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Protein

Calcium-activated potassium channel subunit beta-1

Gene

KCNMB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-activated potassium channel activity Source: GO_Central
  • potassium channel regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.14.1.2 the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-1
Alternative name(s):
BK channel subunit beta-1
Short name:
BKbeta
Short name:
BKbeta1
Short name:
Hbeta1
Calcium-activated potassium channel, subfamily M subunit beta-1
Short name:
Calcium-activated potassium channel subunit beta
Charybdotoxin receptor subunit beta-1
K(VCA)beta-1
Maxi K channel subunit beta-1
Slo-beta-1
Short name:
Slo-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNMB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145936.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6285 KCNMB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603951 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16558

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini40 – 157ExtracellularSequence analysisAdd BLAST118
Transmembranei158 – 178Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini179 – 191CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3779

MalaCards human disease database

More...
MalaCardsi
KCNMB1
MIMi608622 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000145936

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA221

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3038495

Drug and drug target database

More...
DrugBanki
DB01110 Miconazole
DB00721 Procaine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNMB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495100

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870461 – 191Calcium-activated potassium channel subunit beta-1Add BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16558

PeptideAtlas

More...
PeptideAtlasi
Q16558

PRoteomics IDEntifications database

More...
PRIDEi
Q16558

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60914
60915 [Q16558-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16558

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145936 Expressed in 146 organ(s), highest expression level in cauda epididymis

CleanEx database of gene expression profiles

More...
CleanExi
HS_KCNMB1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16558 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109980, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q16558, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000274629

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q16558

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWME Eukaryota
ENOG41116AX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154116

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052223

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16558

KEGG Orthology (KO)

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KOi
K04937

Identification of Orthologs from Complete Genome Data

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OMAi
MLYHTED

Database of Orthologous Groups

More...
OrthoDBi
1178937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16558

TreeFam database of animal gene trees

More...
TreeFami
TF328589

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu

The PANTHER Classification System

More...
PANTHERi
PTHR10258 PTHR10258, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03185 CaKB, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01450 BKCHANNELB

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q16558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKKLVMAQK RGETRALCLG VTMVVCAVIT YYILVTTVLP LYQKSVWTQE
60 70 80 90 100
SKCHLIETNI RDQEELKGKK VPQYPCLWVN VSAAGRWAVL YHTEDTRDQN
110 120 130 140 150
QQCSYIPGSV DNYQTARADV EKVRAKFQEQ QVFYCFSAPR GNETSVLFQR
160 170 180 190
LYGPQALLFS LFWPTFLLTG GLLIIAMVKS NQYLSILAAQ K
Length:191
Mass (Da):21,797
Last modified:March 23, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i547432FF194E770D
GO
Isoform 2 (identifier: Q16558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-130: CSYIPGSVDNYQTARADVEKVRAKFQEQ → VLNWRDGDTSLYPCQVCEPVPNCPCPRG
     131-191: Missing.

Note: No experimental confirmation available.
Show »
Length:130
Mass (Da):14,858
Checksum:i2E612865F4130EEE
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in KCNMB1 can influence the severity of diastolic hypertension (PubMed:15057310).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01932565E → K Has a protective effect against diastolic hypertension. 1 PublicationCorresponds to variant dbSNP:rs11739136EnsemblClinVar.1
Natural variantiVAR_047009110V → L. Corresponds to variant dbSNP:rs2301149Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009822103 – 130CSYIP…KFQEQ → VLNWRDGDTSLYPCQVCEPV PNCPCPRG in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_009823131 – 191Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25138 mRNA Translation: AAB02394.1
U38907 mRNA Translation: AAA81327.1
U42600 mRNA Translation: AAB16827.1
U42601 Genomic DNA Translation: AAB16825.1
U42603, U42602 Genomic DNA Translation: AAB16826.1
U61536 mRNA Translation: AAB61396.1
U61537 Genomic DNA Translation: AAB61397.1
AF026002 mRNA Translation: AAB88805.1
AY044441 mRNA Translation: AAK95827.1
AY515264 mRNA Translation: AAS20193.1
AK313979 mRNA Translation: BAG36693.1
CH471062 Genomic DNA Translation: EAW61474.1
BC025707 mRNA Translation: AAH25707.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4373.1 [Q16558-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68842

NCBI Reference Sequences

More...
RefSeqi
NP_004128.1, NM_004137.3 [Q16558-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.484099
Hs.744947

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274629; ENSP00000274629; ENSG00000145936 [Q16558-1]
ENST00000521859; ENSP00000427940; ENSG00000145936 [Q16558-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3779

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3779

UCSC genome browser

More...
UCSCi
uc003maq.3 human [Q16558-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25138 mRNA Translation: AAB02394.1
U38907 mRNA Translation: AAA81327.1
U42600 mRNA Translation: AAB16827.1
U42601 Genomic DNA Translation: AAB16825.1
U42603, U42602 Genomic DNA Translation: AAB16826.1
U61536 mRNA Translation: AAB61396.1
U61537 Genomic DNA Translation: AAB61397.1
AF026002 mRNA Translation: AAB88805.1
AY044441 mRNA Translation: AAK95827.1
AY515264 mRNA Translation: AAS20193.1
AK313979 mRNA Translation: BAG36693.1
CH471062 Genomic DNA Translation: EAW61474.1
BC025707 mRNA Translation: AAH25707.1
CCDSiCCDS4373.1 [Q16558-1]
PIRiS68842
RefSeqiNP_004128.1, NM_004137.3 [Q16558-1]
UniGeneiHs.484099
Hs.744947

3D structure databases

ProteinModelPortaliQ16558
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109980, 4 interactors
IntActiQ16558, 2 interactors
STRINGi9606.ENSP00000274629

Chemistry databases

ChEMBLiCHEMBL3038495
DrugBankiDB01110 Miconazole
DB00721 Procaine

Protein family/group databases

TCDBi8.A.14.1.2 the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family

PTM databases

PhosphoSitePlusiQ16558

Polymorphism and mutation databases

BioMutaiKCNMB1
DMDMi292495100

Proteomic databases

PaxDbiQ16558
PeptideAtlasiQ16558
PRIDEiQ16558
ProteomicsDBi60914
60915 [Q16558-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274629; ENSP00000274629; ENSG00000145936 [Q16558-1]
ENST00000521859; ENSP00000427940; ENSG00000145936 [Q16558-2]
GeneIDi3779
KEGGihsa:3779
UCSCiuc003maq.3 human [Q16558-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3779
DisGeNETi3779
EuPathDBiHostDB:ENSG00000145936.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNMB1
HGNCiHGNC:6285 KCNMB1
MalaCardsiKCNMB1
MIMi603951 gene
608622 phenotype
neXtProtiNX_Q16558
OpenTargetsiENSG00000145936
PharmGKBiPA221

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWME Eukaryota
ENOG41116AX LUCA
GeneTreeiENSGT00940000154116
HOVERGENiHBG052223
InParanoidiQ16558
KOiK04937
OMAiMLYHTED
OrthoDBi1178937at2759
PhylomeDBiQ16558
TreeFamiTF328589

Enzyme and pathway databases

ReactomeiR-HSA-1296052 Ca2+ activated K+ channels
R-HSA-418457 cGMP effects

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNMB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3779

Protein Ontology

More...
PROi
PR:Q16558

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145936 Expressed in 146 organ(s), highest expression level in cauda epididymis
CleanExiHS_KCNMB1
GenevisibleiQ16558 HS

Family and domain databases

InterProiView protein in InterPro
IPR003930 K_chnl_Ca-activ_BK_bsu
PANTHERiPTHR10258 PTHR10258, 1 hit
PfamiView protein in Pfam
PF03185 CaKB, 1 hit
PRINTSiPR01450 BKCHANNELB

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCMB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16558
Secondary accession number(s): O00707
, O00708, P78475, Q53YR0, Q8TAX3, Q93005
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 23, 2010
Last modified: January 16, 2019
This is version 156 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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