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UniProtKB - Q16647 (PTGIS_HUMAN)

Entry version 192 (07 Apr 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Prostacyclin synthase

Gene

PTGIS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:18032380, PubMed:25623425, PubMed:12372404, PubMed:15115769). Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) (PubMed:17459323).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=9.55 µM for 6-keto-PGF1alpha1 Publication
  2. KM=30 µM for prostaglandin H21 Publication
  3. KM=60 µM for (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate1 Publication
  4. KM=13 µM for prostaglandin H2 (at 23 degrees Celsius)1 Publication
  1. Vmax=534 mmol/min/pg enzyme with prostaglandin H2 as substrate1 Publication
  2. Vmax=15 µmol/min/mg enzyme with prostaglandin H2 as substrate1 Publication
  3. Vmax=980 mol/min/mol enzyme with prostaglandin H2 as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei106SubstrateBy similarity1
Binding sitei112Substrate; via amide nitrogenBy similarity1
Binding sitei287SubstrateBy similarity1
Binding sitei382SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi441Iron (heme axial ligand)Combined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Lyase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS04738-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		5.3.99.4, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16647

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775, Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-197264, Nicotinamide salvaging
R-HSA-211979, Eicosanoids
R-HSA-211994, Sterols are 12-hydroxylated by CYP8B1
R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q16647

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001097

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostacyclin synthase (EC:5.3.99.43 Publications)
Alternative name(s):
Hydroperoxy icosatetraenoate dehydrataseCurated (EC:4.2.1.1521 Publication)
Prostaglandin I2 synthase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGIS
Synonyms:CYP8, CYP8A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9603, PTGIS

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601699, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16647

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124212.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 20HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Essential hypertension (EHT)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionA condition in which blood pressure is consistently higher than normal with no identifiable cause.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi441C → H: Abolishes prostaglandin-I synthase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5740

MalaCards human disease database

More...MalaCardsi		PTGIS
MIMi145500, phenotype

Open Targets

More...OpenTargetsi		ENSG00000124212

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		243761, NON RARE IN EUROPE: Essential hypertension

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA292

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16647, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4428

Drug and drug target database

More...DrugBanki		DB08675, (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
DB01240, Epoprostenol
DB00812, Phenylbutazone

DrugCentral

More...DrugCentrali		Q16647

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1356

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PTGIS

Domain mapping of disease mutations (DMDM)

More...DMDMi		2493373

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000519101 – 500Prostacyclin synthaseAdd BLAST500

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16647

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16647

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16647

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16647

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16647

PeptideAtlas

More...PeptideAtlasi		Q16647

PRoteomics IDEntifications database

More...PRIDEi		Q16647

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60999

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q16647

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16647

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16647

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124212, Expressed in parietal pleura and 211 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16647, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124212, Tissue enhanced (smooth)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111712, 5 interactors

Protein interaction database and analysis system

More...IntActi		Q16647, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000244043

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q16647

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16647, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1500
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16647

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16647

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni358 – 359Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0684, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153709

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018012_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16647

Identification of Orthologs from Complete Genome Data

More...OMAi		KTLHMAD

Database of Orthologous Groups

More...OrthoDBi		454773at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16647

TreeFam database of animal gene trees

More...TreeFami		TF105090

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001128, Cyt_P450
IPR024204, Cyt_P450_CYP7A1-type
IPR002403, Cyt_P450_E_grp-IV
IPR036396, Cyt_P450_sf
IPR027286, PTGIS

The PANTHER Classification System

More...PANTHERi		PTHR24306:SF4, PTHR24306:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00067, p450, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000047, Cytochrome_CYPVIIA1, 1 hit
PIRSF500628, PTGIS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00465, EP450IV

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48264, SSF48264, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q16647-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWAALLGLL AALLLLLLLS RRRTRRPGEP PLDLGSIPWL GYALDFGKDA 
        60         70         80         90        100
ASFLTRMKEK HGDIFTILVG GRYVTVLLDP HSYDAVVWEP RTRLDFHAYA 
       110        120        130        140        150
IFLMERIFDV QLPHYSPSDE KARMKLTLLH RELQALTEAM YTNLHAVLLG 
       160        170        180        190        200
DATEAGSGWH EMGLLDFSYS FLLRAGYLTL YGIEALPRTH ESQAQDRVHS 
       210        220        230        240        250
ADVFHTFRQL DRLLPKLARG SLSVGDKDHM CSVKSRLWKL LSPARLARRA 
       260        270        280        290        300
HRSKWLESYL LHLEEMGVSE EMQARALVLQ LWATQGNMGP AAFWLLLFLL 
       310        320        330        340        350
KNPEALAAVR GELESILWQA EQPVSQTTTL PQKVLDSTPV LDSVLSESLR 
       360        370        380        390        400
LTAAPFITRE VVVDLAMPMA DGREFNLRRG DRLLLFPFLS PQRDPEIYTD 
       410        420        430        440        450
PEVFKYNRFL NPDGSEKKDF YKDGKRLKNY NMPWGAGHNH CLGRSYAVNS 
       460        470        480        490        500
IKQFVFLVLV HLDLELINAD VEIPEFDLSR YGFGLMQPEH DVPVRYRIRP
Length:500
Mass (Da):57,104
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39595442BFC0B625
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01091538P → L in allele CYP8A1*2. 1 PublicationCorresponds to variant dbSNP:rs1173082660Ensembl.1
Natural variantiVAR_010916118S → R in allele CYP8A1*3. 1 PublicationCorresponds to variant dbSNP:rs5622Ensembl.1
Natural variantiVAR_014634154E → A. Corresponds to variant dbSNP:rs5623Ensembl.1
Natural variantiVAR_014635171F → L. Corresponds to variant dbSNP:rs5624Ensembl.1
Natural variantiVAR_014636236R → C. Corresponds to variant dbSNP:rs5626EnsemblClinVar.1
Natural variantiVAR_010917379R → S in allele CYP8A1*4. 1 PublicationCorresponds to variant dbSNP:rs56195291Ensembl.1
Natural variantiVAR_073186447A → T in allele CYP8A1*5; results in a significantly decreased enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs146531327Ensembl.1
Natural variantiVAR_014637500P → S. Corresponds to variant dbSNP:rs5584Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D38145 mRNA Translation: BAA07343.1
AF297048 mRNA Translation: AAG31781.1
AF297049 mRNA Translation: AAG31782.1
AF297050 mRNA Translation: AAG31783.1
AF297051 mRNA Translation: AAG31784.1
AF297052 mRNA Translation: AAG31785.1
AL118525 Genomic DNA No translation available.
BC101809 mRNA Translation: AAI01810.1
BC101811 mRNA Translation: AAI01812.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13419.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC2231

NCBI Reference Sequences

More...RefSeqi		NP_000952.1, NM_000961.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000244043; ENSP00000244043; ENSG00000124212

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5740

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5740

UCSC genome browser

More...UCSCi		uc002xut.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP8A1 alleles

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38145 mRNA Translation: BAA07343.1
AF297048 mRNA Translation: AAG31781.1
AF297049 mRNA Translation: AAG31782.1
AF297050 mRNA Translation: AAG31783.1
AF297051 mRNA Translation: AAG31784.1
AF297052 mRNA Translation: AAG31785.1
AL118525 Genomic DNA No translation available.
BC101809 mRNA Translation: AAI01810.1
BC101811 mRNA Translation: AAI01812.1
CCDSiCCDS13419.1
PIRiJC2231
RefSeqiNP_000952.1, NM_000961.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IAGX-ray2.15A/B23-500[»]
3B6HX-ray1.62A/B18-500[»]
SMRiQ16647
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111712, 5 interactors
IntActiQ16647, 1 interactor
STRINGi9606.ENSP00000244043

Chemistry databases

BindingDBiQ16647
ChEMBLiCHEMBL4428
DrugBankiDB08675, (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
DB01240, Epoprostenol
DB00812, Phenylbutazone
DrugCentraliQ16647
GuidetoPHARMACOLOGYi1356
SwissLipidsiSLP:000001097

PTM databases

CarbonylDBiQ16647
iPTMnetiQ16647
PhosphoSitePlusiQ16647

Genetic variation databases

BioMutaiPTGIS
DMDMi2493373

Proteomic databases

EPDiQ16647
jPOSTiQ16647
MassIVEiQ16647
MaxQBiQ16647
PaxDbiQ16647
PeptideAtlasiQ16647
PRIDEiQ16647
ProteomicsDBi60999

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2399, 232 antibodies

Genome annotation databases

EnsembliENST00000244043; ENSP00000244043; ENSG00000124212
GeneIDi5740
KEGGihsa:5740
UCSCiuc002xut.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5740
DisGeNETi5740

GeneCards: human genes, protein and diseases

More...GeneCardsi		PTGIS
HGNCiHGNC:9603, PTGIS
HPAiENSG00000124212, Tissue enhanced (smooth)
MalaCardsiPTGIS
MIMi145500, phenotype
601699, gene
neXtProtiNX_Q16647
OpenTargetsiENSG00000124212
Orphaneti243761, NON RARE IN EUROPE: Essential hypertension
PharmGKBiPA292
VEuPathDBiHostDB:ENSG00000124212.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0684, Eukaryota
GeneTreeiENSGT00940000153709
HOGENOMiCLU_018012_1_3_1
InParanoidiQ16647
OMAiKTLHMAD
OrthoDBi454773at2759
PhylomeDBiQ16647
TreeFamiTF105090

Enzyme and pathway databases

BioCyciMetaCyc:HS04738-MONOMER
BRENDAi5.3.99.4, 2681
PathwayCommonsiQ16647
ReactomeiR-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775, Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-193807, Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-197264, Nicotinamide salvaging
R-HSA-211979, Eicosanoids
R-HSA-211994, Sterols are 12-hydroxylated by CYP8B1
R-HSA-2162123, Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
SABIO-RKiQ16647

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5740, 5 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PTGIS, human
EvolutionaryTraceiQ16647

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Prostacyclin_synthase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5740
PharosiQ16647, Tchem

Protein Ontology

More...PROi		PR:Q16647
RNActiQ16647, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124212, Expressed in parietal pleura and 211 other tissues
GenevisibleiQ16647, HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR024204, Cyt_P450_CYP7A1-type
IPR002403, Cyt_P450_E_grp-IV
IPR036396, Cyt_P450_sf
IPR027286, PTGIS
PANTHERiPTHR24306:SF4, PTHR24306:SF4, 1 hit
PfamiView protein in Pfam
PF00067, p450, 1 hit
PIRSFiPIRSF000047, Cytochrome_CYPVIIA1, 1 hit
PIRSF500628, PTGIS, 1 hit
PRINTSiPR00465, EP450IV
SUPFAMiSSF48264, SSF48264, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTGIS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16647
Secondary accession number(s): Q3MII8
, Q9HAX2, Q9HAX3, Q9HAX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 7, 2021
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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