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UniProtKB - Q16576 (RBBP7_HUMAN)

Protein

Histone-binding protein RBBP7

Gene

RBBP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionChaperone, Chromatin regulator, Repressor
Biological processDNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8951664 Neddylation
R-HSA-8953750 Transcriptional Regulation by E2F6
SignaLinkiQ16576

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-binding protein RBBP7
Alternative name(s):
Histone acetyltransferase type B subunit 2
Nucleosome-remodeling factor subunit RBAP46
Retinoblastoma-binding protein 7
Short name:
RBBP-7
Retinoblastoma-binding protein p46
Gene namesi
Name:RBBP7
Synonyms:RBAP46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102054.17
HGNCiHGNC:9890 RBBP7
MIMi300825 gene
neXtProtiNX_Q16576

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5931
OpenTargetsiENSG00000102054
PharmGKBiPA34254

Chemistry databases

ChEMBLiCHEMBL3301388

Polymorphism and mutation databases

BioMutaiRBBP7
DMDMi2494891

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000511952 – 425Histone-binding protein RBBP7Add BLAST424
Isoform 2 (identifier: Q16576-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei4N6-acetyllysine; alternateCombined sources1
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residuei10PhosphothreonineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei119N6-acetyllysineBy similarity1
Cross-linki155Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei159N6-acetyllysine; alternateBy similarity1
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei354PhosphoserineCombined sources1
Isoform 2 (identifier: Q16576-2)
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ16576
PaxDbiQ16576
PeptideAtlasiQ16576
PRIDEiQ16576
ProteomicsDBi60926
60927 [Q16576-2]

PTM databases

iPTMnetiQ16576
PhosphoSitePlusiQ16576
SwissPalmiQ16576

Miscellaneous databases

PMAP-CutDBiQ16576

Expressioni

Gene expression databases

BgeeiENSG00000102054 Expressed in 231 organ(s), highest expression level in right adrenal gland
CleanExiHS_RBBP7
ExpressionAtlasiQ16576 baseline and differential
GenevisibleiQ16576 HS

Organism-specific databases

HPAiCAB037084
HPA060710
HPA060724

Interactioni

Subunit structurei

Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12 (PubMed:12435631). The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (PubMed:7503932, PubMed:10220405). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1. Interacts with CENPA (PubMed:25556658).17 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi111866, 172 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-688 NuRF chromatin remodelling complex
CPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ16576
DIPiDIP-436N
IntActiQ16576, 100 interactors
MINTiQ16576
STRINGi9606.ENSP00000369424

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16576
SMRiQ16576
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16576

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 122WD 1Add BLAST76
Repeati128 – 173WD 2Add BLAST46
Repeati181 – 217WD 3Add BLAST37
Repeati228 – 269WD 4Add BLAST42
Repeati275 – 312WD 5Add BLAST38
Repeati318 – 369WD 6Add BLAST52
Repeati376 – 403WD 7Add BLAST28

Sequence similaritiesi

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0264 Eukaryota
ENOG410XNU9 LUCA
GeneTreeiENSGT00570000079069
HOGENOMiHOG000160330
HOVERGENiHBG053236
InParanoidiQ16576
KOiK11659
OMAiSEDRVAN
OrthoDBiEOG091G0A20
PhylomeDBiQ16576
TreeFamiTF106485

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16576-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP 
        60         70         80         90        100
EVTKPEGKDY ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD 
       110        120        130        140        150
KGEFGGFGSV TGKIECEIKI NHEGEVNRAR YMPQNPHIIA TKTPSSDVLV 
       160        170        180        190        200
FDYTKHPAKP DPSGECNPDL RLRGHQKEGY GLSWNSNLSG HLLSASDDHT 
       210        220        230        240        250
VCLWDINAGP KEGKIVDAKA IFTGHSAVVE DVAWHLLHES LFGSVADDQK 
       260        270        280        290        300
LMIWDTRSNT TSKPSHLVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW 
       310        320        330        340        350
DLRNLKLKLH TFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG 
       360        370        380        390        400
EEQSAEDAED GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI 
       410        420 
WQMAENIYND EESDVTTSEL EGQGS
Length:425
Mass (Da):47,820
Last modified:November 1, 1997 - v1
Checksum:i1A4B4CD1A8E96815
GO
Isoform 2 (identifier: Q16576-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MASKEM → MAAEAGVVGAGASPDGDWRDQACGLLLHVHLSSRLGRAAPVRTGRHLRTV

Note: No experimental confirmation available.Combined sources
Show »
Length:469
Mass (Da):52,314
Checksum:iD668D0B6D5715261
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PC52E9PC52_HUMAN
Histone-binding protein RBBP7
RBBP7
416Annotation score:
Q5JP01Q5JP01_HUMAN
Histone-binding protein RBBP7
RBBP7
285Annotation score:
Q5JP02Q5JP02_HUMAN
Histone-binding protein RBBP7
RBBP7
175Annotation score:
Q5JNZ6Q5JNZ6_HUMAN
Histone-binding protein RBBP7
RBBP7
85Annotation score:
C9JAJ9C9JAJ9_HUMAN
Histone-binding protein RBBP7
RBBP7
37Annotation score:
C9J7L0C9J7L0_HUMAN
Histone-binding protein RBBP7
RBBP7
67Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430161 – 6MASKEM → MAAEAGVVGAGASPDGDWRD QACGLLLHVHLSSRLGRAAP VRTGRHLRTV in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35143 mRNA Translation: AAC50231.1
X72841 mRNA Translation: CAA51360.1
AK091911 mRNA Translation: BAG52439.1
AL929302 Genomic DNA No translation available.
CCDSiCCDS14179.1 [Q16576-1]
CCDS56598.1 [Q16576-2]
PIRiI39181
RefSeqiNP_001185648.1, NM_001198719.1 [Q16576-2]
NP_002884.1, NM_002893.3 [Q16576-1]
UniGeneiHs.495755

Genome annotation databases

EnsembliENST00000380084; ENSP00000369424; ENSG00000102054 [Q16576-2]
ENST00000380087; ENSP00000369427; ENSG00000102054 [Q16576-1]
GeneIDi5931
KEGGihsa:5931
UCSCiuc004cxs.3 human [Q16576-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35143 mRNA Translation: AAC50231.1
X72841 mRNA Translation: CAA51360.1
AK091911 mRNA Translation: BAG52439.1
AL929302 Genomic DNA No translation available.
CCDSiCCDS14179.1 [Q16576-1]
CCDS56598.1 [Q16576-2]
PIRiI39181
RefSeqiNP_001185648.1, NM_001198719.1 [Q16576-2]
NP_002884.1, NM_002893.3 [Q16576-1]
UniGeneiHs.495755

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CFSX-ray2.40B1-411[»]
3CFVX-ray2.60A/B1-411[»]
ProteinModelPortaliQ16576
SMRiQ16576
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111866, 172 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-688 NuRF chromatin remodelling complex
CPX-880 MBD2/NuRD nucleosome remodeling and deacetylase complex
CPX-922 MBD3/NuRD nucleosome remodeling and deacetylase complex
CORUMiQ16576
DIPiDIP-436N
IntActiQ16576, 100 interactors
MINTiQ16576
STRINGi9606.ENSP00000369424

Chemistry databases

ChEMBLiCHEMBL3301388

PTM databases

iPTMnetiQ16576
PhosphoSitePlusiQ16576
SwissPalmiQ16576

Polymorphism and mutation databases

BioMutaiRBBP7
DMDMi2494891

Proteomic databases

EPDiQ16576
PaxDbiQ16576
PeptideAtlasiQ16576
PRIDEiQ16576
ProteomicsDBi60926
60927 [Q16576-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380084; ENSP00000369424; ENSG00000102054 [Q16576-2]
ENST00000380087; ENSP00000369427; ENSG00000102054 [Q16576-1]
GeneIDi5931
KEGGihsa:5931
UCSCiuc004cxs.3 human [Q16576-1]

Organism-specific databases

CTDi5931
DisGeNETi5931
EuPathDBiHostDB:ENSG00000102054.17
GeneCardsiRBBP7
HGNCiHGNC:9890 RBBP7
HPAiCAB037084
HPA060710
HPA060724
MIMi300825 gene
neXtProtiNX_Q16576
OpenTargetsiENSG00000102054
PharmGKBiPA34254
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0264 Eukaryota
ENOG410XNU9 LUCA
GeneTreeiENSGT00570000079069
HOGENOMiHOG000160330
HOVERGENiHBG053236
InParanoidiQ16576
KOiK11659
OMAiSEDRVAN
OrthoDBiEOG091G0A20
PhylomeDBiQ16576
TreeFamiTF106485

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214847 HATs acetylate histones
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8951664 Neddylation
R-HSA-8953750 Transcriptional Regulation by E2F6
SignaLinkiQ16576

Miscellaneous databases

ChiTaRSiRBBP7 human
EvolutionaryTraceiQ16576
GeneWikiiRBBP7
GenomeRNAii5931
PMAP-CutDBiQ16576
PROiPR:Q16576
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102054 Expressed in 231 organ(s), highest expression level in right adrenal gland
CleanExiHS_RBBP7
ExpressionAtlasiQ16576 baseline and differential
GenevisibleiQ16576 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRBBP7_HUMAN
AccessioniPrimary (citable) accession number: Q16576
Secondary accession number(s): Q5JP00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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