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Protein

Male-enhanced antigen 1

Gene

MEA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in spermatogenesis and/or testis development.

Caution

Was originally thought to be the H-Y antigen.Curated
It is uncertain whether Met-1, Met-14 or Met-24 is the initiator.Curated

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • male gonad development Source: ProtInc
  • spermatogenesis Source: ProtInc

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Male-enhanced antigen 1
Short name:
MEA-1
Gene namesi
Name:MEA1
Synonyms:MEA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124733.3
HGNCiHGNC:6986 MEA1
MIMi143170 gene
neXtProtiNX_Q16626

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi4201
OpenTargetsiENSG00000124733
PharmGKBiPA30726

Polymorphism and mutation databases

BioMutaiMEA1
DMDMi239938667

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963411 – 185Male-enhanced antigen 1Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16626
MaxQBiQ16626
PaxDbiQ16626
PeptideAtlasiQ16626
PRIDEiQ16626
ProteomicsDBi60973

PTM databases

iPTMnetiQ16626
PhosphoSitePlusiQ16626

Expressioni

Tissue specificityi

Highly expressed in testis.

Gene expression databases

BgeeiENSG00000124733 Expressed in 232 organ(s), highest expression level in right testis
CleanExiHS_MEA1
GenevisibleiQ16626 HS

Organism-specific databases

HPAiHPA017921

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AP2B1P630102EBI-744921,EBI-432924

Protein-protein interaction databases

BioGridi110365, 12 interactors
IntActiQ16626, 6 interactors
STRINGi9606.ENSP00000244711

Structurei

3D structure databases

ProteinModelPortaliQ16626
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWXB Eukaryota
ENOG41120JT LUCA
GeneTreeiENSGT00390000016927
HOGENOMiHOG000082669
HOVERGENiHBG001597
InParanoidiQ16626
OMAiKMGPERI
OrthoDBiEOG091G0WUD
PhylomeDBiQ16626
TreeFamiTF332365

Family and domain databases

InterProiView protein in InterPro
IPR009685 MEA1
PANTHERiPTHR17005 PTHR17005, 1 hit
PfamiView protein in Pfam
PF06910 MEA1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD022082 PD022082, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q16626-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS
60 70 80 90 100
SEEPEEEQEE TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI
110 120 130 140 150
QALGLHLPDP PLESEDEDEE GATALNNHSS IPMDPEHVEL VKRTMAGVSL
160 170 180
PAPGVPAWAR EISDAQWEDV VQKALQARQA SPAWK
Length:185
Mass (Da):19,905
Last modified:June 16, 2009 - v2
Checksum:iF50E6892FBA7435C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7W8A0A2R8Y7W8_HUMAN
Male-enhanced antigen 1
MEA1
172Annotation score:
A0A2R8Y6W5A0A2R8Y6W5_HUMAN
Male-enhanced antigen 1
MEA1
188Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058297183A → D. Corresponds to variant dbSNP:rs11751058Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27937 mRNA Translation: AAA36208.1
L10400 mRNA Translation: AAA36209.1
BT009831 mRNA Translation: AAP88833.1
AL136304 Genomic DNA No translation available.
BC001754 mRNA Translation: AAH01754.1
CCDSiCCDS4879.1
PIRiA34421
RefSeqiNP_055438.1, NM_014623.3
UniGeneiHs.278362

Genome annotation databases

EnsembliENST00000244711; ENSP00000244711; ENSG00000124733
GeneIDi4201
KEGGihsa:4201
UCSCiuc003otk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMEA1_HUMAN
AccessioniPrimary (citable) accession number: Q16626
Secondary accession number(s): Q5TC36, Q9BV01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 16, 2009
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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