh.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26173 mRNA Translation: AAA93067.1
X64318 mRNA Translation: CAA45597.1
S79880 mRNA Translation: AAB35410.1
EF028070 Genomic DNA Translation: ABK15691.1
CR542049 mRNA Translation: CAG46846.1
AK313970 mRNA Translation: BAG36685.1
AL353764 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62796.1
BC008197 mRNA Translation: AAH08197.1
CCDSiCCDS6690.1
PIRiG01804
RefSeqiNP_001276928.1, NM_001289999.1
NP_001276929.1, NM_001290000.1
NP_005375.2, NM_005384.2
XP_016870232.1, XM_017014743.1
XP_016870233.1, XM_017014744.1
UniGeneiHs.79334

3D structure databases

ProteinModelPortaliQ16649
SMRiQ16649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110855, 16 interactors
IntActiQ16649, 18 interactors
MINTiQ16649
STRINGi9606.ENSP00000297689

PTM databases

iPTMnetiQ16649
PhosphoSitePlusiQ16649

Polymorphism and mutation databases

BioMutaiNFIL3
DMDMi150385077

Proteomic databases

EPDiQ16649
MaxQBiQ16649
PaxDbiQ16649
PeptideAtlasiQ16649
PRIDEiQ16649
ProteomicsDBi61000

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4783
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297689; ENSP00000297689; ENSG00000165030
GeneIDi4783
KEGGihsa:4783
UCSCiuc004arh.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4783
DisGeNETi4783
EuPathDBiHostDB:ENSG00000165030.3

GeneCards: human genes, protein and diseases

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GeneCardsi
NFIL3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0169355
HGNCiHGNC:7787 NFIL3
HPAiHPA003261
MIMi605327 gene
neXtProtiNX_Q16649
OpenTargetsiENSG00000165030
PharmGKBiPA31593

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISXX Eukaryota
ENOG410Z2VS LUCA
GeneTreeiENSGT00940000160540
HOGENOMiHOG000059596
HOVERGENiHBG105717
InParanoidiQ16649
KOiK09059
OMAiKVEAFDH
OrthoDBiEOG091G06SA
PhylomeDBiQ16649
TreeFamiTF328374

Enzyme and pathway databases

ReactomeiR-HSA-400253 Circadian Clock
SignaLinkiQ16649
SIGNORiQ16649

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NFIL3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NFIL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4783

Protein Ontology

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PROi
PR:Q16649

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165030 Expressed in 225 organ(s), highest expression level in ectocervix
CleanExiHS_NFIL3
ExpressionAtlasiQ16649 baseline and differential
GenevisibleiQ16649 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016743 NFIL3/E4BP4
IPR010533 Vert_IL3-reg_TF
PANTHERiPTHR15284:SF1 PTHR15284:SF1, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
PF06529 Vert_IL3-reg_TF, 1 hit
PIRSFiPIRSF019029 bZIP_E4BP4, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFIL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16649
Secondary accession number(s): B2R9Y8
, Q14211, Q6FGQ8, Q96HS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: December 5, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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