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Protein

Cysteine and glycine-rich protein 2

Gene

CSRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB
  • multicellular organism development Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 2
Alternative name(s):
Cysteine-rich protein 2
Short name:
CRP2
LIM domain only protein 5
Short name:
LMO-5
Smooth muscle cell LIM protein
Short name:
SmLIM
Gene namesi
Name:CSRP2
Synonyms:LMO5, SMLIM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000175183.9
HGNCiHGNC:2470 CSRP2
MIMi601871 gene
neXtProtiNX_Q16527

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1466
OpenTargetsiENSG00000175183
PharmGKBiPA26968

Polymorphism and mutation databases

BioMutaiCSRP2
DMDMi2497674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757211 – 193Cysteine and glycine-rich protein 2Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei112N6-acetyllysineBy similarity1
Modified residuei131N6-acetyllysineBy similarity1
Modified residuei137N6-acetyllysine; alternateBy similarity1
Modified residuei137N6-succinyllysine; alternateBy similarity1
Modified residuei161N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ16527
MaxQBiQ16527
PaxDbiQ16527
PeptideAtlasiQ16527
PRIDEiQ16527
ProteomicsDBi60894

PTM databases

iPTMnetiQ16527
PhosphoSitePlusiQ16527

Expressioni

Tissue specificityi

Highly expressed in the aorta, but not in heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000175183
CleanExiHS_CSRP2
ExpressionAtlasiQ16527 baseline and differential
GenevisibleiQ16527 HS

Organism-specific databases

HPAiHPA045617

Interactioni

Subunit structurei

Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM27P143733EBI-2959737,EBI-719493

Protein-protein interaction databases

BioGridi107848, 13 interactors
IntActiQ16527, 17 interactors
MINTiQ16527
STRINGi9606.ENSP00000310901

Structurei

3D structure databases

ProteinModelPortaliQ16527
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 61LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST52
Domaini119 – 170LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi64 – 69Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi63 – 78Gly-richAdd BLAST16
Compositional biasi176 – 187Gly-richAdd BLAST12

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITHU Eukaryota
ENOG41128N9 LUCA
GeneTreeiENSGT00550000074548
HOGENOMiHOG000111233
HOVERGENiHBG051143
InParanoidiQ16527
KOiK09377
PhylomeDBiQ16527
TreeFamiTF313758

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q16527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVWGGGNKC GACGRTVYHA EEVQCDGRSF HRCCFLCMVC RKNLDSTTVA
60 70 80 90 100
IHDEEIYCKS CYGKKYGPKG YGYGQGAGTL NMDRGERLGI KPESVQPHRP
110 120 130 140 150
TTNPNTSKFA QKYGGAEKCS RCGDSVYAAE KIIGAGKPWH KNCFRCAKCG
160 170 180 190
KSLESTTLTE KEGEIYCKGC YAKNFGPKGF GYGQGAGALV HAQ
Length:193
Mass (Da):20,954
Last modified:January 23, 2007 - v3
Checksum:i2E4231D6427579E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46006 mRNA Translation: AAC27344.1
U57646 mRNA Translation: AAC51753.1
U95018 Genomic DNA Translation: AAC51755.1
BT019913 mRNA Translation: AAV38716.1
BC000992 mRNA Translation: AAH00992.1
CCDSiCCDS9015.1
RefSeqiNP_001287894.1, NM_001300965.1
NP_001312.1, NM_001321.2
UniGeneiHs.530904

Genome annotation databases

EnsembliENST00000311083; ENSP00000310901; ENSG00000175183
ENST00000546966; ENSP00000450056; ENSG00000175183
GeneIDi1466
KEGGihsa:1466
UCSCiuc001syl.2 human

Similar proteinsi

Entry informationi

Entry nameiCSRP2_HUMAN
AccessioniPrimary (citable) accession number: Q16527
Secondary accession number(s): Q93030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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