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Protein

BDNF/NT-3 growth factors receptor

Gene

NTRK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.1 Publication

Miscellaneous

Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei572ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei676Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi544 – 552ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processDifferentiation, Neurogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.10.1 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-187024 NGF-independant TRKA activation
R-HSA-9024909 BDNF activates NTRK2 (TRKB) signaling
R-HSA-9025046 NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9026357 NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9032500 Activated NTRK2 signals through FYN
R-HSA-9032759 NTRK2 activates RAC1
R-HSA-9032845 Activated NTRK2 signals through CDK5

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q16620

SIGNOR Signaling Network Open Resource

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SIGNORi
Q16620

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BDNF/NT-3 growth factors receptor (EC:2.7.10.1)
Alternative name(s):
GP145-TrkB
Short name:
Trk-B
Neurotrophic tyrosine kinase receptor type 2
TrkB tyrosine kinase
Tropomyosin-related kinase B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTRK2
Synonyms:TRKB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000148053.15

Human Gene Nomenclature Database

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HGNCi
HGNC:8032 NTRK2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600456 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q16620

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 430ExtracellularSequence analysisAdd BLAST399
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei431 – 454HelicalSequence analysisAdd BLAST24
Topological domaini455 – 822CytoplasmicSequence analysisAdd BLAST368

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epileptic encephalopathy, early infantile, 58 (EIEE58)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE58 is an autosomal dominant condition characterized by onset of refractory seizures in the first days or months of life.
See also OMIM:617830
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080659434Y → C in EIEE58; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs886041091EnsemblClinVar.1
Obesity, hyperphagia, and developmental delay (OBHD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech, and language.
See also OMIM:613886
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080660444 – 822Missing in OBHD. 1 PublicationAdd BLAST379
Natural variantiVAR_080661704T → I in OBHD; unknown pathological significance. 1 Publication1
Natural variantiVAR_065890706Y → C in OBHD; expressed normally on the cell surface; results in markedly impaired ligand-induced phosphorylation as well as impaired downstream MAPK1 phosphorylation. 1 PublicationCorresponds to variant dbSNP:rs121434633Ensembl.1

Keywords - Diseasei

Disease mutation, Epilepsy, Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
4915

MalaCards human disease database

More...
MalaCardsi
NTRK2
MIMi613886 phenotype
617830 phenotype

Open Targets

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OpenTargetsi
ENSG00000148053

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
251612 Pilocytic astrocytoma
442835 Undetermined early-onset epileptic encephalopathy
3451 West syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31818

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4898

Drug and drug target database

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DrugBanki
DB00321 Amitriptyline

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1818

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
NTRK2

Domain mapping of disease mutations (DMDM)

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DMDMi
2497560

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Add BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001672732 – 822BDNF/NT-3 growth factors receptorAdd BLAST791

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 38PROSITE-ProRule annotation1 Publication
Disulfide bondi36 ↔ 45PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi67N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi95N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi121N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi152 ↔ 176PROSITE-ProRule annotation1 Publication
Disulfide bondi154 ↔ 194PROSITE-ProRule annotation1 Publication
Glycosylationi178N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi205N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi218 ↔ 266PROSITE-ProRule annotation1 Publication
Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi254N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi280N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi302 ↔ 345PROSITE-ProRule annotation1 Publication
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi412N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei516Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei702Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei706Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei707Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei817Phosphotyrosine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated.1 Publication
Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q16620

PeptideAtlas

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PeptideAtlasi
Q16620

PRoteomics IDEntifications database

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PRIDEi
Q16620

ProteomicsDB human proteome resource

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ProteomicsDBi
60955
60956 [Q16620-2]
60957 [Q16620-3]
60958 [Q16620-4]
60959 [Q16620-5]
60960 [Q16620-6]
60961 [Q16620-7]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1029

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q16620

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q16620

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148053 Expressed in 222 organ(s), highest expression level in hypothalamus

CleanEx database of gene expression profiles

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CleanExi
HS_NTRK2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16620 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q16620 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB010346
HPA007637

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor. Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway. Interacts with APPL1 (By similarity). Interacts with MAPK8IP3/JIP3 and KLC1; interaction with KLC1 is mediated by MAPK8IP3/JIP3 (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei516Interaction with SHC1By similarity1
Sitei706Interaction with SH2D1ABy similarity1
Sitei817Interaction with PLCG1By similarity1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110970, 24 interactors

Database of interacting proteins

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DIPi
DIP-5720N

Protein interaction database and analysis system

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IntActi
Q16620, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000277120

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q16620

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1822
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q16620

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16620

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q16620

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 61LRRNTAdd BLAST30
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 137LRR 2Add BLAST22
Domaini148 – 196LRRCTAdd BLAST49
Domaini197 – 282Ig-like C2-type 1Add BLAST86
Domaini295 – 365Ig-like C2-type 2Add BLAST71
Domaini538 – 807Protein kinasePROSITE-ProRule annotationAdd BLAST270

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni455 – 466Interaction with MAPK8IP3/JIP3By similarityAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1026 Eukaryota
ENOG410YGKQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155181

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000264255

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG056735

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16620

KEGG Orthology (KO)

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KOi
K04360

Identification of Orthologs from Complete Genome Data

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OMAi
CSCEIMW

Database for complete collections of gene phylogenies

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PhylomeDBi
Q16620

TreeFam database of animal gene trees

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TreeFami
TF106465

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020455 Tyr_kin_neurotrophic_rcpt_2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01939 NTKRECEPTOR
PR01941 NTKRECEPTOR2
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform TrkB (identifier: Q16620-1) [UniParc]FASTAAdd to basket
Also known as: gp145-TrkB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP
60 70 80 90 100
GIVAFPRLEP NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD
110 120 130 140 150
SGLKFVAHKA FLKNSNLQHI NFTRNKLTSL SRKHFRHLDL SELILVGNPF
160 170 180 190 200
TCSCDIMWIK TLQEAKSSPD TQDLYCLNES SKNIPLANLQ IPNCGLPSAN
210 220 230 240 250
LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM NETSHTQGSL
260 270 280 290 300
RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
310 320 330 340 350
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN
360 370 380 390 400
PTHMNNGDYT LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY
410 420 430 440 450
GTAANDIGDT TNRSNEIPST DVTDKTGREH LSVYAVVVIA SVVGFCLLVM
460 470 480 490 500
LFLLKLARHS KFGMKGPASV ISNDDDSASP LHHISNGSNT PSSSEGGPDA
510 520 530 540 550
VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL KRELGEGAFG
560 570 580 590 600
KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI
610 620 630 640 650
VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ
660 670 680 690 700
SQMLHIAQQI AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD
710 720 730 740 750
VYSTDYYRVG GHTMLPIRWM PPESIMYRKF TTESDVWSLG VVLWEIFTYG
760 770 780 790 800
KQPWYQLSNN EVIECITQGR VLQRPRTCPQ EVYELMLGCW QREPHMRKNI
810 820
KGIHTLLQNL AKASPVYLDI LG
Length:822
Mass (Da):91,999
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FEB9159948F0D13
GO
Isoform TrkB-T1 (identifier: Q16620-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-477: PASVISNDDDS → FVLFHKIPLDG
     478-822: Missing.

Note: Non-catalytic isoform.
Show »
Length:477
Mass (Da):53,051
Checksum:iC4A7F565BC88372F
GO
Isoform TrkB-T-Shc (identifier: Q16620-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-537: FVQHIKRHN → WPRGSPKTA
     538-822: Missing.

Show »
Length:537
Mass (Da):59,167
Checksum:i5A8FA252A3871CC1
GO
Isoform 4 (identifier: Q16620-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-465: K → KDFSWFGFGKVKSRQGV

Show »
Length:838
Mass (Da):93,826
Checksum:i130C95A9D8895432
GO
Isoform 5 (identifier: Q16620-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-465: K → KDFSWFGFGKVKSRQGV
     529-537: FVQHIKRHN → WPRGSPKTA
     538-822: Missing.

Show »
Length:553
Mass (Da):60,994
Checksum:iBD98221B9EE1A6C1
GO
Isoform TrkB-T-TK (identifier: Q16620-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     710-735: GGHTMLPIRWMPPESIMYRKFTTESD → SSCADQRPQGPLSLRDPCCICLLRLS
     736-822: Missing.

Show »
Length:735
Mass (Da):81,569
Checksum:i5E0746BCCA281069
GO
Isoform TrkB-N-T1 (identifier: Q16620-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     467-477: PASVISNDDDS → FVLFHKIPLDG
     478-822: Missing.

Show »
Length:321
Mass (Da):35,332
Checksum:i64C146AAB494744E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041470138L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_016320309G → R1 Publication1
Natural variantiVAR_011973338N → Y. Corresponds to variant dbSNP:rs1047856Ensembl.1
Natural variantiVAR_080659434Y → C in EIEE58; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs886041091EnsemblClinVar.1
Natural variantiVAR_080660444 – 822Missing in OBHD. 1 PublicationAdd BLAST379
Natural variantiVAR_049715545G → V. Corresponds to variant dbSNP:rs1075108Ensembl.1
Natural variantiVAR_046518697M → I in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_046519699R → G in a lung carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_080661704T → I in OBHD; unknown pathological significance. 1 Publication1
Natural variantiVAR_065890706Y → C in OBHD; expressed normally on the cell surface; results in markedly impaired ligand-induced phosphorylation as well as impaired downstream MAPK1 phosphorylation. 1 PublicationCorresponds to variant dbSNP:rs121434633Ensembl.1
Natural variantiVAR_046520718R → C in a lung carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1324578301Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0421771 – 156Missing in isoform TrkB-N-T1. 1 PublicationAdd BLAST156
Alternative sequenceiVSP_041942465K → KDFSWFGFGKVKSRQGV in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_002901467 – 477PASVISNDDDS → FVLFHKIPLDG in isoform TrkB-T1 and isoform TrkB-N-T1. 6 PublicationsAdd BLAST11
Alternative sequenceiVSP_002902478 – 822Missing in isoform TrkB-T1 and isoform TrkB-N-T1. 6 PublicationsAdd BLAST345
Alternative sequenceiVSP_002903529 – 537FVQHIKRHN → WPRGSPKTA in isoform TrkB-T-Shc and isoform 5. 1 Publication9
Alternative sequenceiVSP_002904538 – 822Missing in isoform TrkB-T-Shc and isoform 5. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_042178710 – 735GGHTM…TTESD → SSCADQRPQGPLSLRDPCCI CLLRLS in isoform TrkB-T-TK. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_042179736 – 822Missing in isoform TrkB-T-TK. 1 PublicationAdd BLAST87

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U12140 mRNA Translation: AAC51371.1
S76473 mRNA Translation: AAB33109.1
S76474 mRNA Translation: AAB33110.1
X75958 mRNA Translation: CAA53571.1
AF410899 mRNA Translation: AAL67965.1
AF410900 mRNA Translation: AAL67966.1
AF410901 mRNA Translation: AAL67967.1
AF508964 mRNA Translation: AAM77876.1
AB209118 mRNA Translation: BAD92355.1
AK294285 mRNA Translation: BAG57570.1
AL390777 Genomic DNA No translation available.
AL445532 Genomic DNA No translation available.
AL596132 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62688.1
BC031835 mRNA Translation: AAH31835.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35050.1 [Q16620-1]
CCDS35051.1 [Q16620-5]
CCDS35052.1 [Q16620-3]
CCDS35053.1 [Q16620-2]
CCDS6671.1 [Q16620-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A56853
I73631

NCBI Reference Sequences

More...
RefSeqi
NP_001007098.1, NM_001007097.2 [Q16620-2]
NP_001018074.1, NM_001018064.2 [Q16620-1]
NP_001018075.1, NM_001018065.2 [Q16620-5]
NP_001018076.1, NM_001018066.2 [Q16620-3]
NP_006171.2, NM_006180.4 [Q16620-4]
XP_005252058.1, XM_005252001.2 [Q16620-4]
XP_005252060.1, XM_005252003.2 [Q16620-4]
XP_005252061.1, XM_005252004.2 [Q16620-4]
XP_005252063.1, XM_005252006.3 [Q16620-5]
XP_005252064.1, XM_005252007.3 [Q16620-2]
XP_011517020.1, XM_011518718.2 [Q16620-1]
XP_011517022.1, XM_011518720.2 [Q16620-3]
XP_016870240.1, XM_017014751.1 [Q16620-4]
XP_016870241.1, XM_017014752.1 [Q16620-1]
XP_016870242.1, XM_017014753.1 [Q16620-1]
XP_016870243.1, XM_017014754.1 [Q16620-1]
XP_016870244.1, XM_017014755.1 [Q16620-5]
XP_016870245.1, XM_017014756.1 [Q16620-5]
XP_016870246.1, XM_017014757.1 [Q16620-3]
XP_016870247.1, XM_017014758.1 [Q16620-2]
XP_016870248.1, XM_017014759.1 [Q16620-2]
XP_016870249.1, XM_017014760.1 [Q16620-2]
XP_016870250.1, XM_017014761.1 [Q16620-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.494312
Hs.712776

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000277120; ENSP00000277120; ENSG00000148053 [Q16620-4]
ENST00000304053; ENSP00000306167; ENSG00000148053 [Q16620-5]
ENST00000323115; ENSP00000314586; ENSG00000148053 [Q16620-1]
ENST00000359847; ENSP00000352906; ENSG00000148053 [Q16620-2]
ENST00000376208; ENSP00000365381; ENSG00000148053 [Q16620-3]
ENST00000376213; ENSP00000365386; ENSG00000148053 [Q16620-1]
ENST00000376214; ENSP00000365387; ENSG00000148053 [Q16620-4]
ENST00000395882; ENSP00000379221; ENSG00000148053 [Q16620-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4915

UCSC genome browser

More...
UCSCi
uc004anz.1 human [Q16620-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12140 mRNA Translation: AAC51371.1
S76473 mRNA Translation: AAB33109.1
S76474 mRNA Translation: AAB33110.1
X75958 mRNA Translation: CAA53571.1
AF410899 mRNA Translation: AAL67965.1
AF410900 mRNA Translation: AAL67966.1
AF410901 mRNA Translation: AAL67967.1
AF508964 mRNA Translation: AAM77876.1
AB209118 mRNA Translation: BAD92355.1
AK294285 mRNA Translation: BAG57570.1
AL390777 Genomic DNA No translation available.
AL445532 Genomic DNA No translation available.
AL596132 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62688.1
BC031835 mRNA Translation: AAH31835.1
CCDSiCCDS35050.1 [Q16620-1]
CCDS35051.1 [Q16620-5]
CCDS35052.1 [Q16620-3]
CCDS35053.1 [Q16620-2]
CCDS6671.1 [Q16620-4]
PIRiA56853
I73631
RefSeqiNP_001007098.1, NM_001007097.2 [Q16620-2]
NP_001018074.1, NM_001018064.2 [Q16620-1]
NP_001018075.1, NM_001018065.2 [Q16620-5]
NP_001018076.1, NM_001018066.2 [Q16620-3]
NP_006171.2, NM_006180.4 [Q16620-4]
XP_005252058.1, XM_005252001.2 [Q16620-4]
XP_005252060.1, XM_005252003.2 [Q16620-4]
XP_005252061.1, XM_005252004.2 [Q16620-4]
XP_005252063.1, XM_005252006.3 [Q16620-5]
XP_005252064.1, XM_005252007.3 [Q16620-2]
XP_011517020.1, XM_011518718.2 [Q16620-1]
XP_011517022.1, XM_011518720.2 [Q16620-3]
XP_016870240.1, XM_017014751.1 [Q16620-4]
XP_016870241.1, XM_017014752.1 [Q16620-1]
XP_016870242.1, XM_017014753.1 [Q16620-1]
XP_016870243.1, XM_017014754.1 [Q16620-1]
XP_016870244.1, XM_017014755.1 [Q16620-5]
XP_016870245.1, XM_017014756.1 [Q16620-5]
XP_016870246.1, XM_017014757.1 [Q16620-3]
XP_016870247.1, XM_017014758.1 [Q16620-2]
XP_016870248.1, XM_017014759.1 [Q16620-2]
XP_016870249.1, XM_017014760.1 [Q16620-2]
XP_016870250.1, XM_017014761.1 [Q16620-2]
UniGeneiHs.494312
Hs.712776

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HCFX-ray2.70X/Y286-383[»]
1WWBX-ray2.10X283-385[»]
2MFQNMR-B497-519[»]
4ASZX-ray1.70A527-822[»]
4AT3X-ray1.77A527-822[»]
4AT4X-ray2.36A527-822[»]
4AT5X-ray1.71A527-822[»]
5MO9X-ray2.59X278-426[»]
ProteinModelPortaliQ16620
SMRiQ16620
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110970, 24 interactors
DIPiDIP-5720N
IntActiQ16620, 11 interactors
STRINGi9606.ENSP00000277120

Chemistry databases

BindingDBiQ16620
ChEMBLiCHEMBL4898
DrugBankiDB00321 Amitriptyline
GuidetoPHARMACOLOGYi1818

PTM databases

GlyConnecti1029
iPTMnetiQ16620
PhosphoSitePlusiQ16620

Polymorphism and mutation databases

BioMutaiNTRK2
DMDMi2497560

Proteomic databases

PaxDbiQ16620
PeptideAtlasiQ16620
PRIDEiQ16620
ProteomicsDBi60955
60956 [Q16620-2]
60957 [Q16620-3]
60958 [Q16620-4]
60959 [Q16620-5]
60960 [Q16620-6]
60961 [Q16620-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4915
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277120; ENSP00000277120; ENSG00000148053 [Q16620-4]
ENST00000304053; ENSP00000306167; ENSG00000148053 [Q16620-5]
ENST00000323115; ENSP00000314586; ENSG00000148053 [Q16620-1]
ENST00000359847; ENSP00000352906; ENSG00000148053 [Q16620-2]
ENST00000376208; ENSP00000365381; ENSG00000148053 [Q16620-3]
ENST00000376213; ENSP00000365386; ENSG00000148053 [Q16620-1]
ENST00000376214; ENSP00000365387; ENSG00000148053 [Q16620-4]
ENST00000395882; ENSP00000379221; ENSG00000148053 [Q16620-2]
GeneIDi4915
KEGGihsa:4915
UCSCiuc004anz.1 human [Q16620-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4915
DisGeNETi4915
EuPathDBiHostDB:ENSG00000148053.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NTRK2
HGNCiHGNC:8032 NTRK2
HPAiCAB010346
HPA007637
MalaCardsiNTRK2
MIMi600456 gene
613886 phenotype
617830 phenotype
neXtProtiNX_Q16620
OpenTargetsiENSG00000148053
Orphaneti251612 Pilocytic astrocytoma
442835 Undetermined early-onset epileptic encephalopathy
3451 West syndrome
PharmGKBiPA31818

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00940000155181
HOGENOMiHOG000264255
HOVERGENiHBG056735
InParanoidiQ16620
KOiK04360
OMAiCSCEIMW
PhylomeDBiQ16620
TreeFamiTF106465

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-187024 NGF-independant TRKA activation
R-HSA-9024909 BDNF activates NTRK2 (TRKB) signaling
R-HSA-9025046 NTF3 activates NTRK2 (TRKB) signaling
R-HSA-9026357 NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9032500 Activated NTRK2 signals through FYN
R-HSA-9032759 NTRK2 activates RAC1
R-HSA-9032845 Activated NTRK2 signals through CDK5
SignaLinkiQ16620
SIGNORiQ16620

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NTRK2 human
EvolutionaryTraceiQ16620

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TrkB_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4915

Protein Ontology

More...
PROi
PR:Q16620

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148053 Expressed in 222 organ(s), highest expression level in hypothalamus
CleanExiHS_NTRK2
ExpressionAtlasiQ16620 baseline and differential
GenevisibleiQ16620 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020455 Tyr_kin_neurotrophic_rcpt_2
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01941 NTKRECEPTOR2
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTRK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16620
Secondary accession number(s): B1ANZ4
, B4DFV9, Q16675, Q59GJ1, Q8WXJ5, Q8WXJ6, Q8WXJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: December 5, 2018
This is version 209 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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