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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

CALCRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.By similarity1 Publication

GO - Molecular functioni

  • adrenomedullin binding Source: UniProtKB
  • adrenomedullin receptor activity Source: UniProtKB
  • calcitonin gene-related peptide receptor activity Source: UniProtKB
  • calcitonin receptor activity Source: InterPro
  • G protein-coupled receptor activity Source: ProtInc
  • protein transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Protein family/group databases

TCDBi9.A.14.4.12 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:CALCRL
Synonyms:CGRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000064989.12
HGNCiHGNC:16709 CALCRL
MIMi114190 gene
neXtProtiNX_Q16602

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 146ExtracellularSequence analysisAdd BLAST124
Transmembranei147 – 166Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini167 – 173CytoplasmicSequence analysis7
Transmembranei174 – 193Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini194 – 213ExtracellularSequence analysisAdd BLAST20
Transmembranei214 – 236Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini237 – 253CytoplasmicSequence analysisAdd BLAST17
Transmembranei254 – 273Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini274 – 289ExtracellularSequence analysisAdd BLAST16
Transmembranei290 – 313Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini314 – 336CytoplasmicSequence analysisAdd BLAST23
Transmembranei337 – 354Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini355 – 366ExtracellularSequence analysisAdd BLAST12
Transmembranei367 – 388Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini389 – 461CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi72W → A: Strongly reduced affinity for adrenomedullin. 1 Publication1
Mutagenesisi92F → A: Strongly reduced affinity for adrenomedullin. 1 Publication1
Mutagenesisi121W → A: Strongly reduced affinity for adrenomedullin. 1 Publication1

Organism-specific databases

DisGeNETi10203
PharmGKBiPA26033

Chemistry databases

ChEMBLiCHEMBL3798
GuidetoPHARMACOLOGYi47

Polymorphism and mutation databases

DMDMi226693507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001281123 – 461Calcitonin gene-related peptide type 1 receptorAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 74
Disulfide bondi65 ↔ 105
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi88 ↔ 127
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei420PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ16602
PaxDbiQ16602
PeptideAtlasiQ16602
PRIDEiQ16602
ProteomicsDBi60942

PTM databases

iPTMnetiQ16602
PhosphoSitePlusiQ16602

Expressioni

Tissue specificityi

Predominantly expressed in the lung and heart.

Gene expression databases

BgeeiENSG00000064989 Expressed in 181 organ(s), highest expression level in lung
CleanExiHS_CALCRL
ExpressionAtlasiQ16602 baseline and differential
GenevisibleiQ16602 HS

Organism-specific databases

HPAiHPA008070
HPA046515

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115498, 4 interactors
ComplexPortaliCPX-2189 CGRP receptor complex
CPX-2191 Adrenomedullin receptor AM1 complex
CPX-3148 Adrenomedullin receptor AM2 complex
CORUMiQ16602
DIPiDIP-37674N
IntActiQ16602, 4 interactors
STRINGi9606.ENSP00000376177

Chemistry databases

BindingDBiQ16602

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16602
SMRiQ16602
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16602

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOVERGENiHBG102129
InParanoidiQ16602
KOiK04577
OrthoDBiEOG091G027C
PhylomeDBiQ16602
TreeFamiTF315710

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR003289 GPCR_2_CGRP1_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01351 CGRPRECEPTOR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q16602-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKKCTLNFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ
60 70 80 90 100
KIMQDPIQQA EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK
110 120 130 140 150
VTKICDQDGN WFRHPASNRT WTNYTQCNVN THEKVKTALN LFYLTIIGHG
160 170 180 190 200
LSIASLLISL GIFFYFKSLS CQRITLHKNL FFSFVCNSVV TIIHLTAVAN
210 220 230 240 250
NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ
260 270 280 290 300
HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
310 320 330 340 350
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV
360 370 380 390 400
LIPWRPEGKI AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN
410 420 430 440 450
QYKIQFGNSF SNSEALRSAS YTVSTISDGP GYSHDCPSEH LNGKSIHDIE
460
NVLLKPENLY N
Length:461
Mass (Da):52,929
Last modified:April 14, 2009 - v2
Checksum:iAF98E55E5454767C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EN01E7EN01_HUMAN
Calcitonin gene-related peptide typ...
CALCRL
77Annotation score:
B8ZZJ4B8ZZJ4_HUMAN
Calcitonin gene-related peptide typ...
CALCRL
37Annotation score:

Sequence cautioni

The sequence BAF84319 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144L → Q in BAF84319 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0548228N → Y1 PublicationCorresponds to variant dbSNP:rs698577Ensembl.1
Natural variantiVAR_04945316F → L. Corresponds to variant dbSNP:rs13391909Ensembl.1
Natural variantiVAR_049454274R → I. Corresponds to variant dbSNP:rs34010553Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76380 mRNA Translation: AAC41994.1
U17473 mRNA Translation: AAA62158.1
AY389506 mRNA Translation: AAQ91332.1
AK291630 mRNA Translation: BAF84319.1 Different initiation.
AK292998 mRNA Translation: BAF85687.1
AC007319 Genomic DNA Translation: AAY14806.1
AC074020 Genomic DNA Translation: AAY14996.1
CCDSiCCDS2293.1
PIRiJC2477
RefSeqiNP_001258680.1, NM_001271751.1
NP_005786.1, NM_005795.5
UniGeneiHs.470882
Hs.744587

Genome annotation databases

EnsembliENST00000392370; ENSP00000376177; ENSG00000064989
ENST00000409998; ENSP00000386972; ENSG00000064989
ENST00000410068; ENSP00000387190; ENSG00000064989
GeneIDi10203
KEGGihsa:10203
UCSCiuc002upv.6 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76380 mRNA Translation: AAC41994.1
U17473 mRNA Translation: AAA62158.1
AY389506 mRNA Translation: AAQ91332.1
AK291630 mRNA Translation: BAF84319.1 Different initiation.
AK292998 mRNA Translation: BAF85687.1
AC007319 Genomic DNA Translation: AAY14806.1
AC074020 Genomic DNA Translation: AAY14996.1
CCDSiCCDS2293.1
PIRiJC2477
RefSeqiNP_001258680.1, NM_001271751.1
NP_005786.1, NM_005795.5
UniGeneiHs.470882
Hs.744587

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQFX-ray2.60B23-136[»]
3N7PX-ray2.80A/B/C/J23-133[»]
3N7RX-ray2.90A/B23-133[»]
3N7SX-ray2.10A/B23-133[»]
4RWFX-ray1.76A31-116[»]
4RWGX-ray2.44A/B/C31-114[»]
5V6YX-ray2.80A/B/C/D29-144[»]
6D1UX-ray2.05A/B/C29-144[»]
6E3Yelectron microscopy3.30R22-461[»]
ProteinModelPortaliQ16602
SMRiQ16602
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115498, 4 interactors
ComplexPortaliCPX-2189 CGRP receptor complex
CPX-2191 Adrenomedullin receptor AM1 complex
CPX-3148 Adrenomedullin receptor AM2 complex
CORUMiQ16602
DIPiDIP-37674N
IntActiQ16602, 4 interactors
STRINGi9606.ENSP00000376177

Chemistry databases

BindingDBiQ16602
ChEMBLiCHEMBL3798
GuidetoPHARMACOLOGYi47

Protein family/group databases

TCDBi9.A.14.4.12 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ16602
PhosphoSitePlusiQ16602

Polymorphism and mutation databases

DMDMi226693507

Proteomic databases

EPDiQ16602
PaxDbiQ16602
PeptideAtlasiQ16602
PRIDEiQ16602
ProteomicsDBi60942

Protocols and materials databases

DNASUi10203
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392370; ENSP00000376177; ENSG00000064989
ENST00000409998; ENSP00000386972; ENSG00000064989
ENST00000410068; ENSP00000387190; ENSG00000064989
GeneIDi10203
KEGGihsa:10203
UCSCiuc002upv.6 human

Organism-specific databases

CTDi10203
DisGeNETi10203
EuPathDBiHostDB:ENSG00000064989.12
GeneCardsiCALCRL
HGNCiHGNC:16709 CALCRL
HPAiHPA008070
HPA046515
MIMi114190 gene
neXtProtiNX_Q16602
PharmGKBiPA26033
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
HOVERGENiHBG102129
InParanoidiQ16602
KOiK04577
OrthoDBiEOG091G027C
PhylomeDBiQ16602
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Miscellaneous databases

ChiTaRSiCALCRL human
EvolutionaryTraceiQ16602
GeneWikiiCALCRL
GenomeRNAii10203
PROiPR:Q16602
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064989 Expressed in 181 organ(s), highest expression level in lung
CleanExiHS_CALCRL
ExpressionAtlasiQ16602 baseline and differential
GenevisibleiQ16602 HS

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR003289 GPCR_2_CGRP1_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01351 CGRPRECEPTOR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCALRL_HUMAN
AccessioniPrimary (citable) accession number: Q16602
Secondary accession number(s): A8K6G5
, A8KAD3, Q53S02, Q53TS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 14, 2009
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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