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Protein

Zinc finger protein 239

Gene

ZNF239

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • metal ion binding Source: UniProtKB-KW
  • proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
  • RNA binding Source: ProtInc
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ16600

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 239
Alternative name(s):
Zinc finger protein HOK-2
Zinc finger protein MOK-2
Gene namesi
Name:ZNF239
Synonyms:HOK2, MOK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000196793.13
HGNCiHGNC:13031 ZNF239
MIMi601069 gene
neXtProtiNX_Q16600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8187
OpenTargetsiENSG00000196793
PharmGKBiPA37609

Polymorphism and mutation databases

BioMutaiZNF239
DMDMi251757424

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474801 – 458Zinc finger protein 239Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ16600
MaxQBiQ16600
PaxDbiQ16600
PeptideAtlasiQ16600
PRIDEiQ16600
ProteomicsDBi60941

PTM databases

iPTMnetiQ16600
PhosphoSitePlusiQ16600

Expressioni

Gene expression databases

BgeeiENSG00000196793 Expressed in 132 organ(s), highest expression level in endothelial cell
CleanExiHS_ZNF239
GenevisibleiQ16600 HS

Organism-specific databases

HPAiHPA030843
HPA046679

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ15EBI-8787052,EBI-739624

Protein-protein interaction databases

BioGridi113831, 2 interactors
IntActiQ16600, 6 interactors
STRINGi9606.ENSP00000307774

Structurei

3D structure databases

ProteinModelPortaliQ16600
SMRiQ16600
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 229C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ16600
OMAiNCGKILN
OrthoDBiEOG091G02KC
PhylomeDBiQ16600
TreeFamiTF350845

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

Q16600-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTITGSQD CIVNHRGEVD GEPELDISPC QQWGEASSPI SRNRDSVMTL
60 70 80 90 100
QSGCFENIES ETYLPLKVSS QIDTQDSSVK FCKNEPQDHQ ESRRLFVMEE
110 120 130 140 150
STERKVIKGE SCSENLQVKL VSDGQELASP LLNGEATCQN GQLKESLDPI
160 170 180 190 200
DCNCKDIHGW KSQVVSCSQQ RAHTEEKPCD HNNCGKILNT SPDGHPYEKI
210 220 230 240 250
HTAEKQYECS QCGKNFSQSS ELLLHQRDHT EEKPYKCEQC GKGFTRSSSL
260 270 280 290 300
LIHQAVHTDE KPYKCDKCGK GFTRSSSLLI HHAVHTGEKP YKCDKCGKGF
310 320 330 340 350
SQSSKLHIHQ RVHTGEKPYE CEECGMSFSQ RSNLHIHQRV HTGERPYKCG
360 370 380 390 400
ECGKGFSQSS NLHIHRCIHT GEKPYQCYEC GKGFSQSSDL RIHLRVHTGE
410 420 430 440 450
KPYHCGKCGK GFSQSSKLLI HQRVHTGEKP YECSKCGKGF SQSSNLHIHQ

RVHKKDPR
Length:458
Mass (Da):51,591
Last modified:July 7, 2009 - v3
Checksum:i94753A790CB5F559
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti340V → D in CAA57637 (PubMed:8587123).Curated1
Sequence conflicti340V → D in CAA57638 (PubMed:8587123).Curated1
Sequence conflicti448I → S in CAA57637 (PubMed:8587123).Curated1
Sequence conflicti448I → S in CAA57638 (PubMed:8587123).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024205172A → G1 PublicationCorresponds to variant dbSNP:rs2230660Ensembl.1
Natural variantiVAR_024206209C → G1 PublicationCorresponds to variant dbSNP:rs2230661Ensembl.1
Natural variantiVAR_025536266D → E1 PublicationCorresponds to variant dbSNP:rs1128865Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82125 mRNA Translation: CAA57637.1
X82126 Genomic DNA Translation: CAA57638.1
AL450326 Genomic DNA No translation available.
BC026030 mRNA Translation: AAH26030.1
CCDSiCCDS41502.1
RefSeqiNP_001092752.1, NM_001099282.1
NP_001092753.1, NM_001099283.1
NP_001092754.1, NM_001099284.1
NP_001311276.1, NM_001324347.1
NP_001311277.1, NM_001324348.1
NP_001311278.1, NM_001324349.1
NP_001311279.1, NM_001324350.1
NP_001311280.1, NM_001324351.1
NP_005665.2, NM_005674.2
XP_005271889.1, XM_005271832.2
XP_006718066.1, XM_006718003.3
XP_011538540.1, XM_011540238.2
UniGeneiHs.25040

Genome annotation databases

EnsembliENST00000306006; ENSP00000307774; ENSG00000196793
ENST00000374446; ENSP00000363569; ENSG00000196793
ENST00000426961; ENSP00000398202; ENSG00000196793
ENST00000535642; ENSP00000443907; ENSG00000196793
GeneIDi8187
KEGGihsa:8187
UCSCiuc001jaw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82125 mRNA Translation: CAA57637.1
X82126 Genomic DNA Translation: CAA57638.1
AL450326 Genomic DNA No translation available.
BC026030 mRNA Translation: AAH26030.1
CCDSiCCDS41502.1
RefSeqiNP_001092752.1, NM_001099282.1
NP_001092753.1, NM_001099283.1
NP_001092754.1, NM_001099284.1
NP_001311276.1, NM_001324347.1
NP_001311277.1, NM_001324348.1
NP_001311278.1, NM_001324349.1
NP_001311279.1, NM_001324350.1
NP_001311280.1, NM_001324351.1
NP_005665.2, NM_005674.2
XP_005271889.1, XM_005271832.2
XP_006718066.1, XM_006718003.3
XP_011538540.1, XM_011540238.2
UniGeneiHs.25040

3D structure databases

ProteinModelPortaliQ16600
SMRiQ16600
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113831, 2 interactors
IntActiQ16600, 6 interactors
STRINGi9606.ENSP00000307774

PTM databases

iPTMnetiQ16600
PhosphoSitePlusiQ16600

Polymorphism and mutation databases

BioMutaiZNF239
DMDMi251757424

Proteomic databases

EPDiQ16600
MaxQBiQ16600
PaxDbiQ16600
PeptideAtlasiQ16600
PRIDEiQ16600
ProteomicsDBi60941

Protocols and materials databases

DNASUi8187
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306006; ENSP00000307774; ENSG00000196793
ENST00000374446; ENSP00000363569; ENSG00000196793
ENST00000426961; ENSP00000398202; ENSG00000196793
ENST00000535642; ENSP00000443907; ENSG00000196793
GeneIDi8187
KEGGihsa:8187
UCSCiuc001jaw.5 human

Organism-specific databases

CTDi8187
DisGeNETi8187
EuPathDBiHostDB:ENSG00000196793.13
GeneCardsiZNF239
HGNCiHGNC:13031 ZNF239
HPAiHPA030843
HPA046679
MIMi601069 gene
neXtProtiNX_Q16600
OpenTargetsiENSG00000196793
PharmGKBiPA37609
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00870000136402
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ16600
OMAiNCGKILN
OrthoDBiEOG091G02KC
PhylomeDBiQ16600
TreeFamiTF350845

Enzyme and pathway databases

SIGNORiQ16600

Miscellaneous databases

ChiTaRSiZNF239 human
GeneWikiiZNF239
GenomeRNAii8187
PROiPR:Q16600
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196793 Expressed in 132 organ(s), highest expression level in endothelial cell
CleanExiHS_ZNF239
GenevisibleiQ16600 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN239_HUMAN
AccessioniPrimary (citable) accession number: Q16600
Secondary accession number(s): Q5T1G9, Q8TAS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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