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Protein

Protein NKG7

Gene

NKG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NKG7
Alternative name(s):
G-CSF-induced gene 1 protein
Short name:
GIG-1 protein
Granule membrane protein of 17 kDa
Short name:
GMP-17
Natural killer cell protein 7
p15-TIA-1
Gene namesi
Name:NKG7
Synonyms:GIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105374.9
HGNCiHGNC:7830 NKG7
MIMi606008 gene
neXtProtiNX_Q16617

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4818
OpenTargetsiENSG00000105374
PharmGKBiPA31639

Polymorphism and mutation databases

BioMutaiNKG7
DMDMi3914144

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646671 – 165Protein NKG7Add BLAST165

Proteomic databases

PaxDbiQ16617
PeptideAtlasiQ16617
PRIDEiQ16617
ProteomicsDBi60952

PTM databases

PhosphoSitePlusiQ16617

Expressioni

Tissue specificityi

Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

Inductioni

By CSF3/G-CSF.

Gene expression databases

BgeeiENSG00000105374 Expressed in 121 organ(s), highest expression level in leukocyte
CleanExiHS_NKG7
ExpressionAtlasiQ16617 baseline and differential
GenevisibleiQ16617 HS

Organism-specific databases

HPAiHPA071454

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110883, 5 interactors
IntActiQ16617, 36 interactors
STRINGi9606.ENSP00000221978

Structurei

3D structure databases

ProteinModelPortaliQ16617
SMRiQ16617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0HZ Eukaryota
ENOG41113EP LUCA
GeneTreeiENSGT00510000049212
HOGENOMiHOG000113791
HOVERGENiHBG000485
InParanoidiQ16617
OMAiIQTFFSW
OrthoDBiEOG091G0UXL
PhylomeDBiQ16617
TreeFamiTF330587

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q16617-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELCRSLALL GGSLGLMFCL IALSTDFWFE AVGPTHSAHS GLWPTGHGDI
60 70 80 90 100
ISGYIHVTQT FSIMAVLWAL VSVSFLVLSC FPSLFPPGHG PLVSTTAAFA
110 120 130 140 150
AAISMVVAMA VYTSERWDQP PHPQIQTFFS WSFYLGWVSA ILLLCTGALS
160
LGAHCGGPRP GYETL
Length:165
Mass (Da):17,665
Last modified:November 1, 1996 - v1
Checksum:iCEE2901B6DC42A8C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R3G3M0R3G3_HUMAN
Protein NKG7
NKG7
72Annotation score:
M0R0D6M0R0D6_HUMAN
Protein NKG7
NKG7
89Annotation score:
M0QXT6M0QXT6_HUMAN
Protein NKG7
NKG7
85Annotation score:
A0A0B4J2A6A0A0B4J2A6_HUMAN
Natural killer cell group 7 sequenc...
NKG7 hCG_91952
142Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09608 mRNA Translation: AAA18209.1
S69115 mRNA Translation: AAB30078.1
AF305941 Genomic DNA Translation: AAG32329.1
BC015759 mRNA Translation: AAH15759.1
CCDSiCCDS12830.1
PIRiJC2081
RefSeqiNP_005592.1, NM_005601.3
UniGeneiHs.10306

Genome annotation databases

EnsembliENST00000221978; ENSP00000221978; ENSG00000105374
GeneIDi4818
KEGGihsa:4818
UCSCiuc002pwj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09608 mRNA Translation: AAA18209.1
S69115 mRNA Translation: AAB30078.1
AF305941 Genomic DNA Translation: AAG32329.1
BC015759 mRNA Translation: AAH15759.1
CCDSiCCDS12830.1
PIRiJC2081
RefSeqiNP_005592.1, NM_005601.3
UniGeneiHs.10306

3D structure databases

ProteinModelPortaliQ16617
SMRiQ16617
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110883, 5 interactors
IntActiQ16617, 36 interactors
STRINGi9606.ENSP00000221978

PTM databases

PhosphoSitePlusiQ16617

Polymorphism and mutation databases

BioMutaiNKG7
DMDMi3914144

Proteomic databases

PaxDbiQ16617
PeptideAtlasiQ16617
PRIDEiQ16617
ProteomicsDBi60952

Protocols and materials databases

DNASUi4818
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221978; ENSP00000221978; ENSG00000105374
GeneIDi4818
KEGGihsa:4818
UCSCiuc002pwj.4 human

Organism-specific databases

CTDi4818
DisGeNETi4818
EuPathDBiHostDB:ENSG00000105374.9
GeneCardsiNKG7
HGNCiHGNC:7830 NKG7
HPAiHPA071454
MIMi606008 gene
neXtProtiNX_Q16617
OpenTargetsiENSG00000105374
PharmGKBiPA31639
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0HZ Eukaryota
ENOG41113EP LUCA
GeneTreeiENSGT00510000049212
HOGENOMiHOG000113791
HOVERGENiHBG000485
InParanoidiQ16617
OMAiIQTFFSW
OrthoDBiEOG091G0UXL
PhylomeDBiQ16617
TreeFamiTF330587

Miscellaneous databases

GenomeRNAii4818
PROiPR:Q16617
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105374 Expressed in 121 organ(s), highest expression level in leukocyte
CleanExiHS_NKG7
ExpressionAtlasiQ16617 baseline and differential
GenevisibleiQ16617 HS

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKG7_HUMAN
AccessioniPrimary (citable) accession number: Q16617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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