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Protein

Hepatic leukemia factor

Gene

HLF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ16534
SIGNORiQ16534

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatic leukemia factor
Gene namesi
Name:HLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108924.13
HGNCiHGNC:4977 HLF
MIMi142385 gene
neXtProtiNX_Q16534

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi3131
MalaCardsiHLF
OpenTargetsiENSG00000108924
Orphaneti99860 Precursor B-cell acute lymphoblastic leukemia
PharmGKBiPA29311

Polymorphism and mutation databases

BioMutaiHLF
DMDMi6919907

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765101 – 295Hepatic leukemia factorAdd BLAST295

Proteomic databases

PaxDbiQ16534
PeptideAtlasiQ16534
PRIDEiQ16534
ProteomicsDBi60897

PTM databases

PhosphoSitePlusiQ16534

Expressioni

Tissue specificityi

Highly expressed in liver; lower levels in lung and kidney.

Inductioni

Accumulates according to a robust circadian rhythm.By similarity

Gene expression databases

BgeeiENSG00000108924 Expressed in 215 organ(s), highest expression level in frontal cortex
CleanExiHS_HLF
ExpressionAtlasiQ16534 baseline and differential
GenevisibleiQ16534 HS

Organism-specific databases

HPAiHPA068156
HPA071210

Interactioni

Subunit structurei

Binds DNA specifically as homodimer or heterodimer with other PAR factors.

Protein-protein interaction databases

BioGridi109376, 4 interactors
CORUMiQ16534
IntActiQ16534, 28 interactors
STRINGi9606.ENSP00000226067

Structurei

3D structure databases

ProteinModelPortaliQ16534
SMRiQ16534
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 288bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 247Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni248 – 255Leucine-zipperPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 209Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
HOGENOMiHOG000234383
HOVERGENiHBG004983
InParanoidiQ16534
KOiK09057
OMAiMEKMSRQ
OrthoDBiEOG091G0EO0
PhylomeDBiQ16534
TreeFamiTF315869

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029829 HLF
PANTHERiPTHR11988:SF28 PTHR11988:SF28, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q16534-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKMSRPLPL NPTFIPPPYG VLRSLLENPL KLPLHHEDAF SKDKDKEKKL
60 70 80 90 100
DDESNSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS
110 120 130 140 150
PSQHDHSPHP PGLQPASSAA PSVMDLSSRA SAPLHPGIPS PNCMQSPIRP
160 170 180 190 200
GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGQ EMFDPRKRKF
210 220 230 240 250
SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE
260 270 280 290
NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL
Length:295
Mass (Da):33,199
Last modified:November 1, 1996 - v1
Checksum:i80572A727BBB5635
GO
Isoform 2 (identifier: Q16534-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):23,477
Checksum:iCF954DE7F11388D5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4R4I3L4R4_HUMAN
Hepatic leukemia factor
HLF
236Annotation score:
I3L386I3L386_HUMAN
Hepatic leukemia factor
HLF
77Annotation score:

Sequence cautioni

The sequence AAA58445 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_008515253I → F in fusion protein; decreases DNA-binding activity. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0538521 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95585 mRNA Translation: AAA52675.1
M95586 mRNA Translation: AAA58445.1 Different initiation.
X68985 mRNA Translation: CAA48777.1
AK290043 mRNA Translation: BAF82732.1
AK315079 mRNA Translation: BAG37547.1
CR541672 mRNA Translation: CAG46473.1
AC007638 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94544.1
BC036093 mRNA Translation: AAH36093.1
CCDSiCCDS11585.1 [Q16534-1]
CCDS82164.1 [Q16534-2]
PIRiA44064
RefSeqiNP_001317304.1, NM_001330375.1 [Q16534-2]
NP_002117.1, NM_002126.4 [Q16534-1]
UniGeneiHs.196952

Genome annotation databases

EnsembliENST00000226067; ENSP00000226067; ENSG00000108924 [Q16534-1]
ENST00000430986; ENSP00000402496; ENSG00000108924 [Q16534-2]
ENST00000573945; ENSP00000460296; ENSG00000108924 [Q16534-2]
ENST00000575345; ENSP00000460572; ENSG00000108924 [Q16534-2]
GeneIDi3131
KEGGihsa:3131
UCSCiuc002iug.2 human [Q16534-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95585 mRNA Translation: AAA52675.1
M95586 mRNA Translation: AAA58445.1 Different initiation.
X68985 mRNA Translation: CAA48777.1
AK290043 mRNA Translation: BAF82732.1
AK315079 mRNA Translation: BAG37547.1
CR541672 mRNA Translation: CAG46473.1
AC007638 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94544.1
BC036093 mRNA Translation: AAH36093.1
CCDSiCCDS11585.1 [Q16534-1]
CCDS82164.1 [Q16534-2]
PIRiA44064
RefSeqiNP_001317304.1, NM_001330375.1 [Q16534-2]
NP_002117.1, NM_002126.4 [Q16534-1]
UniGeneiHs.196952

3D structure databases

ProteinModelPortaliQ16534
SMRiQ16534
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109376, 4 interactors
CORUMiQ16534
IntActiQ16534, 28 interactors
STRINGi9606.ENSP00000226067

PTM databases

PhosphoSitePlusiQ16534

Polymorphism and mutation databases

BioMutaiHLF
DMDMi6919907

Proteomic databases

PaxDbiQ16534
PeptideAtlasiQ16534
PRIDEiQ16534
ProteomicsDBi60897

Protocols and materials databases

DNASUi3131
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226067; ENSP00000226067; ENSG00000108924 [Q16534-1]
ENST00000430986; ENSP00000402496; ENSG00000108924 [Q16534-2]
ENST00000573945; ENSP00000460296; ENSG00000108924 [Q16534-2]
ENST00000575345; ENSP00000460572; ENSG00000108924 [Q16534-2]
GeneIDi3131
KEGGihsa:3131
UCSCiuc002iug.2 human [Q16534-1]

Organism-specific databases

CTDi3131
DisGeNETi3131
EuPathDBiHostDB:ENSG00000108924.13
GeneCardsiHLF
HGNCiHGNC:4977 HLF
HPAiHPA068156
HPA071210
MalaCardsiHLF
MIMi142385 gene
neXtProtiNX_Q16534
OpenTargetsiENSG00000108924
Orphaneti99860 Precursor B-cell acute lymphoblastic leukemia
PharmGKBiPA29311
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
HOGENOMiHOG000234383
HOVERGENiHBG004983
InParanoidiQ16534
KOiK09057
OMAiMEKMSRQ
OrthoDBiEOG091G0EO0
PhylomeDBiQ16534
TreeFamiTF315869

Enzyme and pathway databases

SignaLinkiQ16534
SIGNORiQ16534

Miscellaneous databases

ChiTaRSiHLF human
GeneWikiiHLF_(gene)
GenomeRNAii3131
PROiPR:Q16534
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108924 Expressed in 215 organ(s), highest expression level in frontal cortex
CleanExiHS_HLF
ExpressionAtlasiQ16534 baseline and differential
GenevisibleiQ16534 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029829 HLF
PANTHERiPTHR11988:SF28 PTHR11988:SF28, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHLF_HUMAN
AccessioniPrimary (citable) accession number: Q16534
Secondary accession number(s): A8K1X8, Q6FHS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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