ECM1

Functionⁱ

Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.3 Publications

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20870722
extracellular matrix structural constituent
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 27068509
interleukin-2 receptor binding Source: Ensembl
laminin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19275936
protease binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16512877
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12604605

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiogenesis Source: UniProtKB-KW
biomineral tissue development Source: UniProtKB-KW
inflammatory response Source: Ensembl
negative regulation of bone mineralization
Source: UniProtKB
Inferred from direct assayⁱ
- 11165938
negative regulation of cytokine-mediated signaling pathway Source: Ensembl
negative regulation of peptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16512877
ossification Source: UniProtKB-KW
platelet degranulation Source: Reactome
positive regulation of angiogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 11292659
positive regulation of endothelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 11292659
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from high throughput mutant phenotypeⁱ
- 12761501
regulation of T cell migration Source: Ensembl
regulation of transcription by RNA polymerase II Source: Ensembl
regulation of type 2 immune response Source: Ensembl
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Angiogenesis, Biomineralization, Mineral balance, Osteogenesis

Biological process

Angiogenesis, Biomineralization, Mineral balance, Osteogenesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation
SIGNORⁱ	Q16610

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Extracellular matrix protein 1 Alternative name(s): Secretory component p85
Gene namesⁱ	Name:ECM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143369.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3153 ECM1
MIMⁱ	602201 gene
neXtProtⁱ	NX_Q16610

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Lipoid proteinosis (LiP)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionRare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_018691	167	F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1893
MalaCards human disease database More...MalaCardsⁱ	ECM1
MIMⁱ	247100 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000143369
Orphanetⁱ	530 Lipoid proteinosis
PharmGKBⁱ	PA27598

Polymorphism and mutation databases

BioMutaⁱ	ECM1
DMDMⁱ	48429255

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	By similarityAdd BLAST		19
ChainⁱPRO_0000021146	20 – 540	Extracellular matrix protein 1Add BLAST		521

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	354	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	444	N-linked (GlcNAc...) (complex) asparagine2 Publications	1
Glycosylationⁱ	530	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q16610
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16610
PaxDbⁱ	Q16610
PeptideAtlas More...PeptideAtlasⁱ	Q16610
PRIDEⁱ	Q16610
ProteomicsDBⁱ	60944 60945 [Q16610-2] 60946 [Q16610-3] 60947 [Q16610-4]

PTM databases

GlyConnectⁱ	1228
iPTMnetⁱ	Q16610
PhosphoSitePlusⁱ	Q16610

Expressionⁱ

Tissue specificityⁱ

Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000143369 Expressed in 213 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_ECM1
ExpressionAtlasⁱ	Q16610 baseline and differential
Genevisibleⁱ	Q16610 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027241

HPAⁱ

HPA027241

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with HSPG2 (via C-terminus). Interacts with EFEMP1/FBLN3 and LAMB3. Interacts with MMP9.3 Publications

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20870722
interleukin-2 receptor binding Source: Ensembl
laminin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19275936
protease binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16512877
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12604605

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108222, 31 interactors
IntActⁱ	Q16610, 39 interactors
STRINGⁱ	9606.ENSP00000358045

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16610
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	150 – 279	1Add BLAST		130
Repeatⁱ	283 – 405	2Add BLAST		123

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	150 – 405	2 X approximate repeatsAdd BLAST		256

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVN8 Eukaryota ENOG4111TGN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006215
HOVERGENⁱ	HBG005561
InParanoidⁱ	Q16610
OMAⁱ	CCHYPPS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NAE
PhylomeDBⁱ	Q16610
TreeFamⁱ	TF330786

Family and domain databases

InterProⁱ	View protein in InterPro IPR008605 ECM1 IPR020858 Serum_albumin-like
PANTHERⁱ	PTHR16776 PTHR16776, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05782 ECM1, 1 hit
SUPFAMⁱ	SSF48552 SSF48552, 2 hits

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q16610-1) [UniParc]FASTA Add to basket

Also known as: 1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP 
        60         70         80         90        100
LSRSLPMDHP DSSQHGPPFE GQSQVQPPPS QEATPLQQEK LLPAQLPAEK 
       110        120        130        140        150
EVGPPLPQEA VPLQKELPSL QHPNEQKEGT PAPFGDQSHP EPESWNAAQH 
       160        170        180        190        200
CQQDRSQGGW GHRLDGFPPG RPSPDNLNQI CLPNRQHVVY GPWNLPQSSY 
       210        220        230        240        250
SHLTRQGETL NFLEIGYSRC CHCRSHTNRL ECAKLVWEEA MSRFCEAEFS 
       260        270        280        290        300
VKTRPHWCCT RQGEARFSCF QEEAPQPHYQ LRACPSHQPD ISSGLELPFP 
       310        320        330        340        350
PGVPTLDNIK NICHLRRFRS VPRNLPATDP LQRELLALIQ LEREFQRCCR 
       360        370        380        390        400
QGNNHTCTWK AWEDTLDKYC DREYAVKTHH HLCCRHPPSP TRDECFARRA 
       410        420        430        440        450
PYPNYDRDIL TIDIGRVTPN LMGHLCGNQR VLTKHKHIPG LIHNMTARCC 
       460        470        480        490        500
DLPFPEQACC AEEEKLTFIN DLCGPRRNIW RDPALCCYLS PGDEQVNCFN 
       510        520        530        540
INYLRNVALV SGDTENAKGQ GEQGSTGGTN ISSTSEPKEE

Length:540

Mass (Da):60,674

Last modified:June 7, 2004 - v2

Checksum:ⁱEA575895CDE068BE

GO

Isoform 2 (identifier: Q16610-2) [UniParc]FASTA Add to basket

Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
237-361: Missing.

« Hide

        10         20         30         40         50
MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP 
        60         70         80         90        100
LSRSLPMDHP DSSQHGPPFE GQSQVQPPPS QEATPLQQEK LLPAQLPAEK 
       110        120        130        140        150
EVGPPLPQEA VPLQKELPSL QHPNEQKEGT PAPFGDQSHP EPESWNAAQH 
       160        170        180        190        200
CQQDRSQGGW GHRLDGFPPG RPSPDNLNQI CLPNRQHVVY GPWNLPQSSY 
       210        220        230        240        250
SHLTRQGETL NFLEIGYSRC CHCRSHTNRL ECAKLVWEDT LDKYCDREYA 
       260        270        280        290        300
VKTHHHLCCR HPPSPTRDEC FARRAPYPNY DRDILTIDIG RVTPNLMGHL 
       310        320        330        340        350
CGNQRVLTKH KHIPGLIHNM TARCCDLPFP EQACCAEEEK LTFINDLCGP 
       360        370        380        390        400
RRNIWRDPAL CCYLSPGDEQ VNCFNINYLR NVALVSGDTE NAKGQGEQGS 
       410 
TGGTNISSTS EPKEE

Show »

Length:415

Mass (Da):46,099

Checksum:ⁱE6878AE9DEF1D5AC

GO

Isoform 3 (identifier: Q16610-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     72-81: QSQVQPPPSQ → MALPLRDRVK
     237-241: WEEAM → VRLGS
     242-540: Missing.

« Hide

        10         20         30         40         50
MALPLRDRVK EATPLQQEKL LPAQLPAEKE VGPPLPQEAV PLQKELPSLQ 
        60         70         80         90        100
HPNEQKEGTP APFGDQSHPE PESWNAAQHC QQDRSQGGWG HRLDGFPPGR 
       110        120        130        140        150
PSPDNLNQIC LPNRQHVVYG PWNLPQSSYS HLTRQGETLN FLEIGYSRCC 
       160        170
HCRSHTNRLE CAKLVVRLGS

Show »

Length:170

Mass (Da):19,069

Checksum:ⁱ4C3B05692F1D1C8C

GO

Isoform 4 (identifier: Q16610-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
74-74: Q → GKEGRGPRPHSQPWLGERVGCSHIPPSI

« Hide

        10         20         30         40         50
MGTTARAALV LTYLAVASAA SEGGFTATGQ RQLRPEHFQE VGYAAPPSPP 
        60         70         80         90        100
LSRSLPMDHP DSSQHGPPFE GQSGKEGRGP RPHSQPWLGE RVGCSHIPPS 
       110        120        130        140        150
IVQPPPSQEA TPLQQEKLLP AQLPAEKEVG PPLPQEAVPL QKELPSLQHP 
       160        170        180        190        200
NEQKEGTPAP FGDQSHPEPE SWNAAQHCQQ DRSQGGWGHR LDGFPPGRPS 
       210        220        230        240        250
PDNLNQICLP NRQHVVYGPW NLPQSSYSHL TRQGETLNFL EIGYSRCCHC 
       260        270        280        290        300
RSHTNRLECA KLVWEEAMSR FCEAEFSVKT RPHWCCTRQG EARFSCFQEE 
       310        320        330        340        350
APQPHYQLRA CPSHQPDISS GLELPFPPGV PTLDNIKNIC HLRRFRSVPR 
       360        370        380        390        400
NLPATDPLQR ELLALIQLER EFQRCCRQGN NHTCTWKAWE DTLDKYCDRE 
       410        420        430        440        450
YAVKTHHHLC CRHPPSPTRD ECFARRAPYP NYDRDILTID IGRVTPNLMG 
       460        470        480        490        500
HLCGNQRVLT KHKHIPGLIH NMTARCCDLP FPEQACCAEE EKLTFINDLC 
       510        520        530        540        550
GPRRNIWRDP ALCCYLSPGD EQVNCFNINY LRNVALVSGD TENAKGQGEQ 
       560 
GSTGGTNISS TSEPKEE

Note: May be due to intron retention.

Show »

Length:567

Mass (Da):63,563

Checksum:ⁱFBCFB0E51CE13735

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	78 – 84	Missing in BAG63622 (PubMed:14702039).Curated		7
Sequence conflictⁱ	520	Q → R in BAF85124 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018690	130	T → M3 PublicationsCorresponds to variant dbSNP:rs3737240Ensembl.	1
Natural variantⁱVAR_018691	167	F → I in LiP. 1 PublicationCorresponds to variant dbSNP:rs121909116EnsemblClinVar.	1
Natural variantⁱVAR_014761	415	G → S4 PublicationsCorresponds to variant dbSNP:rs13294Ensembl.	1
Natural variantⁱVAR_014762	528	G → R. Corresponds to variant dbSNP:rs1050901Ensembl.	1
Natural variantⁱVAR_014763	535	S → F. Corresponds to variant dbSNP:rs1050904Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_036411	1 – 71	Missing in isoform 3. 1 PublicationAdd BLAST	71
Alternative sequenceⁱVSP_036412	72 – 81	QSQVQPPPSQ → MALPLRDRVK in isoform 3. 1 Publication	10
Alternative sequenceⁱVSP_036413	74	Q → GKEGRGPRPHSQPWLGERVG CSHIPPSI in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_036414	237 – 361	Missing in isoform 2. 1 PublicationAdd BLAST	125
Alternative sequenceⁱVSP_036415	237 – 241	WEEAM → VRLGS in isoform 3. 1 Publication	5
Alternative sequenceⁱVSP_036416	242 – 540	Missing in isoform 3. 1 PublicationAdd BLAST	299

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U68186 mRNA Translation: AAB88081.1 U68187 mRNA Translation: AAB88082.1 U65932 mRNA Translation: AAB05933.1 U65938 U65937 Genomic DNA Translation: AAB05934.1 AK097046 mRNA Translation: BAG53412.1 AK292435 mRNA Translation: BAF85124.1 AK301369 mRNA Translation: BAG62911.1 AK302279 mRNA Translation: BAG63622.1 AL356356 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53544.1 CH471121 Genomic DNA Translation: EAW53545.1 CH471121 Genomic DNA Translation: EAW53546.1 BC023505 mRNA Translation: AAH23505.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55632.1 [Q16610-4] CCDS953.1 [Q16610-1] CCDS954.1 [Q16610-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001189787.1, NM_001202858.1 [Q16610-4] NP_004416.2, NM_004425.3 [Q16610-1] NP_073155.2, NM_022664.2 [Q16610-2]
UniGeneⁱ	Hs.81071

Genome annotation databases

Ensemblⁱ	ENST00000346569; ENSP00000271630; ENSG00000143369 [Q16610-2] ENST00000369047; ENSP00000358043; ENSG00000143369 [Q16610-1] ENST00000369049; ENSP00000358045; ENSG00000143369 [Q16610-4]
GeneIDⁱ	1893
KEGGⁱ	hsa:1893
UCSC genome browser More...UCSCⁱ	uc001eus.4 human [Q16610-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16610	Testicular tissue protein Li 61		HUMAN		540	UniRef100_Q16610
Truncated extracellular matrix protein 1		HUMAN		403

Protein	Similar proteins		Species	Score	Length	Source
Q16610	Testicular tissue protein Li 61		HUMAN		540	UniRef90_Q16610
ECM1 isoform 4		PANTR		540
Extracellular matrix protein 1 isoform 1		MACMU		540
Uncharacterized protein		MACFA		540
ECM1 isoform 4		PONAB		540
+18
Q16610-2	ECM1 isoform 6		PANTR		415	UniRef90_Q16610-2
Uncharacterized protein		MACMU		415
Uncharacterized protein		MACFA		415
Uncharacterized protein		COLAP		415
ECM1 isoform 6		PONAB		415
+11
Q16610-3	cDNA, FLJ79289, highly similar to Extracellular matrix protein 1		HUMAN		163	UniRef90_Q16610-3
Q16610-4	Uncharacterized protein		NOMLE		568	UniRef90_Q16610-4
Extracellular matrix protein 1		MACMU		567
Uncharacterized protein		MACFA		567
Uncharacterized protein		COLAP		567
ECM1 isoform 2		PONAB		567
+6

Protein	Similar proteins		Species	Score	Length	Source
Q16610	Extracellular matrix protein 1		MOUSE		559	UniRef50_Q16610
Extracellular matrix protein 1		RAT		562
Testicular tissue protein Li 61		HUMAN		540
Uncharacterized protein		GORGO		540
Extracellular matrix protein 1 isoform 1		MACMU		540
+281
Q16610-2	Uncharacterized protein		NOMLE		415	UniRef50_Q16610-2
Uncharacterized protein		MACMU		415
Uncharacterized protein		MACFA		415
Uncharacterized protein		RHIRO		415
Uncharacterized protein		RHIBE		415
+52
Q16610-3	cDNA, FLJ79289, highly similar to Extracellular matrix protein 1		HUMAN		163	UniRef50_Q16610-3
Uncharacterized protein		CAVPO		184

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U68186 mRNA Translation: AAB88081.1 U68187 mRNA Translation: AAB88082.1 U65932 mRNA Translation: AAB05933.1 U65938 U65937 Genomic DNA Translation: AAB05934.1 AK097046 mRNA Translation: BAG53412.1 AK292435 mRNA Translation: BAF85124.1 AK301369 mRNA Translation: BAG62911.1 AK302279 mRNA Translation: BAG63622.1 AL356356 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53544.1 CH471121 Genomic DNA Translation: EAW53545.1 CH471121 Genomic DNA Translation: EAW53546.1 BC023505 mRNA Translation: AAH23505.1
CCDSⁱ	CCDS55632.1 [Q16610-4] CCDS953.1 [Q16610-1] CCDS954.1 [Q16610-2]
RefSeqⁱ	NP_001189787.1, NM_001202858.1 [Q16610-4] NP_004416.2, NM_004425.3 [Q16610-1] NP_073155.2, NM_022664.2 [Q16610-2]
UniGeneⁱ	Hs.81071

3D structure databases

ProteinModelPortalⁱ	Q16610
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108222, 31 interactors
IntActⁱ	Q16610, 39 interactors
STRINGⁱ	9606.ENSP00000358045

PTM databases

GlyConnectⁱ	1228
iPTMnetⁱ	Q16610
PhosphoSitePlusⁱ	Q16610

Polymorphism and mutation databases

BioMutaⁱ	ECM1
DMDMⁱ	48429255

Proteomic databases

EPDⁱ	Q16610
MaxQBⁱ	Q16610
PaxDbⁱ	Q16610
PeptideAtlasⁱ	Q16610
PRIDEⁱ	Q16610
ProteomicsDBⁱ	60944 60945 [Q16610-2] 60946 [Q16610-3] 60947 [Q16610-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1893
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000346569; ENSP00000271630; ENSG00000143369 [Q16610-2] ENST00000369047; ENSP00000358043; ENSG00000143369 [Q16610-1] ENST00000369049; ENSP00000358045; ENSG00000143369 [Q16610-4]
GeneIDⁱ	1893
KEGGⁱ	hsa:1893
UCSCⁱ	uc001eus.4 human [Q16610-1]

Organism-specific databases

CTDⁱ	1893
DisGeNETⁱ	1893
EuPathDBⁱ	HostDB:ENSG00000143369.14
GeneCardsⁱ	ECM1
HGNCⁱ	HGNC:3153 ECM1
HPAⁱ	HPA027241
MalaCardsⁱ	ECM1
MIMⁱ	247100 phenotype 602201 gene
neXtProtⁱ	NX_Q16610
OpenTargetsⁱ	ENSG00000143369
Orphanetⁱ	530 Lipoid proteinosis
PharmGKBⁱ	PA27598
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVN8 Eukaryota ENOG4111TGN LUCA
GeneTreeⁱ	ENSGT00390000006215
HOVERGENⁱ	HBG005561
InParanoidⁱ	Q16610
OMAⁱ	CCHYPPS
OrthoDBⁱ	EOG091G0NAE
PhylomeDBⁱ	Q16610
TreeFamⁱ	TF330786

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation
SIGNORⁱ	Q16610

Miscellaneous databases

ChiTaRSⁱ	ECM1 human
GeneWikiⁱ	ECM1
GenomeRNAiⁱ	1893
Protein Ontology More...PROⁱ	PR:Q16610
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143369 Expressed in 213 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_ECM1
ExpressionAtlasⁱ	Q16610 baseline and differential
Genevisibleⁱ	Q16610 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008605 ECM1 IPR020858 Serum_albumin-like
PANTHERⁱ	PTHR16776 PTHR16776, 1 hit
Pfamⁱ	View protein in Pfam PF05782 ECM1, 1 hit
SUPFAMⁱ	SSF48552 SSF48552, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ECM1_HUMAN
Accessionⁱ	Q16610Primary (citable) accession number: Q16610 Secondary accession number(s): A8K8S0 Q8IZ60
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	June 7, 2004
	Last modified:	October 10, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16610 (ECM1_HUMAN)

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Extracellular matrix protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ