UniProtKB - Q16552 (IL17_HUMAN)
Interleukin-17A
IL17A
Functioni
GO - Molecular functioni
- cytokine activity Source: ProtInc
- protein homodimerization activity Source: Ensembl
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- apoptotic process Source: ProtInc
- cell-cell signaling Source: ProtInc
- cell death Source: ProtInc
- cellular response to interleukin-1 Source: Ensembl
- cytokine-mediated signaling pathway Source: Reactome
- defense response to fungus Source: Ensembl
- defense response to Gram-negative bacterium Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- fibroblast activation Source: BHF-UCL
- granulocyte migration Source: Ensembl
- immune response Source: ProtInc
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- interleukin-17-mediated signaling pathway Source: UniProtKB
- intestinal epithelial structure maintenance Source: Ensembl
- positive regulation of antimicrobial peptide production Source: Ensembl
- positive regulation of bicellular tight junction assembly Source: Ensembl
- positive regulation of chemokine (C-X-C motif) ligand 1 production Source: UniProtKB
- positive regulation of cytokine production involved in inflammatory response Source: ARUK-UCL
- positive regulation of interleukin-12 production Source: ARUK-UCL
- positive regulation of interleukin-16 production Source: ARUK-UCL
- positive regulation of interleukin-1 beta production Source: ARUK-UCL
- positive regulation of interleukin-23 production Source: BHF-UCL
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of osteoclast differentiation Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of tumor necrosis factor biosynthetic process Source: ARUK-UCL
Keywordsi
Molecular function | Cytokine |
Biological process | Adaptive immunity, Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q16552 |
Reactomei | R-HSA-448424, Interleukin-17 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling |
SIGNORi | Q16552 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-17AShort name: IL-17 Short name: IL-17A Alternative name(s): Cytotoxic T-lymphocyte-associated antigen 8 Short name: CTLA-8 |
Gene namesi | Name:IL17A Synonyms:CTLA8, IL17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112115.5 |
HGNCi | HGNC:5981, IL17A |
MIMi | 603149, gene |
neXtProti | NX_Q16552 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: ProtInc
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 69 | R → A: Impairs binding to IL17RA and IL17RC. 1 Publication | 1 | |
Mutagenesisi | 78 | R → V: Decreases the affinity for IL17RA by 5-fold. 1 Publication | 1 | |
Mutagenesisi | 90 | W → V: Has no effect on the affinity for IL17RA. 1 Publication | 1 | |
Mutagenesisi | 108 | Y → I: Decreases the affinity for IL17RA. 1 Publication | 1 | |
Mutagenesisi | 109 | H → S: Decreases the affinity for IL17RA. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3605 |
OpenTargetsi | ENSG00000112115 |
PharmGKBi | PA29794 |
Miscellaneous databases
Pharosi | Q16552, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3390822 |
DrugBanki | DB11569, Ixekizumab DB09029, Secukinumab |
DrugCentrali | Q16552 |
Polymorphism and mutation databases
BioMutai | IL17A |
DMDMi | 2498481 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 1 PublicationAdd BLAST | 23 | |
ChainiPRO_0000015423 | 24 – 155 | Interleukin-17AAdd BLAST | 132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 94 ↔ 144 | 2 Publications | ||
Disulfide bondi | 99 ↔ 146 | 2 Publications |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q16552 |
PeptideAtlasi | Q16552 |
PRIDEi | Q16552 |
ProteomicsDBi | 60910 |
PTM databases
GlyGeni | Q16552, 1 site |
iPTMneti | Q16552 |
PhosphoSitePlusi | Q16552 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000112115, Expressed in tonsil and 32 other tissues |
Genevisiblei | Q16552, HS |
Organism-specific databases
HPAi | ENSG00000112115, Group enriched (lymphoid tissue, tongue, urinary bladder) |
Interactioni
Subunit structurei
Homodimer (PubMed:19835883). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (PubMed:32187518). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex (PubMed:32187518). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (PubMed:23695682). Heterodimer with IL17F (PubMed:17355969). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (PubMed:32187518). IL17RA and IL17RC chains can not distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:17355969, PubMed:28827714).
5 PublicationsBinary interactionsi
Hide detailsQ16552
With | #Exp. | IntAct |
---|---|---|
DPH2 [Q9BQC3] | 3 | EBI-10237926,EBI-10237931 |
KCNIP4 [Q6PIL6] | 3 | EBI-10237926,EBI-1051469 |
GO - Molecular functioni
- cytokine activity Source: ProtInc
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109818, 11 interactors |
DIPi | DIP-6014N |
IntActi | Q16552, 7 interactors |
STRINGi | 9606.ENSP00000344192 |
Chemistry databases
BindingDBi | Q16552 |
Miscellaneous databases
RNActi | Q16552, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q16552 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q16552 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S5A0, Eukaryota |
GeneTreei | ENSGT00940000161882 |
HOGENOMi | CLU_118641_0_0_1 |
InParanoidi | Q16552 |
OMAi | CPHSFRL |
OrthoDBi | 1469254at2759 |
PhylomeDBi | Q16552 |
TreeFami | TF314701 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN
60 70 80 90 100
IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI
110 120 130 140 150
NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI
VHHVA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z58820 mRNA Translation: CAA91233.1 U32659 mRNA Translation: AAC50341.1 AY460616 Genomic DNA Translation: AAR23263.1 AL391221 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04362.1 BC066251 mRNA Translation: AAH66251.1 BC066252 mRNA Translation: AAH66252.1 BC067503 mRNA Translation: AAH67503.1 BC067504 mRNA Translation: AAH67504.1 BC067505 mRNA Translation: AAH67505.1 |
CCDSi | CCDS4937.1 |
RefSeqi | NP_002181.1, NM_002190.2 |
Genome annotation databases
Ensembli | ENST00000648244; ENSP00000497968; ENSG00000112115 |
GeneIDi | 3605 |
KEGGi | hsa:3605 |
UCSCi | uc003pak.1, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Interleukin-17 entry |
SeattleSNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z58820 mRNA Translation: CAA91233.1 U32659 mRNA Translation: AAC50341.1 AY460616 Genomic DNA Translation: AAR23263.1 AL391221 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04362.1 BC066251 mRNA Translation: AAH66251.1 BC066252 mRNA Translation: AAH66252.1 BC067503 mRNA Translation: AAH67503.1 BC067504 mRNA Translation: AAH67504.1 BC067505 mRNA Translation: AAH67505.1 |
CCDSi | CCDS4937.1 |
RefSeqi | NP_002181.1, NM_002190.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VXS | X-ray | 2.63 | A/B/C/D | 20-155 | [»] | |
4HR9 | X-ray | 2.48 | A/B | 34-155 | [»] | |
4HSA | X-ray | 3.15 | A/B/D/E | 34-155 | [»] | |
4QHU | X-ray | 2.20 | C/D | 24-154 | [»] | |
5HHV | X-ray | 2.20 | A/B | 34-155 | [»] | |
5HHX | X-ray | 3.00 | A/B | 20-155 | [»] | |
5HI3 | X-ray | 2.15 | A/B | 24-155 | [»] | |
5HI4 | X-ray | 1.80 | A/B | 24-155 | [»] | |
5HI5 | X-ray | 1.80 | A/B | 24-155 | [»] | |
5N7W | X-ray | 1.96 | X/Y | 1-155 | [»] | |
5N92 | X-ray | 2.30 | A | 24-155 | [»] | |
5NAN | X-ray | 3.30 | A/D | 24-155 | [»] | |
5VB9 | X-ray | 1.70 | A/B | 38-155 | [»] | |
SMRi | Q16552 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109818, 11 interactors |
DIPi | DIP-6014N |
IntActi | Q16552, 7 interactors |
STRINGi | 9606.ENSP00000344192 |
Chemistry databases
BindingDBi | Q16552 |
ChEMBLi | CHEMBL3390822 |
DrugBanki | DB11569, Ixekizumab DB09029, Secukinumab |
DrugCentrali | Q16552 |
PTM databases
GlyGeni | Q16552, 1 site |
iPTMneti | Q16552 |
PhosphoSitePlusi | Q16552 |
Polymorphism and mutation databases
BioMutai | IL17A |
DMDMi | 2498481 |
Proteomic databases
PaxDbi | Q16552 |
PeptideAtlasi | Q16552 |
PRIDEi | Q16552 |
ProteomicsDBi | 60910 |
Protocols and materials databases
ABCDi | Q16552, 182 sequenced antibodies |
Antibodypediai | 17132, 1814 antibodies |
DNASUi | 3605 |
Genome annotation databases
Ensembli | ENST00000648244; ENSP00000497968; ENSG00000112115 |
GeneIDi | 3605 |
KEGGi | hsa:3605 |
UCSCi | uc003pak.1, human |
Organism-specific databases
CTDi | 3605 |
DisGeNETi | 3605 |
EuPathDBi | HostDB:ENSG00000112115.5 |
GeneCardsi | IL17A |
HGNCi | HGNC:5981, IL17A |
HPAi | ENSG00000112115, Group enriched (lymphoid tissue, tongue, urinary bladder) |
MIMi | 603149, gene |
neXtProti | NX_Q16552 |
OpenTargetsi | ENSG00000112115 |
PharmGKBi | PA29794 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5A0, Eukaryota |
GeneTreei | ENSGT00940000161882 |
HOGENOMi | CLU_118641_0_0_1 |
InParanoidi | Q16552 |
OMAi | CPHSFRL |
OrthoDBi | 1469254at2759 |
PhylomeDBi | Q16552 |
TreeFami | TF314701 |
Enzyme and pathway databases
PathwayCommonsi | Q16552 |
Reactomei | R-HSA-448424, Interleukin-17 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling |
SIGNORi | Q16552 |
Miscellaneous databases
BioGRID-ORCSi | 3605, 4 hits in 840 CRISPR screens |
EvolutionaryTracei | Q16552 |
GeneWikii | IL17A |
GenomeRNAii | 3605 |
Pharosi | Q16552, Tclin |
PROi | PR:Q16552 |
RNActi | Q16552, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112115, Expressed in tonsil and 32 other tissues |
Genevisiblei | Q16552, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL17_HUMAN | |
Accessioni | Q16552Primary (citable) accession number: Q16552 Secondary accession number(s): Q5T2P0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families