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UniProtKB - Q16559 (TAL2_HUMAN)
Protein
T-cell acute lymphocytic leukemia protein 2
Gene
TAL2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- midbrain development Source: Ensembl
- multicellular organism growth Source: Ensembl
- post-embryonic development Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- thalamus development Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q16559 |
SignaLinki | Q16559 |
SIGNORi | Q16559 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell acute lymphocytic leukemia protein 2Short name: TAL-2 Alternative name(s): Class A basic helix-loop-helix protein 19 Short name: bHLHa19 |
Gene namesi | Name:TAL2 Synonyms:BHLHA19 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11557, TAL2 |
MIMi | 186855, gene |
neXtProti | NX_Q16559 |
VEuPathDBi | HostDB:ENSG00000186051 |
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.1 Publication
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 6887 |
OpenTargetsi | ENSG00000186051 |
PharmGKBi | PA36327 |
Miscellaneous databases
Pharosi | Q16559, Tbio |
Genetic variation databases
BioMutai | TAL2 |
DMDMi | 7531207 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127456 | 1 – 108 | T-cell acute lymphocytic leukemia protein 2Add BLAST | 108 |
Proteomic databases
MassIVEi | Q16559 |
PaxDbi | Q16559 |
PeptideAtlasi | Q16559 |
PRIDEi | Q16559 |
PTM databases
iPTMneti | Q16559 |
PhosphoSitePlusi | Q16559 |
Expressioni
Gene expression databases
Bgeei | ENSG00000186051, Expressed in quadriceps femoris and 118 other tissues |
Genevisiblei | Q16559, HS |
Organism-specific databases
HPAi | ENSG00000186051, Tissue enriched (skeletal) |
Interactioni
Binary interactionsi
Q16559
With | #Exp. | IntAct |
---|---|---|
TCF4 [P15884] | 3 | EBI-10237959,EBI-533224 |
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 112750, 9 interactors |
IntActi | Q16559, 6 interactors |
STRINGi | 9606.ENSP00000334547 |
Miscellaneous databases
RNActi | Q16559, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 54 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 89 – 108 | DisorderedSequence analysisAdd BLAST | 20 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000160867 |
HOGENOMi | CLU_158724_0_0_1 |
InParanoidi | Q16559 |
OMAi | EDCGVPS |
OrthoDBi | 1453623at2759 |
PhylomeDBi | Q16559 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q16559-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY
60 70 80 90 100
INFLVKVLGE QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS
PGPSHHIP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81078 Genomic DNA Translation: AAA60613.1 S69377 Genomic DNA Translation: AAC60629.1 AL158070 Genomic DNA No translation available. BC069422 mRNA Translation: AAH69422.1 BC126373 mRNA Translation: AAI26374.1 BC126375 mRNA Translation: AAI26376.1 |
CCDSi | CCDS6767.1 |
PIRi | A41629 |
RefSeqi | NP_005412.1, NM_005421.2 |
Genome annotation databases
Ensembli | ENST00000334077; ENSP00000334547; ENSG00000186051 |
GeneIDi | 6887 |
KEGGi | hsa:6887 |
MANE-Selecti | ENST00000334077.6; ENSP00000334547.3; NM_005421.3; NP_005412.1 |
UCSCi | uc004bct.4, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81078 Genomic DNA Translation: AAA60613.1 S69377 Genomic DNA Translation: AAC60629.1 AL158070 Genomic DNA No translation available. BC069422 mRNA Translation: AAH69422.1 BC126373 mRNA Translation: AAI26374.1 BC126375 mRNA Translation: AAI26376.1 |
CCDSi | CCDS6767.1 |
PIRi | A41629 |
RefSeqi | NP_005412.1, NM_005421.2 |
3D structure databases
SMRi | Q16559 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112750, 9 interactors |
IntActi | Q16559, 6 interactors |
STRINGi | 9606.ENSP00000334547 |
PTM databases
iPTMneti | Q16559 |
PhosphoSitePlusi | Q16559 |
Genetic variation databases
BioMutai | TAL2 |
DMDMi | 7531207 |
Proteomic databases
MassIVEi | Q16559 |
PaxDbi | Q16559 |
PeptideAtlasi | Q16559 |
PRIDEi | Q16559 |
Protocols and materials databases
Antibodypediai | 29308, 75 antibodies from 23 providers |
DNASUi | 6887 |
Genome annotation databases
Ensembli | ENST00000334077; ENSP00000334547; ENSG00000186051 |
GeneIDi | 6887 |
KEGGi | hsa:6887 |
MANE-Selecti | ENST00000334077.6; ENSP00000334547.3; NM_005421.3; NP_005412.1 |
UCSCi | uc004bct.4, human |
Organism-specific databases
CTDi | 6887 |
DisGeNETi | 6887 |
GeneCardsi | TAL2 |
HGNCi | HGNC:11557, TAL2 |
HPAi | ENSG00000186051, Tissue enriched (skeletal) |
MIMi | 186855, gene |
neXtProti | NX_Q16559 |
OpenTargetsi | ENSG00000186051 |
PharmGKBi | PA36327 |
VEuPathDBi | HostDB:ENSG00000186051 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000160867 |
HOGENOMi | CLU_158724_0_0_1 |
InParanoidi | Q16559 |
OMAi | EDCGVPS |
OrthoDBi | 1453623at2759 |
PhylomeDBi | Q16559 |
TreeFami | TF315153 |
Enzyme and pathway databases
PathwayCommonsi | Q16559 |
SignaLinki | Q16559 |
SIGNORi | Q16559 |
Miscellaneous databases
BioGRID-ORCSi | 6887, 3 hits in 1026 CRISPR screens |
ChiTaRSi | TAL2, human |
GeneWikii | TAL2 |
GenomeRNAii | 6887 |
Pharosi | Q16559, Tbio |
PROi | PR:Q16559 |
RNActi | Q16559, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186051, Expressed in quadriceps femoris and 118 other tissues |
Genevisiblei | Q16559, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAL2_HUMAN | |
Accessioni | Q16559Primary (citable) accession number: Q16559 Secondary accession number(s): A0AVI7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot