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Protein

C-C motif chemokine 14

Gene

CCL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.1 Publication

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 14
Alternative name(s):
Chemokine CC-1/CC-3
Short name:
HCC-1/HCC-3
HCC-1(1-74)
NCC-2
Small-inducible cytokine A14
Cleaved into the following 3 chains:
Gene namesi
Name:CCL14
Synonyms:NCC2, SCYA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000276409.4
HGNCiHGNC:10612 CCL14
MIMi601392 gene
neXtProtiNX_Q16627

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6358
OpenTargetsiENSG00000276409
PharmGKBiPA35545

Polymorphism and mutation databases

BioMutaiCCL14
DMDMi2493670

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 193 PublicationsAdd BLAST19
ChainiPRO_000000520420 – 93C-C motif chemokine 14Add BLAST74
ChainiPRO_000000520522 – 93HCC-1(3-74)Add BLAST72
ChainiPRO_000000520623 – 93HCC-1(4-74)Add BLAST71
ChainiPRO_000000520728 – 93HCC-1(9-74)Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26O-linked (GalNAc...) serine; partial1 Publication1
Disulfide bondi35 ↔ 59
Disulfide bondi36 ↔ 75

Post-translational modificationi

The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.
HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ16627
PRIDEiQ16627
ProteomicsDBi60974
60975 [Q16627-2]

PTM databases

iPTMnetiQ16627
PhosphoSitePlusiQ16627

Expressioni

Tissue specificityi

Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.1 Publication

Gene expression databases

BgeeiENSG00000276409 Expressed in 89 organ(s), highest expression level in spleen
CleanExiHS_CCL14
ExpressionAtlasiQ16627 baseline and differential
GenevisibleiQ16627 HS

Organism-specific databases

HPAiCAB004423
HPA030268

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112261, 9 interactors
DIPiDIP-5861N
IntActiQ16627, 6 interactors

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16627
SMRiQ16627
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16627

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ16627
KOiK21092
OMAiICANPRD
OrthoDBiEOG091G14Y2
PhylomeDBiQ16627
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform HCC-1 (identifier: Q16627-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM
60 70 80 90
DYYETNSQCS KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN
Length:93
Mass (Da):10,678
Last modified:November 1, 1997 - v1
Checksum:iDDDB899DC9148836
GO
Isoform HCC-3 (identifier: Q16627-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-27: R → QTGGKPKVVKIQLKLVG

Note: No experimental confirmation available.
Show »
Length:109
Mass (Da):12,297
Checksum:i73591D5CFF6D3C28
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X089A0A087X089_HUMAN
C-C motif chemokine
CCL14
115Annotation score:
A0A0B4J2G5A0A0B4J2G5_HUMAN
C-C motif chemokine 14
CCL14
65Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04870761K → E. Corresponds to variant dbSNP:rs16971802Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00106027R → QTGGKPKVVKIQLKLVG in isoform HCC-3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49270 mRNA Translation: CAA89264.1
Z70292 mRNA Translation: CAA94307.1
Z70293 mRNA Translation: CAA94309.1
Z49269 Genomic DNA Translation: CAA89263.1
AF088219 Genomic DNA Translation: AAC63329.1
AF088219 Genomic DNA Translation: AAF23982.1
CH471147 Genomic DNA Translation: EAW80105.1
CH471147 Genomic DNA Translation: EAW80106.1
CH471147 Genomic DNA Translation: EAW80107.1
CH471147 Genomic DNA Translation: EAW80108.1
BC038289 mRNA Translation: AAH38289.1
BC045165 mRNA Translation: AAH45165.1
CCDSiCCDS32624.1 [Q16627-1]
CCDS45652.1 [Q16627-2]
RefSeqiNP_116738.1, NM_032962.4 [Q16627-2]
NP_116739.1, NM_032963.3 [Q16627-1]
UniGeneiHs.272493
Hs.740501

Genome annotation databases

EnsembliENST00000618404; ENSP00000481023; ENSG00000276409 [Q16627-1]
ENST00000619040; ENSP00000483302; ENSG00000277236 [Q16627-2]
ENST00000622526; ENSP00000479097; ENSG00000276409 [Q16627-2]
ENST00000632700; ENSP00000487948; ENSG00000277236 [Q16627-1]
GeneIDi6358
KEGGihsa:6358
UCSCiuc010wcq.2 human [Q16627-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL14 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49270 mRNA Translation: CAA89264.1
Z70292 mRNA Translation: CAA94307.1
Z70293 mRNA Translation: CAA94309.1
Z49269 Genomic DNA Translation: CAA89263.1
AF088219 Genomic DNA Translation: AAC63329.1
AF088219 Genomic DNA Translation: AAF23982.1
CH471147 Genomic DNA Translation: EAW80105.1
CH471147 Genomic DNA Translation: EAW80106.1
CH471147 Genomic DNA Translation: EAW80107.1
CH471147 Genomic DNA Translation: EAW80108.1
BC038289 mRNA Translation: AAH38289.1
BC045165 mRNA Translation: AAH45165.1
CCDSiCCDS32624.1 [Q16627-1]
CCDS45652.1 [Q16627-2]
RefSeqiNP_116738.1, NM_032962.4 [Q16627-2]
NP_116739.1, NM_032963.3 [Q16627-1]
UniGeneiHs.272493
Hs.740501

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q8RX-ray1.82E/F/G/H28-93[»]
2Q8TX-ray2.23A/B/C/D20-93[»]
ProteinModelPortaliQ16627
SMRiQ16627
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112261, 9 interactors
DIPiDIP-5861N
IntActiQ16627, 6 interactors

PTM databases

iPTMnetiQ16627
PhosphoSitePlusiQ16627

Polymorphism and mutation databases

BioMutaiCCL14
DMDMi2493670

Proteomic databases

PeptideAtlasiQ16627
PRIDEiQ16627
ProteomicsDBi60974
60975 [Q16627-2]

Protocols and materials databases

DNASUi6358
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000618404; ENSP00000481023; ENSG00000276409 [Q16627-1]
ENST00000619040; ENSP00000483302; ENSG00000277236 [Q16627-2]
ENST00000622526; ENSP00000479097; ENSG00000276409 [Q16627-2]
ENST00000632700; ENSP00000487948; ENSG00000277236 [Q16627-1]
GeneIDi6358
KEGGihsa:6358
UCSCiuc010wcq.2 human [Q16627-1]

Organism-specific databases

CTDi6358
DisGeNETi6358
EuPathDBiHostDB:ENSG00000276409.4
GeneCardsiCCL14
H-InvDBiHIX0039168
HGNCiHGNC:10612 CCL14
HPAiCAB004423
HPA030268
MIMi601392 gene
neXtProtiNX_Q16627
OpenTargetsiENSG00000276409
PharmGKBiPA35545
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ16627
KOiK21092
OMAiICANPRD
OrthoDBiEOG091G14Y2
PhylomeDBiQ16627
TreeFamiTF334888

Miscellaneous databases

EvolutionaryTraceiQ16627
GenomeRNAii6358
PROiPR:Q16627
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000276409 Expressed in 89 organ(s), highest expression level in spleen
CleanExiHS_CCL14
ExpressionAtlasiQ16627 baseline and differential
GenevisibleiQ16627 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL14_HUMAN
AccessioniPrimary (citable) accession number: Q16627
Secondary accession number(s): E1P649, E1P650, Q13954
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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