TAZ

Functionⁱ

Some isoforms may be involved in cardiolipin (CL) metabolism.2 Publications

GO - Molecular functionⁱ

1-acylglycerol-3-phosphate O-acyltransferase activity Source: Reactome
1-acylglycerophosphocholine O-acyltransferase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 12930833
O-acyltransferase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac muscle contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17043667
cardiac muscle tissue development
Source: HGNC
Inferred from mutant phenotypeⁱ
- 17043667
cardiolipin acyl-chain remodeling Source: GO_Central
cardiolipin biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19164547
cristae formation
Source: HGNC
Inferred from mutant phenotypeⁱ
- 17043667
heart development
Source: HGNC
Inferred from mutant phenotypeⁱ
- 17043667
hemopoiesis
Source: HGNC
Inferred from mutant phenotypeⁱ
- 17043667
mitochondrial ATP synthesis coupled electron transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 15304507
mitochondrial respiratory chain complex I assembly
Source: HGNC
Inferred from mutant phenotypeⁱ
- 16857210
muscle contraction
Source: HGNC
Inferred from mutant phenotypeⁱ
- 17043667
positive regulation of ATP biosynthetic process Source: Ensembl
positive regulation of cardiolipin metabolic process Source: Ensembl
skeletal muscle tissue development
Source: HGNC
Inferred from mutant phenotypeⁱ
- 17043667

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-1482798 Acyl chain remodeling of CL

Reactomeⁱ

R-HSA-1268020 Mitochondrial protein import
R-HSA-1482798 Acyl chain remodeling of CL

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tafazzin Alternative name(s): Protein G4.5
Gene namesⁱ	Name:TAZ Synonyms:EFE2, G4.5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102125.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11577 TAZ
MIMⁱ	300394 gene
neXtProtⁱ	NX_Q16635

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	1 – 30	Helical; Signal-anchorSequence analysisAdd BLAST		30

Keywords - Cellular componentⁱ

Cytoplasm, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Barth syndrome (BTHS)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn X-linked disease characterized by dilated cardiomyopathy with endocardial fibroelastosis, a predominantly proximal skeletal myopathy, growth retardation, neutropenia, and organic aciduria, particularly excess of 3-methylglutaconic acid. Additional features include hypertrophic cardiomyopathy, isolated left ventricular non-compaction, ventricular arrhythmia, motor delay, poor appetite, fatigue and exercise intolerance, hypoglycemia, lactic acidosis, hyperammonemia, and dramatic late catch-up growth after growth delay throughout childhood.

Keywords - Diseaseⁱ

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6901
GeneReviewsⁱ	TAZ
MalaCards human disease database More...MalaCardsⁱ	TAZ
MIMⁱ	302060 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000102125
Orphanetⁱ	111 Barth syndrome 154 Familial isolated dilated cardiomyopathy 54260 Left ventricular noncompaction
PharmGKBⁱ	PA36341

Polymorphism and mutation databases

BioMutaⁱ	TAZ
DMDMⁱ	2498992

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000220928	1 – 292	TafazzinAdd BLAST		292

Proteomic databases

EPDⁱ	Q16635
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16635
PaxDbⁱ	Q16635
PeptideAtlas More...PeptideAtlasⁱ	Q16635
PRIDEⁱ	Q16635
ProteomicsDBⁱ	60983 60984 [Q16635-2] 60985 [Q16635-3] 60986 [Q16635-4] 60987 [Q16635-5] 60988 [Q16635-6] 60989 [Q16635-7] 60990 [Q16635-8] 60991 [Q16635-9]

PTM databases

iPTMnetⁱ	Q16635
PhosphoSitePlusⁱ	Q16635

Expressionⁱ

Tissue specificityⁱ

High levels in cardiac and skeletal muscle. Up to 10 isoforms can be present in different amounts in different tissues. Most isoforms are ubiquitous. Isoforms that lack the N-terminus are found in leukocytes and fibroblasts, but not in heart and skeletal muscle. Some forms appear restricted to cardiac and skeletal muscle or to leukocytes.

Gene expression databases

Bgeeⁱ	ENSG00000102125 Expressed in 177 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_TAZ
ExpressionAtlasⁱ	Q16635 baseline and differential
Genevisibleⁱ	Q16635 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039557

HPAⁱ

HPA039557

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112764, 117 interactors
IntActⁱ	Q16635, 2 interactors
STRINGⁱ	9606.ENSP00000299328

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	124 – 194	HydrophilicAdd BLAST		71

Domainⁱ

The hydrophilic domain may serve as an exposed loop interacting with other proteins.

Sequence similaritiesⁱ

Belongs to the taffazin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2847 Eukaryota ENOG410XT5T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018621
HOVERGENⁱ	HBG055923
InParanoidⁱ	Q16635
KEGG Orthology (KO) More...KOⁱ	K13511
OMAⁱ	IVHSGFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DPL
PhylomeDBⁱ	Q16635
TreeFamⁱ	TF313862

Family and domain databases

InterProⁱ	View protein in InterPro IPR002123 Plipid/glycerol_acylTrfase IPR000872 Tafazzin
PANTHERⁱ	PTHR12497 PTHR12497, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit
PRINTSⁱ	PR00979 TAFAZZIN
SMARTⁱ	View protein in SMART SM00563 PlsC, 1 hit

Sequences (9+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 9 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 9 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q16635-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL 
        60         70         80         90        100
YELIEKRGPA TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA 
       110        120        130        140        150
DICFTKELHS HFFSLGKCVP VCRGAEFFQA ENEGKGVLDT GRHMPGAGKR 
       160        170        180        190        200
REKGDGVYQK GMDFILEKLN HGDWVHIFPE GKVNMSSEFL RFKWGIGRLI 
       210        220        230        240        250
AECHLNPIIL PLWHVGMNDV LPNSPPYFPR FGQKITVLIG KPFSALPVLE 
       260        270        280        290 
RLRAENKSAV EMRKALTDFI QEEFQHLKTQ AEQLHNHLQP GR

Length:292

Mass (Da):33,459

Last modified:November 1, 1996 - v1

Checksum:ⁱ2805E0962DC4FE52

GO

Isoform 2 (identifier: Q16635-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
1-24: Missing.

« Hide

        10         20         30         40         50
MGLVGTYSCF WTKYMNHLTV HNREVLYELI EKRGPATPLI TVSNHQSCMD 
        60         70         80         90        100
DPHLWGILKL RHIWNLKLMR WTPAAADICF TKELHSHFFS LGKCVPVCRG 
       110        120        130        140        150
AEFFQAENEG KGVLDTGRHM PGAGKRREKG DGVYQKGMDF ILEKLNHGDW 
       160        170        180        190        200
VHIFPEGKVN MSSEFLRFKW GIGRLIAECH LNPIILPLWH VGMNDVLPNS 
       210        220        230        240        250
PPYFPRFGQK ITVLIGKPFS ALPVLERLRA ENKSAVEMRK ALTDFIQEEF 
       260 
QHLKTQAEQL HNHLQPGR

Show »

Length:268

Mass (Da):30,803

Checksum:ⁱ857BFA0FC9DFB6EA

GO

Isoform 3 (identifier: Q16635-3) [UniParc]FASTA Add to basket

Also known as: Del_exon_5

The sequence of this isoform differs from the canonical sequence as follows:
124-153: Missing.

« Hide

        10         20         30         40         50
MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL 
        60         70         80         90        100
YELIEKRGPA TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA 
       110        120        130        140        150
DICFTKELHS HFFSLGKCVP VCRGDGVYQK GMDFILEKLN HGDWVHIFPE 
       160        170        180        190        200
GKVNMSSEFL RFKWGIGRLI AECHLNPIIL PLWHVGMNDV LPNSPPYFPR 
       210        220        230        240        250
FGQKITVLIG KPFSALPVLE RLRAENKSAV EMRKALTDFI QEEFQHLKTQ 
       260 
AEQLHNHLQP GR

Show »

Length:262

Mass (Da):30,203

Checksum:ⁱAE7F4EBF505C7F63

GO

Isoform 4 (identifier: Q16635-4) [UniParc]FASTA Add to basket

Also known as: Del_exon_6

The sequence of this isoform differs from the canonical sequence as follows:
154-180: Missing.

« Hide

        10         20         30         40         50
MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL 
        60         70         80         90        100
YELIEKRGPA TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA 
       110        120        130        140        150
DICFTKELHS HFFSLGKCVP VCRGAEFFQA ENEGKGVLDT GRHMPGAGKR 
       160        170        180        190        200
REKGKVNMSS EFLRFKWGIG RLIAECHLNP IILPLWHVGM NDVLPNSPPY 
       210        220        230        240        250
FPRFGQKITV LIGKPFSALP VLERLRAENK SAVEMRKALT DFIQEEFQHL 
       260 
KTQAEQLHNH LQPGR

Show »

Length:265

Mass (Da):30,331

Checksum:ⁱE2FFF553E9576B5A

GO

Isoform 5 (identifier: Q16635-5) [UniParc]FASTA Add to basket

Also known as: Del_exon_7

The sequence of this isoform differs from the canonical sequence as follows:
181-194: Missing.

« Hide

        10         20         30         40         50
MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL 
        60         70         80         90        100
YELIEKRGPA TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA 
       110        120        130        140        150
DICFTKELHS HFFSLGKCVP VCRGAEFFQA ENEGKGVLDT GRHMPGAGKR 
       160        170        180        190        200
REKGDGVYQK GMDFILEKLN HGDWVHIFPE GIGRLIAECH LNPIILPLWH 
       210        220        230        240        250
VGMNDVLPNS PPYFPRFGQK ITVLIGKPFS ALPVLERLRA ENKSAVEMRK 
       260        270 
ALTDFIQEEF QHLKTQAEQL HNHLQPGR

Show »

Length:278

Mass (Da):31,748

Checksum:ⁱ350624E72B677BE8

GO

Isoform 6 (identifier: Q16635-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-24: Missing.
181-194: Missing.

« Hide

        10         20         30         40         50
MGLVGTYSCF WTKYMNHLTV HNREVLYELI EKRGPATPLI TVSNHQSCMD 
        60         70         80         90        100
DPHLWGILKL RHIWNLKLMR WTPAAADICF TKELHSHFFS LGKCVPVCRG 
       110        120        130        140        150
AEFFQAENEG KGVLDTGRHM PGAGKRREKG DGVYQKGMDF ILEKLNHGDW 
       160        170        180        190        200
VHIFPEGIGR LIAECHLNPI ILPLWHVGMN DVLPNSPPYF PRFGQKITVL 
       210        220        230        240        250
IGKPFSALPV LERLRAENKS AVEMRKALTD FIQEEFQHLK TQAEQLHNHL 

QPGR

Show »

Length:254

Mass (Da):29,092

Checksum:ⁱCA3073742FC132D0

GO

Isoform 7 (identifier: Q16635-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
124-153: Missing.
181-194: Missing.

« Hide

        10         20         30         40         50
MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL 
        60         70         80         90        100
YELIEKRGPA TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA 
       110        120        130        140        150
DICFTKELHS HFFSLGKCVP VCRGDGVYQK GMDFILEKLN HGDWVHIFPE 
       160        170        180        190        200
GIGRLIAECH LNPIILPLWH VGMNDVLPNS PPYFPRFGQK ITVLIGKPFS 
       210        220        230        240 
ALPVLERLRA ENKSAVEMRK ALTDFIQEEF QHLKTQAEQL HNHLQPGR

Show »

Length:248

Mass (Da):28,492

Checksum:ⁱE23FAFFC359721CA

GO

Isoform 8 (identifier: Q16635-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-24: Missing.
124-153: Missing.

« Hide

        10         20         30         40         50
MGLVGTYSCF WTKYMNHLTV HNREVLYELI EKRGPATPLI TVSNHQSCMD 
        60         70         80         90        100
DPHLWGILKL RHIWNLKLMR WTPAAADICF TKELHSHFFS LGKCVPVCRG 
       110        120        130        140        150
DGVYQKGMDF ILEKLNHGDW VHIFPEGKVN MSSEFLRFKW GIGRLIAECH 
       160        170        180        190        200
LNPIILPLWH VGMNDVLPNS PPYFPRFGQK ITVLIGKPFS ALPVLERLRA 
       210        220        230 
ENKSAVEMRK ALTDFIQEEF QHLKTQAEQL HNHLQPGR

Show »

Length:238

Mass (Da):27,547

Checksum:ⁱ53323D6698054515

GO

Isoform 9 (identifier: Q16635-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     124-153: Missing.
     181-194: Missing.

« Hide

        10         20         30         40         50
MGLVGTYSCF WTKYMNHLTV HNREVLYELI EKRGPATPLI TVSNHQSCMD 
        60         70         80         90        100
DPHLWGILKL RHIWNLKLMR WTPAAADICF TKELHSHFFS LGKCVPVCRG 
       110        120        130        140        150
DGVYQKGMDF ILEKLNHGDW VHIFPEGIGR LIAECHLNPI ILPLWHVGMN 
       160        170        180        190        200
DVLPNSPPYF PRFGQKITVL IGKPFSALPV LERLRAENKS AVEMRKALTD 
       210        220 
FIQEEFQHLK TQAEQLHNHL QPGR

Show »

Length:224

Mass (Da):25,836

Checksum:ⁱ94B5C890BB4DEAAC

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J699	C9J699_HUMAN	Tafazzin Tafazzin	TAZ	184	Annotation score:
A0A087WWD5	A0A087WWD5_HUMAN	Tafazzin isoform 4 Tafazzin isoform 4	TAZ	95	Annotation score:
A0A087WYT1	A0A087WYT1_HUMAN	Tafazzin Tafazzin	TAZ	196	Annotation score:
A0A087X0T0	A0A087X0T0_HUMAN	Tafazzin Tafazzin	TAZ	170	Annotation score:
F6Y2X3	F6Y2X3_HUMAN	Tafazzin isoform 1 Tafazzin isoform 1	TAZ	262	Annotation score:
H7C2I9	H7C2I9_HUMAN	Tafazzin Tafazzin	TAZ	34	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014110	94	R → S in BTHS. 1 PublicationCorresponds to variant dbSNP:rs104894942EnsemblClinVar.	1
Natural variantⁱVAR_014111	118	C → R in BTHS. 1 PublicationCorresponds to variant dbSNP:rs104894937EnsemblClinVar.	1
Natural variantⁱVAR_014112	197	G → R in BTHS. 1 PublicationCorresponds to variant dbSNP:rs132630277EnsemblClinVar.	1
Natural variantⁱVAR_068434	240	G → R in BTHS. 1 PublicationCorresponds to variant dbSNP:rs387907218EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_011609	1 – 24	Missing in isoform 2, isoform 6, isoform 8 and isoform 9. CuratedAdd BLAST	24
Alternative sequenceⁱVSP_004451	124 – 153	Missing in isoform 3, isoform 7, isoform 8 and isoform 9. CuratedAdd BLAST	30
Alternative sequenceⁱVSP_004452	154 – 180	Missing in isoform 4. CuratedAdd BLAST	27
Alternative sequenceⁱVSP_004453	181 – 194	Missing in isoform 5, isoform 6, isoform 7 and isoform 9. CuratedAdd BLAST	14

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92763, X92764 Genomic DNA Translation: CAA63419.1 X92762 mRNA Translation: CAA63418.1 AY231461 mRNA Translation: AAO84335.1 AY231462 mRNA Translation: AAO84336.1 AY231463 mRNA Translation: AAO84337.1 AY231464 mRNA Translation: AAO84338.1 AY258036 mRNA Translation: AAO84339.1 AY258037 mRNA Translation: AAO84340.1 AY258038 mRNA Translation: AAO84341.1 AY258039 mRNA Translation: AAO84342.1 AK291848 mRNA Translation: BAF84537.1 BX936347 Genomic DNA Translation: CAI43207.1 BX936347 Genomic DNA Translation: CAI43208.1 BX936347 Genomic DNA Translation: CAI43209.1 BX936347 Genomic DNA Translation: CAI43211.1 BX936347 Genomic DNA Translation: CAM45851.1 CH471172 Genomic DNA Translation: EAW72720.1 CH471172 Genomic DNA Translation: EAW72728.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14748.1 [Q16635-1] CCDS14749.1 [Q16635-3] CCDS14750.1 [Q16635-5] CCDS35450.1 [Q16635-7]
NCBI Reference Sequences More...RefSeqⁱ	NP_000107.1, NM_000116.4 [Q16635-1] NP_001290394.1, NM_001303465.1 NP_851828.1, NM_181311.3 [Q16635-3] NP_851829.1, NM_181312.3 [Q16635-5] NP_851830.1, NM_181313.3 [Q16635-7]
UniGeneⁱ	Hs.409911

Genome annotation databases

Ensemblⁱ	ENST00000475699; ENSP00000419854; ENSG00000102125 [Q16635-5] ENST00000601016; ENSP00000469981; ENSG00000102125 [Q16635-1] ENST00000612460; ENSP00000481037; ENSG00000102125 [Q16635-3] ENST00000613002; ENSP00000478154; ENSG00000102125 [Q16635-7]
GeneIDⁱ	6901
KEGGⁱ	hsa:6901
UCSC genome browser More...UCSCⁱ	uc033fbm.2 human [Q16635-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16635	Tafazzin isoform 2 (Fragment)		HUMAN		292	UniRef100_Q16635
Isoform 2 of Tafazzin		HUMAN		268
Tafazzin isoform 4		HUMAN		95
Q16635-3	Tafazzin isoform 5 (Fragment)		HUMAN		262	UniRef100_Q16635-3
Isoform 8 of Tafazzin		HUMAN		238
Q16635-5	Tafazzin isoform 3 (Fragment)		HUMAN		278	UniRef100_Q16635-5
Isoform 6 of Tafazzin		HUMAN		254
Q16635-6	Isoform 5 of Tafazzin		HUMAN		278	UniRef100_Q16635-5
Tafazzin isoform 3 (Fragment)		HUMAN		278
Q16635-7	Tafazzin isoform 6 (Fragment)		HUMAN		248	UniRef100_Q16635-7
Isoform 9 of Tafazzin		HUMAN		224
Q16635-8	Isoform 3 of Tafazzin		HUMAN		262	UniRef100_Q16635-3
Tafazzin isoform 5 (Fragment)		HUMAN		262
Q16635-9	Isoform 7 of Tafazzin		HUMAN		248	UniRef100_Q16635-7
Tafazzin isoform 6 (Fragment)		HUMAN		248

Protein	Similar proteins		Species	Score	Length	Source
Q16635	Tafazzin		PONPY		292	UniRef90_Q16635
Tafazzin		PANTR		292
Tafazzin		GORGO		292
Tafazzin isoform 2 (Fragment)		HUMAN		292
Uncharacterized protein		PAPAN		298
+34
Q16635-3	Tafazzin		ERYPA		262	UniRef90_Q16635-3
Tafazzin		SAISC		262
Tafazzin		MACMU		262
Tafazzin isoform 5 (Fragment)		HUMAN		262
Tafazzin		MOUSE		263
+112
Q16635-5	Tafazzin isoform 3 (Fragment)		HUMAN		278	UniRef90_Q16635-5
Uncharacterized protein		PAPAN		284
TAZ isoform 5		PONAB		278
Uncharacterized protein		PROCO		276
Uncharacterized protein		AOTNA		273
+2
Q16635-6	Isoform 5 of Tafazzin		HUMAN		278	UniRef90_Q16635-5
Uncharacterized protein		PAPAN		284
TAZ isoform 5		PONAB		278
Uncharacterized protein		PROCO		276
Uncharacterized protein		AOTNA		273
+2
Q16635-7	Tafazzin isoform 6 (Fragment)		HUMAN		248	UniRef90_Q16635-7
tafazzin isoform X3		ODORO		248
tafazzin isoform X2		ERIEU		248
tafazzin isoform X2		Enhydra lutris kenyoni		248
TAZ isoform 4		PONAB		248
+22
Q16635-8	Isoform 3 of Tafazzin		HUMAN		262	UniRef90_Q16635-3
Tafazzin		ERYPA		262
Tafazzin		SAISC		262
Tafazzin		MACMU		262
Tafazzin		MOUSE		263
+112
Q16635-9	Isoform 7 of Tafazzin		HUMAN		248	UniRef90_Q16635-7
tafazzin isoform X3		ODORO		248
tafazzin isoform X2		ERIEU		248
tafazzin isoform X2		Enhydra lutris kenyoni		248
TAZ isoform 4		PONAB		248
+22

Protein	Similar proteins		Species	Score	Length	Source
Q16635	Tafazzin		GORGO		292	UniRef50_Q16635
Tafazzin		PONPY		292
Tafazzin		PANTR		292
Tafazzin		MACMU		262
Tafazzin		ERYPA		262
+242
Q16635-4	Uncharacterized protein		FELCA		267	UniRef50_Q16635-4
Tafazzin isoform 2		CAMFR		220
Tafazzin (Fragment)		SAISC		191
Uncharacterized protein		Cebus capucinus imitator		247
Uncharacterized protein		PROCO		208
+71
Q16635-7	Tafazzin isoform 6 (Fragment)		HUMAN		248	UniRef50_Q16635-7
tafazzin isoform X2		LIPVE		248
tafazzin isoform X3		LEPWE		248
tafazzin isoform X4		NEOSC		248
Tafazzin-like isoform 1		CRIGR		248
+24
Q16635-9	Isoform 7 of Tafazzin		HUMAN		248	UniRef50_Q16635-7
tafazzin isoform X2		LIPVE		248
tafazzin isoform X3		LEPWE		248
tafazzin isoform X4		NEOSC		248
Tafazzin-like isoform 1		CRIGR		248
+24

Cross-referencesⁱ

Web resourcesⁱ

TAZbase

TAZ mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92763, X92764 Genomic DNA Translation: CAA63419.1 X92762 mRNA Translation: CAA63418.1 AY231461 mRNA Translation: AAO84335.1 AY231462 mRNA Translation: AAO84336.1 AY231463 mRNA Translation: AAO84337.1 AY231464 mRNA Translation: AAO84338.1 AY258036 mRNA Translation: AAO84339.1 AY258037 mRNA Translation: AAO84340.1 AY258038 mRNA Translation: AAO84341.1 AY258039 mRNA Translation: AAO84342.1 AK291848 mRNA Translation: BAF84537.1 BX936347 Genomic DNA Translation: CAI43207.1 BX936347 Genomic DNA Translation: CAI43208.1 BX936347 Genomic DNA Translation: CAI43209.1 BX936347 Genomic DNA Translation: CAI43211.1 BX936347 Genomic DNA Translation: CAM45851.1 CH471172 Genomic DNA Translation: EAW72720.1 CH471172 Genomic DNA Translation: EAW72728.1
CCDSⁱ	CCDS14748.1 [Q16635-1] CCDS14749.1 [Q16635-3] CCDS14750.1 [Q16635-5] CCDS35450.1 [Q16635-7]
RefSeqⁱ	NP_000107.1, NM_000116.4 [Q16635-1] NP_001290394.1, NM_001303465.1 NP_851828.1, NM_181311.3 [Q16635-3] NP_851829.1, NM_181312.3 [Q16635-5] NP_851830.1, NM_181313.3 [Q16635-7]
UniGeneⁱ	Hs.409911

3D structure databases

ProteinModelPortalⁱ	Q16635
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112764, 117 interactors
IntActⁱ	Q16635, 2 interactors
STRINGⁱ	9606.ENSP00000299328

PTM databases

iPTMnetⁱ	Q16635
PhosphoSitePlusⁱ	Q16635

Polymorphism and mutation databases

BioMutaⁱ	TAZ
DMDMⁱ	2498992

Proteomic databases

EPDⁱ	Q16635
MaxQBⁱ	Q16635
PaxDbⁱ	Q16635
PeptideAtlasⁱ	Q16635
PRIDEⁱ	Q16635
ProteomicsDBⁱ	60983 60984 [Q16635-2] 60985 [Q16635-3] 60986 [Q16635-4] 60987 [Q16635-5] 60988 [Q16635-6] 60989 [Q16635-7] 60990 [Q16635-8] 60991 [Q16635-9]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6901
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000475699; ENSP00000419854; ENSG00000102125 [Q16635-5] ENST00000601016; ENSP00000469981; ENSG00000102125 [Q16635-1] ENST00000612460; ENSP00000481037; ENSG00000102125 [Q16635-3] ENST00000613002; ENSP00000478154; ENSG00000102125 [Q16635-7]
GeneIDⁱ	6901
KEGGⁱ	hsa:6901
UCSCⁱ	uc033fbm.2 human [Q16635-1]

Organism-specific databases

CTDⁱ	6901
DisGeNETⁱ	6901
EuPathDBⁱ	HostDB:ENSG00000102125.15
GeneCardsⁱ	TAZ
GeneReviewsⁱ	TAZ
HGNCⁱ	HGNC:11577 TAZ
HPAⁱ	HPA039557
MalaCardsⁱ	TAZ
MIMⁱ	300394 gene 302060 phenotype
neXtProtⁱ	NX_Q16635
OpenTargetsⁱ	ENSG00000102125
Orphanetⁱ	111 Barth syndrome 154 Familial isolated dilated cardiomyopathy 54260 Left ventricular noncompaction
PharmGKBⁱ	PA36341
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2847 Eukaryota ENOG410XT5T LUCA
GeneTreeⁱ	ENSGT00390000018621
HOVERGENⁱ	HBG055923
InParanoidⁱ	Q16635
KOⁱ	K13511
OMAⁱ	IVHSGFE
OrthoDBⁱ	EOG091G0DPL
PhylomeDBⁱ	Q16635
TreeFamⁱ	TF313862

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-1482798 Acyl chain remodeling of CL

Reactomeⁱ

R-HSA-1268020 Mitochondrial protein import
R-HSA-1482798 Acyl chain remodeling of CL

Miscellaneous databases

ChiTaRSⁱ	TAZ human
GeneWikiⁱ	Tafazzin
GenomeRNAiⁱ	6901
Protein Ontology More...PROⁱ	PR:Q16635
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102125 Expressed in 177 organ(s), highest expression level in small intestine Peyer's patch
CleanExⁱ	HS_TAZ
ExpressionAtlasⁱ	Q16635 baseline and differential
Genevisibleⁱ	Q16635 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002123 Plipid/glycerol_acylTrfase IPR000872 Tafazzin
PANTHERⁱ	PTHR12497 PTHR12497, 1 hit
Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit
PRINTSⁱ	PR00979 TAFAZZIN
SMARTⁱ	View protein in SMART SM00563 PlsC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAZ_HUMAN
Accessionⁱ	Q16635Primary (citable) accession number: Q16635 Secondary accession number(s): A3KQT2 Q86XR0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q16635 (TAZ_HUMAN)

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Tafazzin

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Polymorphism and mutation databases

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Sequence databases

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PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

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Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ