TAL2

Functionⁱ

GO - Molecular functionⁱ

DNA binding
Source: ProtInc
Traceable author statementⁱ
- 1763056
protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

midbrain development Source: Ensembl
multicellular organism growth Source: Ensembl
post-embryonic development Source: Ensembl
thalamus development Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-cell acute lymphocytic leukemia protein 2 Short name: TAL-2 Alternative name(s): Class A basic helix-loop-helix protein 19 Short name: bHLHa19
Gene namesⁱ	Name:TAL2 Synonyms:BHLHA19
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000186051.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11557 TAL2
MIMⁱ	186855 gene
neXtProtⁱ	NX_Q16559

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.1 Publication

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6887
Open Targets More...OpenTargetsⁱ	ENSG00000186051
PharmGKBⁱ	PA36327

Polymorphism and mutation databases

BioMutaⁱ	TAL2
DMDMⁱ	7531207

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127456	1 – 108	T-cell acute lymphocytic leukemia protein 2Add BLAST		108

Proteomic databases

PaxDbⁱ	Q16559
PeptideAtlas More...PeptideAtlasⁱ	Q16559
PRIDEⁱ	Q16559
ProteomicsDBⁱ	60916

PTM databases

iPTMnetⁱ	Q16559
PhosphoSitePlusⁱ	Q16559

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000186051 Expressed in 81 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_TAL2
Genevisibleⁱ	Q16559 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030886

HPAⁱ

HPA030886

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TCF4	P15884	3	EBI-10237959,EBI-533224

With

Entry

#Exp.

IntAct

Notes

TCF4

P15884

3

EBI-10237959,EBI-533224

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112750, 7 interactors
IntActⁱ	Q16559, 1 interactor
STRINGⁱ	9606.ENSP00000334547

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q16559
SMRⁱ	Q16559
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 54	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000129920
HOVERGENⁱ	HBG004515
InParanoidⁱ	Q16559
KEGG Orthology (KO) More...KOⁱ	K09068
OMAⁱ	HLPGLEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ESI
PhylomeDBⁱ	Q16559
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q16559-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY 
        60         70         80         90        100
INFLVKVLGE QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS 

PGPSHHIP

Length:108

Mass (Da):12,291

Last modified:November 1, 1996 - v1

Checksum:ⁱDE9D67D940EF4749

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81078 Genomic DNA Translation: AAA60613.1 S69377 Genomic DNA Translation: AAC60629.1 AL158070 Genomic DNA No translation available. BC069422 mRNA Translation: AAH69422.1 BC126373 mRNA Translation: AAI26374.1 BC126375 mRNA Translation: AAI26376.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6767.1
PIRⁱ	A41629
NCBI Reference Sequences More...RefSeqⁱ	NP_005412.1, NM_005421.2
UniGeneⁱ	Hs.247978

Genome annotation databases

Ensemblⁱ	ENST00000334077; ENSP00000334547; ENSG00000186051
GeneIDⁱ	6887
KEGGⁱ	hsa:6887
UCSC genome browser More...UCSCⁱ	uc004bct.4 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Protein	Similar proteins		Species	Score	Length	Source
Q16559	TAL bHLH transcription factor 2		PANTR		108	UniRef100_Q16559
Uncharacterized protein		PANPA		108
Uncharacterized protein		NOMLE		108
TAL bHLH transcription factor 2		GORGO		108

Protein	Similar proteins		Species	Score	Length	Source
Q16559	TAL bHLH transcription factor 2		PANTR		108	UniRef90_Q16559
Uncharacterized protein		PANPA		108
Uncharacterized protein		NOMLE		108
TAL bHLH transcription factor 2		GORGO		108
T-cell acute lymphocytic leukemia protein 2 (Fragment)		ESCRO		110
+2

Protein	Similar proteins		Species	Score	Length	Source
Q16559	TAL bHLH transcription factor 2		PANTR		108	UniRef50_Q16559
Uncharacterized protein		PANPA		108
Uncharacterized protein		NOMLE		108
TAL bHLH transcription factor 2		GORGO		108
T-cell acute lymphocytic leukemia protein 2 (Fragment)		ESCRO		110
+55

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81078 Genomic DNA Translation: AAA60613.1 S69377 Genomic DNA Translation: AAC60629.1 AL158070 Genomic DNA No translation available. BC069422 mRNA Translation: AAH69422.1 BC126373 mRNA Translation: AAI26374.1 BC126375 mRNA Translation: AAI26376.1
CCDSⁱ	CCDS6767.1
PIRⁱ	A41629
RefSeqⁱ	NP_005412.1, NM_005421.2
UniGeneⁱ	Hs.247978

3D structure databases

ProteinModelPortalⁱ	Q16559
SMRⁱ	Q16559
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112750, 7 interactors
IntActⁱ	Q16559, 1 interactor
STRINGⁱ	9606.ENSP00000334547

PTM databases

iPTMnetⁱ	Q16559
PhosphoSitePlusⁱ	Q16559

Polymorphism and mutation databases

BioMutaⁱ	TAL2
DMDMⁱ	7531207

Proteomic databases

PaxDbⁱ	Q16559
PeptideAtlasⁱ	Q16559
PRIDEⁱ	Q16559
ProteomicsDBⁱ	60916

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6887
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000334077; ENSP00000334547; ENSG00000186051
GeneIDⁱ	6887
KEGGⁱ	hsa:6887
UCSCⁱ	uc004bct.4 human

Organism-specific databases

CTDⁱ	6887
DisGeNETⁱ	6887
EuPathDBⁱ	HostDB:ENSG00000186051.6
GeneCardsⁱ	TAL2
HGNCⁱ	HGNC:11557 TAL2
HPAⁱ	HPA030886
MIMⁱ	186855 gene
neXtProtⁱ	NX_Q16559
OpenTargetsⁱ	ENSG00000186051
PharmGKBⁱ	PA36327
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000129920
HOVERGENⁱ	HBG004515
InParanoidⁱ	Q16559
KOⁱ	K09068
OMAⁱ	HLPGLEN
OrthoDBⁱ	EOG091G0ESI
PhylomeDBⁱ	Q16559
TreeFamⁱ	TF315153

Miscellaneous databases

ChiTaRSⁱ	TAL2 human
GeneWikiⁱ	TAL2
GenomeRNAiⁱ	6887
Protein Ontology More...PROⁱ	PR:Q16559
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000186051 Expressed in 81 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_TAL2
Genevisibleⁱ	Q16559 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAL2_HUMAN
Accessionⁱ	Q16559Primary (citable) accession number: Q16559 Secondary accession number(s): A0AVI7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	September 12, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q16559 (TAL2_HUMAN)

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T-cell acute lymphocytic leukemia protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ