IL17A

Functionⁱ

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).3 Publications

GO - Molecular functionⁱ

cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 7499828

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 7499828
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 7499828
cell death
Source: ProtInc
Traceable author statementⁱ
- 8390535
cellular response to interleukin-1 Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
defense response to fungus Source: Ensembl
fibroblast activation
Source: BHF-UCL
Inferred from direct assayⁱ
- 21145111
granulocyte migration Source: Ensembl
immune response
Source: ProtInc
Traceable author statementⁱ
- 7499828
inflammatory response Source: InterPro
interleukin-17-mediated signaling pathway Source: Reactome
positive regulation of cytokine production involved in inflammatory response Source: Ensembl
positive regulation of interleukin-23 production
Source: BHF-UCL
Inferred from direct assayⁱ
- 21145111
positive regulation of interleukin-6 secretion Source: Ensembl
positive regulation of osteoclast differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17888176
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 16982811

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine

Molecular function

Cytokine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-448424 Interleukin-17 signaling R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORⁱ	Q16552

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-17A Short name: IL-17 Short name: IL-17A Alternative name(s): Cytotoxic T-lymphocyte-associated antigen 8 Short name: CTLA-8
Gene namesⁱ	Name:IL17A Synonyms:CTLA8, IL17
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112115.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5981 IL17A
MIMⁱ	603149 gene
neXtProtⁱ	NX_Q16552

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3605
Open Targets More...OpenTargetsⁱ	ENSG00000112115
PharmGKBⁱ	PA29794

Chemistry databases

ChEMBLⁱ	CHEMBL3390822
Drug and drug target database More...DrugBankⁱ	DB11569 Ixekizumab DB09029 Secukinumab

Polymorphism and mutation databases

BioMutaⁱ	IL17A
DMDMⁱ	2498481

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	1 PublicationAdd BLAST		23
ChainⁱPRO_0000015423	24 – 155	Interleukin-17AAdd BLAST		132

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	94 ↔ 144	1 Publication
Disulfide bondⁱ	99 ↔ 146	1 Publication

Post-translational modificationⁱ

Found both in glycosylated and nonglycosylated forms.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q16552
PeptideAtlas More...PeptideAtlasⁱ	Q16552
PRIDEⁱ	Q16552
ProteomicsDBⁱ	60910

PTM databases

iPTMnetⁱ	Q16552
PhosphoSitePlusⁱ	Q16552

Expressionⁱ

Tissue specificityⁱ

Restricted to activated memory T-cells.

Gene expression databases

Bgeeⁱ	ENSG00000112115 Expressed in 19 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_IL17A
Genevisibleⁱ	Q16552 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052258

HPAⁱ

HPA052258

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:19835883). Heterodimer with IL17F (PubMed:17355969).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DPH2	Q9BQC3	3	EBI-10237926,EBI-10237931

With

Entry

#Exp.

IntAct

Notes

DPH2

Q9BQC3

3

EBI-10237926,EBI-10237931

GO - Molecular functionⁱ

cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 7499828

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109818, 10 interactors
Database of interacting proteins More...DIPⁱ	DIP-6014N
IntActⁱ	Q16552, 2 interactors
STRINGⁱ	9606.ENSP00000344192

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	35 – 39	Combined sources	5
Beta strandⁱ	43 – 49	Combined sources	7
Beta strandⁱ	50 – 52	Combined sources	3
Helixⁱ	60 – 62	Combined sources	3
Helixⁱ	66 – 69	Combined sources	4
Beta strandⁱ	70 – 72	Combined sources	3
Beta strandⁱ	74 – 80	Combined sources	7
Beta strandⁱ	84 – 86	Combined sources	3
Beta strandⁱ	88 – 95	Combined sources	8
Beta strandⁱ	97 – 100	Combined sources	4
Beta strandⁱ	104 – 107	Combined sources	4
Beta strandⁱ	110 – 126	Combined sources	17
Beta strandⁱ	133 – 147	Combined sources	15
Beta strandⁱ	151 – 153	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q16552
SMRⁱ	Q16552
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q16552

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-17 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J12P Eukaryota ENOG410YS4N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149108
HOGENOMⁱ	HOG000064520
HOVERGENⁱ	HBG006143
InParanoidⁱ	Q16552
KEGG Orthology (KO) More...KOⁱ	K05489
OMAⁱ	HMNSVPI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RG1
PhylomeDBⁱ	Q16552
TreeFamⁱ	TF314701

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020440 IL-17_chr IPR010345 IL-17_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06083 IL17, 1 hit
PRINTSⁱ	PR01932 INTRLEUKIN17
SUPFAMⁱ	SSF57501 SSF57501, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q16552-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN 
        60         70         80         90        100
IHNRNTNTNP KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI 
       110        120        130        140        150
NADGNVDYHM NSVPIQQEIL VLRREPPHCP NSFRLEKILV SVGCTCVTPI 

VHHVA

Length:155

Mass (Da):17,504

Last modified:November 1, 1996 - v1

Checksum:ⁱ2BCAE9CB2F4886D1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z58820 mRNA Translation: CAA91233.1 U32659 mRNA Translation: AAC50341.1 AY460616 Genomic DNA Translation: AAR23263.1 AL391221 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04362.1 BC066251 mRNA Translation: AAH66251.1 BC066252 mRNA Translation: AAH66252.1 BC067503 mRNA Translation: AAH67503.1 BC067504 mRNA Translation: AAH67504.1 BC067505 mRNA Translation: AAH67505.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4937.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002181.1, NM_002190.2
UniGeneⁱ	Hs.41724

Genome annotation databases

Ensemblⁱ	ENST00000340057; ENSP00000344192; ENSG00000112115
GeneIDⁱ	3605
KEGGⁱ	hsa:3605
UCSC genome browser More...UCSCⁱ	uc003pak.1 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q16552	Interleukin 17A (Fragment)		HUMAN		46	UniRef100_Q16552
UPI0000595B10		HUMAN		132

Protein	Similar proteins		Species	Score	Length	Source
Q16552	Interleukin 17A (Fragment)		HUMAN		46	UniRef90_Q16552
Interleukin 17A		MACMU		155
IL17A isoform 1		PANTR		155
Uncharacterized protein		PANPA		155
Interleukin 17A		MACFA		155
+22

Protein	Similar proteins		Species	Score	Length	Source
Q16552	Interleukin-17A		BOVIN		153	UniRef50_Q16552
Interleukin-17A		MOUSE		158
Interleukin-17A		RAT		150
Interleukin-17A		PIG		153
Interleukin 17A (Fragment)		HUMAN		46
+159

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Interleukin-17 entry

SeattleSNPs

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z58820 mRNA Translation: CAA91233.1 U32659 mRNA Translation: AAC50341.1 AY460616 Genomic DNA Translation: AAR23263.1 AL391221 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04362.1 BC066251 mRNA Translation: AAH66251.1 BC066252 mRNA Translation: AAH66252.1 BC067503 mRNA Translation: AAH67503.1 BC067504 mRNA Translation: AAH67504.1 BC067505 mRNA Translation: AAH67505.1
CCDSⁱ	CCDS4937.1
RefSeqⁱ	NP_002181.1, NM_002190.2
UniGeneⁱ	Hs.41724

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VXS	X-ray	2.63	A/B/C/D	20-155	[»]
	4HR9	X-ray	2.48	A/B	34-155	[»]
	4HSA	X-ray	3.15	A/B/D/E	34-155	[»]
	4QHU	X-ray	2.20	C/D	24-154	[»]
	5HHV	X-ray	2.20	A/B	34-155	[»]
	5HHX	X-ray	3.00	A/B	20-155	[»]
	5HI3	X-ray	2.15	A/B	24-155	[»]
	5HI4	X-ray	1.80	A/B	24-155	[»]
	5HI5	X-ray	1.80	A/B	24-155	[»]
	5N92	X-ray	2.30	A	24-155	[»]
	5NAN	X-ray	3.30	A/D	24-155	[»]
	5VB9	X-ray	1.70	A/B	38-155	[»]
ProteinModelPortalⁱ	Q16552
SMRⁱ	Q16552
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109818, 10 interactors
DIPⁱ	DIP-6014N
IntActⁱ	Q16552, 2 interactors
STRINGⁱ	9606.ENSP00000344192

Chemistry databases

ChEMBLⁱ	CHEMBL3390822
DrugBankⁱ	DB11569 Ixekizumab DB09029 Secukinumab

PTM databases

iPTMnetⁱ	Q16552
PhosphoSitePlusⁱ	Q16552

Polymorphism and mutation databases

BioMutaⁱ	IL17A
DMDMⁱ	2498481

Proteomic databases

PaxDbⁱ	Q16552
PeptideAtlasⁱ	Q16552
PRIDEⁱ	Q16552
ProteomicsDBⁱ	60910

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3605
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340057; ENSP00000344192; ENSG00000112115
GeneIDⁱ	3605
KEGGⁱ	hsa:3605
UCSCⁱ	uc003pak.1 human

Organism-specific databases

CTDⁱ	3605
DisGeNETⁱ	3605
EuPathDBⁱ	HostDB:ENSG00000112115.5
GeneCardsⁱ	IL17A
HGNCⁱ	HGNC:5981 IL17A
HPAⁱ	HPA052258
MIMⁱ	603149 gene
neXtProtⁱ	NX_Q16552
OpenTargetsⁱ	ENSG00000112115
PharmGKBⁱ	PA29794
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J12P Eukaryota ENOG410YS4N LUCA
GeneTreeⁱ	ENSGT00920000149108
HOGENOMⁱ	HOG000064520
HOVERGENⁱ	HBG006143
InParanoidⁱ	Q16552
KOⁱ	K05489
OMAⁱ	HMNSVPI
OrthoDBⁱ	EOG091G0RG1
PhylomeDBⁱ	Q16552
TreeFamⁱ	TF314701

Enzyme and pathway databases

Reactomeⁱ	R-HSA-448424 Interleukin-17 signaling R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORⁱ	Q16552

Miscellaneous databases

EvolutionaryTraceⁱ	Q16552
GeneWikiⁱ	IL17A
GenomeRNAiⁱ	3605
Protein Ontology More...PROⁱ	PR:Q16552
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112115 Expressed in 19 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_IL17A
Genevisibleⁱ	Q16552 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR020440 IL-17_chr IPR010345 IL-17_fam
Pfamⁱ	View protein in Pfam PF06083 IL17, 1 hit
PRINTSⁱ	PR01932 INTRLEUKIN17
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL17_HUMAN
Accessionⁱ	Q16552Primary (citable) accession number: Q16552 Secondary accession number(s): Q5T2P0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	October 10, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q16552 (IL17_HUMAN)

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Interleukin-17A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ