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Entry version 168 (13 Feb 2019)
Sequence version 3 (07 Jun 2005)
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Protein

Atypical chemokine receptor 1

Gene

ACKR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Atypical chemokine receptor 1
Alternative name(s):
Duffy antigen/chemokine receptor
Fy glycoprotein
Short name:
GpFy
Glycoprotein D
Plasmodium vivax receptor
CD_antigen: CD234
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACKR1
Synonyms:DARC, FY, GPD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000213088.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4035 ACKR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613665 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16570

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 63ExtracellularSequence analysisAdd BLAST63
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei64 – 84Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini85 – 95CytoplasmicSequence analysisAdd BLAST11
Transmembranei96 – 116Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini117 – 129ExtracellularSequence analysisAdd BLAST13
Transmembranei130 – 153Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini154 – 166CytoplasmicSequence analysisAdd BLAST13
Transmembranei167 – 187Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini188 – 207ExtracellularSequence analysisAdd BLAST20
Transmembranei208 – 228Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini229 – 244CytoplasmicSequence analysisAdd BLAST16
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 287ExtracellularSequence analysisAdd BLAST22
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 336CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2532

MalaCards human disease database

More...
MalaCardsi
ACKR1
MIMi110700 phenotype
611162 phenotype
611862 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000213088

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28451

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2321626

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACKR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67476970

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001525851 – 336Atypical chemokine receptor 1Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi16N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 2761 Publication
Disulfide bondi129 ↔ 1951 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16570

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16570

PeptideAtlas

More...
PeptideAtlasi
Q16570

PRoteomics IDEntifications database

More...
PRIDEi
Q16570

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60923
60924 [Q16570-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16570

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16570

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213088 Expressed in 193 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16570 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16570 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016421
HPA017672

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PVDRP222903EBI-15935975,EBI-15935953From Plasmodium vivax (strain Salvador I).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108808, 3 interactors

Database of interacting proteins

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DIPi
DIP-3783N

Protein interaction database and analysis system

More...
IntActi
Q16570, 2 interactors

Molecular INTeraction database

More...
MINTi
Q16570

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357103

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NUUX-ray1.95C16-43[»]
4NUVX-ray2.60C/D14-43[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16570

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16570

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHK3 Eukaryota
ENOG41119V5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006372

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051419

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16570

KEGG Orthology (KO)

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KOi
K06574

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCVATPL

Database of Orthologous Groups

More...
OrthoDBi
1194550at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16570

TreeFam database of animal gene trees

More...
TreeFami
TF105419

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15010 7tmA_ACKR1_DARC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005384 Duffy_chemokine_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR14181 PTHR14181, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 2 (identifier: Q16570-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP
60 70 80 90 100
CHSCNLLDDS ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA
110 120 130 140 150
QLAVGSALFS IVVPVLAPGL GSTRSSALCS LGYCVWYGSA FAQALLLGCH
160 170 180 190 200
ASLGHRLGAG QVPGLTLGLT VGIWGVAALL TLPVTLASGA SGGLCTLIYS
210 220 230 240 250
TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG PWMNILWAWF
260 270 280 290 300
IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT
310 320 330
PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS
Length:336
Mass (Da):35,553
Last modified:June 7, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3F2A3E71D972E2D
GO
Isoform 1 (identifier: Q16570-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MGNCLHR → MASSGYVLQ

Show »
Length:338
Mass (Da):35,678
Checksum:i5AC412B001F07F5B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JY94Q5JY94_HUMAN
Atypical chemokine receptor 1
ACKR1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

DARC is responsible for the Duffy blood group system (FY) [MIMi:110700]. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and Asp-42 to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by the malarial parasite Plasmodium vivax. This allele is found predominantly in population of African origin [MIMi:611162].
Genetic variations in DARC define the white blood cell count quantitative trait locus 1 (WBCQ1) [MIMi:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, used to determine evidence of acute inflammation or infection. Peripheral WBC is the sum of several cell types including neutrophils and lymphocytes, which are the most common types of WBC, as well as less common cell types such as eosinophils, basophils, and monocytes. Elevated WBC has been associated with risk of coronary heart disease, cancer, and all-cause mortality. White blood cell levels have widespread clinical applications including assessment of patients undergoing chemotherapy and evaluation of infection.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00348042G → D Antigen Fy(b). 5 PublicationsCorresponds to variant dbSNP:rs12075EnsemblClinVar.1
Natural variantiVAR_01506889R → C Antigen Fy(x). 3 PublicationsCorresponds to variant dbSNP:rs34599082EnsemblClinVar.1
Natural variantiVAR_015069100A → T2 PublicationsCorresponds to variant dbSNP:rs13962Ensembl.1
Natural variantiVAR_044116203L → Q. Corresponds to variant dbSNP:rs3027020Ensembl.1
Natural variantiVAR_044117326S → F2 PublicationsCorresponds to variant dbSNP:rs17851570Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0013231 – 7MGNCLHR → MASSGYVLQ in isoform 1. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U01839 mRNA Translation: AAC50055.1
X85785 Genomic DNA Translation: CAA59770.1
S76830 Genomic DNA Translation: AAB33239.1
AF055992 Genomic DNA Translation: AAC72301.1
AF030521 mRNA Translation: AAD20435.1
AM887935 Genomic DNA Translation: CAP12644.1
AL035403 Genomic DNA No translation available.
BC017817 mRNA Translation: AAH17817.1
AF100634 Genomic DNA Translation: AAF02415.1
AF100634 Genomic DNA Translation: AAF02416.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1183.1 [Q16570-1]
CCDS44252.1 [Q16570-2]

Protein sequence database of the Protein Information Resource

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PIRi
I52608

NCBI Reference Sequences

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RefSeqi
NP_001116423.1, NM_001122951.2 [Q16570-2]
NP_002027.2, NM_002036.3 [Q16570-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.153381

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368121; ENSP00000357103; ENSG00000213088 [Q16570-2]
ENST00000368122; ENSP00000357104; ENSG00000213088 [Q16570-1]
ENST00000537147; ENSP00000441985; ENSG00000213088 [Q16570-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2532

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2532

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Wikipedia

Duffy antigen entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01839 mRNA Translation: AAC50055.1
X85785 Genomic DNA Translation: CAA59770.1
S76830 Genomic DNA Translation: AAB33239.1
AF055992 Genomic DNA Translation: AAC72301.1
AF030521 mRNA Translation: AAD20435.1
AM887935 Genomic DNA Translation: CAP12644.1
AL035403 Genomic DNA No translation available.
BC017817 mRNA Translation: AAH17817.1
AF100634 Genomic DNA Translation: AAF02415.1
AF100634 Genomic DNA Translation: AAF02416.1
CCDSiCCDS1183.1 [Q16570-1]
CCDS44252.1 [Q16570-2]
PIRiI52608
RefSeqiNP_001116423.1, NM_001122951.2 [Q16570-2]
NP_002027.2, NM_002036.3 [Q16570-1]
UniGeneiHs.153381

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NUUX-ray1.95C16-43[»]
4NUVX-ray2.60C/D14-43[»]
ProteinModelPortaliQ16570
SMRiQ16570
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108808, 3 interactors
DIPiDIP-3783N
IntActiQ16570, 2 interactors
MINTiQ16570
STRINGi9606.ENSP00000357103

Chemistry databases

ChEMBLiCHEMBL2321626

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiQ16570
PhosphoSitePlusiQ16570

Polymorphism and mutation databases

BioMutaiACKR1
DMDMi67476970

Proteomic databases

jPOSTiQ16570
PaxDbiQ16570
PeptideAtlasiQ16570
PRIDEiQ16570
ProteomicsDBi60923
60924 [Q16570-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2532
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368121; ENSP00000357103; ENSG00000213088 [Q16570-2]
ENST00000368122; ENSP00000357104; ENSG00000213088 [Q16570-1]
ENST00000537147; ENSP00000441985; ENSG00000213088 [Q16570-1]
GeneIDi2532
KEGGihsa:2532

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2532
DisGeNETi2532
EuPathDBiHostDB:ENSG00000213088.9

GeneCards: human genes, protein and diseases

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GeneCardsi
ACKR1
HGNCiHGNC:4035 ACKR1
HPAiHPA016421
HPA017672
MalaCardsiACKR1
MIMi110700 phenotype
611162 phenotype
611862 phenotype
613665 gene
neXtProtiNX_Q16570
OpenTargetsiENSG00000213088
PharmGKBiPA28451

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHK3 Eukaryota
ENOG41119V5 LUCA
GeneTreeiENSGT00390000006372
HOVERGENiHBG051419
InParanoidiQ16570
KOiK06574
OMAiHCVATPL
OrthoDBi1194550at2759
PhylomeDBiQ16570
TreeFamiTF105419

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACKR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Duffy_antigen_system

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2532

Protein Ontology

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PROi
PR:Q16570

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213088 Expressed in 193 organ(s), highest expression level in ectocervix
ExpressionAtlasiQ16570 baseline and differential
GenevisibleiQ16570 HS

Family and domain databases

CDDicd15010 7tmA_ACKR1_DARC, 1 hit
InterProiView protein in InterPro
IPR005384 Duffy_chemokine_rcpt
PANTHERiPTHR14181 PTHR14181, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACKR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16570
Secondary accession number(s): A8YPG5
, O75898, Q16300, Q8WWE3, Q9UJP0, Q9UKZ5, Q9UKZ6, Q9UQE1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 7, 2005
Last modified: February 13, 2019
This is version 168 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  9. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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