CAMK4

Functionⁱ

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4⁺/CD8⁺ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.8 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Activity regulationⁱ

Activated by Ca²⁺/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca²⁺/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	75	ATPPROSITE-ProRule annotation		1
Active siteⁱ	164	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	52 – 60	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
calcium-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calmodulin binding Source: UniProtKB-KW
calmodulin-dependent protein kinase activity
Source: CACAO
Inferred from direct assayⁱ
- 8107230

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
inflammatory response Source: UniProtKB-KW
intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
long-term memory
Source: UniProtKB
Inferred from genetic interactionⁱ
- 18829949
myeloid dendritic cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17909078
peptidyl-serine phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 8855261
protein phosphorylation
Source: ProtInc
Traceable author statementⁱ
- 8089075
regulation of osteoclast differentiation
Source: UniProtKB
Traceable author statementⁱ
- 18930438
regulation of T cell differentiation in thymus
Source: UniProtKB
Traceable author statementⁱ
- 18930438
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 8089075

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Adaptive immunity, Immunity, Inflammatory response
Ligand	ATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.17 2681
Reactomeⁱ	R-HSA-111932 CaMK IV-mediated phosphorylation of CREB R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-442717 CREB phosphorylation through the activation of CaMKK R-HSA-442745 Activation of CaMK IV
SignaLinkⁱ	Q16566
SIGNORⁱ	Q16566

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calcium/calmodulin-dependent protein kinase type IV (EC:2.7.11.17) Short name: CaMK IV Alternative name(s): CaM kinase-GR
Gene namesⁱ	Name:CAMK4 Synonyms:CAMK, CAMK-GR, CAMKIV
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152495.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1464 CAMK4
MIMⁱ	114080 gene
neXtProtⁱ	NX_Q16566

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	12	S → A: Loss of activity. 1 Publication	1
Mutagenesisⁱ	13	S → A: Loss of activity. 1 Publication	1
Mutagenesisⁱ	57 – 58	TS → AA: Loss of phosphorylation of CREB1. 1 Publication	2
Mutagenesisⁱ	75	K → E: Loss of activity; dominant negative form. 1 Publication	1
Mutagenesisⁱ	189	S → A: Increases phosphorylation of CREB1 2-fold. Decreases total O-linked glycosylation 2-fold. Increases ATP-binding affinity. 1 Publication	1
Mutagenesisⁱ	200	T → A: Loss of activation by CaMKK1 or CaMKK2. 1 Publication	1
Mutagenesisⁱ	309 – 312	HMDT → DEDD: Fully active Ca2+/CaM-independent kinase; when associated with 320-A-A-321. 1 Publication	4
Mutagenesisⁱ	320 – 321	FN → DD: Fully active Ca2+/CaM-independent kinase; when associated with 309-A--A-312. Loss of interaction with PPP2CA/PPP2CB. 2 Publications	2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	814
Open Targets More...OpenTargetsⁱ	ENSG00000152495
PharmGKBⁱ	PA26050

Chemistry databases

ChEMBLⁱ	CHEMBL2494

ChEMBLⁱ

CHEMBL2494

Polymorphism and mutation databases

BioMutaⁱ	CAMK4
DMDMⁱ	2499586

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086106	1 – 473	Calcium/calmodulin-dependent protein kinase type IVAdd BLAST		473

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	12	Phosphoserine; by autocatalysis1 Publication	1
Modified residueⁱ	13	Phosphoserine; by autocatalysis1 Publication	1
Glycosylationⁱ	57	O-linked (GlcNAc) threonine1 Publication	1
Glycosylationⁱ	58	O-linked (GlcNAc) serine1 Publication	1
Glycosylationⁱ	137	O-linked (GlcNAc) serine1 Publication	1
Glycosylationⁱ	189	O-linked (GlcNAc) serine1 Publication	1
Modified residueⁱ	200	Phosphothreonine; by CaMKK1 and CaMKK23 Publications	1
Modified residueⁱ	336	Phosphoserine; by autocatalysisBy similarity	1
Modified residueⁱ	341	PhosphoserineBy similarity	1
Glycosylationⁱ	344	O-linked (GlcNAc) serine1 Publication	1
Glycosylationⁱ	345	O-linked (GlcNAc) serine1 Publication	1
Glycosylationⁱ	356	O-linked (GlcNAc) serine1 Publication	1
Modified residueⁱ	360	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.3 Publications

Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.3 Publications

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q16566
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q16566
PaxDbⁱ	Q16566
PeptideAtlas More...PeptideAtlasⁱ	Q16566
PRIDEⁱ	Q16566
ProteomicsDBⁱ	60921

PTM databases

iPTMnetⁱ	Q16566
PhosphoSitePlusⁱ	Q16566

Miscellaneous databases

PMAP-CutDBⁱ	Q16566

PMAP-CutDBⁱ

Q16566

Expressionⁱ

Tissue specificityⁱ

Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.3 Publications

Developmental stageⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152495 Expressed in 145 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_CAMK4
ExpressionAtlasⁱ	Q16566 baseline and differential
Genevisibleⁱ	Q16566 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004347 HPA011753 HPA017206

HPAⁱ

CAB004347
HPA011753
HPA017206

Interactionⁱ

Subunit structureⁱ

Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca²⁺/calmodulin.By similarity2 Publications

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107264, 12 interactors
Database of interacting proteins More...DIPⁱ	DIP-41997N
IntActⁱ	Q16566, 2 interactors
STRINGⁱ	9606.ENSP00000282356

Chemistry databases

BindingDBⁱ

Q16566

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	36 – 38	Combined sources	3
Helixⁱ	42 – 44	Combined sources	3
Beta strandⁱ	46 – 54	Combined sources	9
Beta strandⁱ	56 – 65	Combined sources	10
Turnⁱ	66 – 68	Combined sources	3
Beta strandⁱ	71 – 78	Combined sources	8
Helixⁱ	91 – 95	Combined sources	5
Beta strandⁱ	104 – 109	Combined sources	6
Beta strandⁱ	111 – 118	Combined sources	8
Helixⁱ	126 – 130	Combined sources	5
Helixⁱ	138 – 157	Combined sources	20
Helixⁱ	167 – 169	Combined sources	3
Beta strandⁱ	170 – 176	Combined sources	7
Beta strandⁱ	181 – 183	Combined sources	3
Helixⁱ	205 – 207	Combined sources	3
Helixⁱ	210 – 213	Combined sources	4
Helixⁱ	221 – 236	Combined sources	16
Helixⁱ	247 – 255	Combined sources	9
Turnⁱ	263 – 268	Combined sources	6
Helixⁱ	271 – 278	Combined sources	8
Helixⁱ	285 – 287	Combined sources	3
Helixⁱ	291 – 296	Combined sources	6
Turnⁱ	298 – 301	Combined sources	4
Helixⁱ	311 – 335	Combined sources	25

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16566
SMRⁱ	Q16566
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q16566

EvolutionaryTraceⁱ

Q16566

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 300	Protein kinasePROSITE-ProRule annotationAdd BLAST		255

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	305 – 321	Autoinhibitory domainAdd BLAST	17
Regionⁱ	306 – 323	PP2A-bindingAdd BLAST	18
Regionⁱ	322 – 341	Calmodulin-bindingSequence analysisAdd BLAST	20

Domainⁱ

The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.1 Publication

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118944
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG108055
InParanoidⁱ	Q16566
KEGG Orthology (KO) More...KOⁱ	K05869
OMAⁱ	YWIDGSN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HK9
PhylomeDBⁱ	Q16566
TreeFamⁱ	TF351230

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q16566-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES 
        60         70         80         90        100
ELGRGATSIV YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN 
       110        120        130        140        150
IIKLKEIFET PTEISLVLEL VTGGELFDRI VEKGYYSERD AADAVKQILE 
       160        170        180        190        200
AVAYLHENGI VHRDLKPENL LYATPAPDAP LKIADFGLSK IVEHQVLMKT 
       210        220        230        240        250
VCGTPGYCAP EILRGCAYGP EVDMWSVGII TYILLCGFEP FYDERGDQFM 
       260        270        280        290        300
FRRILNCEYY FISPWWDEVS LNAKDLVRKL IVLDPKKRLT TFQALQHPWV 
       310        320        330        340        350
TGKAANFVHM DTAQKKLQEF NARRKLKAAV KAVVASSRLG SASSSHGSIQ 
       360        370        380        390        400
ESHKASRDPS PIQDGNEDMK AIPEGEKIQG DGAQAAVKGA QAELMKVQAL 
       410        420        430        440        450
EKVKGADINA EEAPKMVPKA VEDGIKVADL ELEEGLAEEK LKTVEEAAAP 
       460        470 
REGQGSSAVG FEVPQQDVIL PEY

Length:473

Mass (Da):51,926

Last modified:November 1, 1996 - v1

Checksum:ⁱEFEE51E5612326DC

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RE65	D6RE65_HUMAN	Calcium/calmodulin-dependent protei... Calcium/calmodulin-dependent protein kinase type IV	CAMK4	142	Annotation score:
D6REY7	D6REY7_HUMAN	Calcium/calmodulin-dependent protei... Calcium/calmodulin-dependent protein kinase type IV	CAMK4	109	Annotation score:
D6RCD6	D6RCD6_HUMAN	Calcium/calmodulin-dependent protei... Calcium/calmodulin-dependent protein kinase type IV	CAMK4	88	Annotation score:

Sequence cautionⁱ

The sequence AAH16695 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040604	150	E → G in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040605	178	D → N1 PublicationCorresponds to variant dbSNP:rs35548075Ensembl.	1
Natural variantⁱVAR_040606	465	Q → R1 PublicationCorresponds to variant dbSNP:rs56360861Ensembl.	1
Natural variantⁱVAR_040607	469	I → M in a lung large cell carcinoma sample; somatic mutation. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D30742 mRNA Translation: BAA06403.1 L17000 mRNA Translation: AAA35639.1 L24959 mRNA Translation: AAA18251.1 CH471086 Genomic DNA Translation: EAW49033.1 CH471086 Genomic DNA Translation: EAW49034.1 BC016695 mRNA Translation: AAH16695.2 Different initiation. BC025687 mRNA Translation: AAH25687.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4103.1
PIRⁱ	A53036
NCBI Reference Sequences More...RefSeqⁱ	NP_001310303.1, NM_001323374.1 NP_001310304.1, NM_001323375.1 NP_001735.1, NM_001744.5
UniGeneⁱ	Hs.438801 Hs.591269

Genome annotation databases

Ensemblⁱ	ENST00000282356; ENSP00000282356; ENSG00000152495 ENST00000512453; ENSP00000422634; ENSG00000152495
GeneIDⁱ	814
KEGGⁱ	hsa:814
UCSC genome browser More...UCSCⁱ	uc003kpf.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16566	calcium/calmodulin-dependent protein kinase type IV		DELLE		529	UniRef90_Q16566
calcium/calmodulin-dependent protein kinase type IV isoform X1		Yangtze finless porpoise		529
Calcium/calmodulin-dependent protein kinase type IV (Fragment)		ESCRO		164
Calcium/calmodulin-dependent protein kinase type IV		NEOVI		475
Calcium/calmodulin dependent protein kinase IV		CALJA		473
+66

Protein	Similar proteins		Species	Score	Length	Source
Q16566	Calcium/calmodulin-dependent protein kinase type IV		RAT		474	UniRef50_Q16566
Calcium/calmodulin-dependent protein kinase type IV		MOUSE		469
calcium/calmodulin-dependent protein kinase type IV isoform X1		Yangtze finless porpoise		529
Calcium/calmodulin-dependent protein kinase type IV (Fragment)		ESCRO		164
calcium/calmodulin-dependent protein kinase type IV		DELLE		529
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D30742 mRNA Translation: BAA06403.1 L17000 mRNA Translation: AAA35639.1 L24959 mRNA Translation: AAA18251.1 CH471086 Genomic DNA Translation: EAW49033.1 CH471086 Genomic DNA Translation: EAW49034.1 BC016695 mRNA Translation: AAH16695.2 Different initiation. BC025687 mRNA Translation: AAH25687.1
CCDSⁱ	CCDS4103.1
PIRⁱ	A53036
RefSeqⁱ	NP_001310303.1, NM_001323374.1 NP_001310304.1, NM_001323375.1 NP_001735.1, NM_001744.5
UniGeneⁱ	Hs.438801 Hs.591269

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2W4O	X-ray	2.17	A	15-340	[»]
ProteinModelPortalⁱ	Q16566
SMRⁱ	Q16566
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107264, 12 interactors
DIPⁱ	DIP-41997N
IntActⁱ	Q16566, 2 interactors
STRINGⁱ	9606.ENSP00000282356

Chemistry databases

BindingDBⁱ	Q16566
ChEMBLⁱ	CHEMBL2494

PTM databases

iPTMnetⁱ	Q16566
PhosphoSitePlusⁱ	Q16566

Polymorphism and mutation databases

BioMutaⁱ	CAMK4
DMDMⁱ	2499586

Proteomic databases

EPDⁱ	Q16566
MaxQBⁱ	Q16566
PaxDbⁱ	Q16566
PeptideAtlasⁱ	Q16566
PRIDEⁱ	Q16566
ProteomicsDBⁱ	60921

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	814
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000282356; ENSP00000282356; ENSG00000152495 ENST00000512453; ENSP00000422634; ENSG00000152495
GeneIDⁱ	814
KEGGⁱ	hsa:814
UCSCⁱ	uc003kpf.4 human

Organism-specific databases

CTDⁱ	814
DisGeNETⁱ	814
EuPathDBⁱ	HostDB:ENSG00000152495.10
GeneCardsⁱ	CAMK4
HGNCⁱ	HGNC:1464 CAMK4
HPAⁱ	CAB004347 HPA011753 HPA017206
MIMⁱ	114080 gene
neXtProtⁱ	NX_Q16566
OpenTargetsⁱ	ENSG00000152495
PharmGKBⁱ	PA26050
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0032 Eukaryota ENOG410XRMJ LUCA
GeneTreeⁱ	ENSGT00760000118944
HOGENOMⁱ	HOG000233016
HOVERGENⁱ	HBG108055
InParanoidⁱ	Q16566
KOⁱ	K05869
OMAⁱ	YWIDGSN
OrthoDBⁱ	EOG091G0HK9
PhylomeDBⁱ	Q16566
TreeFamⁱ	TF351230

Enzyme and pathway databases

BRENDAⁱ	2.7.11.17 2681
Reactomeⁱ	R-HSA-111932 CaMK IV-mediated phosphorylation of CREB R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-442717 CREB phosphorylation through the activation of CaMKK R-HSA-442745 Activation of CaMK IV
SignaLinkⁱ	Q16566
SIGNORⁱ	Q16566

Miscellaneous databases

ChiTaRSⁱ	CAMK4 human
EvolutionaryTraceⁱ	Q16566
GeneWikiⁱ	CAMK4
GenomeRNAiⁱ	814
PMAP-CutDBⁱ	Q16566
Protein Ontology More...PROⁱ	PR:Q16566
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152495 Expressed in 145 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_CAMK4
ExpressionAtlasⁱ	Q16566 baseline and differential
Genevisibleⁱ	Q16566 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCC4_HUMAN
Accessionⁱ	Q16566Primary (citable) accession number: Q16566 Secondary accession number(s): D3DSZ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

UniProtKB

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UniProtKB - Q16566 (KCC4_HUMAN)

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Calcium/calmodulin-dependent protein kinase type IV

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ