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UniProtKB - Q16610 (ECM1_HUMAN)

Entry version 183 (25 May 2022)
Sequence version 2 (07 Jun 2004)
Previous versions | rss
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Protein

Extracellular matrix protein 1

Gene

ECM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Biomineralization, Mineral balance, Osteogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16610

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q16610

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16610

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extracellular matrix protein 1
Alternative name(s):
Secretory component p85
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ECM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3153, ECM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602201, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16610

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143369

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lipoid proteinosis (LiP)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018691167F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		1893

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		ECM1

MalaCards human disease database

More...MalaCardsi		ECM1
MIMi247100, phenotype

Open Targets

More...OpenTargetsi		ENSG00000143369

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		530, Lipoid proteinosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27598

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16610, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ECM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		48429255

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002114620 – 540Extracellular matrix protein 1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q16610

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q16610

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q16610

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q16610

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16610

PeptideAtlas

More...PeptideAtlasi		Q16610

PRoteomics IDEntifications database

More...PRIDEi		Q16610

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60944 [Q16610-1]
60945 [Q16610-2]
60946 [Q16610-3]
60947 [Q16610-4]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1228, 20 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q16610, 12 sites, 21 N-linked glycans (4 sites), 3 O-linked glycans (6 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16610

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16610

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143369, Expressed in lower esophagus mucosa and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q16610, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16610, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143369, Tissue enhanced (epididymis, esophagus)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with HSPG2 (via C-terminus).

Interacts with EFEMP1/FBLN3 and LAMB3.

Interacts with MMP9.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108222, 153 interactors

Protein interaction database and analysis system

More...IntActi		Q16610, 73 interactors

Molecular INTeraction database

More...MINTi		Q16610

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358045

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16610, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q16610

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati150 – 2791Add BLAST130
Repeati283 – 4052Add BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 85DisorderedSequence analysisAdd BLAST45
Regioni120 – 175DisorderedSequence analysisAdd BLAST56
Regioni150 – 4052 X approximate repeatsAdd BLAST256
Regioni515 – 540DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi66 – 85Polar residuesSequence analysisAdd BLAST20
Compositional biasi142 – 156Polar residuesSequence analysisAdd BLAST15
Compositional biasi516 – 534Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RY3T, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006215

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038587_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16610

Identification of Orthologs from Complete Genome Data

More...OMAi		QTNCFNI

Database of Orthologous Groups

More...OrthoDBi		509393at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16610

TreeFam database of animal gene trees

More...TreeFami		TF330786

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008605, ECM1
IPR020858, Serum_albumin-like

The PANTHER Classification System

More...PANTHERi		PTHR16776, PTHR16776, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05782, ECM1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48552, SSF48552, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16610-1) [UniParc]FASTAAdd to basket
Also known as: 1a

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP 
        60         70         80         90        100
LSRSLPMDHP DSSQHGPPFE GQSQVQPPPS QEATPLQQEK LLPAQLPAEK 
       110        120        130        140        150
EVGPPLPQEA VPLQKELPSL QHPNEQKEGT PAPFGDQSHP EPESWNAAQH 
       160        170        180        190        200
CQQDRSQGGW GHRLDGFPPG RPSPDNLNQI CLPNRQHVVY GPWNLPQSSY 
       210        220        230        240        250
SHLTRQGETL NFLEIGYSRC CHCRSHTNRL ECAKLVWEEA MSRFCEAEFS 
       260        270        280        290        300
VKTRPHWCCT RQGEARFSCF QEEAPQPHYQ LRACPSHQPD ISSGLELPFP 
       310        320        330        340        350
PGVPTLDNIK NICHLRRFRS VPRNLPATDP LQRELLALIQ LEREFQRCCR 
       360        370        380        390        400
QGNNHTCTWK AWEDTLDKYC DREYAVKTHH HLCCRHPPSP TRDECFARRA 
       410        420        430        440        450
PYPNYDRDIL TIDIGRVTPN LMGHLCGNQR VLTKHKHIPG LIHNMTARCC 
       460        470        480        490        500
DLPFPEQACC AEEEKLTFIN DLCGPRRNIW RDPALCCYLS PGDEQVNCFN 
       510        520        530        540
INYLRNVALV SGDTENAKGQ GEQGSTGGTN ISSTSEPKEE
Length:540
Mass (Da):60,674
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA575895CDE068BE
GO
Isoform 2 (identifier: Q16610-2) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     237-361: Missing.

Show »
Length:415
Mass (Da):46,099
Checksum:iE6878AE9DEF1D5AC
GO
Isoform 3 (identifier: Q16610-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     72-81: QSQVQPPPSQ → MALPLRDRVK
     237-241: WEEAM → VRLGS
     242-540: Missing.

Show »
Length:170
Mass (Da):19,069
Checksum:i4C3B05692F1D1C8C
GO
Isoform 4 (identifier: Q16610-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-74: Q → GKEGRGPRPHSQPWLGERVGCSHIPPSI

Note: May be due to intron retention.Curated
Show »
Length:567
Mass (Da):63,563
Checksum:iFBCFB0E51CE13735
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78 – 84Missing in BAG63622 (PubMed:14702039).Curated7
Sequence conflicti520Q → R in BAF85124 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018690130T → M3 PublicationsCorresponds to variant dbSNP:rs3737240Ensembl.1
Natural variantiVAR_018691167F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar.1
Natural variantiVAR_014761415G → S4 PublicationsCorresponds to variant dbSNP:rs13294Ensembl.1
Natural variantiVAR_014762528G → R. Corresponds to variant dbSNP:rs1050901Ensembl.1
Natural variantiVAR_014763535S → F. Corresponds to variant dbSNP:rs1050904Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0364111 – 71Missing in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_03641272 – 81QSQVQPPPSQ → MALPLRDRVK in isoform 3. 1 Publication10
Alternative sequenceiVSP_03641374Q → GKEGRGPRPHSQPWLGERVG CSHIPPSI in isoform 4. 1 Publication1
Alternative sequenceiVSP_036414237 – 361Missing in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_036415237 – 241WEEAM → VRLGS in isoform 3. 1 Publication5
Alternative sequenceiVSP_036416242 – 540Missing in isoform 3. 1 PublicationAdd BLAST299

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U68186 mRNA Translation: AAB88081.1
U68187 mRNA Translation: AAB88082.1
U65932 mRNA Translation: AAB05933.1
U65938 U65937 Genomic DNA Translation: AAB05934.1
AK097046 mRNA Translation: BAG53412.1
AK292435 mRNA Translation: BAF85124.1
AK301369 mRNA Translation: BAG62911.1
AK302279 mRNA Translation: BAG63622.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53544.1
CH471121 Genomic DNA Translation: EAW53545.1
CH471121 Genomic DNA Translation: EAW53546.1
BC023505 mRNA Translation: AAH23505.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55632.1 [Q16610-4]
CCDS953.1 [Q16610-1]
CCDS954.1 [Q16610-2]

NCBI Reference Sequences

More...RefSeqi		NP_001189787.1, NM_001202858.1 [Q16610-4]
NP_004416.2, NM_004425.3 [Q16610-1]
NP_073155.2, NM_022664.2 [Q16610-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346569.6; ENSP00000271630.6; ENSG00000143369.15 [Q16610-2]
ENST00000369047.9; ENSP00000358043.4; ENSG00000143369.15
ENST00000369049.8; ENSP00000358045.4; ENSG00000143369.15 [Q16610-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1893

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1893

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000369047.9; ENSP00000358043.4; NM_004425.4; NP_004416.2

UCSC genome browser

More...UCSCi		uc001eus.4, human [Q16610-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68186 mRNA Translation: AAB88081.1
U68187 mRNA Translation: AAB88082.1
U65932 mRNA Translation: AAB05933.1
U65938 U65937 Genomic DNA Translation: AAB05934.1
AK097046 mRNA Translation: BAG53412.1
AK292435 mRNA Translation: BAF85124.1
AK301369 mRNA Translation: BAG62911.1
AK302279 mRNA Translation: BAG63622.1
AL356356 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53544.1
CH471121 Genomic DNA Translation: EAW53545.1
CH471121 Genomic DNA Translation: EAW53546.1
BC023505 mRNA Translation: AAH23505.1
CCDSiCCDS55632.1 [Q16610-4]
CCDS953.1 [Q16610-1]
CCDS954.1 [Q16610-2]
RefSeqiNP_001189787.1, NM_001202858.1 [Q16610-4]
NP_004416.2, NM_004425.3 [Q16610-1]
NP_073155.2, NM_022664.2 [Q16610-2]

3D structure databases

AlphaFoldDBiQ16610
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi108222, 153 interactors
IntActiQ16610, 73 interactors
MINTiQ16610
STRINGi9606.ENSP00000358045

PTM databases

GlyConnecti1228, 20 N-Linked glycans (4 sites), 1 O-Linked glycan (1 site)
GlyGeniQ16610, 12 sites, 21 N-linked glycans (4 sites), 3 O-linked glycans (6 sites)
iPTMnetiQ16610
PhosphoSitePlusiQ16610

Genetic variation databases

BioMutaiECM1
DMDMi48429255

Proteomic databases

EPDiQ16610
jPOSTiQ16610
MassIVEiQ16610
MaxQBiQ16610
PaxDbiQ16610
PeptideAtlasiQ16610
PRIDEiQ16610
ProteomicsDBi60944 [Q16610-1]
60945 [Q16610-2]
60946 [Q16610-3]
60947 [Q16610-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20285, 504 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		1893

Genome annotation databases

EnsembliENST00000346569.6; ENSP00000271630.6; ENSG00000143369.15 [Q16610-2]
ENST00000369047.9; ENSP00000358043.4; ENSG00000143369.15
ENST00000369049.8; ENSP00000358045.4; ENSG00000143369.15 [Q16610-4]
GeneIDi1893
KEGGihsa:1893
MANE-SelectiENST00000369047.9; ENSP00000358043.4; NM_004425.4; NP_004416.2
UCSCiuc001eus.4, human [Q16610-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1893
DisGeNETi1893

GeneCards: human genes, protein and diseases

More...GeneCardsi		ECM1
GeneReviewsiECM1
HGNCiHGNC:3153, ECM1
HPAiENSG00000143369, Tissue enhanced (epididymis, esophagus)
MalaCardsiECM1
MIMi247100, phenotype
602201, gene
neXtProtiNX_Q16610
OpenTargetsiENSG00000143369
Orphaneti530, Lipoid proteinosis
PharmGKBiPA27598
VEuPathDBiHostDB:ENSG00000143369

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RY3T, Eukaryota
GeneTreeiENSGT00390000006215
HOGENOMiCLU_038587_0_0_1
InParanoidiQ16610
OMAiQTNCFNI
OrthoDBi509393at2759
PhylomeDBiQ16610
TreeFamiTF330786

Enzyme and pathway databases

PathwayCommonsiQ16610
ReactomeiR-HSA-114608, Platelet degranulation
SignaLinkiQ16610
SIGNORiQ16610

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1893, 8 hits in 1080 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ECM1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ECM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1893
PharosiQ16610, Tbio

Protein Ontology

More...PROi		PR:Q16610
RNActiQ16610, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143369, Expressed in lower esophagus mucosa and 228 other tissues
ExpressionAtlasiQ16610, baseline and differential
GenevisibleiQ16610, HS

Family and domain databases

InterProiView protein in InterPro
IPR008605, ECM1
IPR020858, Serum_albumin-like
PANTHERiPTHR16776, PTHR16776, 1 hit
PfamiView protein in Pfam
PF05782, ECM1, 1 hit
SUPFAMiSSF48552, SSF48552, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16610
Secondary accession number(s): A8K8S0
, B4DW49, B4DY60, O43266, Q5T5G4, Q5T5G5, Q5T5G6, Q8IZ60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2004
Last modified: May 25, 2022
This is version 183 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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