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Protein

Putative apolipoprotein(a)-like protein 2

Gene

LPAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Putative apolipoprotein(a)-like protein 2
Short name:
Apo(a)-like protein 2
Short name:
Lp(a)-liker protein 2
Alternative name(s):
Apolipoprotein a-related gene C protein
Short name:
Apo(a)rg-C
Gene namesi
Name:LPAL2
Synonyms:APOARGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:21210 LPAL2
MIMi611682 gene
neXtProtiNX_Q16609

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi80350

Polymorphism and mutation databases

DMDMi74739884

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031756622 – 132Putative apolipoprotein(a)-like protein 2Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 105PROSITE-ProRule annotation
Disulfide bondi49 ↔ 88PROSITE-ProRule annotation
Disulfide bondi77 ↔ 100PROSITE-ProRule annotation
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ16609
PRIDEiQ16609
ProteomicsDBi60943

Expressioni

Tissue specificityi

Expressed in liver but not in other tissues tested.1 Publication

Gene expression databases

CleanExiHS_LPAL2

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VAC14Q08AM65EBI-10238012,EBI-2107455

Protein-protein interaction databases

IntActiQ16609, 9 interactors

Structurei

3D structure databases

ProteinModelPortaliQ16609
SMRiQ16609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 105KringlePROSITE-ProRule annotationAdd BLAST79

Domaini

The signal sequence and the kringle domain are highly similar to the apolipoprotein(a) precursor protein. This protein is however much shorter and does not contain any peptidase region.

Keywords - Domaini

Kringle, Signal

Phylogenomic databases

HOVERGENiHBG072100
InParanoidiQ16609
PhylomeDBiQ16609

Family and domain databases

Gene3Di2.40.20.10, 1 hit
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
SMARTiView protein in SMART
SM00130 KR, 1 hit
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKEVVLLL LLFLKSAPTE TGPSVQECYH SNGQSYRGTY FTTVTGRTCQ
60 70 80 90 100
AWSSMTPHQH SRTPEKYPND GLISNYCRNP DCSAGPWCYT TDPNVRWEYC
110 120 130
NLTRCSDDEG TVFVPLTVIP VPSLEDSFIQ VA
Length:132
Mass (Da):14,886
Last modified:November 1, 1996 - v1
Checksum:i3794AD30A586DBBA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05110091T → M. Corresponds to variant dbSNP:rs7749199Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19517 mRNA Translation: AAA85692.1
U19518 mRNA Translation: AAA85693.1
CH471051 Genomic DNA Translation: EAW47597.1
CH471051 Genomic DNA Translation: EAW47598.1
UniGeneiHs.654503

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLPAL2_HUMAN
AccessioniPrimary (citable) accession number: Q16609
Secondary accession number(s): E1P5B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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