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Protein

Drebrin

Gene

DBN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.1 Publication

GO - Molecular functioni

  • actin binding Source: ProtInc
  • cadherin binding Source: BHF-UCL
  • profilin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

SignaLinkiQ16643

Names & Taxonomyi

Protein namesi
Recommended name:
Drebrin
Alternative name(s):
Developmentally-regulated brain protein
Gene namesi
Name:DBN1
Synonyms:D0S117E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113758.13
HGNCiHGNC:2695 DBN1
MIMi126660 gene
neXtProtiNX_Q16643

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1627
OpenTargetsiENSG00000113758
PharmGKBiPA27163

Polymorphism and mutation databases

BioMutaiDBN1
DMDMi215274247

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00000800082 – 649DrebrinAdd BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei141PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1 Publication1
Modified residuei331PhosphothreonineCombined sources1
Modified residuei335PhosphothreonineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei345PhosphoserineBy similarity1
Modified residuei346PhosphothreonineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei497PhosphothreonineCombined sources1
Modified residuei601PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ16643
MaxQBiQ16643
PaxDbiQ16643
PeptideAtlasiQ16643
PRIDEiQ16643
ProteomicsDBi60996
60997 [Q16643-2]

2D gel databases

OGPiQ16643

PTM databases

iPTMnetiQ16643
PhosphoSitePlusiQ16643
SwissPalmiQ16643

Expressioni

Tissue specificityi

Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000113758
CleanExiHS_DBN1
ExpressionAtlasiQ16643 baseline and differential
GenevisibleiQ16643 HS

Organism-specific databases

HPAiHPA051452
HPA056940

Interactioni

Subunit structurei

Interacts with RUFY3 (By similarity). Binds F-actin. Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (PubMed:20215400).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin binding Source: ProtInc
  • cadherin binding Source: BHF-UCL
  • profilin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107995, 239 interactors
IntActiQ16643, 224 interactors
MINTiQ16643
STRINGi9606.ENSP00000292385

Structurei

Secondary structure

1649
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 21Combined sources12
Beta strandi23 – 26Combined sources4
Beta strandi29 – 34Combined sources6
Beta strandi40 – 49Combined sources10
Helixi50 – 54Combined sources5
Helixi55 – 57Combined sources3
Beta strandi62 – 70Combined sources9
Beta strandi72 – 74Combined sources3
Beta strandi79 – 86Combined sources8
Helixi92 – 99Combined sources8
Helixi102 – 108Combined sources7
Beta strandi114 – 120Combined sources7
Helixi121 – 123Combined sources3
Helixi126 – 132Combined sources7

3D structure databases

ProteinModelPortaliQ16643
SMRiQ16643
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 134ADF-HPROSITE-ProRule annotationAdd BLAST132

Phylogenomic databases

eggNOGiENOG410IP00 Eukaryota
ENOG410YAV7 LUCA
GeneTreeiENSGT00530000062953
HOGENOMiHOG000015304
HOVERGENiHBG000823
InParanoidiQ16643
OMAiPCSHLDS
OrthoDBiEOG091G05KP
PhylomeDBiQ16643
TreeFamiTF318935

Family and domain databases

Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR028438 Drebrin
PANTHERiPTHR10829:SF1 PTHR10829:SF1, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16643-1) [UniParc]FASTAAdd to basket
Also known as: Drebrin E, drebrin E2, Embryonic drebrin

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG
60 70 80 90 100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS
110 120 130 140 150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL
160 170 180 190 200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL
210 220 230 240 250
DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ TLEAEEAKRR
260 270 280 290 300
LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV
310 320 330 340 350
ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE
360 370 380 390 400
QIERALDEVT SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP
410 420 430 440 450
MEEPPQAQAP PRGPGSPAED LMFMESAEQA VLAAPVEPAT ADATEIHDAA
460 470 480 490 500
DTIETDTATA DTTVANNVPP AATSLIDLWP GNGEGASTLQ GEPRAPTPPS
510 520 530 540 550
GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP ATFCDPEEVE
560 570 580 590 600
GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ
610 620 630 640
SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD
Length:649
Mass (Da):71,429
Last modified:November 25, 2008 - v4
Checksum:iA7DF1AE3776C0BEA
GO
Isoform 2 (identifier: Q16643-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-29: VSFSGHRLELLAAYEEVIREESAADW → HPWHGTAALASSQAWRDGRERQALVSCR

Note: No experimental confirmation available.
Show »
Length:651
Mass (Da):71,599
Checksum:i89DA14954246C0A3
GO
Isoform 3 (identifier: Q16643-3) [UniParc]FASTAAdd to basket
Also known as: Drebrin A

The sequence of this isoform differs from the canonical sequence as follows:
     319-319: G → GRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPC

Note: No experimental confirmation available.
Show »
Length:695
Mass (Da):76,300
Checksum:iC4E1FEC8D932603C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035910278E → K in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047365446I → V4 PublicationsCorresponds to variant dbSNP:rs2544809Ensembl.1
Natural variantiVAR_047366553S → P4 PublicationsCorresponds to variant dbSNP:rs28538572Ensembl.1
Natural variantiVAR_035911640E → Q in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0281754 – 29VSFSG…SAADW → HPWHGTAALASSQAWRDGRE RQALVSCR in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_053443319G → GRPYCPFIKASDSGPSSSSS SSSSPPRTPFPYITCHRTPN LSSSLPC in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17530 mRNA Translation: BAA04480.1
U00802 mRNA Translation: AAA16256.1
AK314645 mRNA Translation: BAG37207.1
AL110225 mRNA Translation: CAB53683.1
AC145098 Genomic DNA No translation available.
BC000283 mRNA Translation: AAH00283.1
BC007281 mRNA Translation: AAH07281.1
BC007567 mRNA Translation: AAH07567.1
BC114553 mRNA No translation available.
CCDSiCCDS4420.1 [Q16643-1]
CCDS4421.1 [Q16643-2]
PIRiJN0809
T14763
RefSeqiNP_004386.2, NM_004395.3
NP_543157.1, NM_080881.2
XP_005265884.1, XM_005265827.3 [Q16643-3]
XP_016864629.1, XM_017009140.1 [Q16643-2]
UniGeneiHs.130316

Genome annotation databases

EnsembliENST00000292385; ENSP00000292385; ENSG00000113758 [Q16643-2]
ENST00000309007; ENSP00000308532; ENSG00000113758 [Q16643-1]
ENST00000393565; ENSP00000377195; ENSG00000113758 [Q16643-3]
GeneIDi1627
KEGGihsa:1627
UCSCiuc003mgx.3 human [Q16643-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDREB_HUMAN
AccessioniPrimary (citable) accession number: Q16643
Secondary accession number(s): A8MV58, B2RBG0, Q9UFZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: July 18, 2018
This is version 179 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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