UniProtKB - Q16643 (DREB_HUMAN)

BLAST

>sp|Q16643|DREB_HUMAN Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4
MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFEN
QKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASS
VEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQF
WEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQ
TLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERV
ASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVT
SSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAED
LMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWP
GNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPP
ATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQ
SQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

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History
Entry version 182 (07 Nov 2018)
Sequence version 4 (25 Nov 2008)
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Protein

Drebrin

Gene

DBN1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.1 Publication

GO - Molecular functionⁱ

actin binding
Source: ProtInc
Traceable author statementⁱ
- 8216329
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
profilin binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization Source: UniProtKB
cell communication by chemical coupling Source: Ensembl
cell communication by electrical coupling Source: Ensembl
maintenance of protein location in cell Source: Ensembl
neural precursor cell proliferation Source: Ensembl
regulation of dendrite development
Source: UniProtKB
Non-traceable author statementⁱ
- 12009525
regulation of neuronal synaptic plasticity
Source: UniProtKB
Non-traceable author statementⁱ
- 12009525

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Developmental protein
Biological process	Differentiation, Neurogenesis

Enzyme and pathway databases

SignaLinkⁱ	Q16643

SignaLinkⁱ

Q16643

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Drebrin Alternative name(s): Developmentally-regulated brain protein
Gene namesⁱ	Name:DBN1 Synonyms:D0S117E
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000113758.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2695 DBN1
MIMⁱ	126660 gene
neXtProtⁱ	NX_Q16643

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1627
Open Targets More...OpenTargetsⁱ	ENSG00000113758
PharmGKBⁱ	PA27163

Polymorphism and mutation databases

BioMutaⁱ	DBN1
DMDMⁱ	215274247

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources2 Publications
ChainⁱPRO_0000080008	2 – 649	DrebrinAdd BLAST		648

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources2 Publications	1
Modified residueⁱ	141	PhosphoserineCombined sources	1
Modified residueⁱ	142	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	331	PhosphothreonineCombined sources	1
Modified residueⁱ	335	PhosphothreonineCombined sources	1
Modified residueⁱ	337	PhosphoserineCombined sources	1
Modified residueⁱ	339	PhosphoserineCombined sources	1
Modified residueⁱ	345	PhosphoserineBy similarity	1
Modified residueⁱ	346	PhosphothreonineCombined sources	1
Modified residueⁱ	416	PhosphoserineCombined sources	1
Modified residueⁱ	497	PhosphothreonineCombined sources	1
Modified residueⁱ	601	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q16643
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16643
PaxDbⁱ	Q16643
PeptideAtlas More...PeptideAtlasⁱ	Q16643
PRIDEⁱ	Q16643
ProteomicsDBⁱ	60996 60997 [Q16643-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	Q16643

OGPⁱ

Q16643

PTM databases

iPTMnetⁱ	Q16643
PhosphoSitePlusⁱ	Q16643
SwissPalmⁱ	Q16643

Expressionⁱ

Tissue specificityⁱ

Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000113758 Expressed in 225 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_DBN1
ExpressionAtlasⁱ	Q16643 baseline and differential
Genevisibleⁱ	Q16643 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051452 HPA056940

HPAⁱ

HPA051452
HPA056940

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AFDN	P55196	4	EBI-351394,EBI-365875
Afdn	O35889	3	EBI-351394,EBI-6654073	From Rattus norvegicus.
CXCR4	P61073	5	EBI-351394,EBI-489411
DBN1	Q16643-1	2	EBI-351394,EBI-8757328
GRB2	P62993	4	EBI-351394,EBI-401755
GRN	P28799	5	EBI-351394,EBI-747754
PTEN	P60484	5	EBI-351394,EBI-696162
TINF2	Q9BSI4	2	EBI-351394,EBI-717399

GO - Molecular functionⁱ

actin binding
Source: ProtInc
Traceable author statementⁱ
- 8216329
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
profilin binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107995, 242 interactors
IntActⁱ	Q16643, 226 interactors
Molecular INTeraction database More...MINTⁱ	Q16643
STRINGⁱ	9606.ENSP00000292385

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	10 – 21	Combined sources	12
Beta strandⁱ	23 – 26	Combined sources	4
Beta strandⁱ	29 – 34	Combined sources	6
Beta strandⁱ	40 – 49	Combined sources	10
Helixⁱ	50 – 54	Combined sources	5
Helixⁱ	55 – 57	Combined sources	3
Beta strandⁱ	62 – 70	Combined sources	9
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	79 – 86	Combined sources	8
Helixⁱ	92 – 99	Combined sources	8
Helixⁱ	102 – 108	Combined sources	7
Beta strandⁱ	114 – 120	Combined sources	7
Helixⁱ	121 – 123	Combined sources	3
Helixⁱ	126 – 132	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16643
SMRⁱ	Q16643
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 134	ADF-HPROSITE-ProRule annotationAdd BLAST		132

Phylogenomic databases

eggNOGⁱ	ENOG410IP00 Eukaryota ENOG410YAV7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062953
HOGENOMⁱ	HOG000015304
HOVERGENⁱ	HBG000823
InParanoidⁱ	Q16643
OMAⁱ	PCSHLDS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05KP
PhylomeDBⁱ	Q16643
TreeFamⁱ	TF318935

Family and domain databases

Gene3Dⁱ	3.40.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028438 Drebrin
PANTHERⁱ	PTHR10829:SF1 PTHR10829:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 1 hit
SMARTⁱ	View protein in SMART SM00102 ADF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q16643-1) [UniParc]FASTA Add to basket

Also known as: Drebrin E, drebrin E2, Embryonic drebrin

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG 
        60         70         80         90        100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS 
       110        120        130        140        150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL 
       160        170        180        190        200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL 
       210        220        230        240        250
DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ TLEAEEAKRR 
       260        270        280        290        300
LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV 
       310        320        330        340        350
ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE 
       360        370        380        390        400
QIERALDEVT SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP 
       410        420        430        440        450
MEEPPQAQAP PRGPGSPAED LMFMESAEQA VLAAPVEPAT ADATEIHDAA 
       460        470        480        490        500
DTIETDTATA DTTVANNVPP AATSLIDLWP GNGEGASTLQ GEPRAPTPPS 
       510        520        530        540        550
GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP ATFCDPEEVE 
       560        570        580        590        600
GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ 
       610        620        630        640 
SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD

Length:649

Mass (Da):71,429

Last modified:November 25, 2008 - v4

Checksum:ⁱA7DF1AE3776C0BEA

Isoform 2 (identifier: Q16643-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
4-29: VSFSGHRLELLAAYEEVIREESAADW → HPWHGTAALASSQAWRDGRERQALVSCR

« Hide

        10         20         30         40         50
MAGHPWHGTA ALASSQAWRD GRERQALVSC RALYTYEDGS DDLKLAASGE 
        60         70         80         90        100
GGLQELSGHF ENQKVMYGFC SVKDSQAALP KYVLINWVGE DVPDARKCAC 
       110        120        130        140        150
ASHVAKVAEF FQGVDVIVNA SSVEDIDAGA IGQRLSNGLA RLSSPVLHRL 
       160        170        180        190        200
RLREDENAEP VGTTYQKTDA AVEMKRINRE QFWEQAKKEE ELRKEEERKK 
       210        220        230        240        250
ALDERLRFEQ ERMEQERQEQ EERERRYRER EQQIEEHRRK QQTLEAEEAK 
       260        270        280        290        300
RRLKEQSIFG DHRDEEEETH MKKSESEVEE AAAIIAQRPD NPREFFKQQE 
       310        320        330        340        350
RVASASAGSC DVPSPFNHRP GSHLDSHRRM APTPIPTRSP SDSSTASTPV 
       360        370        380        390        400
AEQIERALDE VTSSQPPPLP PPPPPAQETQ EPSPILDSEE TRAAAPQAWA 
       410        420        430        440        450
GPMEEPPQAQ APPRGPGSPA EDLMFMESAE QAVLAAPVEP ATADATEIHD 
       460        470        480        490        500
AADTIETDTA TADTTVANNV PPAATSLIDL WPGNGEGAST LQGEPRAPTP 
       510        520        530        540        550
PSGTEVTLAE VPLLDEVAPE PLLPAGEGCA TLLNFDELPE PPATFCDPEE 
       560        570        580        590        600
VEGESLAAPQ TPTLPSALEE LEQEQEPEPH LLTNGETTQK EGTQASEGYF 
       610        620        630        640        650
SQSQEEEFAQ SEELCAKAPP PVFYNKPPEI DITCWDADPV PEEEEGFEGG 

D

Note: No experimental confirmation available.

Show »

Length:651

Mass (Da):71,599

Checksum:ⁱ89DA14954246C0A3

Isoform 3 (identifier: Q16643-3) [UniParc]FASTA Add to basket

Also known as: Drebrin A

The sequence of this isoform differs from the canonical sequence as follows:
319-319: G → GRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPC

« Hide

        10         20         30         40         50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG 
        60         70         80         90        100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS 
       110        120        130        140        150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL 
       160        170        180        190        200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL 
       210        220        230        240        250
DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ TLEAEEAKRR 
       260        270        280        290        300
LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV 
       310        320        330        340        350
ASASAGSCDV PSPFNHRPGR PYCPFIKASD SGPSSSSSSS SSPPRTPFPY 
       360        370        380        390        400
ITCHRTPNLS SSLPCSHLDS HRRMAPTPIP TRSPSDSSTA STPVAEQIER 
       410        420        430        440        450
ALDEVTSSQP PPLPPPPPPA QETQEPSPIL DSEETRAAAP QAWAGPMEEP 
       460        470        480        490        500
PQAQAPPRGP GSPAEDLMFM ESAEQAVLAA PVEPATADAT EIHDAADTIE 
       510        520        530        540        550
TDTATADTTV ANNVPPAATS LIDLWPGNGE GASTLQGEPR APTPPSGTEV 
       560        570        580        590        600
TLAEVPLLDE VAPEPLLPAG EGCATLLNFD ELPEPPATFC DPEEVEGESL 
       610        620        630        640        650
AAPQTPTLPS ALEELEQEQE PEPHLLTNGE TTQKEGTQAS EGYFSQSQEE 
       660        670        680        690 
EFAQSEELCA KAPPPVFYNK PPEIDITCWD ADPVPEEEEG FEGGD

Note: No experimental confirmation available.

Show »

Length:695

Mass (Da):76,300

Checksum:ⁱC4E1FEC8D932603C

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6R9W4	D6R9W4_HUMAN	Drebrin Drebrin	DBN1	317	Annotation score:
D6RFI1	D6RFI1_HUMAN	Drebrin Drebrin	DBN1	124	Annotation score:
D6RCR4	D6RCR4_HUMAN	Drebrin Drebrin	DBN1	93	Annotation score:
D6R9Q9	D6R9Q9_HUMAN	Drebrin Drebrin	DBN1	391	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_035910	278	E → K in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_047365	446	I → V4 PublicationsCorresponds to variant dbSNP:rs2544809Ensembl.	1
Natural variantⁱVAR_047366	553	S → P4 PublicationsCorresponds to variant dbSNP:rs28538572Ensembl.	1
Natural variantⁱVAR_035911	640	E → Q in a breast cancer sample; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_028175	4 – 29	VSFSG…SAADW → HPWHGTAALASSQAWRDGRE RQALVSCR in isoform 2. 1 PublicationAdd BLAST		26
Alternative sequenceⁱVSP_053443	319	G → GRPYCPFIKASDSGPSSSSS SSSSPPRTPFPYITCHRTPN LSSSLPC in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D17530 mRNA Translation: BAA04480.1 U00802 mRNA Translation: AAA16256.1 AK314645 mRNA Translation: BAG37207.1 AL110225 mRNA Translation: CAB53683.1 AC145098 Genomic DNA No translation available. BC000283 mRNA Translation: AAH00283.1 BC007281 mRNA Translation: AAH07281.1 BC007567 mRNA Translation: AAH07567.1 BC114553 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4420.1 [Q16643-1] CCDS4421.1 [Q16643-2] CCDS87354.1 [Q16643-3]
PIRⁱ	JN0809 T14763
NCBI Reference Sequences More...RefSeqⁱ	NP_004386.2, NM_004395.3 NP_543157.1, NM_080881.2 XP_005265884.1, XM_005265827.3 XP_016864629.1, XM_017009140.1 [Q16643-2]
UniGeneⁱ	Hs.130316

Genome annotation databases

Ensemblⁱ	ENST00000292385; ENSP00000292385; ENSG00000113758 [Q16643-2] ENST00000309007; ENSP00000308532; ENSG00000113758 [Q16643-1] ENST00000393565; ENSP00000377195; ENSG00000113758 [Q16643-3]
GeneIDⁱ	1627
KEGGⁱ	hsa:1627
UCSC genome browser More...UCSCⁱ	uc003mgx.3 human [Q16643-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16643	drebrin isoform X1		Florida manatee		662	UniRef90_Q16643
Drebrin isoform a		HETGA		661
Drebrin 1		BOVIN		660
Drebrin 1		OTOGA		657
Uncharacterized protein		MUSPF		656
+33
Q16643-2	drebrin isoform X1		LEPWE		655	UniRef90_Q16643-2
drebrin isoform X5		NEOSC		655
DBN1 isoform 7		PANTR		651
Drebrin 1		GORGO		651
Uncharacterized protein		PANPA		646
+10
Q16643-3	Drebrin 1		CALJA		696	UniRef90_Q16643-3
Uncharacterized protein		CERAT		696
Uncharacterized protein		PAPAN		695
DBN1 isoform 4		PONAB		695
Drebrin A		HUMAN		695
+33

Protein	Similar proteins		Species	Score	Length	Source
Q16643	Drebrin		RAT		707	UniRef50_Q07266
Drebrin		MOUSE		706
drebrin isoform X1		DELLE		699
drebrin isoform X1		ODORO		698
Uncharacterized protein		PROCO		696
+291

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D17530 mRNA Translation: BAA04480.1 U00802 mRNA Translation: AAA16256.1 AK314645 mRNA Translation: BAG37207.1 AL110225 mRNA Translation: CAB53683.1 AC145098 Genomic DNA No translation available. BC000283 mRNA Translation: AAH00283.1 BC007281 mRNA Translation: AAH07281.1 BC007567 mRNA Translation: AAH07567.1 BC114553 mRNA No translation available.
CCDSⁱ	CCDS4420.1 [Q16643-1] CCDS4421.1 [Q16643-2] CCDS87354.1 [Q16643-3]
PIRⁱ	JN0809 T14763
RefSeqⁱ	NP_004386.2, NM_004395.3 NP_543157.1, NM_080881.2 XP_005265884.1, XM_005265827.3 XP_016864629.1, XM_017009140.1 [Q16643-2]
UniGeneⁱ	Hs.130316

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5Y1Z	X-ray	2.68	A/B	1-135	[»]
ProteinModelPortalⁱ	Q16643
SMRⁱ	Q16643
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107995, 242 interactors
IntActⁱ	Q16643, 226 interactors
MINTⁱ	Q16643
STRINGⁱ	9606.ENSP00000292385

PTM databases

iPTMnetⁱ	Q16643
PhosphoSitePlusⁱ	Q16643
SwissPalmⁱ	Q16643

Polymorphism and mutation databases

BioMutaⁱ	DBN1
DMDMⁱ	215274247

2D gel databases

OGPⁱ	Q16643

OGPⁱ

Q16643

Proteomic databases

EPDⁱ	Q16643
MaxQBⁱ	Q16643
PaxDbⁱ	Q16643
PeptideAtlasⁱ	Q16643
PRIDEⁱ	Q16643
ProteomicsDBⁱ	60996 60997 [Q16643-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1627
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000292385; ENSP00000292385; ENSG00000113758 [Q16643-2] ENST00000309007; ENSP00000308532; ENSG00000113758 [Q16643-1] ENST00000393565; ENSP00000377195; ENSG00000113758 [Q16643-3]
GeneIDⁱ	1627
KEGGⁱ	hsa:1627
UCSCⁱ	uc003mgx.3 human [Q16643-1]

Organism-specific databases

CTDⁱ	1627
DisGeNETⁱ	1627
EuPathDBⁱ	HostDB:ENSG00000113758.13
GeneCardsⁱ	DBN1
H-InvDBⁱ	HIX0005464
HGNCⁱ	HGNC:2695 DBN1
HPAⁱ	HPA051452 HPA056940
MIMⁱ	126660 gene
neXtProtⁱ	NX_Q16643
OpenTargetsⁱ	ENSG00000113758
PharmGKBⁱ	PA27163
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IP00 Eukaryota ENOG410YAV7 LUCA
GeneTreeⁱ	ENSGT00530000062953
HOGENOMⁱ	HOG000015304
HOVERGENⁱ	HBG000823
InParanoidⁱ	Q16643
OMAⁱ	PCSHLDS
OrthoDBⁱ	EOG091G05KP
PhylomeDBⁱ	Q16643
TreeFamⁱ	TF318935

Enzyme and pathway databases

SignaLinkⁱ	Q16643

SignaLinkⁱ

Q16643

Miscellaneous databases

ChiTaRSⁱ	DBN1 human
GeneWikiⁱ	DBN1
GenomeRNAiⁱ	1627
Protein Ontology More...PROⁱ	PR:Q16643
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000113758 Expressed in 225 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_DBN1
ExpressionAtlasⁱ	Q16643 baseline and differential
Genevisibleⁱ	Q16643 HS

Family and domain databases

Gene3Dⁱ	3.40.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR002108 ADF-H IPR029006 ADF-H/Gelsolin-like_dom_sf IPR028438 Drebrin
PANTHERⁱ	PTHR10829:SF1 PTHR10829:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF00241 Cofilin_ADF, 1 hit
SMARTⁱ	View protein in SMART SM00102 ADF, 1 hit
PROSITEⁱ	View protein in PROSITE PS51263 ADF_H, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DREB_HUMAN
Accessionⁱ	Q16643Primary (citable) accession number: Q16643 Secondary accession number(s): A8MV58, B2RBG0, Q9UFZ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 182 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - Q16643 (DREB_HUMAN)

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Drebrin

DBN1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

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Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ