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Entry version 194 (10 Apr 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Dihydropyrimidinase-related protein 2

Gene

DPYSL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.3 Publications

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-437239 Recycling pathway of L1

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16555

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M38.975

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 2
Short name:
DRP-2
Alternative name(s):
Collapsin response mediator protein 2
Short name:
CRMP-2
N2A3
Unc-33-like phosphoprotein 2
Short name:
ULIP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPYSL2
Synonyms:CRMP2, ULIP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000092964.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3014 DPYSL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602463 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16555

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi71D → N: Inhibits axon outgrowth formation in hippocampal neurons and decreases binding to CYFIP1. 1 Publication1
Mutagenesisi507S → A: No effect. 1 Publication1
Mutagenesisi509T → A: Greatly diminishes binding to 3F4 antibody. 1 Publication1
Mutagenesisi512T → A: No effect. 1 Publication1
Mutagenesisi514T → A: No effect. 1 Publication1
Mutagenesisi517S → A: No effect. 1 Publication1
Mutagenesisi518S → A: Greatly diminishes binding to 3F4 antibody. 1 Publication1
Mutagenesisi521T → A: No effect. 1 Publication1
Mutagenesisi522S → A: Greatly diminishes binding to 3F4 antibody. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1808

Open Targets

More...
OpenTargetsi
ENSG00000092964

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27472

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPYSL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3122051

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001659131 – 572Dihydropyrimidinase-related protein 2Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32Phosphotyrosine; by FYN1 Publication1
Modified residuei258N6-succinyllysineBy similarity1
Modified residuei259PhosphoserineBy similarity1
Modified residuei431PhosphotyrosineBy similarity1
Modified residuei465PhosphoserineBy similarity1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei504S-nitrosocysteineBy similarity1
Modified residuei507PhosphoserineBy similarity1
Modified residuei509PhosphothreonineCombined sources1 Publication1
Modified residuei512PhosphothreonineBy similarity1
Modified residuei514Phosphothreonine; by GSK3-betaCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1 Publication1
Modified residuei521PhosphothreonineBy similarity1
Modified residuei522Phosphoserine; by DYRK2Combined sources2 Publications1
Modified residuei537PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1
Modified residuei555Phosphothreonine; by ROCK2By similarity1
Modified residuei565Asymmetric dimethylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.2 Publications
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.By similarity2 Publications

Keywords - PTMi

Methylation, Phosphoprotein, S-nitrosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16555

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16555

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q16555

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16555

PeptideAtlas

More...
PeptideAtlasi
Q16555

PRoteomics IDEntifications database

More...
PRIDEi
Q16555

ProteomicsDB human proteome resource

More...
ProteomicsDBi
60912

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q16555-1 [Q16555-1]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00257508
Q16555

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
Q16555

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16555

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16555

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q16555

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000092964 Expressed in 251 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16555 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16555 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018719
HPA002381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108142, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q16555, 21 interactors

Molecular INTeraction database

More...
MINTi
Q16555

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309539

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1572
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GSEX-ray2.40A/B/C/D13-490[»]
2VM8X-ray1.90A/B/C/D13-490[»]
5LXXX-ray1.25A/B13-490[»]
5MKVX-ray1.80A/B/C/D13-516[»]
5MLEX-ray2.48A/C13-516[»]
5X1AX-ray1.82A1-525[»]
5X1CX-ray2.10A/B13-490[»]
5X1DX-ray2.20A1-525[»]
5YZ5X-ray1.80A1-525[»]
5YZAX-ray2.30A1-525[»]
5YZBX-ray2.80A1-525[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q16555

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q16555

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16555

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2584 Eukaryota
COG0044 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182699

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000219145

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000806

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q16555

KEGG Orthology (KO)

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KOi
K07528

Database of Orthologous Groups

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OrthoDBi
719800at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16555

TreeFam database of animal gene trees

More...
TreeFami
TF314706

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01314 D-HYD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006680 Amidohydro-rel
IPR030615 DRP2
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase

The PANTHER Classification System

More...
PANTHERi
PTHR11647:SF56 PTHR11647:SF56, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01979 Amidohydro_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02033 D-hydantoinase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16555-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI
60 70 80 90 100
VPGGVKTIEA HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG
110 120 130 140 150
TTMIIDHVVP EPGTSLLAAF DQWREWADSK SCCDYSLHVD ISEWHKGIQE
160 170 180 190 200
EMEALVKDHG VNSFLVYMAF KDRFQLTDCQ IYEVLSVIRD IGAIAQVHAE
210 220 230 240 250
NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRAI TIANQTNCPL
260 270 280 290 300
YITKVMSKSS AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL
360 370 380 390 400
IPEGTNGTEE RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR
410 420 430 440 450
IAVGSDADLV IWDPDSVKTI SAKTHNSSLE YNIFEGMECR GSPLVVISQG
460 470 480 490 500
KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD
510 520 530 540 550
GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI
560 570
PRRTTQRIVA PPGGRANITS LG
Length:572
Mass (Da):62,294
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CDB6CF7F5C308AD
GO
Isoform 2 (identifier: Q16555-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):58,163
Checksum:i31806BFCB5FAE16D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1C7CYX9A0A1C7CYX9_HUMAN
Dihydropyrimidinase-related protein...
DPYSL2
677Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFU4E5RFU4_HUMAN
Dihydropyrimidinase-related protein...
DPYSL2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022016118A → T. Corresponds to variant dbSNP:rs2228979Ensembl.1
Natural variantiVAR_036316481R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1337153084Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449411 – 36Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U17279 mRNA Translation: AAA93202.1
D78013 mRNA Translation: BAA11191.1
U97105 mRNA Translation: AAC05793.1
AB020777 Genomic DNA Translation: BAA86991.1
AK291287 mRNA Translation: BAF83976.1
AK299077 mRNA Translation: BAG61143.1
AC015564 Genomic DNA No translation available.
AC015743 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63573.1
CH471080 Genomic DNA Translation: EAW63574.1
BC056408 mRNA Translation: AAH56408.1
BC067109 mRNA Translation: AAH67109.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59096.1 [Q16555-2]
CCDS6051.1 [Q16555-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC5317

NCBI Reference Sequences

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RefSeqi
NP_001184222.1, NM_001197293.2
NP_001231533.1, NM_001244604.1 [Q16555-2]
NP_001377.1, NM_001386.5 [Q16555-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.593187

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000311151; ENSP00000309539; ENSG00000092964 [Q16555-1]
ENST00000523027; ENSP00000431117; ENSG00000092964 [Q16555-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1808

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1808

UCSC genome browser

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UCSCi
uc003xfb.3 human [Q16555-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17279 mRNA Translation: AAA93202.1
D78013 mRNA Translation: BAA11191.1
U97105 mRNA Translation: AAC05793.1
AB020777 Genomic DNA Translation: BAA86991.1
AK291287 mRNA Translation: BAF83976.1
AK299077 mRNA Translation: BAG61143.1
AC015564 Genomic DNA No translation available.
AC015743 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63573.1
CH471080 Genomic DNA Translation: EAW63574.1
BC056408 mRNA Translation: AAH56408.1
BC067109 mRNA Translation: AAH67109.1
CCDSiCCDS59096.1 [Q16555-2]
CCDS6051.1 [Q16555-1]
PIRiJC5317
RefSeqiNP_001184222.1, NM_001197293.2
NP_001231533.1, NM_001244604.1 [Q16555-2]
NP_001377.1, NM_001386.5 [Q16555-1]
UniGeneiHs.593187

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GSEX-ray2.40A/B/C/D13-490[»]
2VM8X-ray1.90A/B/C/D13-490[»]
5LXXX-ray1.25A/B13-490[»]
5MKVX-ray1.80A/B/C/D13-516[»]
5MLEX-ray2.48A/C13-516[»]
5X1AX-ray1.82A1-525[»]
5X1CX-ray2.10A/B13-490[»]
5X1DX-ray2.20A1-525[»]
5YZ5X-ray1.80A1-525[»]
5YZAX-ray2.30A1-525[»]
5YZBX-ray2.80A1-525[»]
ProteinModelPortaliQ16555
SMRiQ16555
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108142, 62 interactors
IntActiQ16555, 21 interactors
MINTiQ16555
STRINGi9606.ENSP00000309539

Protein family/group databases

MEROPSiM38.975

PTM databases

iPTMnetiQ16555
PhosphoSitePlusiQ16555
SwissPalmiQ16555

Polymorphism and mutation databases

BioMutaiDPYSL2
DMDMi3122051

2D gel databases

REPRODUCTION-2DPAGEiIPI00257508
Q16555
UCD-2DPAGEiQ16555

Proteomic databases

EPDiQ16555
jPOSTiQ16555
MaxQBiQ16555
PaxDbiQ16555
PeptideAtlasiQ16555
PRIDEiQ16555
ProteomicsDBi60912
TopDownProteomicsiQ16555-1 [Q16555-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311151; ENSP00000309539; ENSG00000092964 [Q16555-1]
ENST00000523027; ENSP00000431117; ENSG00000092964 [Q16555-2]
GeneIDi1808
KEGGihsa:1808
UCSCiuc003xfb.3 human [Q16555-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1808
DisGeNETi1808
EuPathDBiHostDB:ENSG00000092964.16

GeneCards: human genes, protein and diseases

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GeneCardsi
DPYSL2
HGNCiHGNC:3014 DPYSL2
HPAiCAB018719
HPA002381
MIMi602463 gene
neXtProtiNX_Q16555
OpenTargetsiENSG00000092964
PharmGKBiPA27472

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00950000182699
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ16555
KOiK07528
OrthoDBi719800at2759
PhylomeDBiQ16555
TreeFamiTF314706

Enzyme and pathway databases

ReactomeiR-HSA-399956 CRMPs in Sema3A signaling
R-HSA-437239 Recycling pathway of L1
SIGNORiQ16555

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DPYSL2 human
EvolutionaryTraceiQ16555

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DPYSL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1808

Protein Ontology

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PROi
PR:Q16555

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000092964 Expressed in 251 organ(s), highest expression level in brain
ExpressionAtlasiQ16555 baseline and differential
GenevisibleiQ16555 HS

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 1 hit
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030615 DRP2
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF56 PTHR11647:SF56, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPYL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16555
Secondary accession number(s): A8K5H2
, B4DR31, D3DSS7, O00424
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 10, 2019
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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