Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 194 (12 Aug 2020)
Sequence version 2 (22 Jul 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Proprotein convertase subtilisin/kexin type 7

Gene

PCSK7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by zinc and copper.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei187Charge relay systemPROSITE-ProRule annotation1
Active sitei228Charge relay systemPROSITE-ProRule annotation1
Active sitei406Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.B27, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q16549

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q16549

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q16549

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S08.077

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)
Alternative name(s):
Lymphoma proprotein convertase
Prohormone convertase 7
Proprotein convertase 7
Short name:
PC7
Proprotein convertase 8
Short name:
PC8
Short name:
hPC8
Subtilisin/kexin-like protease PC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCSK7
Synonyms:LPC, PC7, PC8, SPC7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160613.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8748, PCSK7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604872, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q16549

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini142 – 667ExtracellularSequence analysisAdd BLAST526
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei668 – 688HelicalSequence analysisAdd BLAST21
Topological domaini689 – 785CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9159

Open Targets

More...
OpenTargetsi
ENSG00000160613

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33094

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q16549, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2232

DrugCentral

More...
DrugCentrali
Q16549

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2387

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PCSK7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205830663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37By similarityAdd BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002711438 – 141By similarityAdd BLAST104
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000027115142 – 785Proprotein convertase subtilisin/kexin type 7Add BLAST644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cysteine residues in the cytoplasmic tail are probably palmitoylated.1 Publication
N-glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei141 – 142Cleavage; by autolysisBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Lipoprotein, Palmitate, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q16549

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q16549

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q16549

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q16549

PeptideAtlas

More...
PeptideAtlasi
Q16549

PRoteomics IDEntifications database

More...
PRIDEi
Q16549

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
60909

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q16549, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q16549

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q16549

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q16549

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160613, Expressed in left coronary artery and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q16549, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q16549, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000160613, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114604, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q16549, 1 interactor

Molecular INTeraction database

More...
MINTi
Q16549

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325917

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16549

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16549, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16549

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini153 – 473Peptidase S8PROSITE-ProRule annotationAdd BLAST321
Domaini481 – 618P/Homo BPROSITE-ProRule annotationAdd BLAST138

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S8 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3525, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157676

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16549

KEGG Orthology (KO)

More...
KOi
K08673

Identification of Orthologs from Complete Genome Data

More...
OMAi
THPCRGN

Database of Orthologous Groups

More...
OrthoDBi
473018at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16549

TreeFam database of animal gene trees

More...
TreeFami
TF314277

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR034182, Kexin/furin
IPR002884, P_dom
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR032815, S8_pro-domain
IPR038466, S8_pro-domain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01483, P_proprotein, 1 hit
PF00082, Peptidase_S8, 1 hit
PF16470, S8_pro-domain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723, SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785, SSF49785, 1 hit
SSF52743, SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51829, P_HOMO_B, 1 hit
PS51892, SUBTILASE, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q16549-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKGRQKVPH LDAPLGLPTC LWLELAGLFL LVPWVMGLAG TGGPDGQGTG
60 70 80 90 100
GPSWAVHLES LEGDGEEETL EQQADALAQA AGLVNAGRIG ELQGHYLFVQ
110 120 130 140 150
PAGHRPALEV EAIRQQVEAV LAGHEAVRWH SEQRLLRRAK RSVHFNDPKY
160 170 180 190 200
PQQWHLNNRR SPGRDINVTG VWERNVTGRG VTVVVVDDGV EHTIQDIAPN
210 220 230 240 250
YSPEGSYDLN SNDPDPMPHP DVENGNHHGT RCAGEIAAVP NNSFCAVGVA
260 270 280 290 300
YGSRIAGIRV LDGPLTDSME AVAFNKHYQI NDIYSCSWGP DDDGKTVDGP
310 320 330 340 350
HQLGKAALQH GVIAGRQGFG SIFVVASGNG GQHNDNCNYD GYANSIYTVT
360 370 380 390 400
IGAVDEEGRM PFYAEECASM LAVTFSGGDK MLRSIVTTDW DLQKGTGCTE
410 420 430 440 450
GHTGTSAAAP LAAGMIALML QVRPCLTWRD VQHIIVFTAT RYEDRRAEWV
460 470 480 490 500
TNEAGFSHSH QHGFGLLNAW RLVNAAKIWT SVPYLASYVS PVLKENKAIP
510 520 530 540 550
QSPRSLEVLW NVSRMDLEMS GLKTLEHVAV TVSITHPRRG SLELKLFCPS
560 570 580 590 600
GMMSLIGAPR SMDSDPNGFN DWTFSTVRCW GERARGTYRL VIRDVGDESF
610 620 630 640 650
QVGILRQWQL TLYGSVWSAV DIRDRQRLLE SAMSGKYLHD DFALPCPPGL
660 670 680 690 700
KIPEEDGYTI TPNTLKTLVL VGCFTVFWTV YYMLEVYLSQ RNVASNQVCR
710 720 730 740 750
SGPCHWPHRS RKAKEEGTEL ESVPLCSSKD PDEVETESRG PPTTSDLLAP
760 770 780
DLLEQGDWSL SQNKSALDCP HQHLDVPHGK EEQIC
Length:785
Mass (Da):86,247
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A268754766C32DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMC0E9PMC0_HUMAN
Proprotein convertase subtilisin/ke...
PCSK7
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6PK65Q6PK65_HUMAN
PCSK7 protein
PCSK7
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIW7E9PIW7_HUMAN
Proprotein convertase subtilisin/ke...
PCSK7
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLM0E9PLM0_HUMAN
Proprotein convertase subtilisin/ke...
PCSK7
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GX40A0A1B0GX40_HUMAN
Proprotein convertase subtilisin/ke...
PCSK7
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52P → A in AAC50417 (PubMed:8615762).Curated1
Sequence conflicti52P → A in AAB03087 (PubMed:8564950).Curated1
Sequence conflicti112A → P in AAC50417 (PubMed:8615762).Curated1
Sequence conflicti112A → P in AAB03087 (PubMed:8564950).Curated1
Sequence conflicti228H → R in BAD96627 (Ref. 6) Curated1
Sequence conflicti353A → T in ACA06037 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044419688L → V. Corresponds to variant dbSNP:rs608620Ensembl.1
Natural variantiVAR_044420689S → N. Corresponds to variant dbSNP:rs45539233Ensembl.1
Natural variantiVAR_044421700R → M. Corresponds to variant dbSNP:rs45574931Ensembl.1
Natural variantiVAR_044422708H → Y. Corresponds to variant dbSNP:rs473131Ensembl.1
Natural variantiVAR_044423711R → Q. Corresponds to variant dbSNP:rs473093Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U40623 mRNA Translation: AAC50417.1
U33849 mRNA Translation: AAB03087.1
BT006870 mRNA Translation: AAP35516.1
AK312429 mRNA Translation: BAG35338.1
AK222907 mRNA Translation: BAD96627.1
EF445005 Genomic DNA Translation: ACA06036.1
EF445005 Genomic DNA Translation: ACA06037.1
CH471065 Genomic DNA Translation: EAW67305.1
BC010696 mRNA Translation: AAH10696.1
AF057710 Genomic DNA Translation: AAD55137.1
AB231710 mRNA Translation: BAE46876.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8382.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S64706

NCBI Reference Sequences

More...
RefSeqi
NP_004707.2, NM_004716.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000320934; ENSP00000325917; ENSG00000160613

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9159

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9159

UCSC genome browser

More...
UCSCi
uc001pqr.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40623 mRNA Translation: AAC50417.1
U33849 mRNA Translation: AAB03087.1
BT006870 mRNA Translation: AAP35516.1
AK312429 mRNA Translation: BAG35338.1
AK222907 mRNA Translation: BAD96627.1
EF445005 Genomic DNA Translation: ACA06036.1
EF445005 Genomic DNA Translation: ACA06037.1
CH471065 Genomic DNA Translation: EAW67305.1
BC010696 mRNA Translation: AAH10696.1
AF057710 Genomic DNA Translation: AAD55137.1
AB231710 mRNA Translation: BAE46876.1
CCDSiCCDS8382.1
PIRiS64706
RefSeqiNP_004707.2, NM_004716.3

3D structure databases

SMRiQ16549
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114604, 1 interactor
IntActiQ16549, 1 interactor
MINTiQ16549
STRINGi9606.ENSP00000325917

Chemistry databases

BindingDBiQ16549
ChEMBLiCHEMBL2232
DrugCentraliQ16549
GuidetoPHARMACOLOGYi2387

Protein family/group databases

MEROPSiS08.077

PTM databases

GlyGeniQ16549, 4 sites
iPTMnetiQ16549
PhosphoSitePlusiQ16549
SwissPalmiQ16549

Polymorphism and mutation databases

BioMutaiPCSK7
DMDMi205830663

Proteomic databases

EPDiQ16549
jPOSTiQ16549
MassIVEiQ16549
PaxDbiQ16549
PeptideAtlasiQ16549
PRIDEiQ16549
ProteomicsDBi60909

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32336, 138 antibodies

The DNASU plasmid repository

More...
DNASUi
9159

Genome annotation databases

EnsembliENST00000320934; ENSP00000325917; ENSG00000160613
GeneIDi9159
KEGGihsa:9159
UCSCiuc001pqr.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9159
DisGeNETi9159
EuPathDBiHostDB:ENSG00000160613.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCSK7
HGNCiHGNC:8748, PCSK7
HPAiENSG00000160613, Low tissue specificity
MIMi604872, gene
neXtProtiNX_Q16549
OpenTargetsiENSG00000160613
PharmGKBiPA33094

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3525, Eukaryota
GeneTreeiENSGT00940000157676
InParanoidiQ16549
KOiK08673
OMAiTHPCRGN
OrthoDBi473018at2759
PhylomeDBiQ16549
TreeFamiTF314277

Enzyme and pathway databases

BRENDAi3.4.21.B27, 2681
PathwayCommonsiQ16549
SignaLinkiQ16549
SIGNORiQ16549

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9159, 24 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PCSK7, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PCSK7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9159
PharosiQ16549, Tchem

Protein Ontology

More...
PROi
PR:Q16549
RNActiQ16549, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160613, Expressed in left coronary artery and 224 other tissues
ExpressionAtlasiQ16549, baseline and differential
GenevisibleiQ16549, HS

Family and domain databases

CDDicd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979, Galactose-bd-like_sf
IPR034182, Kexin/furin
IPR002884, P_dom
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR032815, S8_pro-domain
IPR038466, S8_pro-domain_sf
PfamiView protein in Pfam
PF01483, P_proprotein, 1 hit
PF00082, Peptidase_S8, 1 hit
PF16470, S8_pro-domain, 1 hit
PRINTSiPR00723, SUBTILISIN
SUPFAMiSSF49785, SSF49785, 1 hit
SSF52743, SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829, P_HOMO_B, 1 hit
PS51892, SUBTILASE, 1 hit
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCSK7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16549
Secondary accession number(s): B0YJ60
, Q3C1X1, Q53GM4, Q96FK8, Q9UL57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 22, 2008
Last modified: August 12, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again