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Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

CARTPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide, Neurotransmitter

Enzyme and pathway databases

SIGNORiQ16568

Names & Taxonomyi

Protein namesi
Recommended name:
Cocaine- and amphetamine-regulated transcript protein
Cleaved into the following 2 chains:
Gene namesi
Name:CARTPT
Synonyms:CART
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164326.4
HGNCiHGNC:24323 CARTPT
MIMi602606 gene
neXtProtiNX_Q16568

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Obesity

Organism-specific databases

DisGeNETi9607
MalaCardsiCARTPT
OpenTargetsiENSG00000164326
PharmGKBiPA162381084

Chemistry databases

DrugBankiDB00182 Amphetamine

Polymorphism and mutation databases

BioMutaiCARTPT
DMDMi2833274

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000443328 – 116Cocaine- and amphetamine-regulated transcript proteinAdd BLAST89
PeptideiPRO_000000443428 – 66CART(1-39)Add BLAST39
PeptideiPRO_000000443569 – 116CART(42-89)Add BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphotyrosineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Disulfide bondi82 ↔ 100
Disulfide bondi88 ↔ 108
Disulfide bondi102 ↔ 115

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ16568
PeptideAtlasiQ16568
PRIDEiQ16568
ProteomicsDBi60922

PTM databases

iPTMnetiQ16568
PhosphoSitePlusiQ16568

Expressioni

Tissue specificityi

Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.

Inductioni

By leptin.

Gene expression databases

BgeeiENSG00000164326 Expressed in 116 organ(s), highest expression level in hypothalamus
CleanExiHS_CARTPT
GenevisibleiQ16568 HS

Organism-specific databases

HPAiCAB025515
HPA046278

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114970, 45 interactors
IntActiQ16568, 4 interactors
STRINGi9606.ENSP00000296777

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16568
SMRiQ16568
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16568

Family & Domainsi

Sequence similaritiesi

Belongs to the CART family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KJ Eukaryota
ENOG410YRI1 LUCA
GeneTreeiENSGT00390000018319
HOGENOMiHOG000111306
HOVERGENiHBG018929
InParanoidiQ16568
OMAiFGQVPTC
OrthoDBiEOG091G0Y1C
PhylomeDBiQ16568
TreeFamiTF332948

Family and domain databases

Gene3Di4.10.40.30, 1 hit
InterProiView protein in InterPro
IPR009106 CART
IPR036722 CART_C_sf
PANTHERiPTHR16655 PTHR16655, 1 hit
PfamiView protein in Pfam
PF06373 CART, 1 hit
SUPFAMiSSF64546 SSF64546, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16568-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESSRVRLLP LLGAALLLML PLLGTRAQED AELQPRALDI YSAVDDASHE
60 70 80 90 100
KELIEALQEV LKKLKSKRVP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC
110
DCPRGTSCNS FLLKCL
Length:116
Mass (Da):12,829
Last modified:November 1, 1996 - v1
Checksum:iFC396CA2C032AA83
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01219961L → F Cosegregates with obesity phenotype in a large family. 1 PublicationCorresponds to variant dbSNP:rs121909065EnsemblClinVar.1
Natural variantiVAR_01220066S → T1 PublicationCorresponds to variant dbSNP:rs78242624Ensembl.1
Natural variantiVAR_053022113L → M. Corresponds to variant dbSNP:rs12517689Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16826 mRNA Translation: AAB08010.1
U20325 Genomic DNA Translation: AAB08011.1
CR542216 mRNA Translation: CAG47012.1
CH471084 Genomic DNA Translation: EAW95694.1
BC029882 mRNA Translation: AAH29882.1
CCDSiCCDS4011.1
PIRiJC4669
RefSeqiNP_004282.1, NM_004291.3
UniGeneiHs.1707

Genome annotation databases

EnsembliENST00000296777; ENSP00000296777; ENSG00000164326
GeneIDi9607
KEGGihsa:9607
UCSCiuc003kbv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCART_HUMAN
AccessioniPrimary (citable) accession number: Q16568
Secondary accession number(s): Q6FG92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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