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Protein

T-cell acute lymphocytic leukemia protein 2

Gene

TAL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 2
Short name:
TAL-2
Alternative name(s):
Class A basic helix-loop-helix protein 19
Short name:
bHLHa19
Gene namesi
Name:TAL2
Synonyms:BHLHA19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000186051.6
HGNCiHGNC:11557 TAL2
MIMi186855 gene
neXtProtiNX_Q16559

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi6887
OpenTargetsiENSG00000186051
PharmGKBiPA36327

Polymorphism and mutation databases

BioMutaiTAL2
DMDMi7531207

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274561 – 108T-cell acute lymphocytic leukemia protein 2Add BLAST108

Proteomic databases

PaxDbiQ16559
PeptideAtlasiQ16559
PRIDEiQ16559
ProteomicsDBi60916

PTM databases

iPTMnetiQ16559
PhosphoSitePlusiQ16559

Expressioni

Gene expression databases

BgeeiENSG00000186051 Expressed in 81 organ(s), highest expression level in quadriceps femoris
CleanExiHS_TAL2
GenevisibleiQ16559 HS

Organism-specific databases

HPAiHPA030886

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TCF4P158843EBI-10237959,EBI-533224

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112750, 7 interactors
IntActiQ16559, 1 interactor
STRINGi9606.ENSP00000334547

Structurei

3D structure databases

ProteinModelPortaliQ16559
SMRiQ16559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 54bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000129920
HOVERGENiHBG004515
InParanoidiQ16559
KOiK09068
OMAiHLPGLEN
OrthoDBiEOG091G0ESI
PhylomeDBiQ16559
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q16559-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY
60 70 80 90 100
INFLVKVLGE QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS

PGPSHHIP
Length:108
Mass (Da):12,291
Last modified:November 1, 1996 - v1
Checksum:iDE9D67D940EF4749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81078 Genomic DNA Translation: AAA60613.1
S69377 Genomic DNA Translation: AAC60629.1
AL158070 Genomic DNA No translation available.
BC069422 mRNA Translation: AAH69422.1
BC126373 mRNA Translation: AAI26374.1
BC126375 mRNA Translation: AAI26376.1
CCDSiCCDS6767.1
PIRiA41629
RefSeqiNP_005412.1, NM_005421.2
UniGeneiHs.247978

Genome annotation databases

EnsembliENST00000334077; ENSP00000334547; ENSG00000186051
GeneIDi6887
KEGGihsa:6887
UCSCiuc004bct.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81078 Genomic DNA Translation: AAA60613.1
S69377 Genomic DNA Translation: AAC60629.1
AL158070 Genomic DNA No translation available.
BC069422 mRNA Translation: AAH69422.1
BC126373 mRNA Translation: AAI26374.1
BC126375 mRNA Translation: AAI26376.1
CCDSiCCDS6767.1
PIRiA41629
RefSeqiNP_005412.1, NM_005421.2
UniGeneiHs.247978

3D structure databases

ProteinModelPortaliQ16559
SMRiQ16559
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112750, 7 interactors
IntActiQ16559, 1 interactor
STRINGi9606.ENSP00000334547

PTM databases

iPTMnetiQ16559
PhosphoSitePlusiQ16559

Polymorphism and mutation databases

BioMutaiTAL2
DMDMi7531207

Proteomic databases

PaxDbiQ16559
PeptideAtlasiQ16559
PRIDEiQ16559
ProteomicsDBi60916

Protocols and materials databases

DNASUi6887
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334077; ENSP00000334547; ENSG00000186051
GeneIDi6887
KEGGihsa:6887
UCSCiuc004bct.4 human

Organism-specific databases

CTDi6887
DisGeNETi6887
EuPathDBiHostDB:ENSG00000186051.6
GeneCardsiTAL2
HGNCiHGNC:11557 TAL2
HPAiHPA030886
MIMi186855 gene
neXtProtiNX_Q16559
OpenTargetsiENSG00000186051
PharmGKBiPA36327
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000129920
HOVERGENiHBG004515
InParanoidiQ16559
KOiK09068
OMAiHLPGLEN
OrthoDBiEOG091G0ESI
PhylomeDBiQ16559
TreeFamiTF315153

Miscellaneous databases

ChiTaRSiTAL2 human
GeneWikiiTAL2
GenomeRNAii6887
PROiPR:Q16559
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186051 Expressed in 81 organ(s), highest expression level in quadriceps femoris
CleanExiHS_TAL2
GenevisibleiQ16559 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAL2_HUMAN
AccessioniPrimary (citable) accession number: Q16559
Secondary accession number(s): A0AVI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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