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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3AR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  • complement component C3a receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
R-HSA-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3AR1
Synonyms:AZ3B, C3R1, HNFAG09
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000171860.4
HGNCiHGNC:1319 C3AR1
MIMi605246 gene
neXtProtiNX_Q16581

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 46Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini47 – 57CytoplasmicSequence analysisAdd BLAST11
Transmembranei58 – 80Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini81 – 96ExtracellularSequence analysisAdd BLAST16
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 340ExtracellularSequence analysisAdd BLAST180
Transmembranei341 – 360Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini361 – 377CytoplasmicSequence analysisAdd BLAST17
Transmembranei378 – 400Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini401 – 417ExtracellularSequence analysisAdd BLAST17
Transmembranei418 – 438Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini439 – 482CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi719
OpenTargetsiENSG00000171860
PharmGKBiPA25898

Chemistry databases

ChEMBLiCHEMBL4761
GuidetoPHARMACOLOGYi31

Polymorphism and mutation databases

BioMutaiC3AR1
DMDMi37538305

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692021 – 482C3a anaphylatoxin chemotactic receptorAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Modified residuei174Sulfotyrosine1 Publication1
Modified residuei184Sulfotyrosine1 Publication1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266O-linked (GalNAc...) serine1 Publication1
Modified residuei318Sulfotyrosine1 Publication1
Modified residuei459PhosphoserineBy similarity1
Modified residuei463PhosphothreonineBy similarity1

Post-translational modificationi

Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.1 Publication
O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiQ16581
PeptideAtlasiQ16581
PRIDEiQ16581
ProteomicsDBi60928

PTM databases

GlyConnecti811
iPTMnetiQ16581
PhosphoSitePlusiQ16581
UniCarbKBiQ16581

Expressioni

Tissue specificityi

Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.

Gene expression databases

BgeeiENSG00000171860
CleanExiHS_C3AR1
ExpressionAtlasiQ16581 baseline and differential
GenevisibleiQ16581 HS

Organism-specific databases

HPAiCAB009405

Interactioni

Protein-protein interaction databases

BioGridi107180, 101 interactors
STRINGi9606.ENSP00000302079

Chemistry databases

BindingDBiQ16581

Structurei

3D structure databases

ProteinModelPortaliQ16581
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUVF Eukaryota
ENOG410YBJQ LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000261616
HOVERGENiHBG002433
InParanoidiQ16581
KOiK04009
OMAiTVWFLHL
OrthoDBiEOG091G0AEJ
PhylomeDBiQ16581
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR001644 Anaphtx_C3AR1
IPR002234 Anphylx_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF28 PTHR24225:SF28, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR01104 ANPHYLATOXNR
PR01060 C3ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q16581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL
60 70 80 90 100
KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS
110 120 130 140 150
IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA
160 170 180 190 200
FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI
210 220 230 240 250
VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT
260 270 280 290 300
SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA
310 320 330 340 350
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV
360 370 380 390 400
IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS
410 420 430 440 450
LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI
460 470 480
QGILEAAFSE ELTRSTHCPS NNVISERNST TV
Length:482
Mass (Da):53,864
Last modified:October 3, 2003 - v2
Checksum:i287E219D98CED203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151F → C in AAC50657 (PubMed:8702752).Curated1
Sequence conflicti203P → R in AAC50374 (PubMed:8605247).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019164136V → A1 PublicationCorresponds to variant dbSNP:rs11567806Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28488 mRNA Translation: AAC50374.1
Z73157 mRNA Translation: CAA97504.1
U62027 mRNA Translation: AAC50657.1
AB065870 Genomic DNA Translation: BAC06088.1
AY268431 Genomic DNA Translation: AAP23198.1
AY455929 Genomic DNA Translation: AAR13862.1
BC020742 mRNA Translation: AAH20742.1
CCDSiCCDS8588.1
PIRiS65766
RefSeqiNP_001313404.1, NM_001326475.1
NP_001313406.1, NM_001326477.1
NP_004045.1, NM_004054.3
UniGeneiHs.504656
Hs.591148

Genome annotation databases

EnsembliENST00000307637; ENSP00000302079; ENSG00000171860
GeneIDi719
KEGGihsa:719
UCSCiuc001qtv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiC3AR_HUMAN
AccessioniPrimary (citable) accession number: Q16581
Secondary accession number(s): O43771, Q92868
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2003
Last modified: June 20, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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