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Protein

Zinc finger protein 74

Gene

ZNF74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in RNA metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri248 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • regulation of transcription, DNA-templated Source: ProtInc

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 74
Alternative name(s):
Zinc finger protein 520
hZNF7
Gene namesi
Name:ZNF74
Synonyms:ZNF520
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000185252.17
HGNCiHGNC:13144 ZNF74
MIMi194548 gene
neXtProtiNX_Q16587

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7625
OpenTargetsiENSG00000185252
PharmGKBiPA37718

Polymorphism and mutation databases

BioMutaiZNF74
DMDMi292495055

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473831 – 644Zinc finger protein 74Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki582Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ16587
PaxDbiQ16587
PeptideAtlasiQ16587
PRIDEiQ16587
ProteomicsDBi60933
60934 [Q16587-2]
60935 [Q16587-3]
60936 [Q16587-4]

PTM databases

iPTMnetiQ16587
PhosphoSitePlusiQ16587

Expressioni

Tissue specificityi

Highly expressed in the fetal brain.

Gene expression databases

BgeeiENSG00000185252 Expressed in 165 organ(s), highest expression level in adrenal tissue
CleanExiHS_ZNF74
ExpressionAtlasiQ16587 baseline and differential
GenevisibleiQ16587 HS

Organism-specific databases

HPAiHPA003354

Interactioni

Protein-protein interaction databases

BioGridi113444, 20 interactors
IntActiQ16587, 3 interactors
MINTiQ16587
STRINGi9606.ENSP00000349098

Structurei

3D structure databases

ProteinModelPortaliQ16587
SMRiQ16587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 114KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri248 – 270C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri276 – 298C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri416 – 438C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri444 – 466C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri472 – 494C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri500 – 522C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri528 – 550C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri556 – 578C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150958
HOGENOMiHOG000074097
HOVERGENiHBG018163
InParanoidiQ16587
KOiK09228
OMAiKLLCVVQ
OrthoDBiEOG091G02KC
PhylomeDBiQ16587
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q16587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV
60 70 80 90 100
DFTQEEWGQL DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE
110 120 130 140 150
PWSMQREVPR GPCPEWELKA VPSQQQGICK EEPAQEPIME RPLGGAQAWG
160 170 180 190 200
RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP LRCPLFAQQR VPEGGPLLDT
210 220 230 240 250
RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG AGAGEGEFVC
260 270 280 290 300
GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG
310 320 330 340 350
EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH
360 370 380 390 400
LRVHTGEKPY RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH
410 420 430 440 450
SSLTVHEKIH SGDKPFKCSD CEKAFNSRSR LTLHQRTHTG EKPFKCADCG
460 470 480 490 500
KGFSCHAYLL VHRRIHSGEK PFKCNECGKA FSSHAYLIVH RRIHTGEKPF
510 520 530 540 550
DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN HCLIKHQKIH
560 570 580 590 600
SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG
610 620 630 640
SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN
Length:644
Mass (Da):72,207
Last modified:March 23, 2010 - v3
Checksum:i87E5AA122BBC82F1
GO
Isoform 1 (identifier: Q16587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Show »
Length:573
Mass (Da):64,291
Checksum:i446498FAA8BE73E7
GO
Isoform 3 (identifier: Q16587-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-114: Missing.

Show »
Length:612
Mass (Da):68,593
Checksum:iCBF6A98883C7FA99
GO
Isoform 4 (identifier: Q16587-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MEIPAPEPEK...LENYQNLLAL → MPSPPFSPRA

Show »
Length:572
Mass (Da):64,056
Checksum:i7AAF6926643B4E12
GO
Isoform 5 (identifier: Q16587-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-178: ALSSQDPALS...AMVWDVPVEE → GIGEFQGCGC...AGHTQERPGH
     179-644: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):17,930
Checksum:i99A6F8B0619384A6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MDQ6B5MDQ6_HUMAN
Zinc finger protein 74
ZNF74
212Annotation score:
C9J3V1C9J3V1_HUMAN
Zinc finger protein 74
ZNF74
50Annotation score:
F8WDT0F8WDT0_HUMAN
Zinc finger protein 74
ZNF74
69Annotation score:

Sequence cautioni

The sequence AAF21777 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence AAF21778 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence AAF21779 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence AAF21780 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence CAA50632 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated
The sequence CAA63379 differs from that shown. Reason: Frameshift at positions 164 and 173.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171V → A in AAH13395 (PubMed:15489334).Curated1
Sequence conflicti517V → M in CAA63379 (PubMed:8663113).Curated1
Sequence conflicti517V → M in CAA50632 (PubMed:8268910).Curated1
Sequence conflicti517V → M in AAF21777 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21778 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21779 (Ref. 4) Curated1
Sequence conflicti517V → M in AAF21780 (Ref. 4) Curated1
Sequence conflicti569S → P in BAH13068 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012993117E → K2 PublicationsCorresponds to variant dbSNP:rs3747076Ensembl.1
Natural variantiVAR_012994623 – 624KL → NF. 2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068931 – 82MEIPA…NLLAL → MPSPPFSPRA in isoform 4. CuratedAdd BLAST82
Alternative sequenceiVSP_0068911 – 71Missing in isoform 1. 3 PublicationsAdd BLAST71
Alternative sequenceiVSP_04553012 – 178ALSSQ…VPVEE → GIGEFQGCGCGLHPGGVGST RLPSEGLVPGCDVGELPEPS CPRTSTAQARCDLSSGTRRG AMEHAEGSPQRALSRMGAEG GALSTAGHLQRRTGPGAHHG AAPRRGAGVGAPGRCSAEES GCALGARTCHGLGRPCRGIP PQVSPLRPATRSRGGTLAGH TQERPGH in isoform 5. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_00689283 – 114Missing in isoform 3. CuratedAdd BLAST32
Alternative sequenceiVSP_045531179 – 644Missing in isoform 5. 1 PublicationAdd BLAST466

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92715 mRNA Translation: CAA63379.1 Frameshift.
X71623 mRNA Translation: CAA50632.1 Frameshift.
CR456616 mRNA Translation: CAG30502.1
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21777.1 Frameshift.
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21778.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21779.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21780.1 Frameshift.
AK299569 mRNA Translation: BAH13068.1
AC007731 Genomic DNA No translation available.
BC013395 mRNA Translation: AAH13395.1
BC056902 mRNA No translation available.
X63182 Genomic DNA Translation: CAC16149.1
CCDSiCCDS42982.1 [Q16587-1]
CCDS58794.1 [Q16587-5]
PIRiI39311
RefSeqiNP_001243452.1, NM_001256523.1 [Q16587-5]
NP_001243453.1, NM_001256524.1 [Q16587-1]
NP_001243454.1, NM_001256525.1 [Q16587-2]
NP_003417.2, NM_003426.3 [Q16587-1]
UniGeneiHs.517418

Genome annotation databases

EnsembliENST00000400451; ENSP00000383301; ENSG00000185252 [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252 [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252 [Q16587-3]
ENST00000611540; ENSP00000483077; ENSG00000185252 [Q16587-1]
GeneIDi7625
KEGGihsa:7625
UCSCiuc002zsh.5 human [Q16587-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92715 mRNA Translation: CAA63379.1 Frameshift.
X71623 mRNA Translation: CAA50632.1 Frameshift.
CR456616 mRNA Translation: CAG30502.1
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21777.1 Frameshift.
AF072567, AF072557, AF072562 Genomic DNA Translation: AAF21778.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21779.1 Frameshift.
AF072567, AF072562 Genomic DNA Translation: AAF21780.1 Frameshift.
AK299569 mRNA Translation: BAH13068.1
AC007731 Genomic DNA No translation available.
BC013395 mRNA Translation: AAH13395.1
BC056902 mRNA No translation available.
X63182 Genomic DNA Translation: CAC16149.1
CCDSiCCDS42982.1 [Q16587-1]
CCDS58794.1 [Q16587-5]
PIRiI39311
RefSeqiNP_001243452.1, NM_001256523.1 [Q16587-5]
NP_001243453.1, NM_001256524.1 [Q16587-1]
NP_001243454.1, NM_001256525.1 [Q16587-2]
NP_003417.2, NM_003426.3 [Q16587-1]
UniGeneiHs.517418

3D structure databases

ProteinModelPortaliQ16587
SMRiQ16587
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113444, 20 interactors
IntActiQ16587, 3 interactors
MINTiQ16587
STRINGi9606.ENSP00000349098

PTM databases

iPTMnetiQ16587
PhosphoSitePlusiQ16587

Polymorphism and mutation databases

BioMutaiZNF74
DMDMi292495055

Proteomic databases

EPDiQ16587
PaxDbiQ16587
PeptideAtlasiQ16587
PRIDEiQ16587
ProteomicsDBi60933
60934 [Q16587-2]
60935 [Q16587-3]
60936 [Q16587-4]

Protocols and materials databases

DNASUi7625
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400451; ENSP00000383301; ENSG00000185252 [Q16587-1]
ENST00000403682; ENSP00000384750; ENSG00000185252 [Q16587-5]
ENST00000405993; ENSP00000385855; ENSG00000185252 [Q16587-3]
ENST00000611540; ENSP00000483077; ENSG00000185252 [Q16587-1]
GeneIDi7625
KEGGihsa:7625
UCSCiuc002zsh.5 human [Q16587-1]

Organism-specific databases

CTDi7625
DisGeNETi7625
EuPathDBiHostDB:ENSG00000185252.17
GeneCardsiZNF74
HGNCiHGNC:13144 ZNF74
HPAiHPA003354
MIMi194548 gene
neXtProtiNX_Q16587
OpenTargetsiENSG00000185252
PharmGKBiPA37718
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150958
HOGENOMiHOG000074097
HOVERGENiHBG018163
InParanoidiQ16587
KOiK09228
OMAiKLLCVVQ
OrthoDBiEOG091G02KC
PhylomeDBiQ16587
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GeneWikiiZNF74
GenomeRNAii7625
PROiPR:Q16587
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185252 Expressed in 165 organ(s), highest expression level in adrenal tissue
CleanExiHS_ZNF74
ExpressionAtlasiQ16587 baseline and differential
GenevisibleiQ16587 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF74_HUMAN
AccessioniPrimary (citable) accession number: Q16587
Secondary accession number(s): B5MCE3
, B7Z5Y2, Q6IBV2, Q6PJP1, Q9UC04, Q9UF05, Q9UF06, Q9UF07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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