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Entry version 191 (10 Feb 2021)
Sequence version 3 (23 Mar 2010)
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Protein

Zinc finger protein 74

Gene

ZNF74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in RNA metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri248 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q16587

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 74
Alternative name(s):
Zinc finger protein 520
hZNF7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF74
Synonyms:ZNF520
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13144, ZNF74

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
194548, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16587

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000185252.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7625

Open Targets

More...
OpenTargetsi
ENSG00000185252

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37718

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16587, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF74

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495055

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473831 – 644Zinc finger protein 74Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki582Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16587

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16587

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16587

PeptideAtlas

More...
PeptideAtlasi
Q16587

PRoteomics IDEntifications database

More...
PRIDEi
Q16587

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
6037
60933 [Q16587-1]
60934 [Q16587-2]
60935 [Q16587-3]
60936 [Q16587-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16587

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16587

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the fetal brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185252, Expressed in cortical plate and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16587, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16587, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185252, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
113444, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q16587, 4 interactors

Molecular INTeraction database

More...
MINTi
Q16587

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483077

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16587, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16587

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 114KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri248 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162000

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16587

Identification of Orthologs from Complete Genome Data

More...
OMAi
GGPCPEW

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16587

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q16587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV
60 70 80 90 100
DFTQEEWGQL DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE
110 120 130 140 150
PWSMQREVPR GPCPEWELKA VPSQQQGICK EEPAQEPIME RPLGGAQAWG
160 170 180 190 200
RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP LRCPLFAQQR VPEGGPLLDT
210 220 230 240 250
RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG AGAGEGEFVC
260 270 280 290 300
GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG
310 320 330 340 350
EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH
360 370 380 390 400
LRVHTGEKPY RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH
410 420 430 440 450
SSLTVHEKIH SGDKPFKCSD CEKAFNSRSR LTLHQRTHTG EKPFKCADCG
460 470 480 490 500
KGFSCHAYLL VHRRIHSGEK PFKCNECGKA FSSHAYLIVH RRIHTGEKPF
510 520 530 540 550
DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN HCLIKHQKIH
560 570 580 590 600
SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG
610 620 630 640
SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN
Length:644
Mass (Da):72,207
Last modified:March 23, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87E5AA122BBC82F1
GO
Isoform 1 (identifier: Q16587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:573
Mass (Da):64,291
Checksum:i446498FAA8BE73E7
GO
Isoform 3 (identifier: Q16587-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-114: Missing.

Show »
Length:612
Mass (Da):68,593
Checksum:iCBF6A98883C7FA99
GO
Isoform 4 (identifier: Q16587-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA

Show »
Length:572
Mass (Da):64,056
Checksum:i7AAF6926643B4E12
GO
Isoform 5 (identifier: Q16587-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
     179-644: Missing.

Show »
Length:178
Mass (Da):17,930
Checksum:i99A6F8B0619384A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MDQ6B5MDQ6_HUMAN
Zinc finger protein 74
ZNF74
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3V1C9J3V1_HUMAN
Zinc finger protein 74
ZNF74
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDT0F8WDT0_HUMAN
Zinc finger protein 74
ZNF74
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF21777 differs from that shown. Reason: Frameshift.Curated
The sequence AAF21778 differs from that shown. Reason: Frameshift.Curated
The sequence AAF21779 differs from that shown. Reason: Frameshift.Curated
The sequence AAF21780 differs from that shown. Reason: Frameshift.Curated
The sequence CAA50632 differs from that shown. Reason: Frameshift.Curated
The sequence CAA63379 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171V → A in AAH13395 (PubMed:15489334).Curated1
Sequence conflicti517V → M in CAA63379 (PubMed:8663113).Curated1
Sequence conflicti517V → M in CAA50632 (PubMed:8268910).Curated1
Sequence conflicti517V → M in AAF21777 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21778 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21779 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21780 (Ref. 4) Curated1
Sequence conflicti569S → P in BAH13068 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012993117E → K2 PublicationsCorresponds to variant dbSNP:rs3747076Ensembl.1
Natural variantiVAR_012994623 – 624KL → NF. 2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0068931 – 82MEIPA…NLLAL → MPSPPFSPRA in isoform 4. CuratedAdd BLAST82
Alternative sequenceiVSP_0068911 – 71Missing in isoform 1. 3 PublicationsAdd BLAST71
Alternative sequenceiVSP_04553012 – 178ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_00689283 – 114Missing in isoform 3. CuratedAdd BLAST32
Alternative sequenceiVSP_045531179 – 644Missing in isoform 5. 1 PublicationAdd BLAST466

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X92715 mRNA Translation: CAA63379.1 Frameshift.
X71623 mRNA Translation: CAA50632.1 Frameshift.
CR456616 mRNA Translation: CAG30502.1
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21777.1 Frameshift.
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21778.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21779.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21780.1 Frameshift.
AK299569 mRNA Translation: BAH13068.1
AC007731 Genomic DNA No translation available.
BC013395 mRNA Translation: AAH13395.1
BC056902 mRNA No translation available.
X63182 Genomic DNA Translation: CAC16149.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42982.1 [Q16587-1]
CCDS58794.1 [Q16587-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
I39311

NCBI Reference Sequences

More...
RefSeqi
NP_001243452.1, NM_001256523.1 [Q16587-5]
NP_001243453.1, NM_001256524.1 [Q16587-1]
NP_001243454.1, NM_001256525.1 [Q16587-2]
NP_003417.2, NM_003426.3 [Q16587-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400451; ENSP00000383301; ENSG00000185252 [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252 [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252 [Q16587-3]
ENST00000611540; ENSP00000483077; ENSG00000185252 [Q16587-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7625

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7625

UCSC genome browser

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UCSCi
uc002zsh.5, human [Q16587-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92715 mRNA Translation: CAA63379.1 Frameshift.
X71623 mRNA Translation: CAA50632.1 Frameshift.
CR456616 mRNA Translation: CAG30502.1
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21777.1 Frameshift.
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21778.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21779.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21780.1 Frameshift.
AK299569 mRNA Translation: BAH13068.1
AC007731 Genomic DNA No translation available.
BC013395 mRNA Translation: AAH13395.1
BC056902 mRNA No translation available.
X63182 Genomic DNA Translation: CAC16149.1
CCDSiCCDS42982.1 [Q16587-1]
CCDS58794.1 [Q16587-5]
PIRiI39311
RefSeqiNP_001243452.1, NM_001256523.1 [Q16587-5]
NP_001243453.1, NM_001256524.1 [Q16587-1]
NP_001243454.1, NM_001256525.1 [Q16587-2]
NP_003417.2, NM_003426.3 [Q16587-1]

3D structure databases

SMRiQ16587
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113444, 21 interactors
IntActiQ16587, 4 interactors
MINTiQ16587
STRINGi9606.ENSP00000483077

PTM databases

iPTMnetiQ16587
PhosphoSitePlusiQ16587

Genetic variation databases

BioMutaiZNF74
DMDMi292495055

Proteomic databases

jPOSTiQ16587
MassIVEiQ16587
PaxDbiQ16587
PeptideAtlasiQ16587
PRIDEiQ16587
ProteomicsDBi6037
60933 [Q16587-1]
60934 [Q16587-2]
60935 [Q16587-3]
60936 [Q16587-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
316, 73 antibodies

The DNASU plasmid repository

More...
DNASUi
7625

Genome annotation databases

EnsembliENST00000400451; ENSP00000383301; ENSG00000185252 [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252 [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252 [Q16587-3]
ENST00000611540; ENSP00000483077; ENSG00000185252 [Q16587-1]
GeneIDi7625
KEGGihsa:7625
UCSCiuc002zsh.5, human [Q16587-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7625
DisGeNETi7625

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF74
HGNCiHGNC:13144, ZNF74
HPAiENSG00000185252, Low tissue specificity
MIMi194548, gene
neXtProtiNX_Q16587
OpenTargetsiENSG00000185252
PharmGKBiPA37718
VEuPathDBiHostDB:ENSG00000185252.17

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162000
HOGENOMiCLU_002678_44_5_1
InParanoidiQ16587
OMAiGGPCPEW
OrthoDBi1318335at2759
PhylomeDBiQ16587
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ16587
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
7625, 22 hits in 896 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ZNF74

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7625
PharosiQ16587, Tbio

Protein Ontology

More...
PROi
PR:Q16587
RNActiQ16587, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185252, Expressed in cortical plate and 185 other tissues
ExpressionAtlasiQ16587, baseline and differential
GenevisibleiQ16587, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF74_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16587
Secondary accession number(s): B5MCE3
, B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: February 10, 2021
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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