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Entry version 192 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Hsp90 co-chaperone Cdc37

Gene

CDC37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q16543

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1227986, Signaling by ERBB2
R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-5637810, Constitutive Signaling by EGFRvIII
R-HSA-8863795, Downregulation of ERBB2 signaling
R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2
R-HSA-9652282, Drug-mediated inhibition of ERBB2 signaling
R-HSA-9664565, Signaling by ERBB2 KD Mutants
R-HSA-9665233, Resistance of ERBB2 KD mutants to trastuzumab
R-HSA-9665244, Resistance of ERBB2 KD mutants to sapitinib
R-HSA-9665245, Resistance of ERBB2 KD mutants to tesevatinib
R-HSA-9665246, Resistance of ERBB2 KD mutants to neratinib
R-HSA-9665247, Resistance of ERBB2 KD mutants to osimertinib
R-HSA-9665249, Resistance of ERBB2 KD mutants to afatinib
R-HSA-9665250, Resistance of ERBB2 KD mutants to AEE788
R-HSA-9665251, Resistance of ERBB2 KD mutants to lapatinib
R-HSA-9665348, Signaling by ERBB2 ECD mutants
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants
R-HSA-9665737, Drug resistance in ERBB2 TMD/JMD mutants

SIGNOR Signaling Network Open Resource

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SIGNORi
Q16543

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q16543, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hsp90 co-chaperone Cdc37
Alternative name(s):
Hsp90 chaperone protein kinase-targeting subunit
p50Cdc37
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDC37
Synonyms:CDC37A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105401.6

Human Gene Nomenclature Database

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HGNCi
HGNC:1735, CDC37

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605065, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q16543

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
11140

Open Targets

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OpenTargetsi
ENSG00000105401

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA402

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q16543, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1795123

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CDC37

Domain mapping of disease mutations (DMDM)

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DMDMi
21542000

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001950571 – 378Hsp90 co-chaperone Cdc37Add BLAST378
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004231972 – 378Hsp90 co-chaperone Cdc37, N-terminally processedAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylvaline; in Hsp90 co-chaperone Cdc37, N-terminally processedCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei78N6-acetyllysineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei154N6-acetyllysineCombined sources1
Modified residuei377PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively sumoylated by UBE2I.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q16543

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q16543

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q16543

MaxQB - The MaxQuant DataBase

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MaxQBi
Q16543

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q16543

PeptideAtlas

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PeptideAtlasi
Q16543

PRoteomics IDEntifications database

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PRIDEi
Q16543

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
60906

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q16543

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q16543

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q16543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q16543

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q16543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105401, Expressed in left lobe of thyroid gland and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q16543, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q16543, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000105401, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23 (PubMed:29127155).

Forms a complex with Hsp90/HSP90AB1 and CDK6 (PubMed:9482106).

Interacts with HSP90AA1 (PubMed:23569206, PubMed:27353360).

Interacts with AR, CDK4, CDK6 and EIF2AK1 (PubMed:11036079, PubMed:11085988, PubMed:9150368, PubMed:9482106).

Interacts with RB1 (By similarity).

Interacts with KSR1 (PubMed:10409742).

Interacts with FLCN, FNIP1 and FNIP2 (PubMed:27353360).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q16543
With#Exp.IntAct
ACTB [P60709]3EBI-295634,EBI-353944
ACTG1 [P63261]3EBI-295634,EBI-351292
AKT1 [P31749]4EBI-295634,EBI-296087
AKT3 [Q9Y243]2EBI-295634,EBI-296115
AMOTL2 [Q9Y2J4]3EBI-295634,EBI-746752
APOE [P02649]3EBI-295634,EBI-1222467
AURKB [Q96GD4]4EBI-295634,EBI-624291
BEND7 - isoform 2 [Q8N7W2-2]3EBI-295634,EBI-10181188
BHLHB9 [Q6PI77]3EBI-295634,EBI-11519926
BLZF1 [Q9H2G9]3EBI-295634,EBI-2548012
BTBD3 [Q9Y2F9]3EBI-295634,EBI-311155
CAMK2A [Q9UQM7]5EBI-295634,EBI-1383687
CAMK2B - isoform 2 [Q13554-3]3EBI-295634,EBI-11523526
CAMK2G - isoform 5 [Q13555-5]3EBI-295634,EBI-12020154
CARD10 [Q9BWT7]3EBI-295634,EBI-3866279
CARD9 - isoform 2 [Q9H257-2]3EBI-295634,EBI-11530605
CAVIN1 [Q6NZI2]3EBI-295634,EBI-2559016
CBY2 - isoform 2 [Q8NA61-2]3EBI-295634,EBI-11524851
CCDC138 - isoform 2 [Q96M89-2]3EBI-295634,EBI-10972887
CCDC152 [Q4G0S7]3EBI-295634,EBI-18398007
CCDC91 - isoform 2 [Q7Z6B0-2]3EBI-295634,EBI-12012082
CCHCR1 - isoform 3 [Q8TD31-3]3EBI-295634,EBI-10175300
CDK15 [Q96Q40]2EBI-295634,EBI-1051975
CDK4 [P11802]12EBI-295634,EBI-295644
CDK6 [Q00534]3EBI-295634,EBI-295663
CDK9 [P50750]3EBI-295634,EBI-1383449
CEP55 [Q53EZ4]3EBI-295634,EBI-747776
CEP70 [Q8NHQ1]3EBI-295634,EBI-739624
CGGBP1 [Q9UFW8]3EBI-295634,EBI-723153
CHUK [O15111]4EBI-295634,EBI-81249
CT45A1 [Q5HYN5]3EBI-295634,EBI-12051833
CTAG1B [P78358]3EBI-295634,EBI-1188472
CUL4B [Q13620]2EBI-295634,EBI-456067
CUTC [Q9NTM9]3EBI-295634,EBI-714918
DISC1 - isoform 2 [Q9NRI5-2]3EBI-295634,EBI-11988027
EGFR [P00533]11EBI-295634,EBI-297353
ERBB2 [P04626]3EBI-295634,EBI-641062
FAM118A [Q9NWS6]3EBI-295634,EBI-8638992
FAM9B [Q8IZU0]3EBI-295634,EBI-10175124
FATE1 [Q969F0]3EBI-295634,EBI-743099
FBXW2 [Q9UKT8]2EBI-295634,EBI-914727
FER [P16591]2EBI-295634,EBI-1380661
FKBP4 [Q02790]3EBI-295634,EBI-1047444
FYN [P06241]3EBI-295634,EBI-515315
GAS7 - isoform 1 [O60861-1]3EBI-295634,EBI-11745923
GAS8 [O95995]3EBI-295634,EBI-1052570
GFAP [P14136]3EBI-295634,EBI-744302
GMCL1 [Q96IK5]3EBI-295634,EBI-2548508
GOLGA2 [Q08379]3EBI-295634,EBI-618309
GOLGA6L9 [A6NEM1]3EBI-295634,EBI-5916454
GRAMD2B [Q96HH9]3EBI-295634,EBI-2832937
GRIPAP1 [Q4V328]3EBI-295634,EBI-717919
HOMER3 [Q9NSC5]3EBI-295634,EBI-748420
HSF2BP [O75031]3EBI-295634,EBI-7116203
HSP90AA1 [P07900]14EBI-295634,EBI-296047
HSP90AB1 [P08238]11EBI-295634,EBI-352572
IFIT3 [O14879]4EBI-295634,EBI-745127
IKBKB [O14920]4EBI-295634,EBI-81266
IKBKE [Q14164]3EBI-295634,EBI-307369
IKBKG [Q9Y6K9]6EBI-295634,EBI-81279
IKZF3 [Q9UKT9]3EBI-295634,EBI-747204
JRK - isoform 2 [O75564-2]3EBI-295634,EBI-17181882
KATNBL1 [Q9H079]3EBI-295634,EBI-715394
KCTD13 [Q8WZ19]3EBI-295634,EBI-742916
KCTD9 [Q7L273]3EBI-295634,EBI-4397613
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-295634,EBI-14069005
KLHL2 [O95198]3EBI-295634,EBI-746999
KRT75 [O95678]3EBI-295634,EBI-2949715
KRT76 [Q01546]3EBI-295634,EBI-2952745
KSR2 [Q6VAB6]6EBI-295634,EBI-6424389
LMNB2 [Q03252]3EBI-295634,EBI-2830427
LRRK2 [Q5S007]7EBI-295634,EBI-5323863
LZTS1 [Q9Y250]3EBI-295634,EBI-1216080
MAD1L1 [Q9Y6D9]3EBI-295634,EBI-742610
MAP3K14 [Q99558]5EBI-295634,EBI-358011
MAP3K7 - isoform 1A [O43318-2]5EBI-295634,EBI-358700
MDFI [Q99750]3EBI-295634,EBI-724076
MID1 [O15344]3EBI-295634,EBI-2340316
MIPOL1 [Q8TD10]3EBI-295634,EBI-2548751
MRPL9 [Q9BYD2]3EBI-295634,EBI-726059
NECAB1 [Q8N987]3EBI-295634,EBI-11956853
NECAB2 - isoform 2 [Q7Z6G3-2]3EBI-295634,EBI-10172876
NOS3 [P29474]4EBI-295634,EBI-1391623
NRIP3 [Q9NQ35]3EBI-295634,EBI-10311735
NT5C1A [Q9BXI3]3EBI-295634,EBI-10441581
PAICS [P22234]3EBI-295634,EBI-712261
PDE9A - isoform PDE9A2 [O76083-2]3EBI-295634,EBI-11524542
PDIK1L [Q8N165]2EBI-295634,EBI-6423298
PIBF1 [Q4G0R1]3EBI-295634,EBI-14066006
PNMA2 [Q9UL42]3EBI-295634,EBI-302355
POU6F2 [P78424]3EBI-295634,EBI-12029004
PPP5C [P53041]5EBI-295634,EBI-716663
PRKAR1B [P31321]3EBI-295634,EBI-2805516
PRMT1 - isoform 3 [Q99873-3]3EBI-295634,EBI-17165527
PRMT5 [O14744]3EBI-295634,EBI-351098
PRPH [P41219]3EBI-295634,EBI-752074
PRR20D [P86480]3EBI-295634,EBI-12754095
PSEN1 [P49768]3EBI-295634,EBI-297277
PSKH2 [Q96QS6]2EBI-295634,EBI-6424813
PSMC6 [P62333]3EBI-295634,EBI-357669
PTK6 [Q13882]4EBI-295634,EBI-1383632
RABGEF1 - isoform 3 [Q9UJ41-4]3EBI-295634,EBI-14093916
RAF1 [P04049]6EBI-295634,EBI-365996
REEP6 - isoform 2 [Q96HR9-2]3EBI-295634,EBI-14065960
ROPN1 [Q9HAT0]3EBI-295634,EBI-1378139
SEPTIN3 [Q9UH03]3EBI-295634,EBI-727037
SQSTM1 [Q13501]8EBI-295634,EBI-307104
SRC [P12931]4EBI-295634,EBI-621482
SRRM4 [A7MD48]3EBI-295634,EBI-3867173
SSNA1 [O43805]3EBI-295634,EBI-2515299
STK11 [Q15831]3EBI-295634,EBI-306838
STK32A - isoform 2 [Q8WU08-2]3EBI-295634,EBI-13046508
STK38L [Q9Y2H1]6EBI-295634,EBI-991501
STX1A [Q16623]3EBI-295634,EBI-712466
SYCE2 [Q6PIF2]3EBI-295634,EBI-11958386
SYCP3 [Q8IZU3]3EBI-295634,EBI-7574149
TCF4 - isoform SEF2-1D [P15884-3]3EBI-295634,EBI-13636688
THAP1 [Q9NVV9]3EBI-295634,EBI-741515
THAP7 [Q9BT49]3EBI-295634,EBI-741350
TNFAIP1 [Q13829]3EBI-295634,EBI-2505861
TNIP1 [Q15025]3EBI-295634,EBI-357849
TRAF2 [Q12933]3EBI-295634,EBI-355744
TRAF3 [Q13114]3EBI-295634,EBI-357631
TRAF5 [O00463]3EBI-295634,EBI-523498
TRIM54 [Q9BYV2]3EBI-295634,EBI-2130429
USHBP1 [Q8N6Y0]3EBI-295634,EBI-739895
YES1 [P07947]4EBI-295634,EBI-515331
ZBED1 [O96006]3EBI-295634,EBI-740037
ZBTB26 [Q9HCK0]3EBI-295634,EBI-3918996
ZBTB8A [Q96BR9]3EBI-295634,EBI-742740
ZNF276 [Q8N554]3EBI-295634,EBI-750821
ZNF655 [Q8N720]3EBI-295634,EBI-625509
ZNF837 [Q96EG3]3EBI-295634,EBI-11962574
ZNF843 [Q8N446]2EBI-295634,EBI-6428016
EIF2AK1 [P33279] from Oryctolagus cuniculus.3EBI-295634,EBI-640100
P11500 from Oryctolagus cuniculus.3EBI-295634,EBI-640126

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116312, 409 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3285, HSP90B-CDC37 chaperone complex
CPX-3288, HSP90A-CDC37 chaperone complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q16543

Database of interacting proteins

More...
DIPi
DIP-27560N

Protein interaction database and analysis system

More...
IntActi
Q16543, 396 interactors

Molecular INTeraction database

More...
MINTi
Q16543

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222005

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q16543

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q16543, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1378
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q16543

Small Angle Scattering Biological Data Bank

More...
SASBDBi
Q16543

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q16543

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q16543

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDC37 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2260, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013443

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q16543

KEGG Orthology (KO)

More...
KOi
K09554

Database of Orthologous Groups

More...
OrthoDBi
786744at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q16543

TreeFam database of animal gene trees

More...
TreeFami
TF101059

Family and domain databases

Database of protein disorder

More...
DisProti
DP01420

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.610, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004918, Cdc37
IPR013873, Cdc37_C
IPR013874, Cdc37_Hsp90-bd
IPR038189, Cdc37_Hsp90-bd_sf
IPR013855, Cdc37_N_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12800, PTHR12800, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08564, CDC37_C, 1 hit
PF08565, CDC37_M, 1 hit
PF03234, CDC37_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01069, CDC37_C, 1 hit
SM01070, CDC37_M, 1 hit
SM01071, CDC37_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q16543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL
60 70 80 90 100
DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ
110 120 130 140 150
KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT
160 170 180 190 200
FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH LVCEETANYL VIWCIDLEVE
210 220 230 240 250
EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK IKTADRQYME
260 270 280 290 300
GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES
310 320 330 340 350
LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE
360 370
AKEGEEAGPG DPLLEAVPKT GDEKDVSV
Length:378
Mass (Da):44,468
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55BFEFFF3C2A5442
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKQ2K7EKQ2_HUMAN
Hsp90 co-chaperone Cdc37
CDC37
353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQA9K7EQA9_HUMAN
Hsp90 chaperone protein kinase-targ...
CDC37
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL68K7EL68_HUMAN
Hsp90 co-chaperone Cdc37
CDC37
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ06K7EJ06_HUMAN
Hsp90 co-chaperone Cdc37
CDC37
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIU0K7EIU0_HUMAN
Hsp90 co-chaperone Cdc37
CDC37
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022220360G → E1 PublicationCorresponds to variant dbSNP:rs280528Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43077 mRNA Translation: AAB63979.1
U63131 mRNA Translation: AAB04798.1
AY864824 Genomic DNA Translation: AAW34362.1
BT006796 mRNA Translation: AAP35442.1
CH471106 Genomic DNA Translation: EAW84101.1
BC000083 mRNA Translation: AAH00083.1
BC008793 mRNA Translation: AAH08793.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12237.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G02313

NCBI Reference Sequences

More...
RefSeqi
NP_008996.1, NM_007065.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222005; ENSP00000222005; ENSG00000105401

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11140

UCSC genome browser

More...
UCSCi
uc002mof.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43077 mRNA Translation: AAB63979.1
U63131 mRNA Translation: AAB04798.1
AY864824 Genomic DNA Translation: AAW34362.1
BT006796 mRNA Translation: AAP35442.1
CH471106 Genomic DNA Translation: EAW84101.1
BC000083 mRNA Translation: AAH00083.1
BC008793 mRNA Translation: AAH08793.1
CCDSiCCDS12237.1
PIRiG02313
RefSeqiNP_008996.1, NM_007065.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1US7X-ray2.30B127-378[»]
2K5BNMR-B148-276[»]
2N5XNMR-A288-378[»]
2NCANMR-A1-126[»]
2W0GX-ray1.88A148-276[»]
5FWKelectron microscopy3.90E1-378[»]
5FWLelectron microscopy9.00E1-378[»]
5FWMelectron microscopy8.00E1-378[»]
5FWPelectron microscopy7.20E1-378[»]
5HPEX-ray2.27A5-20[»]
BMRBiQ16543
SASBDBiQ16543
SMRiQ16543
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116312, 409 interactors
ComplexPortaliCPX-3285, HSP90B-CDC37 chaperone complex
CPX-3288, HSP90A-CDC37 chaperone complex
CORUMiQ16543
DIPiDIP-27560N
IntActiQ16543, 396 interactors
MINTiQ16543
STRINGi9606.ENSP00000222005

Chemistry databases

BindingDBiQ16543
ChEMBLiCHEMBL1795123

Protein family/group databases

MoonDBiQ16543, Predicted

PTM databases

iPTMnetiQ16543
MetOSiteiQ16543
PhosphoSitePlusiQ16543
SwissPalmiQ16543

Polymorphism and mutation databases

BioMutaiCDC37
DMDMi21542000

Proteomic databases

EPDiQ16543
jPOSTiQ16543
MassIVEiQ16543
MaxQBiQ16543
PaxDbiQ16543
PeptideAtlasiQ16543
PRIDEiQ16543
ProteomicsDBi60906
TopDownProteomicsiQ16543

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1136, 546 antibodies

The DNASU plasmid repository

More...
DNASUi
11140

Genome annotation databases

EnsembliENST00000222005; ENSP00000222005; ENSG00000105401
GeneIDi11140
KEGGihsa:11140
UCSCiuc002mof.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11140
DisGeNETi11140
EuPathDBiHostDB:ENSG00000105401.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDC37
HGNCiHGNC:1735, CDC37
HPAiENSG00000105401, Low tissue specificity
MIMi605065, gene
neXtProtiNX_Q16543
OpenTargetsiENSG00000105401
PharmGKBiPA402

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2260, Eukaryota
GeneTreeiENSGT00390000013443
InParanoidiQ16543
KOiK09554
OrthoDBi786744at2759
PhylomeDBiQ16543
TreeFamiTF101059

Enzyme and pathway databases

PathwayCommonsiQ16543
ReactomeiR-HSA-1227986, Signaling by ERBB2
R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-5637810, Constitutive Signaling by EGFRvIII
R-HSA-8863795, Downregulation of ERBB2 signaling
R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2
R-HSA-9652282, Drug-mediated inhibition of ERBB2 signaling
R-HSA-9664565, Signaling by ERBB2 KD Mutants
R-HSA-9665233, Resistance of ERBB2 KD mutants to trastuzumab
R-HSA-9665244, Resistance of ERBB2 KD mutants to sapitinib
R-HSA-9665245, Resistance of ERBB2 KD mutants to tesevatinib
R-HSA-9665246, Resistance of ERBB2 KD mutants to neratinib
R-HSA-9665247, Resistance of ERBB2 KD mutants to osimertinib
R-HSA-9665249, Resistance of ERBB2 KD mutants to afatinib
R-HSA-9665250, Resistance of ERBB2 KD mutants to AEE788
R-HSA-9665251, Resistance of ERBB2 KD mutants to lapatinib
R-HSA-9665348, Signaling by ERBB2 ECD mutants
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants
R-HSA-9665737, Drug resistance in ERBB2 TMD/JMD mutants
SIGNORiQ16543

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11140, 706 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDC37, human
EvolutionaryTraceiQ16543

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CDC37

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11140
PharosiQ16543, Tbio

Protein Ontology

More...
PROi
PR:Q16543
RNActiQ16543, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105401, Expressed in left lobe of thyroid gland and 235 other tissues
ExpressionAtlasiQ16543, baseline and differential
GenevisibleiQ16543, HS

Family and domain databases

DisProtiDP01420
Gene3Di1.20.58.610, 1 hit
InterProiView protein in InterPro
IPR004918, Cdc37
IPR013873, Cdc37_C
IPR013874, Cdc37_Hsp90-bd
IPR038189, Cdc37_Hsp90-bd_sf
IPR013855, Cdc37_N_dom
PANTHERiPTHR12800, PTHR12800, 1 hit
PfamiView protein in Pfam
PF08564, CDC37_C, 1 hit
PF08565, CDC37_M, 1 hit
PF03234, CDC37_N, 1 hit
SMARTiView protein in SMART
SM01069, CDC37_C, 1 hit
SM01070, CDC37_M, 1 hit
SM01071, CDC37_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC37_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q16543
Secondary accession number(s): Q53YA2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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