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Protein

Cardiotrophin-1

Gene

CTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • leukemia inhibitory factor receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiQ16619
SIGNORiQ16619

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotrophin-1
Short name:
CT-1
Gene namesi
Name:CTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000150281.6
HGNCiHGNC:2499 CTF1
MIMi600435 gene
neXtProtiNX_Q16619

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1489
OpenTargetsiENSG00000150281
PharmGKBiPA27002

Polymorphism and mutation databases

BioMutaiCTF1
DMDMi2498265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000587621 – 201Cardiotrophin-1Add BLAST201

Proteomic databases

PaxDbiQ16619
PeptideAtlasiQ16619
PRIDEiQ16619
ProteomicsDBi60953
60954 [Q16619-2]

PTM databases

iPTMnetiQ16619
PhosphoSitePlusiQ16619

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000150281 Expressed in 113 organ(s), highest expression level in thoracic aorta
CleanExiHS_CTF1
GenevisibleiQ16619 HS

Organism-specific databases

HPAiCAB025853

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA6P433603EBI-10238077,EBI-1045155

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107871, 3 interactors
DIPiDIP-394N
IntActiQ16619, 1 interactor
STRINGi9606.ENSP00000279804

Structurei

3D structure databases

ProteinModelPortaliQ16619
SMRiQ16619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IWMK Eukaryota
ENOG41119TK LUCA
GeneTreeiENSGT00510000049046
HOGENOMiHOG000112040
HOVERGENiHBG000455
InParanoidiQ16619
KOiK05422
OMAiGLYREWV
OrthoDBiEOG091G0WXG
PhylomeDBiQ16619
TreeFamiTF333266

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010681 PRF/CT
PANTHERiPTHR21353 PTHR21353, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16619-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ
60 70 80 90 100
LQGDPFGLPS FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL
110 120 130 140 150
LDAVCRRQAE LNPRAPRLLR RLEDAARQAR ALGAAVEALL AALGAANRGP
160 170 180 190 200
RAEPPAATAS AASATGVFPA KVLGLRVCGL YREWLSRTEG DLGQLLPGGS

A
Length:201
Mass (Da):21,227
Last modified:November 1, 1996 - v1
Checksum:i0235A7B5745F675F
GO
Isoform 2 (identifier: Q16619-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     9-9: Missing.

Note: No experimental confirmation available.
Show »
Length:200
Mass (Da):21,098
Checksum:i8AF8E579EB779E1F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01493892A → T. Corresponds to variant dbSNP:rs2234933EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0427259Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43033, U43031, U43032 Genomic DNA Translation: AAD12173.1
U43030 mRNA Translation: AAA85229.1
AC135048 Genomic DNA No translation available.
BC036787 mRNA Translation: AAH36787.1
BC064416 mRNA Translation: AAH64416.1
CCDSiCCDS10694.1 [Q16619-1]
CCDS45464.1 [Q16619-2]
PIRiG02312
RefSeqiNP_001136016.1, NM_001142544.1 [Q16619-2]
NP_001321.1, NM_001330.3 [Q16619-1]
UniGeneiHs.483811

Genome annotation databases

EnsembliENST00000279804; ENSP00000279804; ENSG00000150281 [Q16619-1]
ENST00000395019; ENSP00000378465; ENSG00000150281 [Q16619-2]
GeneIDi1489
KEGGihsa:1489
UCSCiuc002dzw.3 human [Q16619-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43033, U43031, U43032 Genomic DNA Translation: AAD12173.1
U43030 mRNA Translation: AAA85229.1
AC135048 Genomic DNA No translation available.
BC036787 mRNA Translation: AAH36787.1
BC064416 mRNA Translation: AAH64416.1
CCDSiCCDS10694.1 [Q16619-1]
CCDS45464.1 [Q16619-2]
PIRiG02312
RefSeqiNP_001136016.1, NM_001142544.1 [Q16619-2]
NP_001321.1, NM_001330.3 [Q16619-1]
UniGeneiHs.483811

3D structure databases

ProteinModelPortaliQ16619
SMRiQ16619
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107871, 3 interactors
DIPiDIP-394N
IntActiQ16619, 1 interactor
STRINGi9606.ENSP00000279804

PTM databases

iPTMnetiQ16619
PhosphoSitePlusiQ16619

Polymorphism and mutation databases

BioMutaiCTF1
DMDMi2498265

Proteomic databases

PaxDbiQ16619
PeptideAtlasiQ16619
PRIDEiQ16619
ProteomicsDBi60953
60954 [Q16619-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279804; ENSP00000279804; ENSG00000150281 [Q16619-1]
ENST00000395019; ENSP00000378465; ENSG00000150281 [Q16619-2]
GeneIDi1489
KEGGihsa:1489
UCSCiuc002dzw.3 human [Q16619-1]

Organism-specific databases

CTDi1489
DisGeNETi1489
EuPathDBiHostDB:ENSG00000150281.6
GeneCardsiCTF1
HGNCiHGNC:2499 CTF1
HPAiCAB025853
MIMi600435 gene
neXtProtiNX_Q16619
OpenTargetsiENSG00000150281
PharmGKBiPA27002
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWMK Eukaryota
ENOG41119TK LUCA
GeneTreeiENSGT00510000049046
HOGENOMiHOG000112040
HOVERGENiHBG000455
InParanoidiQ16619
KOiK05422
OMAiGLYREWV
OrthoDBiEOG091G0WXG
PhylomeDBiQ16619
TreeFamiTF333266

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiQ16619
SIGNORiQ16619

Miscellaneous databases

GenomeRNAii1489
PROiPR:Q16619
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150281 Expressed in 113 organ(s), highest expression level in thoracic aorta
CleanExiHS_CTF1
GenevisibleiQ16619 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010681 PRF/CT
PANTHERiPTHR21353 PTHR21353, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTF1_HUMAN
AccessioniPrimary (citable) accession number: Q16619
Secondary accession number(s): A8MVX4, Q5U5Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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