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Protein

Interleukin-17A

Gene

IL17A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).3 Publications

GO - Molecular functioni

  • cytokine activity Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell-cell signaling Source: ProtInc
  • cell death Source: ProtInc
  • cellular response to interleukin-1 Source: Ensembl
  • cytokine-mediated signaling pathway Source: Reactome
  • defense response to fungus Source: Ensembl
  • fibroblast activation Source: BHF-UCL
  • immune response Source: ProtInc
  • inflammatory response Source: InterPro
  • interleukin-17-mediated signaling pathway Source: Reactome
  • positive regulation of cytokine production involved in inflammatory response Source: Ensembl
  • positive regulation of interleukin-23 production Source: BHF-UCL
  • positive regulation of interleukin-6 secretion Source: Ensembl
  • positive regulation of osteoclast differentiation Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-448424 Interleukin-17 signaling
R-HSA-6785807 Interleukin-4 and 13 signaling
SIGNORiQ16552

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:IL17A
Synonyms:CTLA8, IL17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112115.5
HGNCiHGNC:5981 IL17A
MIMi603149 gene
neXtProtiNX_Q16552

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3605
OpenTargetsiENSG00000112115
PharmGKBiPA29794

Chemistry databases

ChEMBLiCHEMBL3390822
DrugBankiDB11569 Ixekizumab
DB09029 Secukinumab

Polymorphism and mutation databases

BioMutaiIL17A
DMDMi2498481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001542324 – 155Interleukin-17AAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 1441 Publication
Disulfide bondi99 ↔ 1461 Publication

Post-translational modificationi

Found both in glycosylated and nonglycosylated forms.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ16552
PeptideAtlasiQ16552
PRIDEiQ16552
ProteomicsDBi60910

PTM databases

iPTMnetiQ16552
PhosphoSitePlusiQ16552

Expressioni

Tissue specificityi

Restricted to activated memory T-cells.

Gene expression databases

BgeeiENSG00000112115
CleanExiHS_IL17A
GenevisibleiQ16552 HS

Organism-specific databases

HPAiHPA052258

Interactioni

Subunit structurei

Homodimer (PubMed:19835883). Heterodimer with IL17F (PubMed:17355969).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DPH2Q9BQC33EBI-10237926,EBI-10237931

GO - Molecular functioni

  • cytokine activity Source: ProtInc

Protein-protein interaction databases

BioGridi109818, 10 interactors
DIPiDIP-6014N
IntActiQ16552, 2 interactors
STRINGi9606.ENSP00000344192

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 39Combined sources5
Beta strandi43 – 49Combined sources7
Beta strandi50 – 52Combined sources3
Helixi60 – 62Combined sources3
Helixi66 – 69Combined sources4
Beta strandi70 – 72Combined sources3
Beta strandi74 – 80Combined sources7
Beta strandi84 – 86Combined sources3
Beta strandi88 – 95Combined sources8
Beta strandi97 – 100Combined sources4
Beta strandi104 – 107Combined sources4
Beta strandi110 – 126Combined sources17
Beta strandi133 – 147Combined sources15
Beta strandi151 – 153Combined sources3

3D structure databases

ProteinModelPortaliQ16552
SMRiQ16552
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ16552

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J12P Eukaryota
ENOG410YS4N LUCA
GeneTreeiENSGT00920000149108
HOGENOMiHOG000064520
HOVERGENiHBG006143
InParanoidiQ16552
KOiK05489
OMAiHMNSVPI
OrthoDBiEOG091G0RG1
PhylomeDBiQ16552
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q16552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN
60 70 80 90 100
IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI
110 120 130 140 150
NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI

VHHVA
Length:155
Mass (Da):17,504
Last modified:November 1, 1996 - v1
Checksum:i2BCAE9CB2F4886D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z58820 mRNA Translation: CAA91233.1
U32659 mRNA Translation: AAC50341.1
AY460616 Genomic DNA Translation: AAR23263.1
AL391221 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04362.1
BC066251 mRNA Translation: AAH66251.1
BC066252 mRNA Translation: AAH66252.1
BC067503 mRNA Translation: AAH67503.1
BC067504 mRNA Translation: AAH67504.1
BC067505 mRNA Translation: AAH67505.1
CCDSiCCDS4937.1
RefSeqiNP_002181.1, NM_002190.2
UniGeneiHs.41724

Genome annotation databases

EnsembliENST00000340057; ENSP00000344192; ENSG00000112115
GeneIDi3605
KEGGihsa:3605
UCSCiuc003pak.1 human

Similar proteinsi

Entry informationi

Entry nameiIL17_HUMAN
AccessioniPrimary (citable) accession number: Q16552
Secondary accession number(s): Q5T2P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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