UniProtKB - Q16643 (DREB_HUMAN)
Drebrin
DBN1
Functioni
GO - Molecular functioni
- actin binding Source: ProtInc
- actin filament binding Source: GO_Central
- cadherin binding Source: BHF-UCL
- profilin binding Source: UniProtKB
GO - Biological processi
- actin filament organization Source: UniProtKB
- cell communication by chemical coupling Source: Ensembl
- cell communication by electrical coupling Source: Ensembl
- cytoplasmic sequestering of protein Source: UniProtKB
- in utero embryonic development Source: Ensembl
- maintenance of protein location in cell Source: Ensembl
- neural precursor cell proliferation Source: Ensembl
- neuron projection morphogenesis Source: GO_Central
- positive regulation of axon extension Source: GO_Central
- positive regulation of dendritic spine morphogenesis Source: UniProtKB
- positive regulation of receptor localization to synapse Source: UniProtKB
- positive regulation of synaptic plasticity Source: UniProtKB
- postsynaptic actin cytoskeleton organization Source: GO_Central
- regulation of actin filament polymerization Source: GO_Central
- regulation of dendrite development Source: UniProtKB
- regulation of neuronal synaptic plasticity Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Developmental protein |
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q16643 |
SignaLinki | Q16643 |
Names & Taxonomyi
Protein namesi | Recommended name: DrebrinAlternative name(s): Developmentally-regulated brain protein |
Gene namesi | Name:DBN1 Synonyms:D0S117E |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2695, DBN1 |
MIMi | 126660, gene |
neXtProti | NX_Q16643 |
VEuPathDBi | HostDB:ENSG00000113758.13 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 3 Publications
Other locations
- dendrite 1 Publication
- cell cortex 1 Publication
- Cell junction 1 Publication
- growth cone By similarity
Note: In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity).By similarity1 Publication
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- actomyosin Source: UniProtKB
- cortical actin cytoskeleton Source: GO_Central
- cortical cytoskeleton Source: ARUK-UCL
- cytoskeleton Source: ARUK-UCL
Cytosol
- postsynaptic cytosol Source: Ensembl
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- dendrite Source: UniProtKB
- gap junction Source: Ensembl
- glutamatergic synapse Source: Ensembl
- growth cone Source: UniProtKB
- lamellipodium Source: GO_Central
- postsynaptic density Source: GO_Central
- site of polarized growth Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell projection, CytoplasmPathology & Biotechi
Involvement in diseasei
Alzheimer disease (AD)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 10 | R → D or G: Loss of binding to ZMYND8. Loss of ZMYND8 cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 96 | C → Q: Decreased binding to ZMYND8. 1 Publication | 1 |
Keywords - Diseasei
Alzheimer disease, Amyloidosis, NeurodegenerationOrganism-specific databases
DisGeNETi | 1627 |
MIMi | 104300, phenotype |
NIAGADSi | ENSG00000113758 |
OpenTargetsi | ENSG00000113758 |
PharmGKBi | PA27163 |
Miscellaneous databases
Pharosi | Q16643, Tbio |
Genetic variation databases
BioMutai | DBN1 |
DMDMi | 215274247 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000080008 | 2 – 649 | DrebrinAdd BLAST | 648 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources2 Publications | 1 | |
Modified residuei | 141 | PhosphoserineCombined sources | 1 | |
Modified residuei | 142 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 331 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 335 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 337 | PhosphoserineCombined sources | 1 | |
Modified residuei | 339 | PhosphoserineCombined sources | 1 | |
Modified residuei | 345 | PhosphoserineBy similarity | 1 | |
Modified residuei | 346 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 416 | PhosphoserineCombined sources | 1 | |
Modified residuei | 497 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 601 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-347 CPTAC-348 |
EPDi | Q16643 |
jPOSTi | Q16643 |
MassIVEi | Q16643 |
MaxQBi | Q16643 |
PaxDbi | Q16643 |
PeptideAtlasi | Q16643 |
PRIDEi | Q16643 |
ProteomicsDBi | 2155 60996 [Q16643-1] 60997 [Q16643-2] |
2D gel databases
OGPi | Q16643 |
PTM databases
iPTMneti | Q16643 |
MetOSitei | Q16643 |
PhosphoSitePlusi | Q16643 |
SwissPalmi | Q16643 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000113758, Expressed in subventricular zone (outer) (primate) and 235 other tissues |
ExpressionAtlasi | Q16643, baseline and differential |
Genevisiblei | Q16643, HS |
Organism-specific databases
HPAi | ENSG00000113758, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with RUFY3 (By similarity).
Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (PubMed:20215400).
Interacts (via ADF-H domain) with ZMYND8 (via PHD-type Zinc finger, Bromo and PWWP domains); the interaction leads to sequestering of ZMYND8 in the cytoplasm (PubMed:28966017).
By similarity2 PublicationsBinary interactionsi
Hide detailsQ16643
GO - Molecular functioni
- actin binding Source: ProtInc
- actin filament binding Source: GO_Central
- cadherin binding Source: BHF-UCL
- profilin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107995, 291 interactors |
IntActi | Q16643, 244 interactors |
MINTi | Q16643 |
STRINGi | 9606.ENSP00000292385 |
Miscellaneous databases
RNActi | Q16643, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q16643 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 134 | ADF-HPROSITE-ProRule annotationAdd BLAST | 132 |
Phylogenomic databases
eggNOGi | KOG3655, Eukaryota |
GeneTreei | ENSGT00940000159431 |
HOGENOMi | CLU_013085_3_0_1 |
InParanoidi | Q16643 |
OMAi | MSPIPPQ |
OrthoDBi | 885776at2759 |
PhylomeDBi | Q16643 |
TreeFami | TF318935 |
Family and domain databases
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108, ADF-H IPR029006, ADF-H/Gelsolin-like_dom_sf IPR028438, Drebrin |
PANTHERi | PTHR10829:SF1, PTHR10829:SF1, 2 hits |
Pfami | View protein in Pfam PF00241, Cofilin_ADF, 1 hit |
SMARTi | View protein in SMART SM00102, ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263, ADF_H, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG
60 70 80 90 100
LQELSGHFEN QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS
110 120 130 140 150
HVAKVAEFFQ GVDVIVNASS VEDIDAGAIG QRLSNGLARL SSPVLHRLRL
160 170 180 190 200
REDENAEPVG TTYQKTDAAV EMKRINREQF WEQAKKEEEL RKEEERKKAL
210 220 230 240 250
DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ TLEAEEAKRR
260 270 280 290 300
LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV
310 320 330 340 350
ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE
360 370 380 390 400
QIERALDEVT SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP
410 420 430 440 450
MEEPPQAQAP PRGPGSPAED LMFMESAEQA VLAAPVEPAT ADATEIHDAA
460 470 480 490 500
DTIETDTATA DTTVANNVPP AATSLIDLWP GNGEGASTLQ GEPRAPTPPS
510 520 530 540 550
GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP ATFCDPEEVE
560 570 580 590 600
GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ
610 620 630 640
SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6R9W4 | D6R9W4_HUMAN | Drebrin | DBN1 | 317 | Annotation score: | ||
D6R9Q9 | D6R9Q9_HUMAN | Drebrin | DBN1 | 391 | Annotation score: | ||
D6RFI1 | D6RFI1_HUMAN | Drebrin | DBN1 | 124 | Annotation score: | ||
D6RCR4 | D6RCR4_HUMAN | Drebrin | DBN1 | 93 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035910 | 278 | E → K in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_047365 | 446 | I → V4 PublicationsCorresponds to variant dbSNP:rs2544809Ensembl. | 1 | |
Natural variantiVAR_047366 | 553 | S → P4 PublicationsCorresponds to variant dbSNP:rs28538572Ensembl. | 1 | |
Natural variantiVAR_035911 | 640 | E → Q in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028175 | 4 – 29 | VSFSG…SAADW → HPWHGTAALASSQAWRDGRE RQALVSCR in isoform 2. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_053443 | 319 | G → GRPYCPFIKASDSGPSSSSS SSSSPPRTPFPYITCHRTPN LSSSLPC in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17530 mRNA Translation: BAA04480.1 U00802 mRNA Translation: AAA16256.1 AK314645 mRNA Translation: BAG37207.1 AL110225 mRNA Translation: CAB53683.1 AC145098 Genomic DNA No translation available. BC000283 mRNA Translation: AAH00283.1 BC007281 mRNA Translation: AAH07281.1 BC007567 mRNA Translation: AAH07567.1 BC114553 mRNA No translation available. |
CCDSi | CCDS4420.1 [Q16643-1] CCDS4421.1 [Q16643-2] CCDS87354.1 [Q16643-3] |
PIRi | JN0809 T14763 |
RefSeqi | NP_004386.2, NM_004395.3 [Q16643-1] NP_543157.1, NM_080881.2 XP_005265884.1, XM_005265827.3 XP_016864629.1, XM_017009140.1 [Q16643-2] |
Genome annotation databases
Ensembli | ENST00000292385; ENSP00000292385; ENSG00000113758 [Q16643-2] ENST00000309007; ENSP00000308532; ENSG00000113758 [Q16643-1] ENST00000393565; ENSP00000377195; ENSG00000113758 [Q16643-3] |
GeneIDi | 1627 |
KEGGi | hsa:1627 |
UCSCi | uc003mgx.3, human [Q16643-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17530 mRNA Translation: BAA04480.1 U00802 mRNA Translation: AAA16256.1 AK314645 mRNA Translation: BAG37207.1 AL110225 mRNA Translation: CAB53683.1 AC145098 Genomic DNA No translation available. BC000283 mRNA Translation: AAH00283.1 BC007281 mRNA Translation: AAH07281.1 BC007567 mRNA Translation: AAH07567.1 BC114553 mRNA No translation available. |
CCDSi | CCDS4420.1 [Q16643-1] CCDS4421.1 [Q16643-2] CCDS87354.1 [Q16643-3] |
PIRi | JN0809 T14763 |
RefSeqi | NP_004386.2, NM_004395.3 [Q16643-1] NP_543157.1, NM_080881.2 XP_005265884.1, XM_005265827.3 XP_016864629.1, XM_017009140.1 [Q16643-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5Y1Z | X-ray | 2.68 | A/B | 1-135 | [»] | |
5ZZ9 | X-ray | 2.30 | D/E/F | 530-551 | [»] | |
SMRi | Q16643 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107995, 291 interactors |
IntActi | Q16643, 244 interactors |
MINTi | Q16643 |
STRINGi | 9606.ENSP00000292385 |
PTM databases
iPTMneti | Q16643 |
MetOSitei | Q16643 |
PhosphoSitePlusi | Q16643 |
SwissPalmi | Q16643 |
Genetic variation databases
BioMutai | DBN1 |
DMDMi | 215274247 |
2D gel databases
OGPi | Q16643 |
Proteomic databases
CPTACi | CPTAC-347 CPTAC-348 |
EPDi | Q16643 |
jPOSTi | Q16643 |
MassIVEi | Q16643 |
MaxQBi | Q16643 |
PaxDbi | Q16643 |
PeptideAtlasi | Q16643 |
PRIDEi | Q16643 |
ProteomicsDBi | 2155 60996 [Q16643-1] 60997 [Q16643-2] |
Protocols and materials databases
Antibodypediai | 3641, 318 antibodies |
DNASUi | 1627 |
Genome annotation databases
Ensembli | ENST00000292385; ENSP00000292385; ENSG00000113758 [Q16643-2] ENST00000309007; ENSP00000308532; ENSG00000113758 [Q16643-1] ENST00000393565; ENSP00000377195; ENSG00000113758 [Q16643-3] |
GeneIDi | 1627 |
KEGGi | hsa:1627 |
UCSCi | uc003mgx.3, human [Q16643-1] |
Organism-specific databases
CTDi | 1627 |
DisGeNETi | 1627 |
GeneCardsi | DBN1 |
HGNCi | HGNC:2695, DBN1 |
HPAi | ENSG00000113758, Low tissue specificity |
MIMi | 104300, phenotype 126660, gene |
neXtProti | NX_Q16643 |
NIAGADSi | ENSG00000113758 |
OpenTargetsi | ENSG00000113758 |
PharmGKBi | PA27163 |
VEuPathDBi | HostDB:ENSG00000113758.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3655, Eukaryota |
GeneTreei | ENSGT00940000159431 |
HOGENOMi | CLU_013085_3_0_1 |
InParanoidi | Q16643 |
OMAi | MSPIPPQ |
OrthoDBi | 885776at2759 |
PhylomeDBi | Q16643 |
TreeFami | TF318935 |
Enzyme and pathway databases
PathwayCommonsi | Q16643 |
SignaLinki | Q16643 |
Miscellaneous databases
BioGRID-ORCSi | 1627, 9 hits in 995 CRISPR screens |
ChiTaRSi | DBN1, human |
GeneWikii | DBN1 |
GenomeRNAii | 1627 |
Pharosi | Q16643, Tbio |
PROi | PR:Q16643 |
RNActi | Q16643, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113758, Expressed in subventricular zone (outer) (primate) and 235 other tissues |
ExpressionAtlasi | Q16643, baseline and differential |
Genevisiblei | Q16643, HS |
Family and domain databases
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108, ADF-H IPR029006, ADF-H/Gelsolin-like_dom_sf IPR028438, Drebrin |
PANTHERi | PTHR10829:SF1, PTHR10829:SF1, 2 hits |
Pfami | View protein in Pfam PF00241, Cofilin_ADF, 1 hit |
SMARTi | View protein in SMART SM00102, ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263, ADF_H, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DREB_HUMAN | |
Accessioni | Q16643Primary (citable) accession number: Q16643 Secondary accession number(s): A8MV58, B2RBG0, Q9UFZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 25, 2008 | |
Last modified: | April 7, 2021 | |
This is version 202 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references