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UniProtKB - Q16527 (CSRP2_HUMAN)
Protein
Cysteine and glycine-rich protein 2
Gene
CSRP2
Organism
Homo sapiens (Human)
Status
Functioni
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
GO - Molecular functioni
- actinin binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- structural constituent of muscle Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- cell differentiation Source: UniProtKB
- muscle tissue development Source: GO_Central
- sarcomere organization Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q16527 |
SignaLinki | Q16527 |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine and glycine-rich protein 2Alternative name(s): Cysteine-rich protein 2 Short name: CRP2 LIM domain only protein 5 Short name: LMO-5 Smooth muscle cell LIM protein Short name: SmLIM |
Gene namesi | Name:CSRP2 Synonyms:LMO5, SMLIM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2470, CSRP2 |
MIMi | 601871, gene |
neXtProti | NX_Q16527 |
VEuPathDBi | HostDB:ENSG00000175183 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- focal adhesion Source: UniProtKB
- Z disc Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 1466 |
OpenTargetsi | ENSG00000175183 |
PharmGKBi | PA26968 |
Miscellaneous databases
Pharosi | Q16527, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295833 |
Genetic variation databases
BioMutai | CSRP2 |
DMDMi | 2497674 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075721 | 1 – 193 | Cysteine and glycine-rich protein 2Add BLAST | 193 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 91 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 112 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 131 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 137 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 137 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 161 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q16527 |
jPOSTi | Q16527 |
MassIVEi | Q16527 |
MaxQBi | Q16527 |
PaxDbi | Q16527 |
PeptideAtlasi | Q16527 |
PRIDEi | Q16527 |
ProteomicsDBi | 60894 |
PTM databases
iPTMneti | Q16527 |
MetOSitei | Q16527 |
PhosphoSitePlusi | Q16527 |
Expressioni
Tissue specificityi
Highly expressed in the aorta, but not in heart and skeletal muscle.
Gene expression databases
Bgeei | ENSG00000175183, Expressed in frontal cortex and 244 other tissues |
ExpressionAtlasi | Q16527, baseline and differential |
Genevisiblei | Q16527, HS |
Organism-specific databases
HPAi | ENSG00000175183, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction.
Interacts with GLRX3 (By similarity).
By similarityBinary interactionsi
Q16527
With | #Exp. | IntAct |
---|---|---|
ARC [Q7LC44] | 3 | EBI-2959737,EBI-750550 |
COG6 [Q9Y2V7] | 3 | EBI-2959737,EBI-3866319 |
TRIM23 [P36406] | 3 | EBI-2959737,EBI-740098 |
TRIM27 [P14373] | 3 | EBI-2959737,EBI-719493 |
GO - Molecular functioni
- actinin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107848, 30 interactors |
IntActi | Q16527, 21 interactors |
MINTi | Q16527 |
STRINGi | 9606.ENSP00000310901 |
Miscellaneous databases
RNActi | Q16527, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 61 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 119 – 170 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 52 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 64 – 69 | Nuclear localization signalSequence analysis | 6 |
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG1700, Eukaryota |
GeneTreei | ENSGT00940000154980 |
HOGENOMi | CLU_054591_1_0_1 |
InParanoidi | Q16527 |
OrthoDBi | 1214165at2759 |
PhylomeDBi | Q16527 |
TreeFami | TF313758 |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00132, LIM, 2 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q16527-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA
60 70 80 90 100
IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP
110 120 130 140 150
TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG
160 170 180 190
KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VW96 | F8VW96_HUMAN | Cysteine and glycine-rich protein 2 | CSRP2 | 243 | Annotation score: | ||
F8VQR7 | F8VQR7_HUMAN | Cysteine and glycine-rich protein 2 | CSRP2 | 187 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46006 mRNA Translation: AAC27344.1 U57646 mRNA Translation: AAC51753.1 U95018 Genomic DNA Translation: AAC51755.1 BT019913 mRNA Translation: AAV38716.1 BC000992 mRNA Translation: AAH00992.1 |
CCDSi | CCDS9015.1 |
RefSeqi | NP_001287894.1, NM_001300965.1 NP_001312.1, NM_001321.2 |
Genome annotation databases
Ensembli | ENST00000311083; ENSP00000310901; ENSG00000175183 ENST00000546966; ENSP00000450056; ENSG00000175183 |
GeneIDi | 1466 |
KEGGi | hsa:1466 |
MANE-Selecti | ENST00000311083.10; ENSP00000310901.5; NM_001321.3; NP_001312.1 |
UCSCi | uc001syl.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U46006 mRNA Translation: AAC27344.1 U57646 mRNA Translation: AAC51753.1 U95018 Genomic DNA Translation: AAC51755.1 BT019913 mRNA Translation: AAV38716.1 BC000992 mRNA Translation: AAH00992.1 |
CCDSi | CCDS9015.1 |
RefSeqi | NP_001287894.1, NM_001300965.1 NP_001312.1, NM_001321.2 |
3D structure databases
SMRi | Q16527 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107848, 30 interactors |
IntActi | Q16527, 21 interactors |
MINTi | Q16527 |
STRINGi | 9606.ENSP00000310901 |
Chemistry databases
ChEMBLi | CHEMBL4295833 |
PTM databases
iPTMneti | Q16527 |
MetOSitei | Q16527 |
PhosphoSitePlusi | Q16527 |
Genetic variation databases
BioMutai | CSRP2 |
DMDMi | 2497674 |
Proteomic databases
EPDi | Q16527 |
jPOSTi | Q16527 |
MassIVEi | Q16527 |
MaxQBi | Q16527 |
PaxDbi | Q16527 |
PeptideAtlasi | Q16527 |
PRIDEi | Q16527 |
ProteomicsDBi | 60894 |
Protocols and materials databases
Antibodypediai | 29699, 244 antibodies from 34 providers |
DNASUi | 1466 |
Genome annotation databases
Ensembli | ENST00000311083; ENSP00000310901; ENSG00000175183 ENST00000546966; ENSP00000450056; ENSG00000175183 |
GeneIDi | 1466 |
KEGGi | hsa:1466 |
MANE-Selecti | ENST00000311083.10; ENSP00000310901.5; NM_001321.3; NP_001312.1 |
UCSCi | uc001syl.2, human |
Organism-specific databases
CTDi | 1466 |
DisGeNETi | 1466 |
GeneCardsi | CSRP2 |
HGNCi | HGNC:2470, CSRP2 |
HPAi | ENSG00000175183, Low tissue specificity |
MIMi | 601871, gene |
neXtProti | NX_Q16527 |
OpenTargetsi | ENSG00000175183 |
PharmGKBi | PA26968 |
VEuPathDBi | HostDB:ENSG00000175183 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1700, Eukaryota |
GeneTreei | ENSGT00940000154980 |
HOGENOMi | CLU_054591_1_0_1 |
InParanoidi | Q16527 |
OrthoDBi | 1214165at2759 |
PhylomeDBi | Q16527 |
TreeFami | TF313758 |
Enzyme and pathway databases
PathwayCommonsi | Q16527 |
SignaLinki | Q16527 |
Miscellaneous databases
BioGRID-ORCSi | 1466, 7 hits in 1050 CRISPR screens |
GeneWikii | CSRP2 |
GenomeRNAii | 1466 |
Pharosi | Q16527, Tbio |
PROi | PR:Q16527 |
RNActi | Q16527, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175183, Expressed in frontal cortex and 244 other tissues |
ExpressionAtlasi | Q16527, baseline and differential |
Genevisiblei | Q16527, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00132, LIM, 2 hits |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CSRP2_HUMAN | |
Accessioni | Q16527Primary (citable) accession number: Q16527 Secondary accession number(s): Q93030 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 174 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot