UniProtKB - Q16576 (RBBP7_HUMAN)
Histone-binding protein RBBP7
RBBP7
Functioni
GO - Molecular functioni
- RNA binding Source: Ensembl
GO - Biological processi
- cellular heat acclimation Source: UniProtKB
- CENP-A containing nucleosome assembly Source: Reactome
- DNA replication Source: UniProtKB-KW
- negative regulation of cell growth Source: UniProtKB
- negative regulation of G0 to G1 transition Source: Reactome
- negative regulation of gene expression, epigenetic Source: Reactome
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- post-translational protein modification Source: Reactome
- regulation of signal transduction by p53 class mediator Source: Reactome
- response to steroid hormone Source: Ensembl
Keywordsi
Molecular function | Chaperone, Chromatin regulator, Repressor |
Biological process | DNA replication, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q16576 |
Reactomei | R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214841, PKMTs methylate histone lysines R-HSA-3214847, HATs acetylate histones R-HSA-3214858, RMTs methylate histone arginines R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-8951664, Neddylation R-HSA-8953750, Transcriptional Regulation by E2F6 R-HSA-9609690, HCMV Early Events |
SignaLinki | Q16576 |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-binding protein RBBP7Alternative name(s): Histone acetyltransferase type B subunit 2 Nucleosome-remodeling factor subunit RBAP46 Retinoblastoma-binding protein 7 Short name: RBBP-7 Retinoblastoma-binding protein p46 |
Gene namesi | Name:RBBP7 Synonyms:RBAP46 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102054.17 |
HGNCi | HGNC:9890, RBBP7 |
MIMi | 300825, gene |
neXtProti | NX_Q16576 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: HPA
Nucleus
- ESC/E(Z) complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- NuRD complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5931 |
OpenTargetsi | ENSG00000102054 |
PharmGKBi | PA34254 |
Miscellaneous databases
Pharosi | Q16576, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3301388 |
Polymorphism and mutation databases
BioMutai | RBBP7 |
DMDMi | 2494891 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | ||||
ChainiPRO_0000051195 | 2 – 425 | Histone-binding protein RBBP7Add BLAST | 424 | ||
Isoform 2 (identifier: Q16576-2) | |||||
Initiator methioninei | RemovedCombined sources |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 3 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 4 | N6-acetyllysine; alternateCombined sources | 1 | ||
Cross-linki | 4 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | |||
Cross-linki | 4 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate | |||
Modified residuei | 10 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 95 | PhosphoserineCombined sources | 1 | ||
Cross-linki | 101 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 119 | N6-acetyllysineBy similarity | 1 | ||
Cross-linki | 155 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 159 | N6-acetyllysine; alternateBy similarity | 1 | ||
Cross-linki | 159 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | |||
Modified residuei | 354 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: Q16576-2) | |||||
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 13 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q16576 |
jPOSTi | Q16576 |
MassIVEi | Q16576 |
PaxDbi | Q16576 |
PeptideAtlasi | Q16576 |
PRIDEi | Q16576 |
ProteomicsDBi | 60926 [Q16576-1] 60927 [Q16576-2] |
PTM databases
iPTMneti | Q16576 |
MetOSitei | Q16576 |
PhosphoSitePlusi | Q16576 |
SwissPalmi | Q16576 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102054, Expressed in right adrenal gland and 242 other tissues |
ExpressionAtlasi | Q16576, baseline and differential |
Genevisiblei | Q16576, HS |
Organism-specific databases
HPAi | ENSG00000102054, Low tissue specificity |
Interactioni
Subunit structurei
Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (PubMed:18571423). Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2.
Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12 (PubMed:12435631). The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7.
Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) (PubMed:7503932, PubMed:10220405).
Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP.
Interacts with BRCA1, HDAC7 and SUV39H1.
Interacts with CENPA (PubMed:25556658).
17 PublicationsBinary interactionsi
Hide detailsQ16576
Protein-protein interaction databases
BioGRIDi | 111866, 233 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant CPX-688, NuRF chromatin remodelling complex CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q16576 |
DIPi | DIP-436N |
IntActi | Q16576, 141 interactors |
MINTi | Q16576 |
STRINGi | 9606.ENSP00000369424 |
Miscellaneous databases
RNActi | Q16576, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q16576 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16576 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 47 – 122 | WD 1Add BLAST | 76 | |
Repeati | 128 – 173 | WD 2Add BLAST | 46 | |
Repeati | 181 – 217 | WD 3Add BLAST | 37 | |
Repeati | 228 – 269 | WD 4Add BLAST | 42 | |
Repeati | 275 – 312 | WD 5Add BLAST | 38 | |
Repeati | 318 – 369 | WD 6Add BLAST | 52 | |
Repeati | 376 – 403 | WD 7Add BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0264, Eukaryota |
GeneTreei | ENSGT00940000154748 |
InParanoidi | Q16576 |
OMAi | PITDFNW |
OrthoDBi | 831322at2759 |
PhylomeDBi | Q16576 |
TreeFami | TF106485 |
Family and domain databases
DisProti | DP01282 |
Gene3Di | 2.130.10.10, 1 hit |
IDEALi | IID00084 |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR022052, Histone-bd_RBBP4_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12265, CAF1C_H4-bd, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP
60 70 80 90 100
EVTKPEGKDY ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD
110 120 130 140 150
KGEFGGFGSV TGKIECEIKI NHEGEVNRAR YMPQNPHIIA TKTPSSDVLV
160 170 180 190 200
FDYTKHPAKP DPSGECNPDL RLRGHQKEGY GLSWNSNLSG HLLSASDDHT
210 220 230 240 250
VCLWDINAGP KEGKIVDAKA IFTGHSAVVE DVAWHLLHES LFGSVADDQK
260 270 280 290 300
LMIWDTRSNT TSKPSHLVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW
310 320 330 340 350
DLRNLKLKLH TFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG
360 370 380 390 400
EEQSAEDAED GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI
410 420
WQMAENIYND EESDVTTSEL EGQGS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PC52 | E9PC52_HUMAN | Histone-binding protein RBBP7 | RBBP7 | 416 | Annotation score: | ||
Q5JP01 | Q5JP01_HUMAN | Histone-binding protein RBBP7 | RBBP7 | 285 | Annotation score: | ||
Q5JNZ6 | Q5JNZ6_HUMAN | Histone-binding protein RBBP7 | RBBP7 | 85 | Annotation score: | ||
Q5JP02 | Q5JP02_HUMAN | Histone-binding protein RBBP7 | RBBP7 | 175 | Annotation score: | ||
C9JAJ9 | C9JAJ9_HUMAN | Histone-binding protein RBBP7 | RBBP7 | 37 | Annotation score: | ||
C9J7L0 | C9J7L0_HUMAN | Histone-binding protein RBBP7 | RBBP7 | 67 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043016 | 1 – 6 | MASKEM → MAAEAGVVGAGASPDGDWRD QACGLLLHVHLSSRLGRAAP VRTGRHLRTV in isoform 2. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35143 mRNA Translation: AAC50231.1 X72841 mRNA Translation: CAA51360.1 AK091911 mRNA Translation: BAG52439.1 AL929302 Genomic DNA No translation available. |
CCDSi | CCDS14179.1 [Q16576-1] CCDS56598.1 [Q16576-2] |
PIRi | I39181 |
RefSeqi | NP_001185648.1, NM_001198719.1 [Q16576-2] NP_002884.1, NM_002893.3 [Q16576-1] |
Genome annotation databases
Ensembli | ENST00000380084; ENSP00000369424; ENSG00000102054 [Q16576-2] ENST00000380087; ENSP00000369427; ENSG00000102054 [Q16576-1] |
GeneIDi | 5931 |
KEGGi | hsa:5931 |
UCSCi | uc004cxs.3, human [Q16576-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35143 mRNA Translation: AAC50231.1 X72841 mRNA Translation: CAA51360.1 AK091911 mRNA Translation: BAG52439.1 AL929302 Genomic DNA No translation available. |
CCDSi | CCDS14179.1 [Q16576-1] CCDS56598.1 [Q16576-2] |
PIRi | I39181 |
RefSeqi | NP_001185648.1, NM_001198719.1 [Q16576-2] NP_002884.1, NM_002893.3 [Q16576-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3CFS | X-ray | 2.40 | B | 1-411 | [»] | |
3CFV | X-ray | 2.60 | A/B | 1-411 | [»] | |
SMRi | Q16576 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111866, 233 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant CPX-688, NuRF chromatin remodelling complex CPX-880, MBD2/NuRD nucleosome remodeling and deacetylase complex CPX-922, MBD3/NuRD nucleosome remodeling and deacetylase complex |
CORUMi | Q16576 |
DIPi | DIP-436N |
IntActi | Q16576, 141 interactors |
MINTi | Q16576 |
STRINGi | 9606.ENSP00000369424 |
Chemistry databases
ChEMBLi | CHEMBL3301388 |
PTM databases
iPTMneti | Q16576 |
MetOSitei | Q16576 |
PhosphoSitePlusi | Q16576 |
SwissPalmi | Q16576 |
Polymorphism and mutation databases
BioMutai | RBBP7 |
DMDMi | 2494891 |
Proteomic databases
EPDi | Q16576 |
jPOSTi | Q16576 |
MassIVEi | Q16576 |
PaxDbi | Q16576 |
PeptideAtlasi | Q16576 |
PRIDEi | Q16576 |
ProteomicsDBi | 60926 [Q16576-1] 60927 [Q16576-2] |
Protocols and materials databases
Antibodypediai | 24054, 357 antibodies |
Genome annotation databases
Ensembli | ENST00000380084; ENSP00000369424; ENSG00000102054 [Q16576-2] ENST00000380087; ENSP00000369427; ENSG00000102054 [Q16576-1] |
GeneIDi | 5931 |
KEGGi | hsa:5931 |
UCSCi | uc004cxs.3, human [Q16576-1] |
Organism-specific databases
CTDi | 5931 |
DisGeNETi | 5931 |
EuPathDBi | HostDB:ENSG00000102054.17 |
GeneCardsi | RBBP7 |
HGNCi | HGNC:9890, RBBP7 |
HPAi | ENSG00000102054, Low tissue specificity |
MIMi | 300825, gene |
neXtProti | NX_Q16576 |
OpenTargetsi | ENSG00000102054 |
PharmGKBi | PA34254 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0264, Eukaryota |
GeneTreei | ENSGT00940000154748 |
InParanoidi | Q16576 |
OMAi | PITDFNW |
OrthoDBi | 831322at2759 |
PhylomeDBi | Q16576 |
TreeFami | TF106485 |
Enzyme and pathway databases
PathwayCommonsi | Q16576 |
Reactomei | R-HSA-212300, PRC2 methylates histones and DNA R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-3214815, HDACs deacetylate histones R-HSA-3214841, PKMTs methylate histone lysines R-HSA-3214847, HATs acetylate histones R-HSA-3214858, RMTs methylate histone arginines R-HSA-427389, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-606279, Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-8951664, Neddylation R-HSA-8953750, Transcriptional Regulation by E2F6 R-HSA-9609690, HCMV Early Events |
SignaLinki | Q16576 |
Miscellaneous databases
BioGRID-ORCSi | 5931, 24 hits in 475 CRISPR screens |
ChiTaRSi | RBBP7, human |
EvolutionaryTracei | Q16576 |
GeneWikii | RBBP7 |
GenomeRNAii | 5931 |
Pharosi | Q16576, Tbio |
PROi | PR:Q16576 |
RNActi | Q16576, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102054, Expressed in right adrenal gland and 242 other tissues |
ExpressionAtlasi | Q16576, baseline and differential |
Genevisiblei | Q16576, HS |
Family and domain databases
DisProti | DP01282 |
Gene3Di | 2.130.10.10, 1 hit |
IDEALi | IID00084 |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR022052, Histone-bd_RBBP4_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12265, CAF1C_H4-bd, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBBP7_HUMAN | |
Accessioni | Q16576Primary (citable) accession number: Q16576 Secondary accession number(s): Q5JP00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM