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UniProtKB - Q16589 (CCNG2_HUMAN)
Protein
Cyclin-G2
Gene
CCNG2
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in growth regulation and in negative regulation of cell cycle progression.
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- mitotic cell cycle phase transition Source: GO_Central
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division, Mitosis |
Enzyme and pathway databases
PathwayCommonsi | Q16589 |
Reactomei | R-HSA-9617828, FOXO-mediated transcription of cell cycle genes |
SignaLinki | Q16589 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-G2 |
Gene namesi | Name:CCNG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1593, CCNG2 |
MIMi | 603203, gene |
neXtProti | NX_Q16589 |
VEuPathDBi | HostDB:ENSG00000138764 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- nucleus Source: GO_Central
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: GO_Central
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 901 |
OpenTargetsi | ENSG00000138764 |
PharmGKBi | PA26158 |
Miscellaneous databases
Pharosi | Q16589, Tbio |
Genetic variation databases
BioMutai | CCNG2 |
DMDMi | 9087132 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080469 | 1 – 344 | Cyclin-G2Add BLAST | 344 |
Proteomic databases
MassIVEi | Q16589 |
PaxDbi | Q16589 |
PeptideAtlasi | Q16589 |
PRIDEi | Q16589 |
ProteomicsDBi | 4002 60937 [Q16589-1] |
PTM databases
GlyGeni | Q16589, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q16589 |
PhosphoSitePlusi | Q16589 |
Expressioni
Tissue specificityi
High levels in cerebellum, thymus, spleen and prostate. Low levels in skeletal muscle.
Developmental stagei
Expression levels increase through the cell cycle to peak in the mid/late-S phase and decrease during G2/M phase.
Inductioni
Activated by actinomycin-D induced DNA damage.
Gene expression databases
Bgeei | ENSG00000138764, Expressed in amniotic fluid and 248 other tissues |
ExpressionAtlasi | Q16589, baseline and differential |
Genevisiblei | Q16589, HS |
Organism-specific databases
HPAi | ENSG00000138764, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107341, 24 interactors |
IntActi | Q16589, 2 interactors |
MINTi | Q16589 |
STRINGi | 9606.ENSP00000315743 |
Miscellaneous databases
RNActi | Q16589, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 301 – 320 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000156423 |
HOGENOMi | CLU_062642_0_1_1 |
InParanoidi | Q16589 |
OMAi | CEDMMSS |
PhylomeDBi | Q16589 |
TreeFami | TF101007 |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR028895, CCNG2 IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF60, PTHR10177:SF60, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q16589-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKDLGAEHLA GHEGVQLLGL LNVYLEQEER FQPREKGLSL IEATPENDNT
60 70 80 90 100
LCPGLRNAKV EDLRSLANFF GSCTETFVLA VNILDRFLAL MKVKPKHLSC
110 120 130 140 150
IGVCSFLLAA RIVEEDCNIP STHDVIRISQ CKCTASDIKR MEKIISEKLH
160 170 180 190 200
YELEATTALN FLHLYHTIIL CHTSERKEIL SLDKLEAQLK ACNCRLIFSK
210 220 230 240 250
AKPSVLALCL LNLEVETLKS VELLEILLLV KKHSKINDTE FFYWRELVSK
260 270 280 290 300
CLAEYSSPEC CKPDLKKLVW IVSRRTAQNL HNSYYSVPEL PTIPEGGCFD
310 320 330 340
ESESEDSCED MSCGEESLSS SPPSDQECTF FFNFKVAQTL CFPS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RHI3 | D6RHI3_HUMAN | Cyclin-G2 | CCNG2 | 160 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 127 | R → W in CAG46997 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014333 | 4 | L → V1 PublicationCorresponds to variant dbSNP:rs4150050Ensembl. | 1 | |
Natural variantiVAR_014334 | 28 | E → G1 PublicationCorresponds to variant dbSNP:rs4150051EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053893 | 304 – 344 | SEDSC…LCFPS → R in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U47414 mRNA Translation: AAC50689.1 L49506 mRNA Translation: AAC41978.1 AF549495 Genomic DNA Translation: AAN40704.1 AK292029 mRNA Translation: BAF84718.1 AK293899 mRNA Translation: BAG57286.1 CR542181 mRNA Translation: CAG46978.1 CR542200 mRNA Translation: CAG46997.1 BT019503 mRNA Translation: AAV38310.1 AC008638 Genomic DNA No translation available. AC092674 Genomic DNA No translation available. AC104771 Genomic DNA No translation available. AC108144 Genomic DNA No translation available. AC112716 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05812.1 |
CCDSi | CCDS3581.1 [Q16589-1] |
RefSeqi | NP_004345.1, NM_004354.2 [Q16589-1] XP_011530700.1, XM_011532398.1 [Q16589-1] XP_011530701.1, XM_011532399.2 [Q16589-1] |
Genome annotation databases
Ensembli | ENST00000316355.10; ENSP00000315743.5; ENSG00000138764.15 ENST00000395640.5; ENSP00000379002.1; ENSG00000138764.15 ENST00000502280.5; ENSP00000424665.1; ENSG00000138764.15 ENST00000509972.1; ENSP00000426476.1; ENSG00000138764.15 [Q16589-2] |
GeneIDi | 901 |
KEGGi | hsa:901 |
MANE-Selecti | ENST00000316355.10; ENSP00000315743.5; NM_004354.3; NP_004345.1 |
UCSCi | uc003hkn.5, human [Q16589-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U47414 mRNA Translation: AAC50689.1 L49506 mRNA Translation: AAC41978.1 AF549495 Genomic DNA Translation: AAN40704.1 AK292029 mRNA Translation: BAF84718.1 AK293899 mRNA Translation: BAG57286.1 CR542181 mRNA Translation: CAG46978.1 CR542200 mRNA Translation: CAG46997.1 BT019503 mRNA Translation: AAV38310.1 AC008638 Genomic DNA No translation available. AC092674 Genomic DNA No translation available. AC104771 Genomic DNA No translation available. AC108144 Genomic DNA No translation available. AC112716 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05812.1 |
CCDSi | CCDS3581.1 [Q16589-1] |
RefSeqi | NP_004345.1, NM_004354.2 [Q16589-1] XP_011530700.1, XM_011532398.1 [Q16589-1] XP_011530701.1, XM_011532399.2 [Q16589-1] |
3D structure databases
AlphaFoldDBi | Q16589 |
SMRi | Q16589 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107341, 24 interactors |
IntActi | Q16589, 2 interactors |
MINTi | Q16589 |
STRINGi | 9606.ENSP00000315743 |
PTM databases
GlyGeni | Q16589, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q16589 |
PhosphoSitePlusi | Q16589 |
Genetic variation databases
BioMutai | CCNG2 |
DMDMi | 9087132 |
Proteomic databases
MassIVEi | Q16589 |
PaxDbi | Q16589 |
PeptideAtlasi | Q16589 |
PRIDEi | Q16589 |
ProteomicsDBi | 4002 60937 [Q16589-1] |
Protocols and materials databases
Antibodypediai | 13540, 135 antibodies from 26 providers |
DNASUi | 901 |
Genome annotation databases
Ensembli | ENST00000316355.10; ENSP00000315743.5; ENSG00000138764.15 ENST00000395640.5; ENSP00000379002.1; ENSG00000138764.15 ENST00000502280.5; ENSP00000424665.1; ENSG00000138764.15 ENST00000509972.1; ENSP00000426476.1; ENSG00000138764.15 [Q16589-2] |
GeneIDi | 901 |
KEGGi | hsa:901 |
MANE-Selecti | ENST00000316355.10; ENSP00000315743.5; NM_004354.3; NP_004345.1 |
UCSCi | uc003hkn.5, human [Q16589-1] |
Organism-specific databases
CTDi | 901 |
DisGeNETi | 901 |
GeneCardsi | CCNG2 |
HGNCi | HGNC:1593, CCNG2 |
HPAi | ENSG00000138764, Low tissue specificity |
MIMi | 603203, gene |
neXtProti | NX_Q16589 |
OpenTargetsi | ENSG00000138764 |
PharmGKBi | PA26158 |
VEuPathDBi | HostDB:ENSG00000138764 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0653, Eukaryota |
GeneTreei | ENSGT00940000156423 |
HOGENOMi | CLU_062642_0_1_1 |
InParanoidi | Q16589 |
OMAi | CEDMMSS |
PhylomeDBi | Q16589 |
TreeFami | TF101007 |
Enzyme and pathway databases
PathwayCommonsi | Q16589 |
Reactomei | R-HSA-9617828, FOXO-mediated transcription of cell cycle genes |
SignaLinki | Q16589 |
Miscellaneous databases
BioGRID-ORCSi | 901, 12 hits in 1081 CRISPR screens |
ChiTaRSi | CCNG2, human |
GeneWikii | CCNG2 |
GenomeRNAii | 901 |
Pharosi | Q16589, Tbio |
PROi | PR:Q16589 |
RNActi | Q16589, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138764, Expressed in amniotic fluid and 248 other tissues |
ExpressionAtlasi | Q16589, baseline and differential |
Genevisiblei | Q16589, HS |
Family and domain databases
CDDi | cd00043, CYCLIN, 1 hit |
InterProi | View protein in InterPro IPR028895, CCNG2 IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit PTHR10177:SF60, PTHR10177:SF60, 1 hit |
Pfami | View protein in Pfam PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 1 hit |
SUPFAMi | SSF47954, SSF47954, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNG2_HUMAN | |
Accessioni | Q16589Primary (citable) accession number: Q16589 Secondary accession number(s): B4DF25, Q6FGA7, Q6FGC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families