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Protein

C-C motif chemokine 14

Gene

CCL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-C motif chemokine 14
Alternative name(s):
Chemokine CC-1/CC-3
Short name:
HCC-1/HCC-3
HCC-1(1-74)
NCC-2
Small-inducible cytokine A14
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCL14
Synonyms:NCC2, SCYA14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000276409.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10612 CCL14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601392 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16627

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6358

Open Targets

More...
OpenTargetsi
ENSG00000276409

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35545

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCL14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2493670

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 193 PublicationsAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000520420 – 93C-C motif chemokine 14Add BLAST74
ChainiPRO_000000520522 – 93HCC-1(3-74)Add BLAST72
ChainiPRO_000000520623 – 93HCC-1(4-74)Add BLAST71
ChainiPRO_000000520728 – 93HCC-1(9-74)Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi26O-linked (GalNAc...) serine; partial1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 59
Disulfide bondi36 ↔ 75

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q16627

PRoteomics IDEntifications database

More...
PRIDEi
Q16627

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60974
60975 [Q16627-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16627

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16627

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000276409 Expressed in 89 organ(s), highest expression level in spleen

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCL14

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16627 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16627 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004423
HPA030268

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112261, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-5861N

Protein interaction database and analysis system

More...
IntActi
Q16627, 6 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16627

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16627

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16627

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000036685

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG017871

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16627

KEGG Orthology (KO)

More...
KOi
K21092

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICANPRD

Database of Orthologous Groups

More...
OrthoDBi
EOG091G14Y2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16627

TreeFam database of animal gene trees

More...
TreeFami
TF334888

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12015 PTHR12015, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00048 IL8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00199 SCY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54117 SSF54117, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform HCC-1 (identifier: Q16627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM
60 70 80 90
DYYETNSQCS KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN
Length:93
Mass (Da):10,678
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDDB899DC9148836
GO
Isoform HCC-3 (identifier: Q16627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: R → QTGGKPKVVKIQLKLVG

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):12,297
Checksum:i73591D5CFF6D3C28
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X089A0A087X089_HUMAN
C-C motif chemokine
CCL14
115Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J2G5A0A0B4J2G5_HUMAN
C-C motif chemokine 14
CCL14
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04870761K → E. Corresponds to variant dbSNP:rs16971802Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00106027R → QTGGKPKVVKIQLKLVG in isoform HCC-3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49270 mRNA Translation: CAA89264.1
Z70292 mRNA Translation: CAA94307.1
Z70293 mRNA Translation: CAA94309.1
Z49269 Genomic DNA Translation: CAA89263.1
AF088219 Genomic DNA Translation: AAC63329.1
AF088219 Genomic DNA Translation: AAF23982.1
CH471147 Genomic DNA Translation: EAW80105.1
CH471147 Genomic DNA Translation: EAW80106.1
CH471147 Genomic DNA Translation: EAW80107.1
CH471147 Genomic DNA Translation: EAW80108.1
BC038289 mRNA Translation: AAH38289.1
BC045165 mRNA Translation: AAH45165.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32624.1 [Q16627-1]
CCDS45652.1 [Q16627-2]

NCBI Reference Sequences

More...
RefSeqi
NP_116738.1, NM_032962.4 [Q16627-2]
NP_116739.1, NM_032963.3 [Q16627-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.272493
Hs.740501

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000618404; ENSP00000481023; ENSG00000276409 [Q16627-1]
ENST00000619040; ENSP00000483302; ENSG00000277236 [Q16627-2]
ENST00000622526; ENSP00000479097; ENSG00000276409 [Q16627-2]
ENST00000632700; ENSP00000487948; ENSG00000277236 [Q16627-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6358

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6358

UCSC genome browser

More...
UCSCi
uc010wcq.2 human [Q16627-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CCL14 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49270 mRNA Translation: CAA89264.1
Z70292 mRNA Translation: CAA94307.1
Z70293 mRNA Translation: CAA94309.1
Z49269 Genomic DNA Translation: CAA89263.1
AF088219 Genomic DNA Translation: AAC63329.1
AF088219 Genomic DNA Translation: AAF23982.1
CH471147 Genomic DNA Translation: EAW80105.1
CH471147 Genomic DNA Translation: EAW80106.1
CH471147 Genomic DNA Translation: EAW80107.1
CH471147 Genomic DNA Translation: EAW80108.1
BC038289 mRNA Translation: AAH38289.1
BC045165 mRNA Translation: AAH45165.1
CCDSiCCDS32624.1 [Q16627-1]
CCDS45652.1 [Q16627-2]
RefSeqiNP_116738.1, NM_032962.4 [Q16627-2]
NP_116739.1, NM_032963.3 [Q16627-1]
UniGeneiHs.272493
Hs.740501

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q8RX-ray1.82E/F/G/H28-93[»]
2Q8TX-ray2.23A/B/C/D20-93[»]
ProteinModelPortaliQ16627
SMRiQ16627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112261, 9 interactors
DIPiDIP-5861N
IntActiQ16627, 6 interactors

PTM databases

iPTMnetiQ16627
PhosphoSitePlusiQ16627

Polymorphism and mutation databases

BioMutaiCCL14
DMDMi2493670

Proteomic databases

PeptideAtlasiQ16627
PRIDEiQ16627
ProteomicsDBi60974
60975 [Q16627-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6358
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618404; ENSP00000481023; ENSG00000276409 [Q16627-1]
ENST00000619040; ENSP00000483302; ENSG00000277236 [Q16627-2]
ENST00000622526; ENSP00000479097; ENSG00000276409 [Q16627-2]
ENST00000632700; ENSP00000487948; ENSG00000277236 [Q16627-1]
GeneIDi6358
KEGGihsa:6358
UCSCiuc010wcq.2 human [Q16627-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6358
DisGeNETi6358
EuPathDBiHostDB:ENSG00000276409.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCL14

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0039168
HGNCiHGNC:10612 CCL14
HPAiCAB004423
HPA030268
MIMi601392 gene
neXtProtiNX_Q16627
OpenTargetsiENSG00000276409
PharmGKBiPA35545

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153198
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ16627
KOiK21092
OMAiICANPRD
OrthoDBiEOG091G14Y2
PhylomeDBiQ16627
TreeFamiTF334888

Miscellaneous databases

EvolutionaryTraceiQ16627

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6358

Protein Ontology

More...
PROi
PR:Q16627

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000276409 Expressed in 89 organ(s), highest expression level in spleen
CleanExiHS_CCL14
ExpressionAtlasiQ16627 baseline and differential
GenevisibleiQ16627 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCL14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16627
Secondary accession number(s): E1P649, E1P650, Q13954
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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