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Protein

snRNA-activating protein complex subunit 1

Gene

SNAPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.1 Publication

GO - Molecular functioni

  • sequence-specific DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
snRNA-activating protein complex subunit 1
Short name:
SNAPc subunit 1
Alternative name(s):
Proximal sequence element-binding transcription factor subunit gamma
Short name:
PSE-binding factor subunit gamma
Short name:
PTF subunit gamma
Small nuclear RNA-activating complex polypeptide 1
snRNA-activating protein complex 43 kDa subunit
Short name:
SNAPc 43 kDa subunit
Gene namesi
Name:SNAPC1
Synonyms:SNAP43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000023608.4
HGNCiHGNC:11134 SNAPC1
MIMi600591 gene
neXtProtiNX_Q16533

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6617
OpenTargetsiENSG00000023608
PharmGKBiPA35982

Polymorphism and mutation databases

BioMutaiSNAPC1
DMDMi8134716

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000720171 – 368snRNA-activating protein complex subunit 1Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ16533
MaxQBiQ16533
PaxDbiQ16533
PeptideAtlasiQ16533
PRIDEiQ16533
ProteomicsDBi60896

PTM databases

iPTMnetiQ16533
PhosphoSitePlusiQ16533

Expressioni

Gene expression databases

BgeeiENSG00000023608 Expressed in 218 organ(s), highest expression level in cartilage tissue
CleanExiHS_SNAPC1
GenevisibleiQ16533 HS

Organism-specific databases

HPAiHPA067076
HPA072276

Interactioni

Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC1 interacts with SNAPC3, SNAPC4 and TBP.2 Publications

Protein-protein interaction databases

BioGridi112501, 93 interactors
CORUMiQ16533
DIPiDIP-504N
IntActiQ16533, 5 interactors
STRINGi9606.ENSP00000216294

Structurei

3D structure databases

ProteinModelPortaliQ16533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 168SNAPC3-bindingAdd BLAST168
Regioni164 – 268SNAPC4-bindingAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi347 – 352Poly-Glu6

Phylogenomic databases

eggNOGiKOG4746 Eukaryota
ENOG410Z6WG LUCA
GeneTreeiENSGT00390000018691
HOGENOMiHOG000294209
HOVERGENiHBG058831
InParanoidiQ16533
KOiK15208
OMAiCGKMRNL
OrthoDBiEOG091G0R68
PhylomeDBiQ16533
TreeFamiTF324445

Family and domain databases

InterProiView protein in InterPro
IPR019188 SNAPc_SNAP43
PANTHERiPTHR15131 PTHR15131, 1 hit
PfamiView protein in Pfam
PF09808 SNAPc_SNAP43, 1 hit

Sequencei

Sequence statusi: Complete.

Q16533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE
60 70 80 90 100
KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA
110 120 130 140 150
LKDWDEVLKF QQDLVNAQHF DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK
160 170 180 190 200
KIHRAEVTEE FKDPSDRVMK LITSDVLEEM LNVHDHYQNM KHVISVDKSK
210 220 230 240 250
PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN DGEEKMEGNS
260 270 280 290 300
QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ
310 320 330 340 350
VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE
360
NESLSGTEFT ASKKRRKH
Length:368
Mass (Da):42,994
Last modified:November 1, 1996 - v1
Checksum:i324E89CF8B540C32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47542 mRNA Translation: CAA87590.1
U44754 mRNA Translation: AAC50358.1
BC014984 mRNA Translation: AAH14984.1
BC019038 mRNA Translation: AAH19038.1
CCDSiCCDS9755.1
PIRiJC6081
RefSeqiNP_003073.1, NM_003082.3
UniGeneiHs.179312

Genome annotation databases

EnsembliENST00000216294; ENSP00000216294; ENSG00000023608
GeneIDi6617
KEGGihsa:6617
UCSCiuc001xft.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47542 mRNA Translation: CAA87590.1
U44754 mRNA Translation: AAC50358.1
BC014984 mRNA Translation: AAH14984.1
BC019038 mRNA Translation: AAH19038.1
CCDSiCCDS9755.1
PIRiJC6081
RefSeqiNP_003073.1, NM_003082.3
UniGeneiHs.179312

3D structure databases

ProteinModelPortaliQ16533
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112501, 93 interactors
CORUMiQ16533
DIPiDIP-504N
IntActiQ16533, 5 interactors
STRINGi9606.ENSP00000216294

PTM databases

iPTMnetiQ16533
PhosphoSitePlusiQ16533

Polymorphism and mutation databases

BioMutaiSNAPC1
DMDMi8134716

Proteomic databases

EPDiQ16533
MaxQBiQ16533
PaxDbiQ16533
PeptideAtlasiQ16533
PRIDEiQ16533
ProteomicsDBi60896

Protocols and materials databases

DNASUi6617
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216294; ENSP00000216294; ENSG00000023608
GeneIDi6617
KEGGihsa:6617
UCSCiuc001xft.3 human

Organism-specific databases

CTDi6617
DisGeNETi6617
EuPathDBiHostDB:ENSG00000023608.4
GeneCardsiSNAPC1
HGNCiHGNC:11134 SNAPC1
HPAiHPA067076
HPA072276
MIMi600591 gene
neXtProtiNX_Q16533
OpenTargetsiENSG00000023608
PharmGKBiPA35982
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4746 Eukaryota
ENOG410Z6WG LUCA
GeneTreeiENSGT00390000018691
HOGENOMiHOG000294209
HOVERGENiHBG058831
InParanoidiQ16533
KOiK15208
OMAiCGKMRNL
OrthoDBiEOG091G0R68
PhylomeDBiQ16533
TreeFamiTF324445

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

ChiTaRSiSNAPC1 human
GeneWikiiSNAPC1
GenomeRNAii6617
PROiPR:Q16533
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000023608 Expressed in 218 organ(s), highest expression level in cartilage tissue
CleanExiHS_SNAPC1
GenevisibleiQ16533 HS

Family and domain databases

InterProiView protein in InterPro
IPR019188 SNAPc_SNAP43
PANTHERiPTHR15131 PTHR15131, 1 hit
PfamiView protein in Pfam
PF09808 SNAPc_SNAP43, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNPC1_HUMAN
AccessioniPrimary (citable) accession number: Q16533
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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