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UniProtKB - Q16552 (IL17_HUMAN)

Entry version 181 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Interleukin-17A

Gene

IL17A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q16552

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-448424, Interleukin-17 signaling
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q16552

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL17A
Synonyms:CTLA8, IL17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000112115.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:5981, IL17A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603149, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q16552

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3605

Open Targets

More...OpenTargetsi		ENSG00000112115

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29794

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q16552, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3390822

Drug and drug target database

More...DrugBanki		DB11569, Ixekizumab
DB09029, Secukinumab

DrugCentral

More...DrugCentrali		Q16552

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL17A

Domain mapping of disease mutations (DMDM)

More...DMDMi		2498481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001542324 – 155Interleukin-17AAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi94 ↔ 1441 Publication
Disulfide bondi99 ↔ 1461 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Found both in glycosylated and nonglycosylated forms.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q16552

PeptideAtlas

More...PeptideAtlasi		Q16552

PRoteomics IDEntifications database

More...PRIDEi		Q16552

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		60910

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q16552, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q16552

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q16552

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to activated memory T-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112115, Expressed in tonsil and 32 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q16552, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112115, Group enriched (lymphoid tissue, tongue, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:19835883). Heterodimer with IL17F (PubMed:17355969).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109818, 10 interactors

Database of interacting proteins

More...DIPi		DIP-6014N

Protein interaction database and analysis system

More...IntActi		Q16552, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000344192

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q16552

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q16552, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q16552

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q16552

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S5A0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161882

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_118641_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q16552

KEGG Orthology (KO)

More...KOi		K05489

Identification of Orthologs from Complete Genome Data

More...OMAi		CPHSFRL

Database of Orthologous Groups

More...OrthoDBi		1469254at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q16552

TreeFam database of animal gene trees

More...TreeFami		TF314701

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR020440, IL-17_chr
IPR010345, IL-17_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06083, IL17, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01932, INTRLEUKIN17

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57501, SSF57501, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q16552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN 
        60         70         80         90        100
IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI 
       110        120        130        140        150
NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI 

VHHVA
Length:155
Mass (Da):17,504
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BCAE9CB2F4886D1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z58820 mRNA Translation: CAA91233.1
U32659 mRNA Translation: AAC50341.1
AY460616 Genomic DNA Translation: AAR23263.1
AL391221 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04362.1
BC066251 mRNA Translation: AAH66251.1
BC066252 mRNA Translation: AAH66252.1
BC067503 mRNA Translation: AAH67503.1
BC067504 mRNA Translation: AAH67504.1
BC067505 mRNA Translation: AAH67505.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4937.1

NCBI Reference Sequences

More...RefSeqi		NP_002181.1, NM_002190.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000648244; ENSP00000497968; ENSG00000112115

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3605

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3605

UCSC genome browser

More...UCSCi		uc003pak.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-17 entry

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z58820 mRNA Translation: CAA91233.1
U32659 mRNA Translation: AAC50341.1
AY460616 Genomic DNA Translation: AAR23263.1
AL391221 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04362.1
BC066251 mRNA Translation: AAH66251.1
BC066252 mRNA Translation: AAH66252.1
BC067503 mRNA Translation: AAH67503.1
BC067504 mRNA Translation: AAH67504.1
BC067505 mRNA Translation: AAH67505.1
CCDSiCCDS4937.1
RefSeqiNP_002181.1, NM_002190.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VXSX-ray2.63A/B/C/D20-155[»]
4HR9X-ray2.48A/B34-155[»]
4HSAX-ray3.15A/B/D/E34-155[»]
4QHUX-ray2.20C/D24-154[»]
5HHVX-ray2.20A/B34-155[»]
5HHXX-ray3.00A/B20-155[»]
5HI3X-ray2.15A/B24-155[»]
5HI4X-ray1.80A/B24-155[»]
5HI5X-ray1.80A/B24-155[»]
5N7WX-ray1.96X/Y1-155[»]
5N92X-ray2.30A24-155[»]
5NANX-ray3.30A/D24-155[»]
5VB9X-ray1.70A/B38-155[»]
SMRiQ16552
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109818, 10 interactors
DIPiDIP-6014N
IntActiQ16552, 7 interactors
STRINGi9606.ENSP00000344192

Chemistry databases

BindingDBiQ16552
ChEMBLiCHEMBL3390822
DrugBankiDB11569, Ixekizumab
DB09029, Secukinumab
DrugCentraliQ16552

PTM databases

GlyGeniQ16552, 1 site
iPTMnetiQ16552
PhosphoSitePlusiQ16552

Polymorphism and mutation databases

BioMutaiIL17A
DMDMi2498481

Proteomic databases

PaxDbiQ16552
PeptideAtlasiQ16552
PRIDEiQ16552
ProteomicsDBi60910

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q16552, 76 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		17132, 1813 antibodies

The DNASU plasmid repository

More...DNASUi		3605

Genome annotation databases

EnsembliENST00000648244; ENSP00000497968; ENSG00000112115
GeneIDi3605
KEGGihsa:3605
UCSCiuc003pak.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3605
DisGeNETi3605
EuPathDBiHostDB:ENSG00000112115.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL17A
HGNCiHGNC:5981, IL17A
HPAiENSG00000112115, Group enriched (lymphoid tissue, tongue, urinary bladder)
MIMi603149, gene
neXtProtiNX_Q16552
OpenTargetsiENSG00000112115
PharmGKBiPA29794

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S5A0, Eukaryota
GeneTreeiENSGT00940000161882
HOGENOMiCLU_118641_0_0_1
InParanoidiQ16552
KOiK05489
OMAiCPHSFRL
OrthoDBi1469254at2759
PhylomeDBiQ16552
TreeFamiTF314701

Enzyme and pathway databases

PathwayCommonsiQ16552
ReactomeiR-HSA-448424, Interleukin-17 signaling
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
SIGNORiQ16552

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3605, 4 hits in 869 CRISPR screens
EvolutionaryTraceiQ16552

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IL17A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3605
PharosiQ16552, Tclin

Protein Ontology

More...PROi		PR:Q16552
RNActiQ16552, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112115, Expressed in tonsil and 32 other tissues
GenevisibleiQ16552, HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034, Cystine-knot_cytokine
IPR020440, IL-17_chr
IPR010345, IL-17_fam
PfamiView protein in Pfam
PF06083, IL17, 1 hit
PRINTSiPR01932, INTRLEUKIN17
SUPFAMiSSF57501, SSF57501, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16552
Secondary accession number(s): Q5T2P0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 181 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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