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Protein

Serine/arginine-rich splicing factor 7

Gene

SRSF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri104 – 120CCHC-typePROSITE-ProRule annotationAdd BLAST17

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to leukemia inhibitory factor Source: Ensembl
  • mRNA 3'-end processing Source: Reactome
  • mRNA export from nucleus Source: Reactome
  • mRNA processing Source: ProtInc
  • mRNA splicing, via spliceosome Source: Reactome
  • negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
  • RNA export from nucleus Source: Reactome
  • RNA splicing Source: ProtInc

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72187 mRNA 3'-end processing
SIGNORiQ16629

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine-rich splicing factor 7
Alternative name(s):
Splicing factor 9G8
Splicing factor, arginine/serine-rich 7
Gene namesi
Name:SRSF7
Synonyms:SFRS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115875.18
HGNCiHGNC:10789 SRSF7
MIMi600572 gene
neXtProtiNX_Q16629

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi87 – 88RR → EE: Abolishes interaction with NXF1. 1 Publication2
Mutagenesisi97 – 98RR → EE: Abolishes interaction with NXF1. 1 Publication2

Organism-specific databases

DisGeNETi6432
OpenTargetsiENSG00000115875
PharmGKBiPA35705

Polymorphism and mutation databases

BioMutaiSRSF7
DMDMi3929380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819321 – 238Serine/arginine-rich splicing factor 7Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24N6-acetyllysine; alternateCombined sources1
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei32PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei181PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ16629
MaxQBiQ16629
PaxDbiQ16629
PeptideAtlasiQ16629
PRIDEiQ16629
ProteomicsDBi60976
60977 [Q16629-2]
60978 [Q16629-3]
TopDownProteomicsiQ16629-1 [Q16629-1]
Q16629-2 [Q16629-2]
Q16629-3 [Q16629-3]
Q16629-4 [Q16629-4]

2D gel databases

SWISS-2DPAGEiP99058

PTM databases

iPTMnetiQ16629
PhosphoSitePlusiQ16629
SwissPalmiQ16629

Expressioni

Tissue specificityi

Brain, liver, kidney and lung.

Gene expression databases

BgeeiENSG00000115875
CleanExiHS_SFRS7
ExpressionAtlasiQ16629 baseline and differential
GenevisibleiQ16629 HS

Organism-specific databases

HPAiHPA043850
HPA056926

Interactioni

Subunit structurei

Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112330, 109 interactors
CORUMiQ16629
DIPiDIP-31790N
IntActiQ16629, 50 interactors
MINTiQ16629
STRINGi9606.ENSP00000325905

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 16Combined sources5
Helixi24 – 34Combined sources11
Beta strandi38 – 53Combined sources16
Helixi57 – 69Combined sources13
Beta strandi72 – 74Combined sources3
Beta strandi78 – 84Combined sources7

3D structure databases

ProteinModelPortaliQ16629
SMRiQ16629
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16629

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 84RRMPROSITE-ProRule annotationAdd BLAST74
Repeati153 – 16018
Repeati161 – 16828
Repeati169 – 17638
Repeati177 – 18448
Repeati211 – 2185; approximate8
Repeati219 – 2266; approximate8

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 98Sufficient for interaction with NXF1Add BLAST18
Regioni153 – 2266 X 8 AA repeats of R-R-S-R-S-X-S-XAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi121 – 238Arg/Ser-rich (RS domain)Add BLAST118

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri104 – 120CCHC-typePROSITE-ProRule annotationAdd BLAST17

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0107 Eukaryota
ENOG4111N8Y LUCA
GeneTreeiENSGT00910000144115
HOGENOMiHOG000276234
HOVERGENiHBG107480
InParanoidiQ16629
KOiK12896
OMAiSRRRRSX
OrthoDBiEOG091G17YQ
PhylomeDBiQ16629
TreeFamiTF351858

Family and domain databases

CDDicd12646 RRM_SRSF7, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034651 SRSF7_RRM
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Isoforms, often lacking the RS domain and differentially expressed in fetal tissues, may be involved in modulation of 9G8 function.
Isoform 1 (identifier: Q16629-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRYGRYGGE TKVYVGNLGT GAGKGELERA FSYYGPLRTV WIARNPPGFA
60 70 80 90 100
FVEFEDPRDA EDAVRGLDGK VICGSRVRVE LSTGMPRRSR FDRPPARRPF
110 120 130 140 150
DPNDRCYECG EKGHYAYDCH RYSRRRRSRS RSRSHSRSRG RRYSRSRSRS
160 170 180 190 200
RGRRSRSASP RRSRSISLRR SRSASLRRSR SGSIKGSRYF QSPSRSRSRS
210 220 230
RSISRPRSSR SKSRSPSPKR SRSPSGSPRR SASPERMD
Length:238
Mass (Da):27,367
Last modified:November 1, 1996 - v1
Checksum:i49136754D9630853
GO
Isoform 2 (identifier: Q16629-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-135: SRSRSH → AENLRR
     136-238: Missing.

Show »
Length:135
Mass (Da):15,573
Checksum:iD390DEB80ADEA752
GO
Isoform 3 (identifier: Q16629-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-132: SRS → YLF
     133-238: Missing.

Show »
Length:132
Mass (Da):15,257
Checksum:iF586F82752DEDCF0
GO
Isoform 4 (identifier: Q16629-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-220: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):26,012
Checksum:iA2FAEE66A5E4DCE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56D → G in BAG59658 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005872130 – 135SRSRSH → AENLRR in isoform 2. Curated6
Alternative sequenceiVSP_005874130 – 132SRS → YLF in isoform 3. Curated3
Alternative sequenceiVSP_005875133 – 238Missing in isoform 3. CuratedAdd BLAST106
Alternative sequenceiVSP_005873136 – 238Missing in isoform 2. CuratedAdd BLAST103
Alternative sequenceiVSP_045840209 – 220Missing in isoform 4. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22253 mRNA Translation: AAA35495.1
L41887 Genomic DNA Translation: AAA88098.1
AB445102 mRNA Translation: BAI99737.1
AY166860 mRNA Translation: AAN87842.1
BT006745 mRNA Translation: AAP35391.1
AY513287 mRNA Translation: AAT08040.1
AK297161 mRNA Translation: BAG59658.1
AC074366 Genomic DNA Translation: AAX93102.1
CH471053 Genomic DNA Translation: EAX00365.1
CH471053 Genomic DNA Translation: EAX00366.1
BC000997 mRNA Translation: AAH00997.1
BC017369 mRNA Translation: AAH17369.1
BC017908 mRNA Translation: AAH17908.1
BC022328 mRNA Translation: AAH22328.1
CCDSiCCDS33183.1 [Q16629-1]
CCDS56115.1 [Q16629-4]
PIRiA57198
RefSeqiNP_001026854.1, NM_001031684.2 [Q16629-1]
NP_001182375.1, NM_001195446.1 [Q16629-4]
UniGeneiHs.309090

Genome annotation databases

EnsembliENST00000313117; ENSP00000325905; ENSG00000115875 [Q16629-1]
ENST00000431066; ENSP00000398159; ENSG00000115875 [Q16629-3]
ENST00000443213; ENSP00000402544; ENSG00000115875 [Q16629-3]
ENST00000446327; ENSP00000402264; ENSG00000115875 [Q16629-4]
GeneIDi6432
KEGGihsa:6432
UCSCiuc002rqz.3 human [Q16629-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRSF7_HUMAN
AccessioniPrimary (citable) accession number: Q16629
Secondary accession number(s): B4DLU6, G5E9M3, Q564D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 203 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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