Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calcitonin gene-related peptide type 1 receptor

Gene

CALCRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • adrenomedullin binding Source: UniProtKB
  • adrenomedullin receptor activity Source: UniProtKB
  • calcitonin gene-related peptide receptor activity Source: UniProtKB
  • calcitonin receptor activity Source: InterPro
  • G protein-coupled receptor activity Source: ProtInc
  • protein transporter activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.4.12 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CALCRL
Synonyms:CGRPR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000064989.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16709 CALCRL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
114190 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16602

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 146ExtracellularSequence analysisAdd BLAST124
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei147 – 166Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini167 – 173CytoplasmicSequence analysis7
Transmembranei174 – 193Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini194 – 213ExtracellularSequence analysisAdd BLAST20
Transmembranei214 – 236Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini237 – 253CytoplasmicSequence analysisAdd BLAST17
Transmembranei254 – 273Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini274 – 289ExtracellularSequence analysisAdd BLAST16
Transmembranei290 – 313Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini314 – 336CytoplasmicSequence analysisAdd BLAST23
Transmembranei337 – 354Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini355 – 366ExtracellularSequence analysisAdd BLAST12
Transmembranei367 – 388Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini389 – 461CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi72W → A: Strongly reduced affinity for adrenomedullin. 1 Publication1
Mutagenesisi92F → A: Strongly reduced affinity for adrenomedullin. 1 Publication1
Mutagenesisi121W → A: Strongly reduced affinity for adrenomedullin. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
10203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26033

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3798

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
47

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226693507

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001281123 – 461Calcitonin gene-related peptide type 1 receptorAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 74
Disulfide bondi65 ↔ 105
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi88 ↔ 127
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei420PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16602

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16602

PeptideAtlas

More...
PeptideAtlasi
Q16602

PRoteomics IDEntifications database

More...
PRIDEi
Q16602

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60942

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16602

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the lung and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064989 Expressed in 181 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_CALCRL

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16602 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16602 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008070
HPA046515

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115498, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2189 CGRP receptor complex
CPX-2191 Adrenomedullin receptor AM1 complex
CPX-3148 Adrenomedullin receptor AM2 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q16602

Database of interacting proteins

More...
DIPi
DIP-37674N

Protein interaction database and analysis system

More...
IntActi
Q16602, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376177

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16602

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16602

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16602

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16602

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4564 Eukaryota
ENOG410XRS2 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG102129

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16602

KEGG Orthology (KO)

More...
KOi
K04577

Database of Orthologous Groups

More...
OrthoDBi
EOG091G027C

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16602

TreeFam database of animal gene trees

More...
TreeFami
TF315710

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15274 7tmB1_calcitonin_R, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR003289 GPCR_2_CGRP1_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01351 CGRPRECEPTOR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00008 HormR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q16602-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKCTLNFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ
60 70 80 90 100
KIMQDPIQQA EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK
110 120 130 140 150
VTKICDQDGN WFRHPASNRT WTNYTQCNVN THEKVKTALN LFYLTIIGHG
160 170 180 190 200
LSIASLLISL GIFFYFKSLS CQRITLHKNL FFSFVCNSVV TIIHLTAVAN
210 220 230 240 250
NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ
260 270 280 290 300
HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
310 320 330 340 350
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV
360 370 380 390 400
LIPWRPEGKI AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN
410 420 430 440 450
QYKIQFGNSF SNSEALRSAS YTVSTISDGP GYSHDCPSEH LNGKSIHDIE
460
NVLLKPENLY N
Length:461
Mass (Da):52,929
Last modified:April 14, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF98E55E5454767C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EN01E7EN01_HUMAN
Calcitonin gene-related peptide typ...
CALCRL
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZJ4B8ZZJ4_HUMAN
Calcitonin gene-related peptide typ...
CALCRL
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAF84319 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144L → Q in BAF84319 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0548228N → Y1 PublicationCorresponds to variant dbSNP:rs698577Ensembl.1
Natural variantiVAR_04945316F → L. Corresponds to variant dbSNP:rs13391909Ensembl.1
Natural variantiVAR_049454274R → I. Corresponds to variant dbSNP:rs34010553Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L76380 mRNA Translation: AAC41994.1
U17473 mRNA Translation: AAA62158.1
AY389506 mRNA Translation: AAQ91332.1
AK291630 mRNA Translation: BAF84319.1 Different initiation.
AK292998 mRNA Translation: BAF85687.1
AC007319 Genomic DNA Translation: AAY14806.1
AC074020 Genomic DNA Translation: AAY14996.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2293.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC2477

NCBI Reference Sequences

More...
RefSeqi
NP_001258680.1, NM_001271751.1
NP_005786.1, NM_005795.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.470882
Hs.744587

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392370; ENSP00000376177; ENSG00000064989
ENST00000409998; ENSP00000386972; ENSG00000064989
ENST00000410068; ENSP00000387190; ENSG00000064989

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10203

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10203

UCSC genome browser

More...
UCSCi
uc002upv.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76380 mRNA Translation: AAC41994.1
U17473 mRNA Translation: AAA62158.1
AY389506 mRNA Translation: AAQ91332.1
AK291630 mRNA Translation: BAF84319.1 Different initiation.
AK292998 mRNA Translation: BAF85687.1
AC007319 Genomic DNA Translation: AAY14806.1
AC074020 Genomic DNA Translation: AAY14996.1
CCDSiCCDS2293.1
PIRiJC2477
RefSeqiNP_001258680.1, NM_001271751.1
NP_005786.1, NM_005795.5
UniGeneiHs.470882
Hs.744587

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQFX-ray2.60B23-136[»]
3N7PX-ray2.80A/B/C/J23-133[»]
3N7RX-ray2.90A/B23-133[»]
3N7SX-ray2.10A/B23-133[»]
4RWFX-ray1.76A31-116[»]
4RWGX-ray2.44A/B/C31-114[»]
5V6YX-ray2.80A/B/C/D29-144[»]
6D1UX-ray2.05A/B/C29-144[»]
6E3Yelectron microscopy3.30R22-461[»]
ProteinModelPortaliQ16602
SMRiQ16602
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115498, 4 interactors
ComplexPortaliCPX-2189 CGRP receptor complex
CPX-2191 Adrenomedullin receptor AM1 complex
CPX-3148 Adrenomedullin receptor AM2 complex
CORUMiQ16602
DIPiDIP-37674N
IntActiQ16602, 4 interactors
STRINGi9606.ENSP00000376177

Chemistry databases

BindingDBiQ16602
ChEMBLiCHEMBL3798
GuidetoPHARMACOLOGYi47

Protein family/group databases

TCDBi9.A.14.4.12 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ16602
PhosphoSitePlusiQ16602

Polymorphism and mutation databases

DMDMi226693507

Proteomic databases

EPDiQ16602
PaxDbiQ16602
PeptideAtlasiQ16602
PRIDEiQ16602
ProteomicsDBi60942

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10203
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392370; ENSP00000376177; ENSG00000064989
ENST00000409998; ENSP00000386972; ENSG00000064989
ENST00000410068; ENSP00000387190; ENSG00000064989
GeneIDi10203
KEGGihsa:10203
UCSCiuc002upv.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10203
DisGeNETi10203
EuPathDBiHostDB:ENSG00000064989.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CALCRL
HGNCiHGNC:16709 CALCRL
HPAiHPA008070
HPA046515
MIMi114190 gene
neXtProtiNX_Q16602
PharmGKBiPA26033

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOVERGENiHBG102129
InParanoidiQ16602
KOiK04577
OrthoDBiEOG091G027C
PhylomeDBiQ16602
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CALCRL human
EvolutionaryTraceiQ16602

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CALCRL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10203

Protein Ontology

More...
PROi
PR:Q16602

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064989 Expressed in 181 organ(s), highest expression level in lung
CleanExiHS_CALCRL
ExpressionAtlasiQ16602 baseline and differential
GenevisibleiQ16602 HS

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR003289 GPCR_2_CGRP1_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01351 CGRPRECEPTOR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCALRL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16602
Secondary accession number(s): A8K6G5
, A8KAD3, Q53S02, Q53TS5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 14, 2009
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again