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Protein

Pregnancy-specific beta-1-glycoprotein 3

Gene

PSG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • defense response Source: UniProtKB
  • female pregnancy Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 3
Short name:
PS-beta-G-3
Short name:
PSBG-3
Short name:
Pregnancy-specific glycoprotein 3
Alternative name(s):
Carcinoembryonic antigen SG5
Gene namesi
Name:PSG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000221826.9
HGNCiHGNC:9520 PSG3
MIMi176392 gene
neXtProtiNX_Q16557

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221826
PharmGKBiPA33865

Polymorphism and mutation databases

BioMutaiPSG3
DMDMi108935880

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491035 – 428Pregnancy-specific beta-1-glycoprotein 3Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi169 ↔ 217Curated
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ16557
PeptideAtlasiQ16557
PRIDEiQ16557
ProteomicsDBi60913
TopDownProteomicsiQ16557

PTM databases

iPTMnetiQ16557
PhosphoSitePlusiQ16557

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000221826 Expressed in 58 organ(s), highest expression level in chorionic villus
CleanExiHS_PSG3
ExpressionAtlasiQ16557 baseline and differential
GenevisibleiQ16557 HS

Organism-specific databases

HPAiHPA046327

Interactioni

Protein-protein interaction databases

BioGridi111646, 10 interactors
IntActiQ16557, 5 interactors
MINTiQ16557
STRINGi9606.ENSP00000332215

Structurei

3D structure databases

ProteinModelPortaliQ16557
SMRiQ16557
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ16557
KOiK06500
PhylomeDBiQ16557
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q16557-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPLSAPPCT QRITWKGLLL TALLLNFWNL PTTAQVTIEA EPTKVSKGKD
60 70 80 90 100
VLLLVHNLPQ NLAGYIWYKG QMKDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTREDAGSY TLHIVKRGDG TRGETGHFTF TLYLETPKPS
160 170 180 190 200
ISSSNLYPRE DMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLQLSKNKR
210 220 230 240 250
TLFLFGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN
260 270 280 290 300
PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIQDRYGGIR SYPVTLNVLY GPDLPRIYPS FTYYHSGENL
360 370 380 390 400
YLSCFADSNP PAEYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA
410 420
TGMESSKSMT VKVSAPSGTG HLPGLNPL
Length:428
Mass (Da):47,945
Last modified:June 13, 2006 - v2
Checksum:i98750D7CDA426245
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QX68M0QX68_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG3
475Annotation score:
M0QXP2M0QXP2_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG3
91Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330 – 383Missing (PubMed:2302228).CuratedAdd BLAST54
Sequence conflicti412K → E in AAH05924 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02672223L → S4 PublicationsCorresponds to variant dbSNP:rs11559136Ensembl.1
Natural variantiVAR_01567930L → P4 PublicationsCorresponds to variant dbSNP:rs12185496Ensembl.1
Natural variantiVAR_05940930L → S. Corresponds to variant dbSNP:rs12185496Ensembl.1
Natural variantiVAR_026723198N → T. Corresponds to variant dbSNP:rs16976174Ensembl.1
Natural variantiVAR_049921199K → N. Corresponds to variant dbSNP:rs17173152Ensembl.1
Natural variantiVAR_061323290I → N. Corresponds to variant dbSNP:rs28698193Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34420 mRNA Translation: AAA52606.1
M23575 mRNA Translation: AAA52607.1
M37399 mRNA Translation: AAA60958.1
M93061 mRNA Translation: AAA60207.1
S59493 mRNA Translation: AAC60584.1
AC004654 Genomic DNA Translation: AAC15513.1
AC005337 Genomic DNA No translation available.
BC005924 mRNA Translation: AAH05924.2
AH007624 Genomic DNA Translation: AAD28498.1
CCDSiCCDS12611.1
PIRiI57486
JS0032
RefSeqiNP_066296.2, NM_021016.3
UniGeneiHs.654413

Genome annotation databases

EnsembliENST00000327495; ENSP00000332215; ENSG00000221826
ENST00000614582; ENSP00000480223; ENSG00000221826
GeneIDi5671
KEGGihsa:5671
UCSCiuc002oue.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34420 mRNA Translation: AAA52606.1
M23575 mRNA Translation: AAA52607.1
M37399 mRNA Translation: AAA60958.1
M93061 mRNA Translation: AAA60207.1
S59493 mRNA Translation: AAC60584.1
AC004654 Genomic DNA Translation: AAC15513.1
AC005337 Genomic DNA No translation available.
BC005924 mRNA Translation: AAH05924.2
AH007624 Genomic DNA Translation: AAD28498.1
CCDSiCCDS12611.1
PIRiI57486
JS0032
RefSeqiNP_066296.2, NM_021016.3
UniGeneiHs.654413

3D structure databases

ProteinModelPortaliQ16557
SMRiQ16557
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111646, 10 interactors
IntActiQ16557, 5 interactors
MINTiQ16557
STRINGi9606.ENSP00000332215

PTM databases

iPTMnetiQ16557
PhosphoSitePlusiQ16557

Polymorphism and mutation databases

BioMutaiPSG3
DMDMi108935880

Proteomic databases

PaxDbiQ16557
PeptideAtlasiQ16557
PRIDEiQ16557
ProteomicsDBi60913
TopDownProteomicsiQ16557

Protocols and materials databases

DNASUi5671
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327495; ENSP00000332215; ENSG00000221826
ENST00000614582; ENSP00000480223; ENSG00000221826
GeneIDi5671
KEGGihsa:5671
UCSCiuc002oue.4 human

Organism-specific databases

CTDi5671
EuPathDBiHostDB:ENSG00000221826.9
GeneCardsiPSG3
HGNCiHGNC:9520 PSG3
HPAiHPA046327
MIMi176392 gene
neXtProtiNX_Q16557
OpenTargetsiENSG00000221826
PharmGKBiPA33865
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ16557
KOiK06500
PhylomeDBiQ16557
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSiPSG3 human
GeneWikiiPSG3
GenomeRNAii5671
PROiPR:Q16557
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000221826 Expressed in 58 organ(s), highest expression level in chorionic villus
CleanExiHS_PSG3
ExpressionAtlasiQ16557 baseline and differential
GenevisibleiQ16557 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSG3_HUMAN
AccessioniPrimary (citable) accession number: Q16557
Secondary accession number(s): Q08265
, Q9BRW2, Q9UPL4, Q9UQ77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 13, 2006
Last modified: September 12, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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