Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydropyrimidinase-related protein 2

Gene

DPYSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.3 Publications

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

  • dihydropyrimidinase activity Source: ProtInc
  • identical protein binding Source: IntAct
  • microtubule binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-399956 CRMPs in Sema3A signaling
R-HSA-437239 Recycling pathway of L1
SIGNORiQ16555

Protein family/group databases

MEROPSiM38.975

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 2
Short name:
DRP-2
Alternative name(s):
Collapsin response mediator protein 2
Short name:
CRMP-2
N2A3
Unc-33-like phosphoprotein 2
Short name:
ULIP-2
Gene namesi
Name:DPYSL2
Synonyms:CRMP2, ULIP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000092964.16
HGNCiHGNC:3014 DPYSL2
MIMi602463 gene
neXtProtiNX_Q16555

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi71D → N: Inhibits axon outgrowth formation in hippocampal neurons and decreases binding to CYFIP1. 1 Publication1
Mutagenesisi507S → A: No effect. 1 Publication1
Mutagenesisi509T → A: Greatly diminishes binding to 3F4 antibody. 1 Publication1
Mutagenesisi512T → A: No effect. 1 Publication1
Mutagenesisi514T → A: No effect. 1 Publication1
Mutagenesisi517S → A: No effect. 1 Publication1
Mutagenesisi518S → A: Greatly diminishes binding to 3F4 antibody. 1 Publication1
Mutagenesisi521T → A: No effect. 1 Publication1
Mutagenesisi522S → A: Greatly diminishes binding to 3F4 antibody. 1 Publication1

Organism-specific databases

DisGeNETi1808
OpenTargetsiENSG00000092964
PharmGKBiPA27472

Polymorphism and mutation databases

BioMutaiDPYSL2
DMDMi3122051

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659131 – 572Dihydropyrimidinase-related protein 2Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32Phosphotyrosine; by FYN1 Publication1
Modified residuei258N6-succinyllysineBy similarity1
Modified residuei259PhosphoserineBy similarity1
Modified residuei431PhosphotyrosineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei504S-nitrosocysteineBy similarity1
Modified residuei507PhosphoserineBy similarity1
Modified residuei509PhosphothreonineCombined sources1 Publication1
Modified residuei512PhosphothreonineBy similarity1
Modified residuei514Phosphothreonine; by GSK3-betaCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1 Publication1
Modified residuei521PhosphothreonineBy similarity1
Modified residuei522Phosphoserine; by DYRK2Combined sources2 Publications1
Modified residuei537PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1
Modified residuei555Phosphothreonine; by ROCK2By similarity1
Modified residuei565Asymmetric dimethylarginineBy similarity1

Post-translational modificationi

3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.2 Publications
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.By similarity2 Publications

Keywords - PTMi

Methylation, Phosphoprotein, S-nitrosylation

Proteomic databases

EPDiQ16555
MaxQBiQ16555
PaxDbiQ16555
PeptideAtlasiQ16555
PRIDEiQ16555
ProteomicsDBi60912
TopDownProteomicsiQ16555-1 [Q16555-1]

2D gel databases

REPRODUCTION-2DPAGEiIPI00257508
Q16555
UCD-2DPAGEiQ16555

PTM databases

iPTMnetiQ16555
PhosphoSitePlusiQ16555
SwissPalmiQ16555

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000092964 Expressed in 251 organ(s), highest expression level in brain
CleanExiHS_DPYSL2
ExpressionAtlasiQ16555 baseline and differential
GenevisibleiQ16555 HS

Organism-specific databases

HPAiCAB018719
HPA002381

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108142, 59 interactors
IntActiQ16555, 21 interactors
MINTiQ16555
STRINGi9606.ENSP00000309539

Structurei

Secondary structure

1572
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ16555
SMRiQ16555
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16555

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ16555
KOiK07528
OrthoDBiEOG091G05F3
PhylomeDBiQ16555
TreeFamiTF314706

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030615 DRP2
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF56 PTHR11647:SF56, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16555-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI
60 70 80 90 100
VPGGVKTIEA HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG
110 120 130 140 150
TTMIIDHVVP EPGTSLLAAF DQWREWADSK SCCDYSLHVD ISEWHKGIQE
160 170 180 190 200
EMEALVKDHG VNSFLVYMAF KDRFQLTDCQ IYEVLSVIRD IGAIAQVHAE
210 220 230 240 250
NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRAI TIANQTNCPL
260 270 280 290 300
YITKVMSKSS AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL
360 370 380 390 400
IPEGTNGTEE RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR
410 420 430 440 450
IAVGSDADLV IWDPDSVKTI SAKTHNSSLE YNIFEGMECR GSPLVVISQG
460 470 480 490 500
KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD
510 520 530 540 550
GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI
560 570
PRRTTQRIVA PPGGRANITS LG
Length:572
Mass (Da):62,294
Last modified:November 1, 1996 - v1
Checksum:i5CDB6CF7F5C308AD
GO
Isoform 2 (identifier: Q16555-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):58,163
Checksum:i31806BFCB5FAE16D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1C7CYX9A0A1C7CYX9_HUMAN
Dihydropyrimidinase-related protein...
DPYSL2
677Annotation score:
E5RFU4E5RFU4_HUMAN
Dihydropyrimidinase-related protein...
DPYSL2
170Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022016118A → T. Corresponds to variant dbSNP:rs2228979Ensembl.1
Natural variantiVAR_036316481R → C in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0449411 – 36Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17279 mRNA Translation: AAA93202.1
D78013 mRNA Translation: BAA11191.1
U97105 mRNA Translation: AAC05793.1
AB020777 Genomic DNA Translation: BAA86991.1
AK291287 mRNA Translation: BAF83976.1
AK299077 mRNA Translation: BAG61143.1
AC015564 Genomic DNA No translation available.
AC015743 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63573.1
CH471080 Genomic DNA Translation: EAW63574.1
BC056408 mRNA Translation: AAH56408.1
BC067109 mRNA Translation: AAH67109.1
CCDSiCCDS59096.1 [Q16555-2]
CCDS6051.1 [Q16555-1]
PIRiJC5317
RefSeqiNP_001184222.1, NM_001197293.2
NP_001231533.1, NM_001244604.1 [Q16555-2]
NP_001377.1, NM_001386.5 [Q16555-1]
UniGeneiHs.593187

Genome annotation databases

EnsembliENST00000311151; ENSP00000309539; ENSG00000092964 [Q16555-1]
ENST00000523027; ENSP00000431117; ENSG00000092964 [Q16555-2]
GeneIDi1808
KEGGihsa:1808
UCSCiuc003xfb.3 human [Q16555-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17279 mRNA Translation: AAA93202.1
D78013 mRNA Translation: BAA11191.1
U97105 mRNA Translation: AAC05793.1
AB020777 Genomic DNA Translation: BAA86991.1
AK291287 mRNA Translation: BAF83976.1
AK299077 mRNA Translation: BAG61143.1
AC015564 Genomic DNA No translation available.
AC015743 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63573.1
CH471080 Genomic DNA Translation: EAW63574.1
BC056408 mRNA Translation: AAH56408.1
BC067109 mRNA Translation: AAH67109.1
CCDSiCCDS59096.1 [Q16555-2]
CCDS6051.1 [Q16555-1]
PIRiJC5317
RefSeqiNP_001184222.1, NM_001197293.2
NP_001231533.1, NM_001244604.1 [Q16555-2]
NP_001377.1, NM_001386.5 [Q16555-1]
UniGeneiHs.593187

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GSEX-ray2.40A/B/C/D13-490[»]
2VM8X-ray1.90A/B/C/D13-490[»]
5LXXX-ray1.25A/B13-490[»]
5MKVX-ray1.80A/B/C/D13-516[»]
5MLEX-ray2.48A/C13-516[»]
5X1AX-ray1.82A1-525[»]
5X1CX-ray2.10A/B13-490[»]
5X1DX-ray2.20A1-525[»]
5YZ5X-ray1.80A1-525[»]
5YZAX-ray2.30A1-525[»]
5YZBX-ray2.80A1-525[»]
ProteinModelPortaliQ16555
SMRiQ16555
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108142, 59 interactors
IntActiQ16555, 21 interactors
MINTiQ16555
STRINGi9606.ENSP00000309539

Protein family/group databases

MEROPSiM38.975

PTM databases

iPTMnetiQ16555
PhosphoSitePlusiQ16555
SwissPalmiQ16555

Polymorphism and mutation databases

BioMutaiDPYSL2
DMDMi3122051

2D gel databases

REPRODUCTION-2DPAGEiIPI00257508
Q16555
UCD-2DPAGEiQ16555

Proteomic databases

EPDiQ16555
MaxQBiQ16555
PaxDbiQ16555
PeptideAtlasiQ16555
PRIDEiQ16555
ProteomicsDBi60912
TopDownProteomicsiQ16555-1 [Q16555-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311151; ENSP00000309539; ENSG00000092964 [Q16555-1]
ENST00000523027; ENSP00000431117; ENSG00000092964 [Q16555-2]
GeneIDi1808
KEGGihsa:1808
UCSCiuc003xfb.3 human [Q16555-1]

Organism-specific databases

CTDi1808
DisGeNETi1808
EuPathDBiHostDB:ENSG00000092964.16
GeneCardsiDPYSL2
HGNCiHGNC:3014 DPYSL2
HPAiCAB018719
HPA002381
MIMi602463 gene
neXtProtiNX_Q16555
OpenTargetsiENSG00000092964
PharmGKBiPA27472
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ16555
KOiK07528
OrthoDBiEOG091G05F3
PhylomeDBiQ16555
TreeFamiTF314706

Enzyme and pathway databases

ReactomeiR-HSA-399956 CRMPs in Sema3A signaling
R-HSA-437239 Recycling pathway of L1
SIGNORiQ16555

Miscellaneous databases

ChiTaRSiDPYSL2 human
EvolutionaryTraceiQ16555
GeneWikiiDPYSL2
GenomeRNAii1808
PROiPR:Q16555
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000092964 Expressed in 251 organ(s), highest expression level in brain
CleanExiHS_DPYSL2
ExpressionAtlasiQ16555 baseline and differential
GenevisibleiQ16555 HS

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030615 DRP2
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF56 PTHR11647:SF56, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPYL2_HUMAN
AccessioniPrimary (citable) accession number: Q16555
Secondary accession number(s): A8K5H2
, B4DR31, D3DSS7, O00424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again