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Protein

Synaptophysin-like protein 1

Gene

SYPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 1
Alternative name(s):
Pantophysin
Gene namesi
Name:SYPL1
Synonyms:SYPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000008282.8
HGNCiHGNC:11507 SYPL1
neXtProtiNX_Q16563

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 116VesicularSequence analysisAdd BLAST62
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 212VesicularSequence analysisAdd BLAST41
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 259CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000008282
PharmGKBiPA36289

Polymorphism and mutation databases

BioMutaiSYPL1
DMDMi48474786

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791641 – 259Synaptophysin-like protein 1Add BLAST259
Isoform 2 (identifier: Q16563-2)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ16563
MaxQBiQ16563
PaxDbiQ16563
PeptideAtlasiQ16563
PRIDEiQ16563
ProteomicsDBi60919
60920 [Q16563-2]

PTM databases

GlyConnecti1783
iPTMnetiQ16563
PhosphoSitePlusiQ16563
SwissPalmiQ16563

Expressioni

Gene expression databases

BgeeiENSG00000008282 Expressed in 236 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SYPL1
ExpressionAtlasiQ16563 baseline and differential
GenevisibleiQ16563 HS

Organism-specific databases

HPAiHPA014141

Interactioni

Protein-protein interaction databases

BioGridi112722, 10 interactors
IntActiQ16563, 12 interactors

Structurei

3D structure databases

ProteinModelPortaliQ16563
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 237MARVELPROSITE-ProRule annotationAdd BLAST210

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9X Eukaryota
ENOG4111FYV LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiQ16563
OMAiNWKSYVL
OrthoDBiEOG091G0ZEI
PhylomeDBiQ16563
TreeFamiTF315804

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16563-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPNIYLVRQ RISRLGQRMS GFQINLNPLK EPLGFIKVLE WIASIFAFAT
60 70 80 90 100
CGGFKGQTEI QVNCPPAVTE NKTVTATFGY PFRLNEASFQ PPPGVNICDV
110 120 130 140 150
NWKDYVLIGD YSSSAQFYVT FAVFVFLYCI AALLLYVGYT SLYLDSRKLP
160 170 180 190 200
MIDFVVTLVA TFLWLVSTSA WAKALTDIKI ATGHNIIDEL PPCKKKAVLC
210 220 230 240 250
YFGSVTSMGS LNVSVIFGFL NMILWGGNAW FVYKETSLHS PSNTSAPHSQ

GGIPPPTGI
Length:259
Mass (Da):28,565
Last modified:November 1, 1996 - v1
Checksum:i20D553779AA82085
GO
Isoform 2 (identifier: Q16563-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Show »
Length:241
Mass (Da):26,412
Checksum:i74FECF2A10412BA7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYN0C9JYN0_HUMAN
Synaptophysin-like protein 1
SYPL1
224Annotation score:
H7C4J8H7C4J8_HUMAN
Synaptophysin-like protein 1
SYPL1
148Annotation score:
A0A0U1RQT9A0A0U1RQT9_HUMAN
Synaptophysin-like protein 1
SYPL1
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 19LGQRM → HLQGR in X61382 (PubMed:1730063).Curated5
Sequence conflicti163 – 165LWL → CGW (PubMed:1730063).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0085571 – 18Missing in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72481 mRNA Translation: AAB31344.1
X68194 mRNA Translation: CAA48276.1
AC005095 Genomic DNA Translation: AAD50513.1
CH236947 Genomic DNA Translation: EAL24402.1
CH471070 Genomic DNA Translation: EAW83380.1
BC016835 mRNA Translation: AAH16835.3
BC020938 mRNA Translation: AAH20938.1
BC061887 mRNA Translation: AAH61887.1
X61382 mRNA No translation available.
CCDSiCCDS47685.1 [Q16563-2]
CCDS5736.1 [Q16563-1]
PIRiI53171
S20316
RefSeqiNP_006745.1, NM_006754.3 [Q16563-1]
NP_874384.1, NM_182715.2 [Q16563-2]
UniGeneiHs.80919

Genome annotation databases

EnsembliENST00000011473; ENSP00000011473; ENSG00000008282 [Q16563-1]
ENST00000455385; ENSP00000388336; ENSG00000008282 [Q16563-2]
GeneIDi6856
KEGGihsa:6856
UCSCiuc003vdo.5 human [Q16563-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S72481 mRNA Translation: AAB31344.1
X68194 mRNA Translation: CAA48276.1
AC005095 Genomic DNA Translation: AAD50513.1
CH236947 Genomic DNA Translation: EAL24402.1
CH471070 Genomic DNA Translation: EAW83380.1
BC016835 mRNA Translation: AAH16835.3
BC020938 mRNA Translation: AAH20938.1
BC061887 mRNA Translation: AAH61887.1
X61382 mRNA No translation available.
CCDSiCCDS47685.1 [Q16563-2]
CCDS5736.1 [Q16563-1]
PIRiI53171
S20316
RefSeqiNP_006745.1, NM_006754.3 [Q16563-1]
NP_874384.1, NM_182715.2 [Q16563-2]
UniGeneiHs.80919

3D structure databases

ProteinModelPortaliQ16563
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112722, 10 interactors
IntActiQ16563, 12 interactors

PTM databases

GlyConnecti1783
iPTMnetiQ16563
PhosphoSitePlusiQ16563
SwissPalmiQ16563

Polymorphism and mutation databases

BioMutaiSYPL1
DMDMi48474786

Proteomic databases

EPDiQ16563
MaxQBiQ16563
PaxDbiQ16563
PeptideAtlasiQ16563
PRIDEiQ16563
ProteomicsDBi60919
60920 [Q16563-2]

Protocols and materials databases

DNASUi6856
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000011473; ENSP00000011473; ENSG00000008282 [Q16563-1]
ENST00000455385; ENSP00000388336; ENSG00000008282 [Q16563-2]
GeneIDi6856
KEGGihsa:6856
UCSCiuc003vdo.5 human [Q16563-1]

Organism-specific databases

CTDi6856
EuPathDBiHostDB:ENSG00000008282.8
GeneCardsiSYPL1
HGNCiHGNC:11507 SYPL1
HPAiHPA014141
neXtProtiNX_Q16563
OpenTargetsiENSG00000008282
PharmGKBiPA36289
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9X Eukaryota
ENOG4111FYV LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiQ16563
OMAiNWKSYVL
OrthoDBiEOG091G0ZEI
PhylomeDBiQ16563
TreeFamiTF315804

Miscellaneous databases

GeneWikiiSYPL1
GenomeRNAii6856
PROiPR:Q16563

Gene expression databases

BgeeiENSG00000008282 Expressed in 236 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SYPL1
ExpressionAtlasiQ16563 baseline and differential
GenevisibleiQ16563 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYPL1_HUMAN
AccessioniPrimary (citable) accession number: Q16563
Secondary accession number(s): A4D0R2, Q96AR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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