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Protein

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

Gene

PPP2R5E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

  • protein phosphatase regulator activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-196299 Beta-catenin phosphorylation cascade
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-432142 Platelet sensitization by LDL
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated
R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated
R-HSA-5467337 APC truncation mutants have impaired AXIN binding
R-HSA-5467340 AXIN missense mutants destabilize the destruction complex
R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5673000 RAF activation
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-68877 Mitotic Prometaphase
SignaLinkiQ16537

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Alternative name(s):
PP2A B subunit isoform B'-epsilon
PP2A B subunit isoform B56-epsilon
PP2A B subunit isoform PR61-epsilon
PP2A B subunit isoform R5-epsilon
Gene namesi
Name:PPP2R5E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000154001.13
HGNCiHGNC:9313 PPP2R5E
MIMi601647 gene
neXtProtiNX_Q16537

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5529
OpenTargetsiENSG00000154001
PharmGKBiPA33677

Polymorphism and mutation databases

DMDMi7387498

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000714542 – 467Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei7PhosphothreonineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on serine residues.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ16537
MaxQBiQ16537
PaxDbiQ16537
PeptideAtlasiQ16537
PRIDEiQ16537

PTM databases

iPTMnetiQ16537
PhosphoSitePlusiQ16537

Expressioni

Gene expression databases

BgeeiENSG00000154001
CleanExiHS_PPP2R5E
GenevisibleiQ16537 HS

Organism-specific databases

HPAiCAB072342
HPA006034

Interactioni

Subunit structurei

Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111521, 72 interactors
ELMiQ16537
IntActiQ16537, 37 interactors
MINTiQ16537
STRINGi9606.ENSP00000337641

Structurei

3D structure databases

ProteinModelPortaliQ16537
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2085 Eukaryota
ENOG410XQJW LUCA
GeneTreeiENSGT00550000074525
HOGENOMiHOG000067326
HOVERGENiHBG000009
InParanoidiQ16537
KOiK11584
OMAiCCTVFDF
OrthoDBiEOG091G06HU
PhylomeDBiQ16537
TreeFamiTF105556

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002554 PP2A_B56
PANTHERiPTHR10257 PTHR10257, 1 hit
PfamiView protein in Pfam
PF01603 B56, 1 hit
PIRSFiPIRSF028043 PP2A_B56, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q16537-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL
60 70 80 90 100
LKDVPSSEQP ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI
110 120 130 140 150
TISRGCLTEQ TYPEVVRMVS CNIFRTLPPS DSNEFDPEED EPTLEASWPH
160 170 180 190 200
LQLVYEFFIR FLESQEFQPS IAKKYIDQKF VLQLLELFDS EDPRERDYLK
210 220 230 240 250
TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE LLEILGSIIN
260 270 280 290 300
GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE
310 320 330 340 350
PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK
360 370 380 390 400
CVSSPHFQVA ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN
410 420 430 440 450
PAIVALVYNV LKAFMEMNST MFDELTATYK SDRQREKKKE KEREELWKKL
460
EDLELKRGLR RDGIIPT
Length:467
Mass (Da):54,699
Last modified:November 1, 1996 - v1
Checksum:iDD9CE11433F499CF
GO
Isoform 2 (identifier: Q16537-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-435: KSDRQR → N

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):54,043
Checksum:iC37302CC366D270C
GO
Isoform 3 (identifier: Q16537-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:391
Mass (Da):46,180
Checksum:i076E305A94E9F54B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194R → W in BAH14801 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551631 – 76Missing in isoform 3. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_054588430 – 435KSDRQR → N in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69029 mRNA Translation: CAA93153.1
L76703 mRNA Translation: AAB69752.1
AK316430 mRNA Translation: BAH14801.1
AL118555 Genomic DNA No translation available.
AL132992 Genomic DNA No translation available.
AL136038 Genomic DNA No translation available.
BC093766 mRNA Translation: AAH93766.1
BC101479 mRNA Translation: AAI01480.1
BC143231 mRNA Translation: AAI43232.1
BC143234 mRNA Translation: AAI43235.1
CCDSiCCDS61467.1 [Q16537-3]
CCDS61468.1 [Q16537-2]
CCDS9758.1 [Q16537-1]
RefSeqiNP_001269108.1, NM_001282179.1 [Q16537-1]
NP_001269109.1, NM_001282180.1 [Q16537-2]
NP_001269110.1, NM_001282181.1 [Q16537-3]
NP_001269111.1, NM_001282182.1 [Q16537-3]
NP_006237.1, NM_006246.3 [Q16537-1]
UniGeneiHs.334868
Hs.594347

Genome annotation databases

EnsembliENST00000337537; ENSP00000337641; ENSG00000154001 [Q16537-1]
ENST00000422769; ENSP00000404632; ENSG00000154001 [Q16537-3]
ENST00000555899; ENSP00000452396; ENSG00000154001 [Q16537-2]
GeneIDi5529
KEGGihsa:5529
UCSCiuc001xgd.3 human [Q16537-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei2A5E_HUMAN
AccessioniPrimary (citable) accession number: Q16537
Secondary accession number(s): A4FU37
, B7ZAW5, B7ZKK8, B7ZKK9, J3KQN6, Q52LW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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