UniProtKB - Q16610 (ECM1_HUMAN)
Extracellular matrix protein 1
ECM1
Functioni
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
3 PublicationsGO - Molecular functioni
- enzyme binding Source: UniProtKB
- interleukin-2 receptor binding Source: Ensembl
- laminin binding Source: UniProtKB
- protease binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- biomineral tissue development Source: UniProtKB-KW
- chondrocyte development Source: Ensembl
- endochondral bone growth Source: Ensembl
- inflammatory response Source: Ensembl
- negative regulation of bone mineralization Source: UniProtKB
- negative regulation of cytokine-mediated signaling pathway Source: Ensembl
- negative regulation of peptidase activity Source: UniProtKB
- ossification Source: UniProtKB-KW
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- regulation of bone mineralization Source: GO_Central
- regulation of T cell migration Source: Ensembl
- regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of type 2 immune response Source: Ensembl
- signal transduction Source: InterPro
Keywordsi
Biological process | Angiogenesis, Biomineralization, Mineral balance, Osteogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q16610 |
Reactomei | R-HSA-114608, Platelet degranulation |
SignaLinki | Q16610 |
SIGNORi | Q16610 |
Names & Taxonomyi
Protein namesi | Recommended name: Extracellular matrix protein 1Alternative name(s): Secretory component p85 |
Gene namesi | Name:ECM1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3153, ECM1 |
MIMi | 602201, gene |
neXtProti | NX_Q16610 |
VEuPathDBi | HostDB:ENSG00000143369 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- collagen-containing extracellular matrix Source: UniProtKB
- extracellular matrix Source: ProtInc
- platelet dense granule lumen Source: Reactome
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Lipoid proteinosis (LiP)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018691 | 167 | F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1893 |
GeneReviewsi | ECM1 |
MalaCardsi | ECM1 |
MIMi | 247100, phenotype |
OpenTargetsi | ENSG00000143369 |
Orphaneti | 530, Lipoid proteinosis |
PharmGKBi | PA27598 |
Miscellaneous databases
Pharosi | Q16610, Tbio |
Genetic variation databases
BioMutai | ECM1 |
DMDMi | 48429255 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | By similarityAdd BLAST | 19 | |
ChainiPRO_0000021146 | 20 – 540 | Extracellular matrix protein 1Add BLAST | 521 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 354 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 444 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Glycosylationi | 530 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q16610 |
jPOSTi | Q16610 |
MassIVEi | Q16610 |
MaxQBi | Q16610 |
PaxDbi | Q16610 |
PeptideAtlasi | Q16610 |
PRIDEi | Q16610 |
ProteomicsDBi | 60944 [Q16610-1] 60945 [Q16610-2] 60946 [Q16610-3] 60947 [Q16610-4] |
PTM databases
GlyConnecti | 1228, 20 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site) |
GlyGeni | Q16610, 12 sites, 21 N-linked glycans (4 sites), 3 O-linked glycans (6 sites) |
iPTMneti | Q16610 |
PhosphoSitePlusi | Q16610 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000143369, Expressed in lower esophagus mucosa and 228 other tissues |
ExpressionAtlasi | Q16610, baseline and differential |
Genevisiblei | Q16610, HS |
Organism-specific databases
HPAi | ENSG00000143369, Tissue enhanced (epididymis, esophagus) |
Interactioni
Subunit structurei
Interacts (via C-terminus) with HSPG2 (via C-terminus).
Interacts with EFEMP1/FBLN3 and LAMB3.
Interacts with MMP9.
3 PublicationsBinary interactionsi
Q16610
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- interleukin-2 receptor binding Source: Ensembl
- laminin binding Source: UniProtKB
- protease binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108222, 102 interactors |
IntActi | Q16610, 63 interactors |
MINTi | Q16610 |
STRINGi | 9606.ENSP00000358045 |
Miscellaneous databases
RNActi | Q16610, protein |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 150 – 279 | 1Add BLAST | 130 | |
Repeati | 283 – 405 | 2Add BLAST | 123 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 85 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 120 – 175 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 150 – 405 | 2 X approximate repeatsAdd BLAST | 256 | |
Regioni | 515 – 540 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 66 – 85 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 142 – 156 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 516 – 534 | Polar residuesSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502RY3T, Eukaryota |
GeneTreei | ENSGT00390000006215 |
HOGENOMi | CLU_038587_0_0_1 |
InParanoidi | Q16610 |
OMAi | NVKNICH |
OrthoDBi | 509393at2759 |
PhylomeDBi | Q16610 |
TreeFami | TF330786 |
Family and domain databases
InterProi | View protein in InterPro IPR008605, ECM1 IPR020858, Serum_albumin-like |
PANTHERi | PTHR16776, PTHR16776, 1 hit |
Pfami | View protein in Pfam PF05782, ECM1, 1 hit |
SUPFAMi | SSF48552, SSF48552, 2 hits |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP
60 70 80 90 100
LSRSLPMDHP DSSQHGPPFE GQSQVQPPPS QEATPLQQEK LLPAQLPAEK
110 120 130 140 150
EVGPPLPQEA VPLQKELPSL QHPNEQKEGT PAPFGDQSHP EPESWNAAQH
160 170 180 190 200
CQQDRSQGGW GHRLDGFPPG RPSPDNLNQI CLPNRQHVVY GPWNLPQSSY
210 220 230 240 250
SHLTRQGETL NFLEIGYSRC CHCRSHTNRL ECAKLVWEEA MSRFCEAEFS
260 270 280 290 300
VKTRPHWCCT RQGEARFSCF QEEAPQPHYQ LRACPSHQPD ISSGLELPFP
310 320 330 340 350
PGVPTLDNIK NICHLRRFRS VPRNLPATDP LQRELLALIQ LEREFQRCCR
360 370 380 390 400
QGNNHTCTWK AWEDTLDKYC DREYAVKTHH HLCCRHPPSP TRDECFARRA
410 420 430 440 450
PYPNYDRDIL TIDIGRVTPN LMGHLCGNQR VLTKHKHIPG LIHNMTARCC
460 470 480 490 500
DLPFPEQACC AEEEKLTFIN DLCGPRRNIW RDPALCCYLS PGDEQVNCFN
510 520 530 540
INYLRNVALV SGDTENAKGQ GEQGSTGGTN ISSTSEPKEE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 78 – 84 | Missing in BAG63622 (PubMed:14702039).Curated | 7 | |
Sequence conflicti | 520 | Q → R in BAF85124 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018690 | 130 | T → M3 PublicationsCorresponds to variant dbSNP:rs3737240Ensembl. | 1 | |
Natural variantiVAR_018691 | 167 | F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar. | 1 | |
Natural variantiVAR_014761 | 415 | G → S4 PublicationsCorresponds to variant dbSNP:rs13294Ensembl. | 1 | |
Natural variantiVAR_014762 | 528 | G → R. Corresponds to variant dbSNP:rs1050901Ensembl. | 1 | |
Natural variantiVAR_014763 | 535 | S → F. Corresponds to variant dbSNP:rs1050904Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036411 | 1 – 71 | Missing in isoform 3. 1 PublicationAdd BLAST | 71 | |
Alternative sequenceiVSP_036412 | 72 – 81 | QSQVQPPPSQ → MALPLRDRVK in isoform 3. 1 Publication | 10 | |
Alternative sequenceiVSP_036413 | 74 | Q → GKEGRGPRPHSQPWLGERVG CSHIPPSI in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_036414 | 237 – 361 | Missing in isoform 2. 1 PublicationAdd BLAST | 125 | |
Alternative sequenceiVSP_036415 | 237 – 241 | WEEAM → VRLGS in isoform 3. 1 Publication | 5 | |
Alternative sequenceiVSP_036416 | 242 – 540 | Missing in isoform 3. 1 PublicationAdd BLAST | 299 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U68186 mRNA Translation: AAB88081.1 U68187 mRNA Translation: AAB88082.1 U65932 mRNA Translation: AAB05933.1 U65938 , U65933, U65934, U65935, U65936, U65937 Genomic DNA Translation: AAB05934.1 AK097046 mRNA Translation: BAG53412.1 AK292435 mRNA Translation: BAF85124.1 AK301369 mRNA Translation: BAG62911.1 AK302279 mRNA Translation: BAG63622.1 AL356356 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53544.1 CH471121 Genomic DNA Translation: EAW53545.1 CH471121 Genomic DNA Translation: EAW53546.1 BC023505 mRNA Translation: AAH23505.1 |
CCDSi | CCDS55632.1 [Q16610-4] CCDS953.1 [Q16610-1] CCDS954.1 [Q16610-2] |
RefSeqi | NP_001189787.1, NM_001202858.1 [Q16610-4] NP_004416.2, NM_004425.3 [Q16610-1] NP_073155.2, NM_022664.2 [Q16610-2] |
Genome annotation databases
Ensembli | ENST00000346569; ENSP00000271630; ENSG00000143369 [Q16610-2] ENST00000369047; ENSP00000358043; ENSG00000143369 ENST00000369049; ENSP00000358045; ENSG00000143369 [Q16610-4] |
GeneIDi | 1893 |
KEGGi | hsa:1893 |
MANE-Selecti | ENST00000369047.9; ENSP00000358043.4; NM_004425.4; NP_004416.2 |
UCSCi | uc001eus.4, human [Q16610-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U68186 mRNA Translation: AAB88081.1 U68187 mRNA Translation: AAB88082.1 U65932 mRNA Translation: AAB05933.1 U65938 , U65933, U65934, U65935, U65936, U65937 Genomic DNA Translation: AAB05934.1 AK097046 mRNA Translation: BAG53412.1 AK292435 mRNA Translation: BAF85124.1 AK301369 mRNA Translation: BAG62911.1 AK302279 mRNA Translation: BAG63622.1 AL356356 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53544.1 CH471121 Genomic DNA Translation: EAW53545.1 CH471121 Genomic DNA Translation: EAW53546.1 BC023505 mRNA Translation: AAH23505.1 |
CCDSi | CCDS55632.1 [Q16610-4] CCDS953.1 [Q16610-1] CCDS954.1 [Q16610-2] |
RefSeqi | NP_001189787.1, NM_001202858.1 [Q16610-4] NP_004416.2, NM_004425.3 [Q16610-1] NP_073155.2, NM_022664.2 [Q16610-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 108222, 102 interactors |
IntActi | Q16610, 63 interactors |
MINTi | Q16610 |
STRINGi | 9606.ENSP00000358045 |
PTM databases
GlyConnecti | 1228, 20 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site) |
GlyGeni | Q16610, 12 sites, 21 N-linked glycans (4 sites), 3 O-linked glycans (6 sites) |
iPTMneti | Q16610 |
PhosphoSitePlusi | Q16610 |
Genetic variation databases
BioMutai | ECM1 |
DMDMi | 48429255 |
Proteomic databases
EPDi | Q16610 |
jPOSTi | Q16610 |
MassIVEi | Q16610 |
MaxQBi | Q16610 |
PaxDbi | Q16610 |
PeptideAtlasi | Q16610 |
PRIDEi | Q16610 |
ProteomicsDBi | 60944 [Q16610-1] 60945 [Q16610-2] 60946 [Q16610-3] 60947 [Q16610-4] |
Protocols and materials databases
Antibodypediai | 20285, 504 antibodies from 36 providers |
DNASUi | 1893 |
Genome annotation databases
Ensembli | ENST00000346569; ENSP00000271630; ENSG00000143369 [Q16610-2] ENST00000369047; ENSP00000358043; ENSG00000143369 ENST00000369049; ENSP00000358045; ENSG00000143369 [Q16610-4] |
GeneIDi | 1893 |
KEGGi | hsa:1893 |
MANE-Selecti | ENST00000369047.9; ENSP00000358043.4; NM_004425.4; NP_004416.2 |
UCSCi | uc001eus.4, human [Q16610-1] |
Organism-specific databases
CTDi | 1893 |
DisGeNETi | 1893 |
GeneCardsi | ECM1 |
GeneReviewsi | ECM1 |
HGNCi | HGNC:3153, ECM1 |
HPAi | ENSG00000143369, Tissue enhanced (epididymis, esophagus) |
MalaCardsi | ECM1 |
MIMi | 247100, phenotype 602201, gene |
neXtProti | NX_Q16610 |
OpenTargetsi | ENSG00000143369 |
Orphaneti | 530, Lipoid proteinosis |
PharmGKBi | PA27598 |
VEuPathDBi | HostDB:ENSG00000143369 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RY3T, Eukaryota |
GeneTreei | ENSGT00390000006215 |
HOGENOMi | CLU_038587_0_0_1 |
InParanoidi | Q16610 |
OMAi | NVKNICH |
OrthoDBi | 509393at2759 |
PhylomeDBi | Q16610 |
TreeFami | TF330786 |
Enzyme and pathway databases
PathwayCommonsi | Q16610 |
Reactomei | R-HSA-114608, Platelet degranulation |
SignaLinki | Q16610 |
SIGNORi | Q16610 |
Miscellaneous databases
BioGRID-ORCSi | 1893, 6 hits in 1045 CRISPR screens |
ChiTaRSi | ECM1, human |
GeneWikii | ECM1 |
GenomeRNAii | 1893 |
Pharosi | Q16610, Tbio |
PROi | PR:Q16610 |
RNActi | Q16610, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143369, Expressed in lower esophagus mucosa and 228 other tissues |
ExpressionAtlasi | Q16610, baseline and differential |
Genevisiblei | Q16610, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008605, ECM1 IPR020858, Serum_albumin-like |
PANTHERi | PTHR16776, PTHR16776, 1 hit |
Pfami | View protein in Pfam PF05782, ECM1, 1 hit |
SUPFAMi | SSF48552, SSF48552, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ECM1_HUMAN | |
Accessioni | Q16610Primary (citable) accession number: Q16610 Secondary accession number(s): A8K8S0 Q8IZ60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | June 7, 2004 | |
Last modified: | February 23, 2022 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot