PTGIS

Functionⁱ

Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).2 Publications

Catalytic activityⁱ

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.2 Publications

Cofactorⁱ

Kineticsⁱ

K_M=
9.55 µM for 6-keto-PGF1alpha
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans."
  Cho S.A., Rohn-Glowacki K.J., Jarrar Y.B., Yi M., Kim W.Y., Shin J.G., Lee S.J.
  Arch. Biochem. Biophys. 569C:10-18(2015) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, VARIANT THR-447, CHARACTERIZATION OF VARIANT THR-447.
K_M=
13 µM for prostaglandin H2 (at 23 degrees Celsius)
1 Publication
Manual assertion based on experiment inⁱ
- Ref.8
  "Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change."
  Li Y.C., Chiang C.W., Yeh H.C., Hsu P.Y., Whitby F.G., Wang L.H., Chan N.L.
  J. Biol. Chem. 283:2917-2926(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 18-500 IN COMPLEX WITH HEME AND INHIBITOR MINOXIDIL, FUNCTION, CATALYTIC ACTIVITY, COFACTOR, BIOPHYSICOCHEMICAL PROPERTIES.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	106	SubstrateBy similarity	1
Binding siteⁱ	112	Substrate; via amide nitrogenBy similarity	1
Binding siteⁱ	287	SubstrateBy similarity	1
Binding siteⁱ	382	SubstrateBy similarity	1
Metal bindingⁱ	441	Iron (heme axial ligand)Combined sources2 Publications	1

GO - Molecular functionⁱ

heme binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17020766
iron ion binding Source: InterPro
monooxygenase activity Source: InterPro
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
prostaglandin-I synthase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20122998
- 21296955

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11551955
cellular response to hypoxia
Source: UniProtKB
Inferred from direct assayⁱ
- 21296955
cellular response to interleukin-1
Source: UniProtKB
Inferred from expression patternⁱ
- 8185632
cellular response to interleukin-6
Source: UniProtKB
Inferred from expression patternⁱ
- 8185632
cyclooxygenase pathway Source: Reactome
decidualization Source: Ensembl
embryo implantation Source: Ensembl
icosanoid metabolic process Source: Reactome
NAD biosynthesis via nicotinamide riboside salvage pathway Source: Reactome
negative regulation of inflammatory response
Source: UniProtKB
Inferred from direct assayⁱ
- 20159982
negative regulation of NF-kappaB transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20159982
negative regulation of nitric oxide biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20159982
positive regulation of angiogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20122998
positive regulation of execution phase of apoptosis
Source: UniProtKB
Inferred from direct assayⁱ
- 11551955
positive regulation of peroxisome proliferator activated receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11551955
prostaglandin biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20122998
- 21296955

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04738-MONOMER
BRENDAⁱ	5.3.99.4 2681
Reactomeⁱ	R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-197264 Nicotinamide salvaging R-HSA-211979 Eicosanoids R-HSA-211994 Sterols are 12-hydroxylated by CYP8B1 R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Chemistry databases

SwissLipidsⁱ	SLP:000001097

SwissLipidsⁱ

SLP:000001097

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prostacyclin synthase (EC:5.3.99.42 Publications) Alternative name(s): Prostaglandin I2 synthase
Gene namesⁱ	Name:PTGIS Synonyms:CYP8, CYP8A1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000124212.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9603 PTGIS
MIMⁱ	601699 gene
neXtProtⁱ	NX_Q16647

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	1 – 20	HelicalSequence analysisAdd BLAST		20

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Essential hypertension (EHT)1 Publication

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition in which blood pressure is consistently higher than normal with no identifiable cause.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5740
MalaCards human disease database More...MalaCardsⁱ	PTGIS
MIMⁱ	145500 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000124212
PharmGKBⁱ	PA292

Chemistry databases

ChEMBLⁱ	CHEMBL4428
Drug and drug target database More...DrugBankⁱ	DB01240 Epoprostenol DB00812 Phenylbutazone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1356

Polymorphism and mutation databases

BioMutaⁱ	PTGIS
DMDMⁱ	2493373

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051910	1 – 500	Prostacyclin synthaseAdd BLAST		500

Proteomic databases

EPDⁱ	Q16647
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16647
PaxDbⁱ	Q16647
PeptideAtlas More...PeptideAtlasⁱ	Q16647
PRIDEⁱ	Q16647
ProteomicsDBⁱ	60999

PTM databases

CarbonylDBⁱ	Q16647
iPTMnetⁱ	Q16647
PhosphoSitePlusⁱ	Q16647

Expressionⁱ

Tissue specificityⁱ

Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.

Gene expression databases

Bgeeⁱ	ENSG00000124212 Expressed in 196 organ(s), highest expression level in parietal pleura
CleanExⁱ	HS_PTGIS
Genevisibleⁱ	Q16647 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009517 HPA014193 HPA052244

HPAⁱ

CAB009517
HPA014193
HPA052244

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	111712, 4 interactors
STRINGⁱ	9606.ENSP00000244043

Chemistry databases

BindingDBⁱ

Q16647

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	38 – 40	Combined sources	3
Helixⁱ	43 – 48	Combined sources	6
Helixⁱ	50 – 61	Combined sources	12
Beta strandⁱ	63 – 69	Combined sources	7
Beta strandⁱ	72 – 77	Combined sources	6
Helixⁱ	80 – 82	Combined sources	3
Helixⁱ	83 – 87	Combined sources	5
Turnⁱ	91 – 93	Combined sources	3
Beta strandⁱ	94 – 96	Combined sources	3
Helixⁱ	98 – 106	Combined sources	9
Helixⁱ	117 – 125	Combined sources	9
Helixⁱ	130 – 155	Combined sources	26
Beta strandⁱ	160 – 163	Combined sources	4
Helixⁱ	164 – 181	Combined sources	18
Helixⁱ	190 – 219	Combined sources	30
Helixⁱ	224 – 240	Combined sources	17
Helixⁱ	243 – 246	Combined sources	4
Helixⁱ	254 – 265	Combined sources	12
Helixⁱ	270 – 285	Combined sources	16
Helixⁱ	288 – 300	Combined sources	13
Helixⁱ	303 – 318	Combined sources	16
Helixⁱ	333 – 336	Combined sources	4
Helixⁱ	339 – 352	Combined sources	14
Beta strandⁱ	357 – 361	Combined sources	5
Beta strandⁱ	365 – 368	Combined sources	4
Beta strandⁱ	374 – 377	Combined sources	4
Beta strandⁱ	382 – 385	Combined sources	4
Helixⁱ	388 – 392	Combined sources	5
Turnⁱ	395 – 397	Combined sources	3
Beta strandⁱ	398 – 400	Combined sources	3
Turnⁱ	406 – 409	Combined sources	4
Beta strandⁱ	414 – 416	Combined sources	3
Helixⁱ	444 – 460	Combined sources	17
Beta strandⁱ	462 – 468	Combined sources	7
Helixⁱ	478 – 480	Combined sources	3
Beta strandⁱ	482 – 485	Combined sources	4
Beta strandⁱ	488 – 490	Combined sources	3
Beta strandⁱ	493 – 498	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16647
SMRⁱ	Q16647
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q16647

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	358 – 359	Substrate bindingBy similarity		2

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0684 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074551
HOVERGENⁱ	HBG051100
InParanoidⁱ	Q16647
KEGG Orthology (KO) More...KOⁱ	K01831
OMAⁱ	VFHTFRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0767
PhylomeDBⁱ	Q16647
TreeFamⁱ	TF105090

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR024204 Cyt_P450_CYP7A1-type IPR002403 Cyt_P450_E_grp-IV IPR036396 Cyt_P450_sf IPR027286 PTGIS
PANTHERⁱ	PTHR24306:SF4 PTHR24306:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PIRSFⁱ	PIRSF000047 Cytochrome_CYPVIIA1, 1 hit PIRSF500628 PTGIS, 1 hit
PRINTSⁱ	PR00465 EP450IV
SUPFAMⁱ	SSF48264 SSF48264, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q16647-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAWAALLGLL AALLLLLLLS RRRTRRPGEP PLDLGSIPWL GYALDFGKDA 
        60         70         80         90        100
ASFLTRMKEK HGDIFTILVG GRYVTVLLDP HSYDAVVWEP RTRLDFHAYA 
       110        120        130        140        150
IFLMERIFDV QLPHYSPSDE KARMKLTLLH RELQALTEAM YTNLHAVLLG 
       160        170        180        190        200
DATEAGSGWH EMGLLDFSYS FLLRAGYLTL YGIEALPRTH ESQAQDRVHS 
       210        220        230        240        250
ADVFHTFRQL DRLLPKLARG SLSVGDKDHM CSVKSRLWKL LSPARLARRA 
       260        270        280        290        300
HRSKWLESYL LHLEEMGVSE EMQARALVLQ LWATQGNMGP AAFWLLLFLL 
       310        320        330        340        350
KNPEALAAVR GELESILWQA EQPVSQTTTL PQKVLDSTPV LDSVLSESLR 
       360        370        380        390        400
LTAAPFITRE VVVDLAMPMA DGREFNLRRG DRLLLFPFLS PQRDPEIYTD 
       410        420        430        440        450
PEVFKYNRFL NPDGSEKKDF YKDGKRLKNY NMPWGAGHNH CLGRSYAVNS 
       460        470        480        490        500
IKQFVFLVLV HLDLELINAD VEIPEFDLSR YGFGLMQPEH DVPVRYRIRP

Length:500

Mass (Da):57,104

Last modified:November 1, 1996 - v1

Checksum:ⁱ39595442BFC0B625

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_010915	38	P → L in allele CYP8A1*2. 1 PublicationCorresponds to variant dbSNP:rs1173082660Ensembl.	1
Natural variantⁱVAR_010916	118	S → R in allele CYP8A1*3. 1 PublicationCorresponds to variant dbSNP:rs5622Ensembl.	1
Natural variantⁱVAR_014634	154	E → A. Corresponds to variant dbSNP:rs5623Ensembl.	1
Natural variantⁱVAR_014635	171	F → L. Corresponds to variant dbSNP:rs5624Ensembl.	1
Natural variantⁱVAR_014636	236	R → C. Corresponds to variant dbSNP:rs5626Ensembl.	1
Natural variantⁱVAR_010917	379	R → S in allele CYP8A1*4. 1 PublicationCorresponds to variant dbSNP:rs56195291Ensembl.	1
Natural variantⁱVAR_073186	447	A → T in allele CYP8A1*5; results in a significantly decreased enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs146531327Ensembl.	1
Natural variantⁱVAR_014637	500	P → S. Corresponds to variant dbSNP:rs5584Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D38145 mRNA Translation: BAA07343.1 AF297048 mRNA Translation: AAG31781.1 AF297049 mRNA Translation: AAG31782.1 AF297050 mRNA Translation: AAG31783.1 AF297051 mRNA Translation: AAG31784.1 AF297052 mRNA Translation: AAG31785.1 AL118525 Genomic DNA No translation available. BC101809 mRNA Translation: AAI01810.1 BC101811 mRNA Translation: AAI01812.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13419.1
PIRⁱ	JC2231
NCBI Reference Sequences More...RefSeqⁱ	NP_000952.1, NM_000961.3
UniGeneⁱ	Hs.302085

Genome annotation databases

Ensemblⁱ	ENST00000244043; ENSP00000244043; ENSG00000124212
GeneIDⁱ	5740
KEGGⁱ	hsa:5740
UCSC genome browser More...UCSCⁱ	uc002xut.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16647	Prostacyclin synthase (Fragment)		HUMAN		509	UniRef100_Q16647

Protein	Similar proteins		Species	Score	Length	Source
Q16647	Prostacyclin synthase (Fragment)		HUMAN		509	UniRef90_Q16647
Prostacyclin synthase		CALJA		501
Prostacyclin synthase		PANPA		501
Prostacyclin synthase		PONAB		500
Prostacyclin synthase		AOTNA		500
+39

Protein	Similar proteins		Species	Score	Length	Source
Q16647	Prostacyclin synthase		MOUSE		501	UniRef50_Q16647
Prostacyclin synthase		BOVIN		500
Prostacyclin synthase		RAT		501
Prostacyclin synthase (Fragment)		HUMAN		509
Prostacyclin synthase		CALJA		501
+221

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP8A1 alleles

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D38145 mRNA Translation: BAA07343.1 AF297048 mRNA Translation: AAG31781.1 AF297049 mRNA Translation: AAG31782.1 AF297050 mRNA Translation: AAG31783.1 AF297051 mRNA Translation: AAG31784.1 AF297052 mRNA Translation: AAG31785.1 AL118525 Genomic DNA No translation available. BC101809 mRNA Translation: AAI01810.1 BC101811 mRNA Translation: AAI01812.1
CCDSⁱ	CCDS13419.1
PIRⁱ	JC2231
RefSeqⁱ	NP_000952.1, NM_000961.3
UniGeneⁱ	Hs.302085

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2IAG	X-ray	2.15	A/B	23-500	[»]
	3B6H	X-ray	1.62	A/B	18-500	[»]
ProteinModelPortalⁱ	Q16647
SMRⁱ	Q16647
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111712, 4 interactors
STRINGⁱ	9606.ENSP00000244043

Chemistry databases

BindingDBⁱ	Q16647
ChEMBLⁱ	CHEMBL4428
DrugBankⁱ	DB01240 Epoprostenol DB00812 Phenylbutazone
GuidetoPHARMACOLOGYⁱ	1356
SwissLipidsⁱ	SLP:000001097

PTM databases

CarbonylDBⁱ	Q16647
iPTMnetⁱ	Q16647
PhosphoSitePlusⁱ	Q16647

Polymorphism and mutation databases

BioMutaⁱ	PTGIS
DMDMⁱ	2493373

Proteomic databases

EPDⁱ	Q16647
MaxQBⁱ	Q16647
PaxDbⁱ	Q16647
PeptideAtlasⁱ	Q16647
PRIDEⁱ	Q16647
ProteomicsDBⁱ	60999

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000244043; ENSP00000244043; ENSG00000124212
GeneIDⁱ	5740
KEGGⁱ	hsa:5740
UCSCⁱ	uc002xut.4 human

Organism-specific databases

CTDⁱ	5740
DisGeNETⁱ	5740
EuPathDBⁱ	HostDB:ENSG00000124212.5
GeneCardsⁱ	PTGIS
HGNCⁱ	HGNC:9603 PTGIS
HPAⁱ	CAB009517 HPA014193 HPA052244
MalaCardsⁱ	PTGIS
MIMⁱ	145500 phenotype 601699 gene
neXtProtⁱ	NX_Q16647
OpenTargetsⁱ	ENSG00000124212
PharmGKBⁱ	PA292
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0684 Eukaryota COG2124 LUCA
GeneTreeⁱ	ENSGT00550000074551
HOVERGENⁱ	HBG051100
InParanoidⁱ	Q16647
KOⁱ	K01831
OMAⁱ	VFHTFRQ
OrthoDBⁱ	EOG091G0767
PhylomeDBⁱ	Q16647
TreeFamⁱ	TF105090

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04738-MONOMER
BRENDAⁱ	5.3.99.4 2681
Reactomeⁱ	R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-197264 Nicotinamide salvaging R-HSA-211979 Eicosanoids R-HSA-211994 Sterols are 12-hydroxylated by CYP8B1 R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Miscellaneous databases

EvolutionaryTraceⁱ	Q16647
GeneWikiⁱ	Prostacyclin_synthase
GenomeRNAiⁱ	5740
Protein Ontology More...PROⁱ	PR:Q16647
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000124212 Expressed in 196 organ(s), highest expression level in parietal pleura
CleanExⁱ	HS_PTGIS
Genevisibleⁱ	Q16647 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR024204 Cyt_P450_CYP7A1-type IPR002403 Cyt_P450_E_grp-IV IPR036396 Cyt_P450_sf IPR027286 PTGIS
PANTHERⁱ	PTHR24306:SF4 PTHR24306:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PIRSFⁱ	PIRSF000047 Cytochrome_CYPVIIA1, 1 hit PIRSF500628 PTGIS, 1 hit
PRINTSⁱ	PR00465 EP450IV
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTGIS_HUMAN
Accessionⁱ	Q16647Primary (citable) accession number: Q16647 Secondary accession number(s): Q3MII8 , Q9HAX2, Q9HAX3, Q9HAX4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	October 10, 2018
	This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16647 (PTGIS_HUMAN)

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Prostacyclin synthase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ