MAPKAPK3

Functionⁱ

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X₂-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.6 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Activity regulationⁱ

Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited by ligand 5B (2'-[2-(1,3-benzodioxol-5-yl)pyrimidin-4-yl]-5',6'-dihydrospiro[piperidine-4,7'-pyrrolo[3,2-c]pyridin]- 4'(1'h)-one) and ligand P4O (2-[2-(2-fluorophenyl)pyridin-4-yl]-1,5,6,7-tetrahydro- 4h-pyrrolo[3,2-c]pyridin-4-one), 2 ATP-competitive inhibitors.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	73	ATPPROSITE-ProRule annotation		1
Active siteⁱ	166	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	50 – 58	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
calcium-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calmodulin-dependent protein kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
MAP kinase kinase activity
Source: ProtInc
Traceable author statementⁱ
- 10781029
mitogen-activated protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8774846

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Reactome
intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
macropinocytosis Source: UniProtKB
peptidyl-serine phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 15850461
response to cytokine
Source: UniProtKB
Inferred from direct assayⁱ
- 8774846
response to lipopolysaccharide Source: UniProtKB
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8626550
toll-like receptor signaling pathway Source: UniProtKB
vascular endothelial growth factor receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-171007 p38MAPK events R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-450302 activated TAK1 mediates p38 MAPK activation
SignaLinkⁱ	Q16644
SIGNORⁱ	Q16644

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MAP kinase-activated protein kinase 3 (EC:2.7.11.1) Short name: MAPK-activated protein kinase 3 Short name: MAPKAP kinase 3 Short name: MAPKAP-K3 Short name: MAPKAPK-3 Short name: MK-3 Alternative name(s): Chromosome 3p kinase Short name: 3pK
Gene namesⁱ	Name:MAPKAPK3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000114738.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6888 MAPKAPK3
MIMⁱ	602130 gene
neXtProtⁱ	NX_Q16644

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Macular dystrophy, patterned, 3 (MDPT3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of retinal patterned dystrophy, characterized by retinal pigment epithelium and Bruch's membrane changes resembling a 'dry desert land'. It begins around the age of 30 and progresses to retinitis pigmentosa. MDPT3 inheritance is autosomal dominant.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_077085	173	L → P in MDPT3; decreased localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs886037913EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	73	K → M: Higher affinity toward PCH2. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7867
MalaCards human disease database More...MalaCardsⁱ	MAPKAPK3
MIMⁱ	617111 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000114738
Orphanetⁱ	466718 Martinique crinkled retinal pigment epitheliopathy
PharmGKBⁱ	PA30632

Chemistry databases

ChEMBLⁱ	CHEMBL4670
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2095

Polymorphism and mutation databases

BioMutaⁱ	MAPKAPK3
DMDMⁱ	74762148

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086293	1 – 382	MAP kinase-activated protein kinase 3Add BLAST		382

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	201	Phosphothreonine; by MAPK14By similarity	1
Modified residueⁱ	251	Phosphoserine; by MAPK14By similarity	1
Modified residueⁱ	307	Phosphoserine; by autocatalysisBy similarity	1
Modified residueⁱ	313	Phosphothreonine; by MAPK14By similarity	1

Post-translational modificationⁱ

Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q16644
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16644
PaxDbⁱ	Q16644
PeptideAtlas More...PeptideAtlasⁱ	Q16644
PRIDEⁱ	Q16644
ProteomicsDBⁱ	60998

PTM databases

iPTMnetⁱ	Q16644
PhosphoSitePlusⁱ	Q16644

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Expressed in the retinal pigment epithelium (PubMed:26744326).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000114738 Expressed in 232 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	HS_MAPKAPK3
ExpressionAtlasⁱ	Q16644 baseline and differential
Genevisibleⁱ	Q16644 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058275

HPAⁱ

HPA058275

Interactionⁱ

Subunit structureⁱ

Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface (By similarity). Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P27958	5	EBI-1384657,EBI-6377335	From Hepatitis C virus genotype 1a (isolate H).
HSPB1	P04792	3	EBI-1384657,EBI-352682
MAPK14	Q16539	5	EBI-1384657,EBI-73946

GO - Molecular functionⁱ

mitogen-activated protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113617, 30 interactors
ELMⁱ	Q16644
IntActⁱ	Q16644, 27 interactors
Molecular INTeraction database More...MINTⁱ	Q16644
STRINGⁱ	9606.ENSP00000350639

Chemistry databases

BindingDBⁱ

Q16644

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	39 – 41	Combined sources	3
Beta strandⁱ	43 – 53	Combined sources	11
Beta strandⁱ	56 – 63	Combined sources	8
Turnⁱ	64 – 66	Combined sources	3
Beta strandⁱ	69 – 78	Combined sources	10
Helixⁱ	79 – 91	Combined sources	13
Beta strandⁱ	100 – 108	Combined sources	9
Beta strandⁱ	111 – 119	Combined sources	9
Helixⁱ	126 – 131	Combined sources	6
Helixⁱ	140 – 159	Combined sources	20
Helixⁱ	169 – 171	Combined sources	3
Beta strandⁱ	172 – 175	Combined sources	4
Beta strandⁱ	183 – 185	Combined sources	3
Helixⁱ	218 – 237	Combined sources	20
Turnⁱ	267 – 269	Combined sources	3
Beta strandⁱ	271 – 273	Combined sources	3
Helixⁱ	275 – 284	Combined sources	10
Helixⁱ	289 – 291	Combined sources	3
Helixⁱ	295 – 300	Combined sources	6
Helixⁱ	302 – 305	Combined sources	4
Helixⁱ	307 – 309	Combined sources	3
Helixⁱ	317 – 323	Combined sources	7
Helixⁱ	325 – 327	Combined sources	3
Helixⁱ	328 – 343	Combined sources	16
Beta strandⁱ	344 – 346	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16644
SMRⁱ	Q16644
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q16644

EvolutionaryTraceⁱ

Q16644

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 304	Protein kinasePROSITE-ProRule annotationAdd BLAST		261

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	307 – 343	Autoinhibitory helixBy similarityAdd BLAST		37
Regionⁱ	345 – 369	p38 MAPK-binding siteBy similarityAdd BLAST		25

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	335 – 344	Nuclear export signal (NES)By similarity	10
Motifⁱ	350 – 353	Bipartite nuclear localization signal 1By similarity	4
Motifⁱ	364 – 368	Bipartite nuclear localization signal 2By similarity	5

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0604 Eukaryota ENOG410XP8F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150819
HOGENOMⁱ	HOG000233031
HOVERGENⁱ	HBG106948
InParanoidⁱ	Q16644
KEGG Orthology (KO) More...KOⁱ	K04444
OMAⁱ	RMGQYGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14PL
PhylomeDBⁱ	Q16644
TreeFamⁱ	TF312891

Family and domain databases

Gene3Dⁱ	4.10.1170.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR027442 MAPKAPK_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q16644-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDGETAEEQG GPVPPPVAPG GPGLGGAPGG RREPKKYAVT DDYQLSKQVL 
        60         70         80         90        100
GLGVNGKVLE CFHRRTGQKC ALKLLYDSPK ARQEVDHHWQ ASGGPHIVCI 
       110        120        130        140        150
LDVYENMHHG KRCLLIIMEC MEGGELFSRI QERGDQAFTE REAAEIMRDI 
       160        170        180        190        200
GTAIQFLHSH NIAHRDVKPE NLLYTSKEKD AVLKLTDFGF AKETTQNALQ 
       210        220        230        240        250
TPCYTPYYVA PEVLGPEKYD KSCDMWSLGV IMYILLCGFP PFYSNTGQAI 
       260        270        280        290        300
SPGMKRRIRL GQYGFPNPEW SEVSEDAKQL IRLLLKTDPT ERLTITQFMN 
       310        320        330        340        350
HPWINQSMVV PQTPLHTARV LQEDKDHWDE VKEEMTSALA TMRVDYDQVK 
       360        370        380 
IKDLKTSNNR LLNKRRKKQA GSSSASQGCN NQ

Length:382

Mass (Da):42,987

Last modified:November 1, 1996 - v1

Checksum:ⁱ405F958B7F54E6F3

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C0G6	H7C0G6_HUMAN	MAP kinase-activated protein kinase... MAP kinase-activated protein kinase 3	MAPKAPK3	97	Annotation score:
C9J8E1	C9J8E1_HUMAN	MAP kinase-activated protein kinase... MAP kinase-activated protein kinase 3	MAPKAPK3	332	Annotation score:
C9JPW3	C9JPW3_HUMAN	MAP kinase-activated protein kinase... MAP kinase-activated protein kinase 3	MAPKAPK3	119	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040755	28	P → S in a glioblastoma multiforme sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040756	105	E → A in an ovarian endometrioid sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_077085	173	L → P in MDPT3; decreased localization to the nucleus. 1 PublicationCorresponds to variant dbSNP:rs886037913EnsemblClinVar.	1
Natural variantⁱVAR_040757	276	D → Y1 PublicationCorresponds to variant dbSNP:rs56107897Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U43784 mRNA Translation: AAC50428.1 U09578 mRNA Translation: AAD09136.1 AB451303 mRNA Translation: BAG70117.1 CH471055 Genomic DNA Translation: EAW65131.1 BC001662 mRNA Translation: AAH01662.1 BC007591 mRNA Translation: AAH07591.1 BC010407 mRNA Translation: AAH10407.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2832.1
PIRⁱ	JC6094
NCBI Reference Sequences More...RefSeqⁱ	NP_001230854.1, NM_001243925.1 NP_001230855.1, NM_001243926.1 NP_004626.1, NM_004635.4
UniGeneⁱ	Hs.234521 Hs.735013

Genome annotation databases

Ensemblⁱ	ENST00000357955; ENSP00000350639; ENSG00000114738 ENST00000446044; ENSP00000396467; ENSG00000114738 ENST00000621469; ENSP00000478922; ENSG00000114738
GeneIDⁱ	7867
KEGGⁱ	hsa:7867
UCSC genome browser More...UCSCⁱ	uc003day.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16644	Mitogen-activated protein kinase-activated protein kinase 3, isoform CRA_a		HUMAN		382	UniRef100_Q16644
MAP kinase-activated protein kinase 3 (Fragment)		HUMAN		119
MAP kinase-activated protein kinase 3 (Fragment)		HUMAN		332
UPI00020DB123		HUMAN		317

Protein	Similar proteins		Species	Score	Length	Source
Q16644	MAP kinase-activated protein kinase 3		RAT		384	UniRef90_Q16644
MAP kinase-activated protein kinase 3		MOUSE		384
MAP kinase-activated protein kinase 3		BOVIN		384
Mitogen-activated protein kinase-activated protein kinase 3, isoform CRA_a		HUMAN		382
MAP kinase-activated protein kinase 3		DIPOR		385
+131

Protein	Similar proteins		Species	Score	Length	Source
Q16644	Isoform 2 of MAP kinase-activated protein kinase 2		HUMAN		370	UniRef50_P49137-2
MAP kinase-activated protein kinase 3		BOVIN		384
MAP kinase-activated protein kinase 3		MOUSE		384
MAP kinase-activated protein kinase 3		RAT		384
MAP kinase-activated protein kinase mak-2		CAEEL		366
+397

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U43784 mRNA Translation: AAC50428.1 U09578 mRNA Translation: AAD09136.1 AB451303 mRNA Translation: BAG70117.1 CH471055 Genomic DNA Translation: EAW65131.1 BC001662 mRNA Translation: AAH01662.1 BC007591 mRNA Translation: AAH07591.1 BC010407 mRNA Translation: AAH10407.1
CCDSⁱ	CCDS2832.1
PIRⁱ	JC6094
RefSeqⁱ	NP_001230854.1, NM_001243925.1 NP_001230855.1, NM_001243926.1 NP_004626.1, NM_004635.4
UniGeneⁱ	Hs.234521 Hs.735013

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3FHR	X-ray	1.90	A	33-349	[»]
	3FXW	X-ray	2.00	A	33-349	[»]
	3R1N	X-ray	2.09	A	33-349	[»]
	3SHE	X-ray	2.25	A	33-349	[»]
ProteinModelPortalⁱ	Q16644
SMRⁱ	Q16644
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113617, 30 interactors
ELMⁱ	Q16644
IntActⁱ	Q16644, 27 interactors
MINTⁱ	Q16644
STRINGⁱ	9606.ENSP00000350639

Chemistry databases

BindingDBⁱ	Q16644
ChEMBLⁱ	CHEMBL4670
GuidetoPHARMACOLOGYⁱ	2095

PTM databases

iPTMnetⁱ	Q16644
PhosphoSitePlusⁱ	Q16644

Polymorphism and mutation databases

BioMutaⁱ	MAPKAPK3
DMDMⁱ	74762148

Proteomic databases

EPDⁱ	Q16644
MaxQBⁱ	Q16644
PaxDbⁱ	Q16644
PeptideAtlasⁱ	Q16644
PRIDEⁱ	Q16644
ProteomicsDBⁱ	60998

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7867
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357955; ENSP00000350639; ENSG00000114738 ENST00000446044; ENSP00000396467; ENSG00000114738 ENST00000621469; ENSP00000478922; ENSG00000114738
GeneIDⁱ	7867
KEGGⁱ	hsa:7867
UCSCⁱ	uc003day.3 human

Organism-specific databases

CTDⁱ	7867
DisGeNETⁱ	7867
EuPathDBⁱ	HostDB:ENSG00000114738.10
GeneCardsⁱ	MAPKAPK3
HGNCⁱ	HGNC:6888 MAPKAPK3
HPAⁱ	HPA058275
MalaCardsⁱ	MAPKAPK3
MIMⁱ	602130 gene 617111 phenotype
neXtProtⁱ	NX_Q16644
OpenTargetsⁱ	ENSG00000114738
Orphanetⁱ	466718 Martinique crinkled retinal pigment epitheliopathy
PharmGKBⁱ	PA30632
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0604 Eukaryota ENOG410XP8F LUCA
GeneTreeⁱ	ENSGT00930000150819
HOGENOMⁱ	HOG000233031
HOVERGENⁱ	HBG106948
InParanoidⁱ	Q16644
KOⁱ	K04444
OMAⁱ	RMGQYGF
OrthoDBⁱ	EOG091G14PL
PhylomeDBⁱ	Q16644
TreeFamⁱ	TF312891

Enzyme and pathway databases

Reactomeⁱ	R-HSA-171007 p38MAPK events R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-450302 activated TAK1 mediates p38 MAPK activation
SignaLinkⁱ	Q16644
SIGNORⁱ	Q16644

Miscellaneous databases

ChiTaRSⁱ	MAPKAPK3 human
EvolutionaryTraceⁱ	Q16644
GeneWikiⁱ	MAPKAPK3
GenomeRNAiⁱ	7867
Protein Ontology More...PROⁱ	PR:Q16644
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000114738 Expressed in 232 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	HS_MAPKAPK3
ExpressionAtlasⁱ	Q16644 baseline and differential
Genevisibleⁱ	Q16644 HS

Family and domain databases

Gene3Dⁱ	4.10.1170.10, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR027442 MAPKAPK_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MAPK3_HUMAN
Accessionⁱ	Q16644Primary (citable) accession number: Q16644 Secondary accession number(s): B5BU67
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q16644 (MAPK3_HUMAN)

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MAP kinase-activated protein kinase 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ