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Protein

U11/U12 small nuclear ribonucleoprotein 35 kDa protein

Gene

SNRNP35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • RNA splicing Source: HGNC

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U11/U12 small nuclear ribonucleoprotein 35 kDa protein
Short name:
U11/U12 snRNP 35 kDa protein
Short name:
U11/U12-35K
Alternative name(s):
Protein HM-1
U1 snRNP-binding protein homolog
Gene namesi
Name:SNRNP35
Synonyms:HM1, U1SNRNPBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000184209.14
HGNCiHGNC:30852 SNRNP35
neXtProtiNX_Q16560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi11066
OpenTargetsiENSG00000184209
PharmGKBiPA164726115

Polymorphism and mutation databases

DMDMi74754517

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079071 – 246U11/U12 small nuclear ribonucleoprotein 35 kDa proteinAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ16560
MaxQBiQ16560
PaxDbiQ16560
PeptideAtlasiQ16560
PRIDEiQ16560
ProteomicsDBi60917
60918 [Q16560-2]

PTM databases

iPTMnetiQ16560
PhosphoSitePlusiQ16560

Expressioni

Tissue specificityi

Expressed in heart, liver, skeletal muscle and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000184209 Expressed in 223 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SNRNP35
ExpressionAtlasiQ16560 baseline and differential
GenevisibleiQ16560 HS

Organism-specific databases

HPAiHPA059145
HPA067031

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.1 Publication

Protein-protein interaction databases

BioGridi116250, 18 interactors
CORUMiQ16560
IntActiQ16560, 15 interactors
MINTiQ16560
STRINGi9606.ENSP00000403310

Structurei

3D structure databases

ProteinModelPortaliQ16560
SMRiQ16560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 129RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 244Arg-richAdd BLAST91

Phylogenomic databases

eggNOGiKOG0113 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00530000063750
HOGENOMiHOG000006374
HOVERGENiHBG104583
InParanoidiQ16560
KOiK13155
OMAiPENDWER
OrthoDBiEOG091G0NV3
PhylomeDBiQ16560
TreeFamiTF331614

Family and domain databases

CDDicd12237 RRM_snRNP35, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034146 snRNP35_RRM
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16560-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNDWMPIAKE YDPLKAGSID GTDEDPHDRA VWRAMLARYV PNKGVIGDPL
60 70 80 90 100
LTLFVARLNL QTKEDKLKEV FSRYGDIRRL RLVRDLVTGF SKGYAFIEYK
110 120 130 140 150
EERAVIKAYR DADGLVIDQH EIFVDYELER TLKGWIPRRL GGGLGGKKES
160 170 180 190 200
GQLRFGGRDR PFRKPINLPV VKNDLYREGK RERRERSRSR ERHWDSRTRD
210 220 230 240
RDHDRGREKR WQEREPTRVW PDNDWERERD FRDDRIKGRE KKERGK
Length:246
Mass (Da):29,450
Last modified:November 1, 1996 - v1
Checksum:iE420E6D719D3B0C7
GO
Isoform 2 (identifier: Q16560-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKPANM

Show »
Length:251
Mass (Da):29,992
Checksum:iF42379E28EFBD467
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0288551M → MKPANM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44798 mRNA Translation: AAA86654.1
U44799 mRNA Translation: AAA86655.1
AK290127 mRNA Translation: BAF82816.1
CH471054 Genomic DNA Translation: EAW98412.1
BC009622 mRNA Translation: AAH09622.1
BC047678 mRNA Translation: AAH47678.1
BC054034 mRNA Translation: AAH54034.1
BC093671 mRNA Translation: AAH93671.1
BC111955 mRNA Translation: AAI11956.1
BK005197 mRNA Translation: DAA05495.1
CCDSiCCDS45005.1 [Q16560-2]
CCDS9249.1 [Q16560-1]
PIRiG02371
RefSeqiNP_073208.1, NM_022717.3 [Q16560-1]
NP_851030.1, NM_180699.3 [Q16560-2]
XP_006719267.1, XM_006719204.3 [Q16560-1]
XP_016874213.1, XM_017018724.1 [Q16560-2]
UniGeneiHs.632738

Genome annotation databases

EnsembliENST00000350887; ENSP00000340774; ENSG00000184209 [Q16560-1]
ENST00000412157; ENSP00000403310; ENSG00000184209 [Q16560-2]
ENST00000526639; ENSP00000432595; ENSG00000184209 [Q16560-1]
GeneIDi11066
KEGGihsa:11066
UCSCiuc001ufb.2 human [Q16560-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44798 mRNA Translation: AAA86654.1
U44799 mRNA Translation: AAA86655.1
AK290127 mRNA Translation: BAF82816.1
CH471054 Genomic DNA Translation: EAW98412.1
BC009622 mRNA Translation: AAH09622.1
BC047678 mRNA Translation: AAH47678.1
BC054034 mRNA Translation: AAH54034.1
BC093671 mRNA Translation: AAH93671.1
BC111955 mRNA Translation: AAI11956.1
BK005197 mRNA Translation: DAA05495.1
CCDSiCCDS45005.1 [Q16560-2]
CCDS9249.1 [Q16560-1]
PIRiG02371
RefSeqiNP_073208.1, NM_022717.3 [Q16560-1]
NP_851030.1, NM_180699.3 [Q16560-2]
XP_006719267.1, XM_006719204.3 [Q16560-1]
XP_016874213.1, XM_017018724.1 [Q16560-2]
UniGeneiHs.632738

3D structure databases

ProteinModelPortaliQ16560
SMRiQ16560
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116250, 18 interactors
CORUMiQ16560
IntActiQ16560, 15 interactors
MINTiQ16560
STRINGi9606.ENSP00000403310

PTM databases

iPTMnetiQ16560
PhosphoSitePlusiQ16560

Polymorphism and mutation databases

DMDMi74754517

Proteomic databases

EPDiQ16560
MaxQBiQ16560
PaxDbiQ16560
PeptideAtlasiQ16560
PRIDEiQ16560
ProteomicsDBi60917
60918 [Q16560-2]

Protocols and materials databases

DNASUi11066
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350887; ENSP00000340774; ENSG00000184209 [Q16560-1]
ENST00000412157; ENSP00000403310; ENSG00000184209 [Q16560-2]
ENST00000526639; ENSP00000432595; ENSG00000184209 [Q16560-1]
GeneIDi11066
KEGGihsa:11066
UCSCiuc001ufb.2 human [Q16560-1]

Organism-specific databases

CTDi11066
DisGeNETi11066
EuPathDBiHostDB:ENSG00000184209.14
GeneCardsiSNRNP35
HGNCiHGNC:30852 SNRNP35
HPAiHPA059145
HPA067031
neXtProtiNX_Q16560
OpenTargetsiENSG00000184209
PharmGKBiPA164726115
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0113 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00530000063750
HOGENOMiHOG000006374
HOVERGENiHBG104583
InParanoidiQ16560
KOiK13155
OMAiPENDWER
OrthoDBiEOG091G0NV3
PhylomeDBiQ16560
TreeFamiTF331614

Enzyme and pathway databases

ReactomeiR-HSA-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

ChiTaRSiSNRNP35 human
GenomeRNAii11066
PROiPR:Q16560

Gene expression databases

BgeeiENSG00000184209 Expressed in 223 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SNRNP35
ExpressionAtlasiQ16560 baseline and differential
GenevisibleiQ16560 HS

Family and domain databases

CDDicd12237 RRM_snRNP35, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034146 snRNP35_RRM
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU1SBP_HUMAN
AccessioniPrimary (citable) accession number: Q16560
Secondary accession number(s): A8K262, Q5XKN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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