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Entry version 169 (10 Feb 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Lymphocyte antigen 6E

Gene

LY6E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity).By similarity1 Publication
(Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed:28130445, PubMed:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed:28130445, PubMed:30190477).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q16553

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q16553

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lymphocyte antigen 6ECurated
Short name:
Ly-6E
Alternative name(s):
Retinoic acid-induced gene E protein
Short name:
RIG-E
Stem cell antigen 2
Short name:
SCA-2
Thymic shared antigen 1
Short name:
TSA-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LY6EImported
Synonyms:9804, RIGE, SCA2, TSA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6727, LY6E

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601384, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16553

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000160932.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi36L → A: Complete loss of viral entry enhancement. Abolishes inhibition of human coronaviruses entry. 2 Publications1
Mutagenesisi57I → A: About 50% loss of viral entry enhancement. 1 Publication1
Mutagenesisi99N → A: Abolishes inhibition of human coronaviruses entry. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4061

Open Targets

More...
OpenTargetsi
ENSG00000160932

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30491

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16553, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LY6E

Domain mapping of disease mutations (DMDM)

More...
DMDMi
10720072

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003613821 – 101Lymphocyte antigen 6EAdd BLAST81
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000036139102 – 131Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 48By similarity
Disulfide bondi26 ↔ 35By similarity
Disulfide bondi41 ↔ 71By similarity
Disulfide bondi75 ↔ 92By similarity
Disulfide bondi93 ↔ 98By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi101GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16553

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16553

PeptideAtlas

More...
PeptideAtlasi
Q16553

PRoteomics IDEntifications database

More...
PRIDEi
Q16553

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60911

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q16553, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16553

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16553

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid; in promyelocytic leukemia NB4 and in myeloblast HL-60 cell lines. Activated by IFN-alpha in monocytic cell line U-937 and in peripheral blood monocyte cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160932, Expressed in left adrenal gland and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16553, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16553, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160932, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHRNA4.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110239, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q16553, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428572

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16553, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 101UPAR/Ly6Add BLAST81

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SRPS, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153378

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_141358_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16553

Identification of Orthologs from Complete Genome Data

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OMAi
CSPICPG

Database of Orthologous Groups

More...
OrthoDBi
1493078at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16553

TreeFam database of animal gene trees

More...
TreeFami
TF336080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00117, LU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016054, LY6_UPA_recep-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00021, UPAR_LY6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00134, LU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q16553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIFLPVLLA ALLGVERASS LMCFSCLNQK SNLYCLKPTI CSDQDNYCVT
60 70 80 90 100
VSASAGIGNL VTFGHSLSKT CSPACPIPEG VNVGVASMGI SCCQSFLCNF
110 120 130
SAADGGLRAS VTLLGAGLLL SLLPALLRFG P
Length:131
Mass (Da):13,507
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F6D1157741AFC98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGI6E5RGI6_HUMAN
Lymphocyte antigen 6E
LY6E
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI33E5RI33_HUMAN
Lymphocyte antigen 6E
LY6E
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI58E5RI58_HUMAN
Lymphocyte antigen 6E
LY6E
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIQ1E5RIQ1_HUMAN
Lymphocyte antigen 6E
LY6E
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWF8E7EWF8_HUMAN
Lymphocyte antigen 6E
LY6E
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z68179 mRNA Translation: CAA92321.1
U42376 mRNA Translation: AAC50519.1
U56145 mRNA Translation: AAC50616.1
U66711 Genomic DNA Translation: AAB07513.1
AK311983 mRNA Translation: BAG34922.1
CH471162 Genomic DNA Translation: EAW82287.1
CH471162 Genomic DNA Translation: EAW82288.1
CH471162 Genomic DNA Translation: EAW82290.1
BC119708 mRNA Translation: AAI19709.1
BC119709 mRNA Translation: AAI19710.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6394.1

NCBI Reference Sequences

More...
RefSeqi
NP_001120685.1, NM_001127213.1
NP_002337.1, NM_002346.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292494; ENSP00000292494; ENSG00000160932
ENST00000429120; ENSP00000414307; ENSG00000160932
ENST00000520466; ENSP00000428572; ENSG00000160932
ENST00000521003; ENSP00000428169; ENSG00000160932
ENST00000521699; ENSP00000427915; ENSG00000160932
ENST00000522024; ENSP00000428442; ENSG00000160932
ENST00000522971; ENSP00000428159; ENSG00000160932
ENST00000619718; ENSP00000482517; ENSG00000278032
ENST00000631568; ENSP00000488891; ENSG00000278032
ENST00000632424; ENSP00000488421; ENSG00000278032
ENST00000632516; ENSP00000487664; ENSG00000278032
ENST00000632519; ENSP00000488443; ENSG00000278032
ENST00000632812; ENSP00000488556; ENSG00000278032
ENST00000633451; ENSP00000488559; ENSG00000278032

Database of genes from NCBI RefSeq genomes

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GeneIDi
4061

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4061

UCSC genome browser

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UCSCi
uc003yxm.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68179 mRNA Translation: CAA92321.1
U42376 mRNA Translation: AAC50519.1
U56145 mRNA Translation: AAC50616.1
U66711 Genomic DNA Translation: AAB07513.1
AK311983 mRNA Translation: BAG34922.1
CH471162 Genomic DNA Translation: EAW82287.1
CH471162 Genomic DNA Translation: EAW82288.1
CH471162 Genomic DNA Translation: EAW82290.1
BC119708 mRNA Translation: AAI19709.1
BC119709 mRNA Translation: AAI19710.1
CCDSiCCDS6394.1
RefSeqiNP_001120685.1, NM_001127213.1
NP_002337.1, NM_002346.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi110239, 6 interactors
IntActiQ16553, 4 interactors
STRINGi9606.ENSP00000428572

PTM databases

GlyGeniQ16553, 1 site
iPTMnetiQ16553
PhosphoSitePlusiQ16553

Genetic variation databases

BioMutaiLY6E
DMDMi10720072

Proteomic databases

MassIVEiQ16553
PaxDbiQ16553
PeptideAtlasiQ16553
PRIDEiQ16553
ProteomicsDBi60911

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q16553, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
14558, 197 antibodies

The CPTC Antibody Portal

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CPTCi
Q16553, 3 antibodies

Genome annotation databases

EnsembliENST00000292494; ENSP00000292494; ENSG00000160932
ENST00000429120; ENSP00000414307; ENSG00000160932
ENST00000520466; ENSP00000428572; ENSG00000160932
ENST00000521003; ENSP00000428169; ENSG00000160932
ENST00000521699; ENSP00000427915; ENSG00000160932
ENST00000522024; ENSP00000428442; ENSG00000160932
ENST00000522971; ENSP00000428159; ENSG00000160932
ENST00000619718; ENSP00000482517; ENSG00000278032
ENST00000631568; ENSP00000488891; ENSG00000278032
ENST00000632424; ENSP00000488421; ENSG00000278032
ENST00000632516; ENSP00000487664; ENSG00000278032
ENST00000632519; ENSP00000488443; ENSG00000278032
ENST00000632812; ENSP00000488556; ENSG00000278032
ENST00000633451; ENSP00000488559; ENSG00000278032
GeneIDi4061
KEGGihsa:4061
UCSCiuc003yxm.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4061
DisGeNETi4061

GeneCards: human genes, protein and diseases

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GeneCardsi
LY6E
HGNCiHGNC:6727, LY6E
HPAiENSG00000160932, Low tissue specificity
MIMi601384, gene
neXtProtiNX_Q16553
OpenTargetsiENSG00000160932
PharmGKBiPA30491
VEuPathDBiHostDB:ENSG00000160932.10

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502SRPS, Eukaryota
GeneTreeiENSGT00940000153378
HOGENOMiCLU_141358_0_0_1
InParanoidiQ16553
OMAiCSPICPG
OrthoDBi1493078at2759
PhylomeDBiQ16553
TreeFamiTF336080

Enzyme and pathway databases

PathwayCommonsiQ16553
ReactomeiR-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins
SignaLinkiQ16553

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
4061, 6 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LY6E, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LY6E

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4061
PharosiQ16553, Tbio

Protein Ontology

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PROi
PR:Q16553
RNActiQ16553, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160932, Expressed in left adrenal gland and 216 other tissues
ExpressionAtlasiQ16553, baseline and differential
GenevisibleiQ16553, HS

Family and domain databases

CDDicd00117, LU, 1 hit
InterProiView protein in InterPro
IPR016054, LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021, UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134, LU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLY6E_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16553
Secondary accession number(s): B2R4X5, D3DWJ2, Q0VDE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: February 10, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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